Neurochemical Mechanisms of Temperature Regulation and Food Ingestion

  • R. D. Myers
Part of the Advances in Behavioral Biology book series (ABBI, volume 10)


Although the actual concept of a neurohumoral code for a physiological control process may be a relatively straightforward one (Miller, 1965; Myers and Sharpe, 1968a), the specific details of any of the postulated coding systems are virtually unknown. The biological meaning of the term coding, which was used originally by the geneticists, refers to a synaptic systematization of chemical events that either trigger or suppress an efferent pathway (Myers, 1974). As such, the process of systematization can often explain how a physiological or behavioral response is activated or how it is inhibited. But what does this mean in terms of a neuronal process?


Preoptic Area Anterior Hypothalamus Ingestive Behavior Anatomical Mapping Humoral Code 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Avery, D. D., 1971, Intrahypothalamic adrenergic and cholinergic injection effects on temperature and ingestive behavior in the rat, Neuropharmacol. 10: 753–763.CrossRefGoogle Scholar
  2. Feldberg, W. and Myers, R. D., 1964, Effects on temperature of amines injected into the cerebral ventricles. A new concept of temperature regulation, J. Physiol. 173: 226–237.PubMedGoogle Scholar
  3. Fuxe, K., Hökfelt, T. and Ungerstedt, U., 1970, Morphological and functional aspects of central monoamine neurons, Int. Rev. Neurobiol. 13: 93–126.CrossRefGoogle Scholar
  4. Grossman, S. P., 1960, Eating or drinking elicited by direct adrenergic or cholinergic stimulation of hypothalamus, Science 132: 301–302.PubMedCrossRefGoogle Scholar
  5. Hall, D. H. and Myers, R. D., 1972, Temperature changes produced by nicotine injected into the hypothalamus of the conscious monkey, Brain Res. 37: 241–251.PubMedCrossRefGoogle Scholar
  6. Jell, R. M., 1973, Responses of hypothalamic neurones to local temperature and to acetylcholine, noradrenaline and 5-hydroxy-tryptamine, Brain Res. 55: 123–134.PubMedCrossRefGoogle Scholar
  7. Jones, B., Bobillier, P. and Jouvet, M., 1969, Effets de la de-struction des neurones contenant des catecholamines du mesence- phale sur le cycle veille-sommeil du chat, C. R. Soc. Biol. (Paris) 163: 176–180.Google Scholar
  8. Legendre, R. and Pieron, H., 1910, Des résultats histophysiolog- iques de l’injection intra-occipito-atlantoidienne de liquides insomniques. Cr. Soc. Biol. (Paris) 1: 1108–1109.Google Scholar
  9. Miller, N. E., 1965, Chemical coding of behavior in the brain. Science 148: 328–338.PubMedCrossRefGoogle Scholar
  10. Myers, R. D., 1967, Transfusion of cerebrospinal fluid and tissue bound chemical factors between the brains of conscious monkeys: a new neurobiological assay. Physiol. Behav. 2: 373–377.CrossRefGoogle Scholar
  11. Myers, R. D., 1969, Chemical mechanisms in the hypothalamus mediating eating and drinking in the monkey. Ann. N. Y. Acad. Sci. 157: 918–933.PubMedCrossRefGoogle Scholar
  12. Myers, R. D., 1970, The role of hypothalamic transmitter factors in the control of body temperature, in “Physiological and Behavioral Temperature Regulation,” (J. D. Hardy, ed.), pp. 648–666, Charles Thomas, Springfield.Google Scholar
  13. Myers, R. D., 1974, “Chemical Stimulation of the Brain,” Van Nostrand Reinhold, New York.Google Scholar
  14. Myers, R. D. and Beleslin, D. B., 1971, Changes in serotonin release in hypothalamus during cooling or warming of the monkey, Amer. J. Physiol. 220: 1746–1754.PubMedGoogle Scholar
  15. Myers, R. D. and Chinn, C., 1973, Evoked release of hypothalamic norepinephrine during thermoregulation in the cat, Amer. J. Physiol. 224: 230–236.PubMedGoogle Scholar
  16. Myers, R. D. and Sharpe, L. G., 1968a, Chemical activation of ingestive and other hypothalamic regulatory mechanisms, Physiol. Behav. 3: 987–995.CrossRefGoogle Scholar
  17. Myers, R. D. and Sharpe, L. G., 1968b, Temperature in the monkey: transmitter factors released from the brain during thermoregulation, Science 161: 572–573.PubMedCrossRefGoogle Scholar
  18. Myers, R. D. and Waller, M. B., 1973, Differential release of acetylcholine from the hypothalamus and mesencephalon of the monkey during thermoregulation, J. Physiol. 230: 273–293.PubMedGoogle Scholar
  19. Myers, R. D. and Yaksh, T. L., 1969, Control of body temperature in the unanaesthetized monkey by cholinergic and aminergic systems in the hypothalamus, J. Physiol. 202: 483–500.PubMedGoogle Scholar
  20. Rudy, T. and Wolf, H., 1971, The effect of intrahypothalamically injected sympathomimetic amines on temperature regulation in the cat, J. Pharmacol. Exp. Ther. 179: 218–235.PubMedGoogle Scholar
  21. Sharpe, L. G. and Myers, R. D., 1969, Feeding and drinking following stimulation of the diencephalon of the monkey with amines and other substances, Exp. Brain Res. 8: 295–310.PubMedCrossRefGoogle Scholar
  22. Werman, R., 1972, CNS cellular level: membranes, Ann. Rev. Physiol. 34: 337–374.CrossRefGoogle Scholar
  23. Yaksh, T. L. and Efyers, R. D., 1972a, Hypothalamic “coding” in the unanesthetized monkey of noradrenergic sites mediating feeding and thermoregulation, Physiol. Behav. 8: 251–257.PubMedCrossRefGoogle Scholar
  24. Yaksh, T. L. and Myers, R. D., 1972b, Neurohumoral substances released from hypothalamus of the monkey during hunger and satiety, Amer. J. Physiol. 222: 503–515.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • R. D. Myers
    • 1
  1. 1.Laboratory of NeuropsychologyPurdue UniversityWest LafayetteUSA

Personalised recommendations