Advertisement

Modulatory Effects of Acetylcholine and Catecholamines in the Caudate Nucleus During Motor Conditioning

  • H. Brust-Carmona
  • R. Prado-Alcalá
  • J. Grinberg-Zylberbaum
  • J. Alvarez-Leefmans
  • I. Zarco Coronado
Part of the Advances in Behavioral Biology book series (ABBI, volume 10)

Abstract

The caudate nucleus (CN) seems to be an important part of the neuronal circuit which controls the motor conditioned responses (MCR). In fact, lesions of the CN impair the performance of MCR (Thompson, 1959; Chorover and Gross, 1963; Prado et al., 1973). The CN activity is also necessary for the conditioned inhibition of learned motor responses (Brust-Carmona and Zarco-Co ronado, 1971a), Therefore, these facts suggest that in the CN exist both the necessary circuit to activate the elements for the performance of MCR and also neurones which are able to inhibit that activity, A logical postulation would be that the “activating system” is controlled by a certain chemical transmitter process and the “inhibitory system” by a different one.

Keywords

Conditioning Stimulus Caudate Nucleus Retrograde Amnesia Spontaneous Motor Activity Sham Injection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Andeń, N. E., Fuxe, K., Hamberger, B., Hokfelt, T., 1966, Quantitative study of the nigro-neostriatal dopamine neuron system in the rat. Acta Physiol. Scand. 67, 306–312.PubMedCrossRefGoogle Scholar
  2. 2.
    Andeń, N. E., Carlsson, A., Haggendal, J., 1969, Adrenergic mechanisms. Amer. Rev. Pharmacol. 9, 119–134.CrossRefGoogle Scholar
  3. 3.
    Ahlenius, S., Engel, J., 1971, Behavioral and biochemical effects of L-DOPA after inhibition of dopamine-beta-hydro- xylase in reserpine pretreated rats. Naunyn-Schmiedebergs Arch. Pharmak. 270, 349–360.CrossRefGoogle Scholar
  4. 4.
    Barbeu, A., 1962, The pathogenesis of Parkinson1s disease: A new hypothesis. Canad. Med. Assoc. J. 87, 802–807.Google Scholar
  5. 5.
    Bharcava, K. P., Kulshrestha, V. K., Srivastava, G. B., 1972, Central cholinergic and adrenergic mechanisms in the re¬lease of antidiuretic hormone. Brit. J, Pharmacol. 44, 617–627.Google Scholar
  6. 6.
    Brust-Carmona, H., Zarco-Coronado, I., 1971a, Instrumental and inhibitory conditioning in cats. II. Effects of paleocortex and caudate nucleus lesions. Bol. Est. Med. Biol. Mex. 27, 63–71.Google Scholar
  7. 7.
    Brust-Carmona, H., Prado-Alcala, R., Grinberg-Zylberbaum, J., 1971b, Bloqueo reversible de respuestas condicionadas mo-toras por la aplicación de anestésicos locales en el núcleo caudado. Bol. Est. Med. Biol. Méx. 27, 109–114.Google Scholar
  8. 8.
    Butcher, L. L., Rhodes, D. L., Yuwiler, A., 1972, Behavioral and biochemical effects or preferentially protecting mono-amines in the brain against the action of reserpine. Eur. J. Pharmacol. 18, 204–212.PubMedCrossRefGoogle Scholar
  9. 9.
    Carlsson, A., 1959, The occurrence, distribution and physiological role of catecholamines in the nervous systems. Pharmacol. Rev. 2, 490–494.Google Scholar
  10. 10.
    Chorover, S. L., Gross, Ch. G., 1963, Caudate nucleus lesions: Behavioral effects in the rat. Science 141, 826–827.PubMedCrossRefGoogle Scholar
  11. 11.
    Cotzias, G. C., Van Woert, M. H., Schiffer, L., 1967, Aromatic amino acids and modification of Parkinsonism. New Engl. J. Med. 276, 374–379.PubMedCrossRefGoogle Scholar
  12. 12.
    Edwards, A. L., 1968, Experimental design in psychological research. 3rd. Edition, pp. 155–167. Holt, Rinehart and Winston Inc.Google Scholar
  13. 13.
    Ehringer, H., Hornykiewicz, O., 1960, Verteilung von Noradrenalin and Dopamin (3-hydroxytyramin) im Gehirn des Menschen und ihr Verhalten bei Erkrankungen des Extrapyra. midalen Systems. Klin. Wsch. 38, 1236–1239.CrossRefGoogle Scholar
  14. 14.
    Fahn, S., Cote, L. J., 1968, Regional distribution of cholineacetylase in the brain of the rhesus monkey. Brain Res. 7, 323–325.PubMedCrossRefGoogle Scholar
  15. 15.
    Glowinski, J., Iversen, L. L., Axelrod, J., 1966, Regional studies of catecholamine s in the rat brain. XV. Effects of drugs on the disposition and metabolism of H3 norepin-ephrine and H3 dopamine. J. Pharmacol. Exp. Ther. 153, 30–41.PubMedGoogle Scholar
  16. 16.
    Hebb, C. O., Silver, A., 1956, Cholineacetylase in the central nervous system of man and some other mammals. J. Physiol. (Lond) 134, 718–728.Google Scholar
  17. 17.
    Jasper, H. H., Ajmone-Marsan, C., 1954, A stereotaxic atlas of the cat. Nat. Res. Council of Canada, Ottawa.Google Scholar
  18. 18.
    Jouvet, M., 1969, Biogenic amines and the states of sleep. Science 163, 32–41.PubMedCrossRefGoogle Scholar
  19. 19.
    McLennan, H., York, D. H., 1967, The action of dopamine on neurons of the caudate nucleus. J. Physiol. 189, 393–402.PubMedGoogle Scholar
  20. 20.
    Portig, P. J., Vogt, M., 1969, Release into the cerebral ventricles of substances with possible transmitter function in the caudate nucleus. J. Physiol. (Lond) 204, 687–715.Google Scholar
  21. 21.
    Prado-Alcala, R., Grinberg-Zylberbaum, J., Alvarez-Leefmans, J., Gomez, A., Singer, S., Brust-Carmona, H., 1972, A pos¬sible caudate-cholinergic mechanism in two instrumental con¬ditioned responses. Psychopharmacologia (Berl.) 25, 339–346.CrossRefGoogle Scholar
  22. 22.
    Prado-Alcala, R., Grinberg-Zylberbaum, J., Alvarez-Leefmans, J., Brust-Carmona, H., 1973, Suppression of motor conditioning by the injection of 3 M KC1 in the caudate nuclei of cats. Physiol. Behav. 9, 1–6.Google Scholar
  23. 23.
    Seiden, L. S., Peterson, D. D., 1968, Reversal of the reserpine-induced suppression of the conditioned avoidance response by L-DOPA: Correlation of behavioral and biochemical differences in two strains of mice. J. Pharmacol. Exp. Ther. 159, 422–428.PubMedGoogle Scholar
  24. 24.
    Siegel, S., 1956, Nonparametric Statistics for the Behavioral Sciences. New York: McGraw Hill.Google Scholar
  25. 25.
    Stein, L., 1968, Chemistry of reward and punishment. In: Psychopharmacology: A review of progress 1957–1967. D. H. Efron, ed. Public Health Service Publication No. 1836.Google Scholar
  26. 26.
    Thompson, R. L., 1959, Effects of lesions in the caudate nuclei and dorsofrontal cortex on conditioned avoidance behavior in cats. comp. physiol. Psychol. 52, 650–659.CrossRefGoogle Scholar
  27. 27.
    Vogt, M., 1954, The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs. J. Physiol. (Lond) 123, 451–481.Google Scholar
  28. 28.
    Wyers, E. J., Deadwyler, S. A., 1971, Duration and nature of retrograde amnesia produced by stimulation of caudate nucleus. Physiol. Behav. 6, 97–103.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • H. Brust-Carmona
    • 1
  • R. Prado-Alcalá
    • 1
  • J. Grinberg-Zylberbaum
    • 1
  • J. Alvarez-Leefmans
    • 1
  • I. Zarco Coronado
    • 1
  1. 1.Physiology Department, Faculty of MedicineNational University of MexicoMexico 20, D. F.Mexico

Personalised recommendations