Interaction of Amine Systems in the Central Nervous System in the Regulation of the States of Vigilance

  • P. J. Morgane
  • W. C. Stern
Part of the Advances in Behavioral Biology book series (ABBI, volume 10)


One of the unique features of the nervous system is its tremendous organizational complexity. It is this complexity, well adapted to subserve function, which makes the particular site of a chemical reaction in the brain a parameter of essentially equal importance to substrate and enzyme activity in determining outcome. In the nervous system, perhaps more than in any other system in the body, biochemistry recognizes its dependence on structure. It is emphasized at the outset that a knowledge of the anatomical organization of the neurons specialized in neurohumoral function is a prerequisite for any approach to elucidating their roles in behavior. Although more is known about the chemical anatomy of the bio-genic amine and cholinergic systems than other chemical pathways it should be kept in mind that such chemical neuron tracts as the histamine, glycine and GABA systems also play essential roles in behavior. To date, however, little is known of their topographical organization and chemical geometry.


Locus Coeruleus Biogenic Amine Nucleus Raphe Dorsalis Cholinergic Mechanism Raphe Neuron 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • P. J. Morgane
    • 1
  • W. C. Stern
    • 1
  1. 1.Laboratory of NeurophysiologyThe Worcester Foundation for Experimental BiologyShrewsburyUSA

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