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A Neuroendocrinological Approach to the Investigation of Septum

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The Septal Nuclei

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 20))

Abstract

Induction of ovulation in female rats could be driven by stimulation of the septum (13) and blocked by local anesthesia of the septum (23). In infertile rats, an interruption of the dorsal connection of the preoptic area (efferents and afferents paths of the septum) caused a delay in onset of puberty. Bilateral lesions of the medial forebrain bundle or both corticomedial and basomedial regions of the amygdala also resulted in delayed onset of puberty. Once sexual maturity is reached in the corticomedial amygdaloid lesioned rats, the ability to run completely normal estrus cycles, to respond to constant illumination, and to mate, become pregnant and rear litters is retained (5). Lesions severing the dorsal connection of the preoptic area (68), or complete bilaterial section of the stria terminalis and the fimbria in the dorsal part of their course (54) would interrupt the major direct fiber tracts from the forebrain to the medial hypothalamus. After both types of lesion regular cyclic ovulation continued (following an initial diestrus period). In addition, complete removal of neocortex could not block regular estrus cycles and normal pregnancies (10).

This study was supported by AID Contract csd/2821, NSF Grant GB-28817X, NIH Contract 69–2133, NIH Grant HD-06950, National Academy of Science USA and Hungarian Academy of Science. The authors wish to express their gratitude to Miss T. Monkovsky and Mr. H. W. Nentwitch and L. C. Pleasant for their excellent technical assistance, and to Mrs. E. M. Menchaca for determination of plasma LH. Determination of acetylcholine contents in the brain was performed with collaboration of Drs. A. Modak and W. Stavinoha, Department of Pharmacology, The University of Texas Health Science Center at San Antonio, Texas. The electron microscopic pictures were taken by Dr. B. Kosaras, Department of Anatomy (Director, Prof. B. Flerkó) University Medical School, Pécas, Hungary.

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Authors and Affiliations

  1. Department of Anatomy, The University of Texas Health Science Center, San Antonio, Texas, USA

    Nobuyoshi Hagino M.D. & Sadao Yamaoka M.D.

  2. Department of Physiology, Saitama Medical University, Moro, Saitama, Japan

    Nobuyoshi Hagino M.D. & Sadao Yamaoka M.D.

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  1. Nobuyoshi Hagino M.D.
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  1. Wayne State University, Detroit, Michigan, USA

    Jon F. DeFrance

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Hagino, N., Yamaoka, S. (1976). A Neuroendocrinological Approach to the Investigation of Septum. In: DeFrance, J.F. (eds) The Septal Nuclei. Advances in Behavioral Biology, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3084-4_13

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