A Neuroendocrinological Approach to the Investigation of Septum

  • Nobuyoshi Hagino
  • Sadao Yamaoka
Part of the Advances in Behavioral Biology book series (ABBI, volume 20)


Induction of ovulation in female rats could be driven by stimulation of the septum (13) and blocked by local anesthesia of the septum (23). In infertile rats, an interruption of the dorsal connection of the preoptic area (efferents and afferents paths of the septum) caused a delay in onset of puberty. Bilateral lesions of the medial forebrain bundle or both corticomedial and basomedial regions of the amygdala also resulted in delayed onset of puberty. Once sexual maturity is reached in the corticomedial amygdaloid lesioned rats, the ability to run completely normal estrus cycles, to respond to constant illumination, and to mate, become pregnant and rear litters is retained (5). Lesions severing the dorsal connection of the preoptic area (68), or complete bilaterial section of the stria terminalis and the fimbria in the dorsal part of their course (54) would interrupt the major direct fiber tracts from the forebrain to the medial hypothalamus. After both types of lesion regular cyclic ovulation continued (following an initial diestrus period). In addition, complete removal of neocortex could not block regular estrus cycles and normal pregnancies (10).


Arcuate Nucleus Preoptic Area Septal Lesion Medial Forebrain Bundle Medial Preoptic Area 
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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Nobuyoshi Hagino
    • 1
    • 2
  • Sadao Yamaoka
    • 1
    • 2
  1. 1.Department of AnatomyThe University of Texas Health Science CenterSan AntonioUSA
  2. 2.Department of PhysiologySaitama Medical UniversityMoro, SaitamaJapan

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