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5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid During Wakefulness, Sleep and After Electrical Stimulation of Specific Brain Structures

  • Miodrag Radulovački
Part of the Advances in Behavioral Biology book series (ABBI, volume 10)

Abstract

Jouvet has implicated 5-hydroxytryptamine (5-HT, serotonin) in the regulation of slow-wave sleep (SWS). He and his co-workers showed that subtotal destruction of the raphe nuclei decreased the level of 5-HT in the brain and led to a state of severe insomnia (Jouvet et al., 1966) and that the injection of p-chlorophenylalanine (pCPA), which inhibits 5-HT synthesis, produced similar results (Delorme et al., 1966). This effect was reversed by administration of 5-hydroxytryptophan (5-HTP), a precursor of 5-HT, which restored SWS and paradoxical sleep (PS).

Keywords

Electrical Stimulation Dorsal Raphe Nucleus Preoptic Area Immobilization Stress Paradoxical Sleep 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Miodrag Radulovački
    • 1
  1. 1.Department of Pharmacology, College of MedicineUniversity of IllinoisChicagoUSA

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