Analysis of Single Gene Sex Linked Behavioral Mutants in Drosophila Melanogaster

  • D. Dagan
  • W. D. Kaplan
  • K. Ikeda
Part of the Advances in Behavioral Biology book series (ABBI, volume 15)


In order to study the genetic component underlying behavior, one must keep the environment constant and control the genome of the organism. The mechanisms of gene transcription have been studied very thoroughly; the behavioral output of organisms has also received great attention — the link between the two, however, is still largely an open field for research. Over the past 5 years, several hundred single gene sex-linked mutations have been generated in fruit flies with the purpose of analysing them and attempting to gain insight into the inter-relationship between gene and behavior. Although the generation of behavioral mutants has been rather proliferous, detailed analyses of the focus and mechanism of the altered genome’s action are very scarce. It is in such analysis that an interdisciplinary approach is necessary. In the few cases where electrophysiological tools have been applied to analyse these mutants, much additional information was obtained (Hotta and Benzer, 1969; Ikeda and Kaplan, 1970a, 1970b; Pak et al., 1969). After choosing a suitable mutant, one must first localize the focus of the mutated gene’s action. This may be achieved by combined genetic mapping and electrophysiological recordings from the flies’ sensory organs, CNS, peripheral nerves and muscles.


Motor Neuron Culture Bottle Sensory Hair Washout Curve General Inactivity 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    DEWHURST, S. Unpublished results. 1974.Google Scholar
  2. 2.
    DEWHURST, S., MC CAMAN, R. & KAPLAN, W.D. Biochemical Genetics 4:499, 1970.PubMedCrossRefGoogle Scholar
  3. 3.
    FALK, R. Personal Communication. 1974.Google Scholar
  4. 4.
    HERTWECK, R. Z. wiss. Zoöl. 139:559, 1931.Google Scholar
  5. 5.
    HOTTA, Y. & BENZER, S. Nature 222:354, 1969.PubMedCrossRefGoogle Scholar
  6. 6.
    IKEDA, K. & KAPLAN, W.D. Proc. Nat. Acad. Sci. U.S.A. 66:765, 1970a.CrossRefGoogle Scholar
  7. 7.
    IKEDA, K. & KAPLAN, W.D. Proc. Nat. Acad. Sci. U.S.A. 67:1480, 1970b.CrossRefGoogle Scholar
  8. 8.
    KAPLAN, W.D. Genetic and behavioral studies of Drosophila neurological mutants. In: Biology of Behavior, p. 133, Proc. 32nd Ann. Biol. Colloq. (Ed. J.A. Kiger, Jr.), Oregon State Univ. Press. 1971.Google Scholar
  9. 9.
    KAPLAN, W.D. & TROUT, W.E. Genetics 60:191, 1968 (abstract).Google Scholar
  10. 10.
    KIKUCHI, T. Japan J. Genetics 48: No. 2, 105, 1973.CrossRefGoogle Scholar
  11. 11.
    LEWIS, E.B. & BACHER, F. Drosophila Information Service 43:192, 1968.Google Scholar
  12. 12.
    MANNING, A. Behaviour 15:123, 1959.CrossRefGoogle Scholar
  13. 13.
    PAK, W.L., CROSSFIELD, J. & WHITE, N.V. Nature 222:351, 1969.PubMedCrossRefGoogle Scholar
  14. 14.
    PARETO, A. Z. Zellforsch 131:109, 1972.PubMedCrossRefGoogle Scholar
  15. 15.
    PITTMAN, R. Comp. & Gen. Pharm. 2:347, 1971.CrossRefGoogle Scholar
  16. 16.
    WILLIAMSON, R., Kaplan, W.D. & Dagan, D. Nature, In press, 1974.Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • D. Dagan
    • 1
  • W. D. Kaplan
    • 2
  • K. Ikeda
    • 1
  1. 1.Technion School of MedicineDepartment of Biology of BehaviorHaifaIsrael
  2. 2.Departments of Biology and NeurosciencesCity of Hope Medical CenterDuarteUSA

Personalised recommendations