Modulation of Subcortical Inhibitory Mechanisms by Melatonin
The existence of an active arresting subcortical mechanism in the last state of convulsive activity has been suggested by several authors (Jung, 1949; Gastaut and Fisher-Williams, 1959; Fernández Guardiola et al., 196l; Kreindler, 1965). This assumption is based on experimental evidence and the existence of an inhibitory mechanism which integrates descending and ascending influences. Anatomically, this mechanism is located in the cerebellum, the ventral ponto-bulbar reticular formation (Magoun and Rhines, 1946), the caudate nucleus and the diffuse thalamic system. This inhibitory organization might be acting through various kinds of physiological inhibitions: Purpura and Housepian (1961) have shown direct cortical inhibition with prolonged IPSP (more than 200 msec), while Giaquinto et al. (1964) have reported a pre-synaptic inhibition of subcortical origin on spinal reflexes during natural sleep.
KeywordsPineal Gland Galvanic Skin Response Paradoxical Sleep Pyridoxal Phosphate Melatonin Administration
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- Anton-Tay, P., 1971, Pineal-brain relationships. In “The Pineal Gland”, ( G. E. W. Wolstenholme, J. Knight, ed.), pp. 213–227, Churchill, London.Google Scholar
- Fernández-Guardiola, A., Alcaraz, M., and Guzmán-Flores, C., 1956, Modificación de la descarga convulsiva cortical por estimulación mesencefálica, Boletín del Instituto de Estudios Médicos y Biológicos (México) 14: 15–21.Google Scholar
- Martini, L., Fraschini, F., and Motta, M., 1968, Neural control of anterior pituitary functions. Iri Beeent Prog, Hormone Res. (E.B. Astwood, ed), pp. 439–496. Academic Press. New York and London.Google Scholar
- Gastaut, H., and Fischer-Williams, M., 1959, The physiopathology of epileptic seizures, in “Handbook of Physiology” (J. Field ed.), Amer. Physiol. Soc., Washington, pp. 1–329.Google Scholar
- Jouvet, M., 1965, Paradoxical sleep: a study of its nature and mechanism, In “Progress in brain research”, (Akert ed.), Vol. 18, Elsevier, Amsterdam, pp. 20–57Google Scholar
- Kreindler, A., 1955, Epilepsia. Bucaresti, Acad. R.P.R.Google Scholar
- Magoun, H.W., and Rhines, R., 1946, An inhibitory mechanism in the bulbar reticular formation, Neurophysiol, 9: 165–171.Google Scholar
- Ortega, B.G., Anton-Tay, F., Esparza, N., and Cancino, F.M., 1973, Melatonin: Effect on cAMP concentration in the brain. In. Proceeding of the Fourth International Meeting of the International Society for Neurochemistry. Tokyo, Japan. In Press.Google Scholar
- Rechtschaffen, A., and Kales, A,, 1968, A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects, Public Health Service, U. S. Government Printing Office, Washington, D. C. pp. 1–12.Google Scholar