Abstract
Following septal lesions, rats develop a very characteristic hyperreactivity which appears as an exaggerated reaction to normally nonnoxious stimuli. We will report here the results of some recent experiments concerning the behavioral, anatomical, and biochemical aspects of this hyperreactivity.
This project was supported by research grant #1-RO1-MH24213-01 from the National Institute of Mental Health. We express appreciation to Hoffman-LaRoche for donation of the decarboxylase inhibitor.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Butcher, L. L., Engel, J., Fuxe, K. Behavioral, biochemical, and histochemical analyses of the central effects of monoamine precursors after peripheral decarboxylase inhibition. Brain Research, 41 (1972) 387–411.
Dominguez, M. and Longo, V. G. Effects of p-chlorophenylalanine, a-methylaparatyrosine and of other indol-and catechol-amine depletors on the hyperirratability syndrome of septal rats. Physiology and Behavior, 5 (1970) 607–610.
Gage, Fred H. III, and Olton, David S. Hippocampal influence on septal hyperreactivity. Unpublished manuscript.
Nakamura, K. and Thoenen H. Increased irritability: A permanent behavior change induced in the rat by intraventricular administration of 6-hydroxydopamine. Psychopharmacologia (Berl.), 24 (1972) 359–372.
Olton, David S., and Gage, Fred H. III. Role of the fornix in the septal syndrome. Physiology and Behavior, 13 (1974) 269–279.
Richardson, J. S. and Jacobowitz, D. M. Depletion of brain norepenephrine by intraventricular injection of 6-hydroxydopa: A biochemical, histochemical and behavioral study in rats. Brain Research, 58 (1973) 117–133.
Stark, P., and Henderson, J. K. Central cholinergic suppression of hyper-reactivity and aggression in septal-lesioned rats. Neuropharmacology, 11 (1972) 839–847.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Springer Science+Business Media New York
About this chapter
Cite this chapter
Olton, D.S., Gage, F.H. (1976). Behavioral, Anatomical, and Biochemical Aspects of Septal Hyperreactivity. In: DeFrance, J.F. (eds) The Septal Nuclei. Advances in Behavioral Biology, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3084-4_20
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3084-4_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3086-8
Online ISBN: 978-1-4684-3084-4
eBook Packages: Springer Book Archive