Physiological and Pharmacological Analysis of Behavior

  • John A. Harvey
Part of the Advances in Behavioral Biology book series (ABBI, volume 12)


Psychologists have traditionally employed ablation techniques, electrical stimulation, and parenteral or central administration of drugs to examine subsequent effects on behavior. The problems that have arisen with the use of these techniques are described below. However, the one basic problem has been our inability to specify the exact mechanisms by which these procedures exert their effects on behavior. For example the ablation technique is one of the oldest and most extensively used methods for studying brain function. Consequently, we know a great deal about the behavioral changes produced by a variety of cortical and subcortical lesions. However, in most cases we do not know how to interpret the results. First, in almost all cases the lesion is simply described by the primary locus of damage. Rarely does the investigator examine the degeneration occurring outside of this primary locus. Consequently, the anatomical system being affected by a lesion is unknown. More importantly, the ablation technique as employed for study of brain function has not allowed us to specify the mechanism(s) by which lesions produce a change in function.


Fiber System Medial Forebrain Bundle Septal Area Brain Content Pharmacological Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Aghajanian, G.K., Bloom, F.E., and Sheard, M.H. Brain Res., 1969, 13, 266.PubMedCrossRefGoogle Scholar
  2. Andén, N.E., Carlsson, A., Dahlström, A., Fuxe, K., Hillarp, N.Å., and Larsson, K. Life Sei., 1964, 3 523.CrossRefGoogle Scholar
  3. Bloom, F.E., Hoffer, B.J., Nelson, C.N., Sheu, Y., and Siggins, G.R. In Serotonin and Behavior (J. Barchus and E. Usdin, Eds.). New York: Academic Press, 1973, p. 249.Google Scholar
  4. Cannon, W.B. and Rosenblueth, A, The Supersensitivity of Denervated Structures: A Law of Denervation. New York: The MacMillan Co., 1937.Google Scholar
  5. Curtis, D.R. and Crawford, J.M. Ann. Rev. Pharmacol., 1969, 9, 209.PubMedCrossRefGoogle Scholar
  6. Curtis, D.R. and Phillis, J.W. J. Physiol. (Lond), 1960, 153, 17.Google Scholar
  7. Curtis, D.R. and Ryall, R.W. Exp. Brain Res., 1966, 2, 81.PubMedGoogle Scholar
  8. Dahlström, A. and Fuxe, K. Acta Physiol. Scand.62, 1964, Suppl. 232, 1.Google Scholar
  9. De Groat, W.C. Brain Res., 1972, 38, 429.PubMedCrossRefGoogle Scholar
  10. Dominic, J.A. and Moore, K.E. Archs. Int. Pharmacodyn. Ther., 1969, 178, 166,Google Scholar
  11. Eccleston, D., Ranic, M., Roberts, M.H.T., and Straughan, D.W. In Metabolism of Amines in Brain (G. Hooper, Ed.). London: MacMillan, 1969, p. 29.Google Scholar
  12. Falck, B. and Hillarp, H.A. Acta Anatomica, 1959, 38, 277.PubMedCrossRefGoogle Scholar
  13. Gál, E.M., Christiansen, P.A., and Yunger, L.M. Neuropharmacol., 1974, in press.Google Scholar
  14. Giarman, N.J. and Pepeu, G. Brit. J. Pharmacol., 1962, 19, 226.PubMedGoogle Scholar
  15. Giarman, N.J. and Pepeu, G. Brit. J. Pharmacol., 1964, 23, 123.PubMedGoogle Scholar
  16. Green, T.K. and Harvey, J.A. J. Pharmacol. Exptl. Therap., 1974, in press.Google Scholar
  17. Grossman, S.P. and Stumpf, W.E. Science, 1969, 166, 1410.PubMedCrossRefGoogle Scholar
  18. Harvey, J.A. Behavioral Analysis of Drug Action. Chicago: Scott-Foresman, 1971Google Scholar
  19. Harvey, J.A. and Lints, C.E. Science, 1965, 148, 250.PubMedCrossRefGoogle Scholar
  20. Harvey, J.A. and Lints, C.E. J. Comp. Physiol. Psychol., 1971, 74, 28.CrossRefGoogle Scholar
  21. Harvey, J.A. and Gâl, E.M. Science, 1974, 183, 869.PubMedCrossRefGoogle Scholar
  22. Harvey, J.A., Heller, A., and Moore, R.Y. JN Pharmacol. Exptl. Therap., 1963, 140, 103.Google Scholar
  23. Harvey, J.A., Schlosberg, A.J., and Yunger, L.M. Fed. Proc., 1974, in press.Google Scholar
  24. Harvey, J.A., Scholfield, C.N., Graham, L.T., and Aprison, M.H, Trans.Amer. Soc. Neurochem., 1974, 5.Google Scholar
  25. Hedreen, J.C. and Chalmers, J.P. Brain Res., 1972, 47, 1.PubMedCrossRefGoogle Scholar
  26. Heller, A. and Harvey, J.A. The Pharmacol., 1963, 5264.Google Scholar
  27. Heller, A., Harvey, J.A., and Moore, R.Y. Biochem. Pharmacol., 1962, 11, 859.PubMedCrossRefGoogle Scholar
  28. Hökfelt, T. Brain Res., 1970, 22, 147.PubMedCrossRefGoogle Scholar
  29. Holman, R.B. and Vogt, M. J. Physiol. (Lond), 1972, 223, 243.Google Scholar
  30. Houpt, K.A. and Epstein, A.N. Physiol. Beh., 1971, 7 897.CrossRefGoogle Scholar
  31. Jackson, J.H. (1898) In Selected Writings of John Hughlings Jackson, Vol, 2 (J. Taylor, Ed.). London: Staple Press, 1958, p. 422.Google Scholar
  32. Johnson, A.K. In Control Mechanisms of Thirst (J.T. Fitzsimons, G. Peters, and L. Peters, Eds.). Heidelberg: Springer-Verlag, 1974.Google Scholar
  33. Jouvet, M. In Serotonin and Behavior (J. Barchus and E. Usdin, Eds.). New York: Academic Press, 1973, p. 385.Google Scholar
  34. Koe, B.K. and Weissman, A. J. Pharmacol. Exptl. Therap, 1966, 154, 499.Google Scholar
  35. Kostowski, W., Giacalone, E., Garattini, S., and Valzelli, L. Eur. J, Pharmacol., 1969, 7 170.CrossRefGoogle Scholar
  36. Kuhar, M.J., Aghajanian, G.K., and Roth, R.H. Brain Res., 1972, 44, 165.PubMedCrossRefGoogle Scholar
  37. Kuhar, M.J., Sethy, V.H,, Roth, R.H., and Aghajanian, G.K. J_. Neurochem., 1973, 20, 281.Google Scholar
  38. Lewis, P.R. and Shute, C.C.D. Brain, 1967, 90, 521.PubMedCrossRefGoogle Scholar
  39. Manakow, Von C. (1911) In The Cerebral Cortex (G. Von Bonin, Ed.). Springfield: Charles C. Thomas, 1960, p. 231.Google Scholar
  40. Margolis, F.L. Science, 1974, 184, 909.PubMedCrossRefGoogle Scholar
  41. Mitchell, J.P. J. Physiol. (Lond), 1963, 165, 98.Google Scholar
  42. Octmans, G.A. and Harvey, J.A. Physiol. Beh., 1972, 8 , 69.CrossRefGoogle Scholar
  43. Pepeu, G., Mulas, A., Ruffi, A., and Sotgiu, P. Life Sei., 1971, 10, 181.CrossRefGoogle Scholar
  44. Ritter, R.C. Unpublished Ph.D. Dissertation, Univ. Pennsyl., 1974.Google Scholar
  45. Shaskan, E.G. and Snyder, S.H. J. Pharmacol. Exptl. Therap., 1970, 175, 404.Google Scholar
  46. Sheard, M.H. and Aghajanian, G.K. J. Pharmacol. Exptl. Therap., 1968a, 163, 425.Google Scholar
  47. Sheard, M.H. and Aghajanian, G.K. Life Sei., 1968b, 2 19 •CrossRefGoogle Scholar
  48. Shields, P.J. and Eccleston, D. J_. Neurochem., 1972, 19, 265.PubMedCrossRefGoogle Scholar
  49. Shute, C.C.D. and Lewis, P.R. Brain, 1967, 40, 497.CrossRefGoogle Scholar
  50. Simpson, J.R., Grabarits, F., and Harvey, J.A. The Pharmacol., 1967, 9213.Google Scholar
  51. Snyder, S.H., Young, A.B., Bennett, J.P., and Mulder, A.H. Fed. Proc., 1973, 32, 2039.Google Scholar
  52. Sorensen, J.P., Jr. and Harvey, J.A. Physiol. Beh., 1971, J5, 723.CrossRefGoogle Scholar
  53. Spector, S., Sjoerdsma, A., and Udenfriend, S. J. Pharmacol. Exptl. Therap., 1965, 147, 86.Google Scholar
  54. Szerb, J.C. Canad. J. Physiol. Pharmacol., 1964, 42, 303.CrossRefGoogle Scholar
  55. Tenen, S.S. Psychopharmacologia, 1967, 10, 204.PubMedCrossRefGoogle Scholar
  56. Ungerstedt, U. Acta Physiol. Scand., 1971a, Suppl. 367, 1.Google Scholar
  57. Ungerstedt, U. Acta Physiol. Scand., 1971b, Suppl. 367, 69.Google Scholar
  58. Weissman, A., Koe, B.K., and Tenen, S.S. J. Pharmacol. Exptl. Therap., 1966, 151, 339.Google Scholar
  59. Zigmond, M.J., Chalmers, J.P., Simpson, J.R., and Wurtman, R.J, J. Pharmacol. Exptl. Therap., 1971, 179, 20.Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • John A. Harvey
    • 1
  1. 1.Department of PsychologyUniversity of IowaIowa CityUSA

Personalised recommendations