Analysis of Single Gene Sex Linked Behavioral Mutants in Drosophila Melanogaster

  • D. Dagan
  • W. D. Kaplan
  • K. Ikeda
Part of the Advances in Behavioral Biology book series (ABBI, volume 15)


In order to study the genetic component underlying behavior, one must keep the environment constant and control the genome of the organism. The mechanisms of gene transcription have been studied very thoroughly; the behavioral output of organisms has also received great attention — the link between the two, however, is still largely an open field for research. Over the past 5 years, several hundred single gene sex-linked mutations have been generated in fruit flies with the purpose of analysing them and attempting to gain insight into the inter-relationship between gene and behavior. Although the generation of behavioral mutants has been rather proliferous, detailed analyses of the focus and mechanism of the altered genome’s action are very scarce. It is in such analysis that an interdisciplinary approach is necessary. In the few cases where electrophysiological tools have been applied to analyse these mutants, much additional information was obtained (Hotta and Benzer, 1969; Ikeda and Kaplan, 1970a, 1970b; Pak et al., 1969). After choosing a suitable mutant, one must first localize the focus of the mutated gene’s action. This may be achieved by combined genetic mapping and electrophysiological recordings from the flies’ sensory organs, CNS, peripheral nerves and muscles.


Motor Neuron Culture Bottle Sensory Hair Washout Curve General Inactivity 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • D. Dagan
    • 1
  • W. D. Kaplan
    • 2
  • K. Ikeda
    • 1
  1. 1.Technion School of MedicineDepartment of Biology of BehaviorHaifaIsrael
  2. 2.Departments of Biology and NeurosciencesCity of Hope Medical CenterDuarteUSA

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