Organization of the Hippocampal-Septal Axis

  • Allan Siegel
  • Henry Edinger
Part of the Advances in Behavioral Biology book series (ABBI, volume 20)


The series of studies described below and in the following chapter (8) represent an attempt to determine the nature of the neural relationships that exist between the hippocampus and septum of the mammal. It represents a multidisciplinary approach of brain stimulation, neuroanatomy, and neurophysiology.


Dorsal Hippocampus Medial Septum Ventral Hippocampus Lateral Septum Septal Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Adey, W. R., Dunlop, C. W. and Hendrix, C. E. Hippocampal slow waves, Arch. Neurol. (Chic.) 3 (1960) 74–90.CrossRefGoogle Scholar
  2. 2.
    Ahmed, S. S. and Harvey, J. A. Long-term effects of septal lesions and social experience on shock-elicited fighting in rats, J. Comp. Physiol. Psychol., 66 (1968) 596–602.CrossRefGoogle Scholar
  3. 3.
    Andy, O. J., Webster, C. L., Mukawa, J. and Bonn, P. Electrophysiological comparisons of the dorsal and ventral hippo-campus. In. p. Passouant (Ed.), Physiologie de L’Hippocampe, C.N.R.S., Paris, 1961, p. 411.Google Scholar
  4. 4.
    Bard, P. and Mountcastle, V. B. Some forebrain mechanisms involved in expression of rage with special reference to suppression of angry behavior, Ass.Res. Nerv. Ment. Dis., 27 (1948) 362–404.Google Scholar
  5. 5.
    Blanchard, R. J. and Blanchard, D. C. Limbic lesions and reflexive fighting, J. Comp Physiol. Psychol, 66 (1968) 603–605.CrossRefGoogle Scholar
  6. 6.
    Brady, J. V. and Nauta, W. J. H. Subcortical mechanisms in emotional behavior: affective changes following septalGoogle Scholar
  7. forebrain lesions in the albino rat, J. Comp. Physiol. Psychol., 46 (1953) 339–346.CrossRefGoogle Scholar
  8. 7.
    Clody, D. E. and Carlton, D. L. Behavioral effects of lesions of the medial septum of rats, J. Comp. Physiol. Psychol., 67 (1969) 344–351.CrossRefGoogle Scholar
  9. 8.
    Edinger, H. M. and Siegel, A. Functional aspects of the hippocampal-septal axis. This volume.Google Scholar
  10. 9.
    Elul, R. Regional differences in the hippocampus of the cat, Electroenceph. Clin. Neurophysiol., 16 (1964) 470–502.CrossRefGoogle Scholar
  11. 10.
    Green, J. D., Clemente, C. D. and DeGroot, J. Experimentally induced epilepsy with injury to Ammon’s horn, Arch. Neurol. Psychiat. (Chic.), 78 (1957) 259–263.CrossRefGoogle Scholar
  12. 11.
    Harrison, J. M. and Lyon, M. The role of the septal nuclei and components of the fornix in the behavior of the rat, J. Comp. Neurol. 108 (1957) 121–137.CrossRefGoogle Scholar
  13. 12.
    Hernandez-Peon, R., Cevez-Ibarra, G., Morgane, P. J. and Timolaria, C. Limbic cholinergic pathways involved in sleep and emotional behavior, Exp. Neurol, 8 (1963) 93–111.Google Scholar
  14. 13.
    Hughes, K. R. Dorsal and ventral hippocampal lesions and maze learning: influence of preoperative environment, Canad. J. Psychol., 19 (1965) 325–332.Google Scholar
  15. 14.
    Jasper, H. H. and Ajmone Marsan, C. A. Stereotaxic Atlas of the Diencephalon of the cat, Nat. Res. Council Canada: Ottawa, 1954.Google Scholar
  16. 15.
    Johnson, T. N. An experimental study of the fornix and hypothalamotegmental tracts in the cat. J. Comp. Neurol., 125 (1965) 29–40.CrossRefGoogle Scholar
  17. 16.
    Kaada, B. R., Jansen, J. Jr. and Andersen, P. Stimulation of the hippocampus and medial cortical areas in unanesthetized cats, Neurology (Minneap.), 3 (1953) 844–847.CrossRefGoogle Scholar
  18. 17.
    King, F. A. Effects of septal and amygdaloid lesions on emotional behavior and conditioned avoidance responses in the rat, J. Nerv. Ment. Dis., 126 (1958) 57–63.CrossRefGoogle Scholar
  19. 18.
    Maclean, P. D. and Delgado, J. M. R. Electrical and chemical stimulation of fronto-temporal portion of limbic system in the waking animal, Electroenceph. clin. Neurophysiol., 5 (1953) 91–100.Google Scholar
  20. 19.
    Nauta, W. J. H. An experimental study of the fornix system in the rat, J. Comp. Neurol., 104 (1956) 247–271.CrossRefGoogle Scholar
  21. 20.
    Nauta, W. J. H. Hippocampal projections and related neural pathways to the midbrain in the cat. Brain, 81 (1958) 319340.Google Scholar
  22. 21.
    Papez, J. W. A proposed mechanism of emotion, Arch. Neurol. Psychiat. (Chic.), 28 (1937) 725–743.Google Scholar
  23. 22.
    Powell, T. P. S. and Cowan, W. M. An experimental study of the efferent connections of the hippocampus, Brain, 78 (1955) 115–132.CrossRefGoogle Scholar
  24. 23.
    Raisman, G. The connections of the septum. Brain, 89 (1966) 317–348.CrossRefGoogle Scholar
  25. 24.
    Raisman, G., Cowan, W. M. and Powell, T. P. S. An experimental analysis of the efferent projection of the hippocampus, Brain, 89 (1966) 83–108.CrossRefGoogle Scholar
  26. 25.
    Rothfield, L. and Harmar, P. J. On the relation of the hippocampal-fornix system to the control of rage responses in cats, J. Comp. Neurol., 101 (1954) 265–282.CrossRefGoogle Scholar
  27. 26.
    Rubinstein, E. H. and Delgado, J. M. R. Inhibition induced by forebrain stimulation in the monkey, Amer. J. Physiol., 205 (1963) 941–948.Google Scholar
  28. 27.
    Siegel, A., Edinger, H. M. and Ohgami, S. The topographical organization of the hippocampal projection to the septal area: a comparative neuroanatomical analysis in the gerbil, rat, rabbit and cat, J. Comp. Neurol., (1974) (In Press).Google Scholar
  29. 28.
    Siegel, A., and Flynn, J. P. Differential effects of electrical stimulation and lesions of the hippocampus and adjacent regions upon attack behavior in cats, Brain Res., 7 (1968) 252–267.CrossRefGoogle Scholar
  30. 29.
    Siegel, A., Ohgami, S. and Edinger, H. M. Projections of the hippocampus in the squirrel monkey, Society for Neuroscience: St. Louis, Mo., October, (1974) (abs.).Google Scholar
  31. 30.
    Siegel, A., and Skog, D. Effects of electrical stimulation of the septum upon attack behavior elicited from the hypothalamus in the cat. Brain Research, 23 (1970) 371–380.CrossRefGoogle Scholar
  32. 31.
    Siegel, A. and Tassoni, J. P. Differential dfferent projections from the ventral and dorsal hippocampus of the cat, Brain Behay. Evol., 4 (1971) 185–200.Google Scholar
  33. 32.
    Diegel, A. and Tassoni, J. P. Differential efferent projections of the lateral and medial septal nuclei to the hippo-campus in the cat. Brain Behay. Evol. 4 (1971) 201–219.Google Scholar
  34. 33.
    Valenstein, E. S. and Nauta, W. S. H. A comparison of the distribution of the fornix system in the rat, guinea pig, cat and monkey. J. Comp. Neurol., 113 (1959) 337–363.CrossRefGoogle Scholar
  35. 34.
    Yutzey, D. A., Meyer, D. R. and Meyer, P. M. Effects of simultaneous septal and neo-or limbic-cortical lesions upon emotionality in the rat, Brain Research, 5 (1967) 452–458.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Allan Siegel
    • 1
  • Henry Edinger
    • 1
  1. 1.Departments of Anatomy, Physiology, and NeuroscienceNew Jersey Medical SchoolNewarkUSA

Personalised recommendations