Cholinergic Enzyme Activity in the Septum and Related Brain Areas in Deceased Mentally Normal, Chronic Schizophrenic and Organic Brain Syndrome Patients

  • Edward F. Domino
Part of the Advances in Behavioral Biology book series (ABBI, volume 20)


The relationship between the activity of the cholinergic enzymes and mental illness is far from clear. However, we do know a lot concerning the neurochemistry of the cholinergic system. It is now well known that there are two major types of cholinesterases able to hydrolyze acetylcholine (ACh). One type “true” or acetyl-cholinesterase (AChE) is found primarily in “cholinergic” neurons throughout the body, but also in non-neuronal tissues including red blood cells and the placenta. The other type “pseudo” or butyrylcholinesterase (ChE) is found throughout the body, especially in the brain and in the plasma.


AChE Activity Cholinesterase Activity Septal Area Organic Brain Syndrome Medial Amygdala 


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Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Edward F. Domino
    • 1
    • 2
  1. 1.Department of PharmacologyThe Lafayette ClinicDetroitUSA
  2. 2.The University of MichiganAnn ArborUSA

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