The Influence of Experience on Recovery Following Brain Damage in Rodents: Hypotheses Based on Development Research

  • William T. Greenough
  • Barry Fass
  • Timothy J. DeVoogd
Part of the Advances in Behavioral Biology book series (ABBI)


Our contribution to this workshop series is primarily a review of existing literature rather than a presentation of new experimental data. Our central concern is whether experience plays a role in recovery of behavioral function following demonstrable — usually experimentally-induced — brain damage. For the most part, this discussion is restricted to data from rodents and closely assumed species. The discussion focuses upon parallels between interactions of the environment with the developing brain and interactions of the environment with the damaged brain.


Brain Damage Lateral Hypothalamic Septal Lesion Brightness Discrimination Maze Learning 


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  1. Ahmad, S.S., and Harvey, J.A. 1968. Long-term effects of septal lesions and social experience on shock-elicited fighting in rats. J. Comp. Physiol. Psychol. 66:596–602.PubMedGoogle Scholar
  2. Anand, B.K., and Brobeck, J.R. 1951. Hypothalamic control of food intake. Yale J. Biol. Med. 24:123–140.PubMedGoogle Scholar
  3. Balagura, S., Harrell, L., and Ralph, T. 1973. Glucodynamic hormones modify the recovery period after lateral hypothalamic lesions. Science 182:59–60.PubMedGoogle Scholar
  4. Bauer, J.H., and Cooper, R.M. 1964. Effects of posterior cortical lesions on performance of a brightness-discrimination task. J. Comp. Physiol. Psychol. 58:84–92.PubMedGoogle Scholar
  5. Bauer, R.H. 1974. Brightness discrimination of pretrained and nonpretrained hippocampal rats reinforced for choosing brighter or dimmer alternatives. J. Comp. Phvsiol. Psvchol. 87:987–996.Google Scholar
  6. Beach, F. 1940. Effects of cortical lesions upon the copulatory behavior of male rats. J. Comp. Psychol. 29:193–244.Google Scholar
  7. Bennett, E.L., Rosenzweig, M.R., and Wu, S.Y.C. 1973. Excitant and depressant drugs modulate effects of environment on brain weight and cholinesterases. Psychopharm. (Berl.) 33:309–328.Google Scholar
  8. Berger, B.D., Wise, C.D., and Stein, L. 1973. Nerve growth factor: Enhanced recovery of feeding after hypothalamic damage. Science 180:506–508.PubMedGoogle Scholar
  9. Bland, B.H., and Cooper, R.M. 1969. Posterior neodecortication in the rat: Age at operation and experience. J. Comp. Physiol. Psychol. 69:345–354.PubMedGoogle Scholar
  10. Bland, B.H., and Cooper, R.M. 1970. Experience and vision of the posterior neodecorticate rat. Physiol. Behav. 5:211–214.PubMedGoogle Scholar
  11. Brady, J.V., and Nauta, W.J.H. 1955. Subcortical mechanisms in emotional behavior: The duration of affective changes following septal and habenular lesions in the albino rat. J. Comp. Physiol. Psychol. 48:412–420.PubMedGoogle Scholar
  12. Broverman, D.M., Klaiber, E.L., Kobayashi, Y., and Vogel, W. 1968. Roles of activation and inhibition in sex differences in cognitive abilities. Psvchol. Rev. 75:23–50.Google Scholar
  13. Burright, R.G., Donovick, P.J., and Zuromski, E. 1974. Septal lesion and experiential influences on saline and saccharin preference-aversion functions. Physiol. Behav. 12:951–959.PubMedGoogle Scholar
  14. Campbell, B.A., and Spear, N.E. 1972. Ontogeny of memory. Psychol. Rev. 79:215–236.PubMedGoogle Scholar
  15. Chase, M.H., and Wyrwicka, W. 1973. Electrical stimulation of the brain as reinforcement of food consumption in aphagic cats. Exp. Neurol. 40:153–160.PubMedGoogle Scholar
  16. Chow, K.L., and Survis, L. 1958. Retention of over-learned visual habit after temporal cortical ablation in monkey. AMA Arch. Neurol. Psychiat. 79:640–648.Google Scholar
  17. Clemente, C.D. 1964. Regeneration in the vertebrate central nervous system. Int. Rev. Neurobiol. 6:257–301.PubMedGoogle Scholar
  18. Cole, D.D., Sullins, W.R., Jr., and Isaac, W. 1967. Pharmacological modification of the effects of spaced occipital ablations. Psychopharm. (Berl.) 11:311–316.Google Scholar
  19. Cooper, R.M., and Zubek, J.P. 1958. Effects of enriched and restricted early environments on learning ability of bright and dull rats. Canad. J. Psychol. 12:159–164.PubMedGoogle Scholar
  20. Cooper, R.M., Blochert, K.P., Gillespie, L.A., and Miller, L.G. 1972. Translucent occluders and lesions of posterior neocortex in the rat. Physiol. Behav. 8:693–697.PubMedGoogle Scholar
  21. Cox, V.C., and Kakolewski, J.W. 1970. Sex differences in body weight regulation in rats following lateral hypothalamic lesions. Commun. Behav. Biol. 5:195–197.Google Scholar
  22. Cox, V.C., Kakolewski, J.W., and Valenstein, E.S. 1969. Ventromedial hypothalamic lesions and changes in body weight and food consumption in male and female rats. J. Comp. Phvsiol. Psychol. 67:320–326.Google Scholar
  23. Dawson, R.G., Conrad, L., and Lynch, G. 1973. Single and two-stage hippocampal lesions: A similar syndrome. Exp. Neuro1. 40:263–277.Google Scholar
  24. Deagle, J.H., and Lubar, J.F. 1971. Effect of septal lesions in two strains of rats on one-way and shuttle avoidance acquisition. J. Comp. Physiol. Psychol. 77:277–281.PubMedGoogle Scholar
  25. Denenberg, V.H. 1967. Stimulation in infancy, emotional reactivity, and exploratory behavior, pp. 161–190. In D.C. Glass (ed.). Neurophysiology and Emotion. Rockefeller University Press, New York.Google Scholar
  26. Diamond, M.C., Johnson, R.E., and Ingham, C. 1971. Brain plasticity induced by environment and pregnancy. Int. J. Neurosci. 2: 171–178.PubMedGoogle Scholar
  27. DiCara, L.V. 1970. Role of postoperative feeding experience in recovery from lateral hypothalamic damage. J. Comp. Physiol. Psychol. 72:60–65.PubMedGoogle Scholar
  28. Donovick, P.J., Burright, R.G., and Lustbader, S. 1969. Isotonic and hypertonic saline injection following septal lesions. Commun. Behav. Biol. 4:17–22.Google Scholar
  29. Donovick, P.J., Burright, R.G., and Swidler, M.A. 1973. Presurgical rearing environment alters exploration, fluid consumption, and learning of septal lesioned and control rats. Physiol. Behav. 11:543–553.PubMedGoogle Scholar
  30. Donovick, P.J., Burright, R.G., and Bentsen, E.O. 1975. Presurgical dietary history and the behavior of control and septal lesioned rats. Devel. Psychobiol. 8:13–26.Google Scholar
  31. Dru, D., Walker, J.P., and Walker, J.B. 1975. Self-produced locomotion restores visual capacity after striate lesions. Science 187:265–266.PubMedGoogle Scholar
  32. Eidelberg, E., and Stein, D.G. (eds.). 1974. Functional recovery after lesions of the nervous system. Neurosciences Research Program Bull. (Whole No. 12).Google Scholar
  33. Ellen, P., Wilson, A.S., and Powell, E.W. 1964. Septal inhibition and timing behavior in the rat. Exp. Neurol. 10:120–132.PubMedGoogle Scholar
  34. Ellen, P., Aitken, W.C., Jr., and Walker, R. 1973. Pretraining effects on performance of rats with hippocampal lesions. J. Comp. Physiol. Psychol. 84:622–628.PubMedGoogle Scholar
  35. Fass, B., Jordan, H., Rubman, A., Seibel, S., and Stein, D. 1975. Recovery of function after serial or one-stage lesions of the lateral hypothalamic area in rats. Behav. Biol. 14:283–294.PubMedGoogle Scholar
  36. Finger, S., Walbran, B., and Stein, D.G. 1973. Brain damage and behavioral recovery: Serial lesion phenomena. Brain Res. 63: 1–18.PubMedGoogle Scholar
  37. Fonberg, E., Brutkowski, S., and Mempel, E. 1962. Defensive conditioned reflexes and neurotic motor reactions following amygdalectomy in dogs. Acta Biologiae Experimentalis (Warsaw) 22:51–57.PubMedGoogle Scholar
  38. Freeman, B.J., and Ray, O.S. 1972. Strain, sex, and environment effects on appetitively and aversively motivated learning tasks. Devel. Psychobiol. 5:101–109.Google Scholar
  39. Fritsch, G., and Hitzig, E. 1870. Über die electrische Erregbarkeit des Grosshirns. Arch. Anat. Physiol. Wiss. Med. 37:300–332.Google Scholar
  40. Fuller, J.L. 1967. Experiential deprivation and later behavior. Science 158:1645–1652.PubMedGoogle Scholar
  41. Gallinek, A. 1956. Fear and anxiety in the course of electroshock therapy. Amer. J. Psychiat. 113:428–434.PubMedGoogle Scholar
  42. Gazzaniga, M.S. 1974. Determinants of cerebral recovery, pp. 203–216. In D.G. Stein, J.J. Rosen, and N. Butters (eds.). Plasticity and Recovery of Function in the Central Nervous System. Academic Press, New York.Google Scholar
  43. Gazzaniga, M.S., Szer, I.S., and Crane, A.M. 1974. Modification of drinking behavior in the adipsic rat. Exp. Neurol. 42:483–489.PubMedGoogle Scholar
  44. Glass, J.D., and Thomas, G.J. 1970. Effects of cortical ablations upon recovery from the septal syndrome in hooded rats. Physiol. Behav. 5:879–882.PubMedGoogle Scholar
  45. Glendenning, R.L. 1972. Effects of training between two unilateral lesions of visual cortex upon ultimate retention of blackwhite discrimination habits by rats. J. Comp. Physiol. Psychol. 80:216–229.PubMedGoogle Scholar
  46. Glick, S.D. 1974. Changes in drug sensitivity and mechanisms of functional recovery following brain damage, pp. 339–372. In D.G. Stein, J.J. Rosen, and N. Butters (eds.). Plasticity and Recovery of Function in the Central Nervous System. Academic Press, New York.Google Scholar
  47. Glick, S.D., and Greenstein, S. 1972. Facilitation of survival following lateral hypothalamic damage by prior food and water deprivation. Psychon. Sci. 28:163–164.Google Scholar
  48. Glick, S.D., and Greenstein, S. 1974. Facilitation of lateral hypothalamic recovery by postoperative administration of a-methyl-p-tyrosine. Brain Res. 73:180–183.PubMedGoogle Scholar
  49. Gold, R.M. 1966. Aphagia and adipsia produced by unilateral hypothalamic lesions in rats. Amer. J. Physiol. 211:1274–1276.PubMedGoogle Scholar
  50. Gold, R.M. 1970. Hypothalamic hyperphagia: Males get just as fat as females. J. Comp. Physiol. Psychol. 71:347–356.PubMedGoogle Scholar
  51. Goldberger, M.E. 1974. Recovery of movement after CNS lesions in monkeys, pp. 265–338. In D.G. Stein, J.J. Rosen, and N. Butters (eds.). Plasticity and Recovery of Function in the Central Nervous System. Academic Press, New York.Google Scholar
  52. Goldman, P.S. 1971. Functional development of the prefrontal cortex in early life and the problem of neuronal plasticity. Exp, Neurol. 32:366–387.Google Scholar
  53. Goldman, P.S. 1974. An alternative to developmental plasticity: Heterology of CNS structures in infants and adults, pp. 149–174. In D.G. Stein, J.J. Rosen, and N. Butters (eds.). Plasticity and Recovery of Function in the Central Nervous System. Academic Press, New York.Google Scholar
  54. Goldman, P.S., Crawford, H.T., Stokes, L.P., Galkin, T.W., and Rosvold, H.E. 1974. Sex-dependent behavioral effects of cerebral cortical lesions in the developing rhesus monkey. Science 186:540–542.PubMedGoogle Scholar
  55. Gotsick, J.E., and Marshall, R.C. 1972. Time course of the septal rage syndrome. Physiol. Behav. 9:685–687.PubMedGoogle Scholar
  56. Greenough, W.T. 1975. Experiential modification of the developing brain. Amer. Scientist 63:37–46.Google Scholar
  57. Harreil, L.E., and Balagura, S. 1974. The effects of dark and light on the functional recovery following lateral hypothalamic lesions. Life Sci. 15:2079–2088.Google Scholar
  58. Harrell, L.E., Raubeson, R., and Balagura, S. 1974. Acceleration of functional recovery following lateral hypothalamic damage by means of electrical stimulation in the lesioned areas. Physiol. Behav. 12:897–899.PubMedGoogle Scholar
  59. Hebb, D.O. 1949. Organization of Behavior. John Wiley & Sons, New York.Google Scholar
  60. Hein, A. 1972. Acquiring components of visually guided behavior. In A.D. Pick (ed.). Minnesota Symposia on Child Psychology, Vol. 6. University of Minnesota Press, Minneapolis.Google Scholar
  61. Held, R., and Hein, A. 1963. Movement produced stimulation in the development of visually-guided behavior. J. Comp. Physiol. Psychol. 56:872–876.PubMedGoogle Scholar
  62. Henderson, N.D. 1968. The confounding effects of genetic variables in early experience research: Can we ignore them? Devel. Psychobiol. 1:146–152.Google Scholar
  63. Henderson, N.D. 1970. Brain weight increases resulting from environmental enrichment: A directional dominance in mice. Science 169:776–778.PubMedGoogle Scholar
  64. Herndon, J.G., and Neill, D.B. 1973. Amphetamine reversal of sexual impairment following anterior hypothalamic lesions in female rats. Pharmacol., Biochem., Behav. 1:285–288.Google Scholar
  65. Hetherington, A.W., and Ranson, S.W. 1940. Hypothalamic lesions and adiposity in the rat. Anat. Rec. 78:149–172.Google Scholar
  66. Hicks, S.P., and D’Amato, C.J. 1970. Motor-sensory behavior after hemispherectomy in newborn and mature rats. Exp. Neurol. 29: 416–438.PubMedGoogle Scholar
  67. Horel, J.A., Bettinger, L.A., Royce, G.J., and Meyer, D.R. 1966. Role of neocortex in the learning and relearning of two visual habits by the rat. J. Comp. Physiol. Psychol. 61:66–78.PubMedGoogle Scholar
  68. Hubel, D.H. 1967. Effects of distortion of sensory input on the visual system of kittens. The Physiologist 10:17–45.PubMedGoogle Scholar
  69. Hubel, D.H., and Wiesel, T.N. 1970. The period of susceptibility to the physiological effects of unilateral eye closure in kittens. J. Physiol. 206:419–436.PubMedGoogle Scholar
  70. Hughes, K.R. 1965. Dorsel and ventral hippocampus lesions and maze learning:Influence of preoperative environment. Canad. J. Psychol. 19:325–332.PubMedGoogle Scholar
  71. Isaac, W. 1964. Role of stimulation and time in the effects of spaced occipital ablations. Psychol. Rep. 14:151–154.Google Scholar
  72. Isaacson, R.L. 1975. The myth of recovery from early brain damage. In N.R. Ellis (ed.). Aberrant Development in Infancy. Lawrence Erlbaum Associates, Potomac.Google Scholar
  73. Isaacson, R.L., and Kimble, D.P. 1972. Lesions of the limbic system: Their effects upon hypotheses and frustration. Behav. Biol. 7:767–793.PubMedGoogle Scholar
  74. Isaacson, R.L., and Schmaltz, L.W. 1968. Failure to find savings from spaced, two-stage destruction of hippocampus. Commun. Behav. Biol. 1:353–359.Google Scholar
  75. Iwanow-Smolenski, A.G. 1954. Gründzuge der Pathophysiologie der höheren Nerventätigkeit. Akademie Verlag, Berlin.Google Scholar
  76. Jacobson, M. 1969. Development of specific neuronal connections. Science 163:543–547.PubMedGoogle Scholar
  77. Jacobson, M. 1970. Developmental Neurobiology. Holt, Rinehart & Winston, New York.Google Scholar
  78. Johnson, D.A., Poplawski, A., Bieliauskas, L., and Liebert, D. 1972. Recovery of function on a two-way conditioned avoidance task following sptal lesions in infancy: Effects of early handling. Brain Res. 45:282–287.PubMedGoogle Scholar
  79. Kennard, M.A. 1936. Age and other factors in motor recovery from precentral lesions in monkeys. Amer. J. Physiol. 115:138–146.Google Scholar
  80. Kennard, M.A. 1938. Reorganization of motor function in the cerebral cortex of monkeys deprived of motor and premotor areas in infancy. J. Neurophysio1. 1:477–496.Google Scholar
  81. Kimble, D.P. 1968. Hippocampus and internal inhibition. Psychol. Bull. 70:285–295.PubMedGoogle Scholar
  82. King, F.A. 1958. Effects of septal and amygdaloid lesions on emotional behavior and conditioned avoidance responses in the rat. J. Nerv. Mental Dis. 126:57–63.Google Scholar
  83. King, F.A. 1959. Relationship of the “septal syndrome” to genetic differences in emotionality in the rat. Psychol. Rep. 5:11–17.Google Scholar
  84. Kircher, K.A., Braun, J.J., Meyer, D.R., and Meyer, P.M. 1970. Equivalence of simultaneous and successive neocortical ablations in production of impairments of retention of black-white habits in rats. J. Comp. Physiol. Psychol. 71:474–480.Google Scholar
  85. Krieckhaus, E.E., Simmons, H.J., Thomas, G.J., and Kenyon, J. 1964. Septal lesions enhance shock avoidance behavior in the rat. Exp. Neuro1. 9:107–113.Google Scholar
  86. Lashley, K.S. 1929. Brain Mechanisms and Intelligence. University of Chicago Press, Chicago.Google Scholar
  87. Lashley, K.S. 1935. The mechanism of vision: XII. Nervous structures concerned in habits based on reactions to light. Comp. Psychol. Monog. 11:43–79.Google Scholar
  88. Lashley, K.S. 1938. Factors limiting recovery after central nervous lesions. J. Nerv. Ment. Dis. 88:733–755.Google Scholar
  89. LaTorre, J.C. 1968. Effect of differential environmental enrichment on brain weight and on acetylcholinesterase and Cholinesterase activities in mice. Exp. Neuro1. 22:493–503.Google Scholar
  90. Lenneberg, E.H. 1967. Biological Foundations of Language. Wiley, N.Y.Google Scholar
  91. LeVere, T.E., and Morlock, G.W. 1973. Nature of visual recovery following posterior neodecortication in the hooded rat. J. Comp. Physiol. Psychol. 83:62–67.PubMedGoogle Scholar
  92. LeVere, T., and Weiss, J. 1973. Failure of seriatum dorsal hippocampal lesions to spare spatial reversal behavior in rats. J. Comp. Physiol. Psychol. 82:205–210.PubMedGoogle Scholar
  93. Lukaszewska, I., and Thompson, R. 1967. Retention of an overtrained pattern discrimination following pretectal lesion in rats. Psychon. Sci. 8:121–122.Google Scholar
  94. Luria, A.R., Naydin, V.L., Tsvetkova, L.S., and Vinarskaya, E.N. 1969. Restoration of higher cortical function following local brain damage. In R.J. Vinken and G.W. Bruyn (eds.). Handbook of Clinical Neurology, Vol. 3. North-Holland, Amsterdam.Google Scholar
  95. Lynch, G., Stanfield, B., and Cotman, C.W. 1973. Developmental differences in post-lesion axonal growth in the hippocampus. Brain Res. 59:155–168.PubMedGoogle Scholar
  96. Marshall, J.F., and Teitelbaum, P. 1974. Further analysis of sensory inattention following lateral hypothalamic damage in rats. J. Comp. Physiol. Psychol. 86:375–395.PubMedGoogle Scholar
  97. Marshall, J.F., Turner, B.H., and Teitelbaum, P. 1971. Sensory neglect produced by lateral hypothalamic damage. Science 174: 523–525.PubMedGoogle Scholar
  98. Melzack, R. 1969. The role of early experience in emotional arousal. Ann. N.Y. Acad. Sci. 159:721–730.PubMedGoogle Scholar
  99. Meyer, D.R., Isaac, W., and Maher, B. 1958. The role of stimulation in spontaneous reorganization of visual habits. J. Comp. Physiol. Psychol. 51:546–548.PubMedGoogle Scholar
  100. Meyer, P.M., Horel, J.A., and Meyer, D.R. 1963. Effects of dlamphetamine upon placing responses in neodecorticate cats. J. Comp. Physiol. Psychol. 56:402–404.PubMedGoogle Scholar
  101. Miller, L.G., and Cooper, R.M. 1974. Translucent occluders and the role of visual cortex in pattern vision. Brain Res. 79:45–59.PubMedGoogle Scholar
  102. Miller, N.E., Bailey, C.J., and Stevenson, J.A.F. 1950. Decreased “hunger” but increased food intake resulting from hypothalamic lesions. Science 112:256–259.PubMedGoogle Scholar
  103. Milner, B. 1974. Hemispheric specialization: Scope and limitations. In F.O. Schmitt and F.G. Worden (eds.). The Neurosciences Third Study Program. MIT Press, Cambridge.Google Scholar
  104. Milner, P.M. 1970. Physiological Psychology. Holt, Rinehart & Winston, New York.Google Scholar
  105. Monakow, C.V. 1914. Die Lokalisation im Grosshirn und der Abbau der Funktion durch korticale Herde. Excerpted in K.H. Pribram (ed.). Brain and Behavior. I. Mood, States and Mind. 1969. Penguin Books, Baltimore.Google Scholar
  106. Murphy, M.R., and Schneider, G.E. 1970. Olfactory bulb removal eliminates mating behavior in the male golden hamster. Science 167:302–303.PubMedGoogle Scholar
  107. Noell, W.K., and Albrecht, R. 1971. Irreversible effects of visible light on the retina: Role of Vitamin A. Science 172:76–79.PubMedGoogle Scholar
  108. Nonneman, A.J., and Isaacson, R.L. 1973. Task dependent recovery after early brain damage. Behav. Biol. 8:143–172.PubMedGoogle Scholar
  109. Orbach, J., and Fantz, R.L. 1958. Differential effects of temporal neocortical resection on overtrained and nonovertrained visual habits in monkeys. J. Comp. Physiol. Psychol. 51:126–129.PubMedGoogle Scholar
  110. Peeke, H.V.S., LeBoeuf, B.J., and Herz, M.J. 1971. The effect of strychnine administration during development on adult maze learning in the rat, II: Drug administration from day 51–70. Psychopharm. (Berl.) 19:262–265.Google Scholar
  111. Petrinovich, L., and Bliss, D. 1966. Retention of a learned brightness discrimination following ablations of the occipital cortex in the rat. J. Comp. Physiol. Psychol. 61:136–138.PubMedGoogle Scholar
  112. Petrinovich, L., and Carew, T.J. 1969. Interaction of neocortical lesion size and interoperative experience in retention of a learned brightness discrimination. J. Comp. Physiol. Psychol. 68:451–454.PubMedGoogle Scholar
  113. Powers, J.B., and Winans, S.S. 1975. Vomeronasal organ: Critical role in sexual behavior of the male hamster. Science 187: 961–963.PubMedGoogle Scholar
  114. Powley, T.L., and Keesey, R.E. 1970. Relationship of body weight to the lateral hypothalamic feeding syndrome. J. Comp. Physiol. Psychol. 70:25–36.PubMedGoogle Scholar
  115. Raisman, G. 1969. Neuronal plasticity in the septal nuclei of the adult rat. Brain Res. 14:25–48.PubMedGoogle Scholar
  116. Roeder, K.D. 1963. Nerve cells and insect behavior. Harvard University Press, Cambridge.Google Scholar
  117. Rosenzweig, M.R. 1971. Effects of environment on development of brain and of behavior. In E. Tobach (ed.). Biopsychology of Development. Academic Press, New York.Google Scholar
  118. Rosner, B.S. 1970. Brain functions. In P.H. Mussen and M.R. Rosenzweig (eds.). Annual Review of Psychology, Vol. 21. Annual Reviews, Palo Alto.Google Scholar
  119. Rowe, F.A., and Edwards, D.A. 1972. Olfactory bulb removal: Influences on the mating behavior of male mice. Physiol. Behav. 8:37–41.PubMedGoogle Scholar
  120. Rowe, F.A., and Smith, W.E. 1973. Simultaneous and successive olfactory bulb removal. Influences on the mating behavior of male mice. Physiol. Behav. 10:443–449.PubMedGoogle Scholar
  121. Sarno, M.T., Silverman, M., and Sands, E. 1970. Speech therapy and language recovery in severe aphasia. J. Speech & Hearing Res. 13:607–625.Google Scholar
  122. Schmaltz, L.W., and Isaacson, R.L. 1966. The effects of preliminary training conditions upon DRL performance in the hippocampectomized rat. Physiol. Behav. 1:175–182.Google Scholar
  123. Schmaltz, L.W., and Isaacson, R.L. 1968. The effect of blindness on DRL-20 performances exhibited by animals with hippocampal destruction. Psychon. Sci. 11:241–242.Google Scholar
  124. Schwartz, M., and Teitelbaum, P. 1974. Dissociation between learning and remembering in rats with lesions in the lateral hypothalamus. J. Comp. Physiol. Psychol. 87:384–398.PubMedGoogle Scholar
  125. Schwartz, S. 1964. Effect of neocortical lesions and early environmental factors on adult rat behavior. J. Comp. Physiol. Psychol. 57:72–77.PubMedGoogle Scholar
  126. Scott, J.P. 1968. The process of primary socialization in the dog. In G. Newton and S. Levine (eds.). Early Experience and Behavior. C. C. Thomas, Springfield, II.Google Scholar
  127. Scott, J.P., Stewart, J.M., and DeGhett, V.J. 1974. Critical periods in the organization of systems. Devel. Psychobiol. 7:489–513.Google Scholar
  128. Seggie, J. 1968. Effect of somatosensory stimulation on affective behavior of septal rats. J. Comp. Physiol. Psychol. 66:820–822.Google Scholar
  129. Semmes, J., Weinstein, S. Ghent, L., and Teuber, H.L. 1954. Performance on complex tactual tasks after brain injury in man: Analyses by locus of lesion. Amer. J. Physiol. 67:220–240.Google Scholar
  130. Singh, D. 1973. Effects of preoperative training on food-motivated behavior of hypothalamic hyperphagic rats. J. Comp. Physiol. Psychol. 84:47–52.PubMedGoogle Scholar
  131. Singh, D. 1974. Role of preoperative experience on reaction to quinine taste in hypothalamic hyperphagic rats. J. Comp. Physiol. Psychol. 86:674–678.PubMedGoogle Scholar
  132. Singh, D., and Meyer, D.R. 1968. Eating and drinking by rats with lesions of the septum and the ventromedial hypothalamus. J. Comp. Physiol. Psychol. 65:163–166.Google Scholar
  133. Smith, C.J. 1959. Mass action and early environment. J. Comp. Physiol. Psychol. 52:154–156.PubMedGoogle Scholar
  134. Sodetz, F.J., Matalka, E.S., and Bunnell, B.N. 1967. Septal ablation and affective behavior in the golden hamster. Psychon. Sci. 7:189–190.Google Scholar
  135. Sperry, R.W. 1943. Visuomotor coordination in the newt (Triturus viridescens) after regeneration of the optic nerve. J. Comp. Neurol. 79:33–55.Google Scholar
  136. Stein, D.G. 1974. Some variables influencing recovery of function after central nervous system lesions in the rat, pp. 373–428. In D. G. Stein, J.J. Rosen, and N. Butters (eds.). Plasticity and Recovery of Function in the Central Nervous System. Academic Press, New York.Google Scholar
  137. Stein, D.G., Rosen, J.J., Graziadei, J. Mishkin, D., and Brink, J.J. 1969. Central nervous system: Recovery of function. Science 166:528–530.PubMedGoogle Scholar
  138. Stenevi, U., Bjerre, B., Bjorklund, A., and Mobley, W. 1974. Effects of localized intracerebral injections of nerve growth factor on the regenerative growth of lesioned central noradrenergic neurons. Brain Res. 69:217–234.PubMedGoogle Scholar
  139. Stern, P., McDowell, F., Miller, J.M., and Robinson, M. 1971. Factors influencing stroke rehabilitation. Stroke 2:213–218.PubMedGoogle Scholar
  140. Stewart, J.W., and Ades, H.W. 1951. The time factor in reintegration of a learned habit after temporal lobe lesions in the monkey. J. Comp. Physiol. Psychol. 44:479–486.PubMedGoogle Scholar
  141. Stricker, E.M., and Zigmond, M.J. 1975. Recovery of function following damage to central catecholamine-containing neurons: A neurochemical model for the lateral hypothalamic syndrome. In J.M. Sprague and A.N. Epstein (eds.). Progress in Psychobiology and Physiological Psychology, Vol. 6. Academic Press, New York (in press).Google Scholar
  142. Suomi, S.J., Harlow, H.F., and McKinney, W.T., Jr. 1972. Monkey psychiatrists. Amer. J. Psychiat. 128:927–932.PubMedGoogle Scholar
  143. Tees, R.C. 1975. The effects of neonatal striate lesions and visual experience on form discrimination in the rat. Canad. J. Psychol. Rev. Canad. Psychol. 29:66–85.Google Scholar
  144. Tees, R.C. Depth perception after infant and adult visual neocortical lesions in light-and dark-reared rats. Devel. Psychobiol., in press.Google Scholar
  145. Teitelbaum, B. 1973. Sex differences in delayed alternation performance following single or multiple stage frontal lesions in rats. Paper presented at 81st Annual Convention of American Psychological Association in Montreal, Quebec, August 29.Google Scholar
  146. Teitelbaum, P. 1957. Random and food-directed activity in hyperphagic and normal rats. J. Comp. Physiol. Psychol. 50:486–490.PubMedGoogle Scholar
  147. Teitelbaum, P. 1967. The biology of drive. In F.O. Schmitt (ed.). The Neurosciences, A Study Program, Vol. 1. The Rockefeller University Press, New York.Google Scholar
  148. Teitelbaum, P., and Epstein, A.N. 1962. The lateral hypothalamic syndrome: Recovery of feeding and drinking after lateral hypothalamic lesions. Psychol. Rev. 69:74–90.PubMedGoogle Scholar
  149. Teuber, H.-L. 1974a. Why two brains? In F.O. Schmitt and F.G. Worden (eds.). The Neurosciences Third Study Program. The MIT Press, Cambridge.Google Scholar
  150. Teuber, H.-L. 1974b. Recovery of function after lesions of the central nervous system: History and prospects. In E. Eidelberg and D.G. Stein (eds.). Functional Recovery after Lesions of the Nervous System. Neurosciences Research Program Bulletin, 197-200.Google Scholar
  151. Teuber, H.-L., and Rudel, R.G. 1962. Behavior after cerebral lesions in children and adults. Devel. Med. Child. Neurol. 4:3–20.Google Scholar
  152. Thatcher, R.W., and Kimble, D.P. 1966. Effect of amygdaloid lesions on retention of an avoidance response in overtra ined and nonovertrained rats. Psychon. Sci. 6:9–10.Google Scholar
  153. Thompson, R. 1960. Retention of a brightness discrimination following neocortical damage in the rat. J. Comp. Physiol. Psychol. 53:212–215.PubMedGoogle Scholar
  154. Thompson, R. 1965. Centrencephalic theory and interhemispheric transfer of visual habits. Psychol. Rev. 72:385–398.PubMedGoogle Scholar
  155. Thompson, R. 1969. Localization of the “visual memory system” in the white rat. J. Comp. Physiol. Psychol. Monog. 69:4, pt. 2.Google Scholar
  156. Thor, D.H., Ghiselli, W.B., and Ward, T.B. 1974. Infantile handling and sex differences in shock-elicited aggressive responding of hooded rats. Devel. Psychobiol. 7:273–279.Google Scholar
  157. Tower, S.S. 1940. Pyramidal lesion in the monkey. Brain 63:36–90.Google Scholar
  158. Tsang, Y.C. 1937a. Maze learning in rats hemidecorticated in infancy. J. Comp. Psychol. 24:221–254.Google Scholar
  159. Tsang, Y.C. 1937b. Visual sensitivity in rats deprived of visual cortex in infancy. J. Comp. Psychol. 24:255–262.Google Scholar
  160. Ward, A.A., Jr., and Kennard, M.A. 1942. Effect of cholinergic drugs on recovery of function following lesions of the central nervous system in monkeys. Yale J. Biol. & Med. 15:189–229.Google Scholar
  161. Watson, C.W., and Kennard, M.A. 1945. The effect of anticonvulsant drugs on recovery of function following cerebral cortical lesions. J. Neurophysiol. 8:221–231.Google Scholar
  162. Weese, G.D., Neimand, D., and Finger, S. 1973. Cortical lesions and somesthesis in rats: Effects of training and overtraining prior to surgery. Exp. Brain Res. 16:542–550.PubMedGoogle Scholar
  163. Weinstein, S., and Teuber, H.-L. 1957. The role of preinjury education and intelligence level in intellectual loss after brain injury. J. Comp. Physiol. Psychol. 50:535–539.PubMedGoogle Scholar
  164. Weinstein, S., Teuber, H.-L., Ghent, L., and Semmes, J. 1955. Complex visual task performance after penetrating brain injury in man. Amer. Psychol. 10:408 (abst.).Google Scholar
  165. Welch, B.L. 1965. Psychophysiological response to the mean level of environmental stimulation: A theory of environmental integration, pp. 39–96. In D.M. Rioch (ed.). Medical Aspects of Stress in the Military Climate. U.S. Government Printing Office, Washington, D.C.Google Scholar
  166. Wepman, J.M. 1951. Recovery from Aphasia. Ronald Press Co., New York.Google Scholar
  167. Wheatley, M.D. 1944. The hypothalamus and affective behavior in cats. Arch. Neurol. Psychiat. (Chicago) 52:296–316.Google Scholar
  168. Will, B.E., Rosenzweig, M.R., and Bennett, E.L. Effects of differential environments on recovery from neonatal brain lesions, measured by problem-solving scores and brain dimensions. In preparation.Google Scholar
  169. Will, B.E., Rosenzweig, M.R., Bennett, E.L., Hebert, M., and Morimoto, H. Relatively brief environmental enrichment aids recovery of learning capacity and alters brain measures after postweaning brain lesions in rats. In preparation.Google Scholar
  170. Winans, S.S., and Powers, J.B. 1974. Neonatal and two-stage olfactory bulbectomy: Effects on male hamster sexual behavior. Behav. Biol. 10:461–471.PubMedGoogle Scholar
  171. Wolgin, D.L., and Teitelbaum, P. 1974. The role of activation and sensory stimuli in the recovery of feeding following lateral hypothalamic lesions in the cat. Paper presented at the Eastern Psychological Association meetings, Philadelphia, April 18–20.Google Scholar
  172. Worthington, C.S., and Isaac, W. 1967. Occipital ablation and retention of a visual conditioned avoidance response in the rat. Psychon. Sci. 8:289–290.Google Scholar

Copyright information

© Plenum Press, New York 1976

Authors and Affiliations

  • William T. Greenough
    • 1
  • Barry Fass
    • 1
  • Timothy J. DeVoogd
    • 1
  1. 1.Department of Psychology and Neural and Behavioral Biology ProgramUniversity of Illinois at Urbana/ChampaignChampaignUSA

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