Modulatory Effects of Acetylcholine and Catecholamines in the Caudate Nucleus During Motor Conditioning

  • H. Brust-Carmona
  • R. Prado-Alcalá
  • J. Grinberg-Zylberbaum
  • J. Alvarez-Leefmans
  • I. Zarco Coronado
Part of the Advances in Behavioral Biology book series (ABBI, volume 10)


The caudate nucleus (CN) seems to be an important part of the neuronal circuit which controls the motor conditioned responses (MCR). In fact, lesions of the CN impair the performance of MCR (Thompson, 1959; Chorover and Gross, 1963; Prado et al., 1973). The CN activity is also necessary for the conditioned inhibition of learned motor responses (Brust-Carmona and Zarco-Co ronado, 1971a), Therefore, these facts suggest that in the CN exist both the necessary circuit to activate the elements for the performance of MCR and also neurones which are able to inhibit that activity, A logical postulation would be that the “activating system” is controlled by a certain chemical transmitter process and the “inhibitory system” by a different one.


Conditioning Stimulus Caudate Nucleus Retrograde Amnesia Spontaneous Motor Activity Sham Injection 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • H. Brust-Carmona
    • 1
  • R. Prado-Alcalá
    • 1
  • J. Grinberg-Zylberbaum
    • 1
  • J. Alvarez-Leefmans
    • 1
  • I. Zarco Coronado
    • 1
  1. 1.Physiology Department, Faculty of MedicineNational University of MexicoMexico 20, D. F.Mexico

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