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Neuropharmacology of Hyperkinetic Behavior: Response to Methylphenidate Correlated with Degree of Activity and Brain Damage

  • J. Gordon Millichap
Part of the Advances in Behavioral Biology book series (ABBI, volume 8)

Abstract

Neurological mechanisms of hyperkinesia are not completely understood. Diffuse brain lesions are thought to be a major cause of a large percentage of clinical cases of hyperactive behavior (Strauss and Lehtinen, 1947). In a recent study (Millichap et al., 1968) on hyperkinesia in children, fifty-seven per cent of the patients had a history of brain injury or other cerebral damage, and all but one patient had neurological signs of minimal brain dysfunction. In certain cases where the diagnosis of brain damage may be uncertain, other etiological factors such as delayed maturation of the brain and psychogenic disorders have been invoked (Eisenberg, 1964). In many patients the hyperactivity may be controlled and learning disabilities benefited by various drugs (Millichap and Fowler, 1967), and central nervous system stimulants such as methylphenidate (Ritalin) and dextroamphetamine (Dexedrine) are most effective. In contrast, phenobarbital has an excitant effect (Millichap and Millichap, 1966) and is contraindicated in the treatment of hyperactive behavior. The paradoxical calming effect of stimulants on hyperactive children has not been fully explained and the present clinical and laboratory studies were designed to investigate the relation of the degree of activity and brain damage to the drug response and to develop an experimental model for the development of new pharmacological therapies for hyperactivity.

Keywords

Locomotor Activity Brain Damage Auditory Perception Orbital Surface Hyperactive Behavior 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baily, P. and Davis, E.W., 1942, The syndrome of obstinate progression in the cat, Proc. Soc. Exp. Biol. Med. 51: 307.Google Scholar
  2. Beach, F.A., 1941, Effects of Brain lesions upon running activity in the male rat, J. Comp. Psychol. 31: 145.CrossRefGoogle Scholar
  3. Davis, G.D., 1958, Caudate lesions and spontaneous locomotion in the monkey, Neurology 8: 135.PubMedCrossRefGoogle Scholar
  4. Eisenberg, L., 1964, Behavioral manifestations of cerebral damage in childhood, in: “Brain Damage in Children”, (Birch X., ed.), Williams & Wilkins, Baltimore.Google Scholar
  5. Kennard, M.A., Spencer, S., and Fountain, G., Jr., 1941, Hyperactivity in monkeys following lesions of the frontal lobes, J. Neurophysiol. 4: 512.Google Scholar
  6. Livingston, R.B., Fulton, J.F., Delgado, J.M.R., Sachs, E., Brendler, S.J. and Davis, G.D., 1948, Stimulation and regional ablation of orbital surface of frontal lobe, in: “The Frontal Lobes”, Res. Publ. Ass. Nerv. Ment. Dis. 27: 405.Google Scholar
  7. Magoun, H.W., 1963, The Waking Brain, Charles C. Thomas, 2nd ed.Google Scholar
  8. Maire, F.W, and Patton, H.D., 1954, Hyperactivity and pulmonary edema from rostral hypothalamic lesions in rats, Amer. J. Physiol. 178: 315.PubMedGoogle Scholar
  9. Millichap, J.G. and Boldrey, E.E., 1967, Studies in hyperkinetic behavior. II. Laboratory and clinical evaluations of drug treatments, Neurology 17: 467.PubMedCrossRefGoogle Scholar
  10. Millichap, J.G. and Fowler, G.W.,1967, Treatment of minimal brain dysfunction syndromes: Selection of drugs for children with hyperactivity and learning disabilities, in: “Pediatric Neurology,” Ped. Clin. N. Amer. 14: 767.Google Scholar
  11. Millichap, J.G. and Millichap, P.A., 1966, Circadian analysis of phenobarbital-induced hyperkinesia in mice and hamsters, Proc. Soc. Exp. Biol. Med. 121: 754.Google Scholar
  12. Millichap, J.G., Egan, R.W., Hart, W.H. and Sturgis, L.H., 1969, Auditory perceptual deficit correlated with EEG dysrhythmias. Response to diphenylhydantoin sodium, Neurology 19: 870.PubMedCrossRefGoogle Scholar
  13. Millichap, J.G., Aymat, F., Sturgis, L.H., Larsen, K.W. and Egan, R.A., 1968, Hyperkinetic behavior and learning disorders. III. Battery of neuropsychological tests in controlled trial of methlphenidate, Am. J. Dis. Child. 116: 235.PubMedGoogle Scholar
  14. Ruch, T.C. and Shenkin, H.A., 1943, The relation of area 13 on orbital surface of frontal lobes to hyperactivity and hyperphagia in monkeys, J. Neurophysiol. 6: 349.Google Scholar
  15. Schulman, J.L. and Reisman, J.M., 1959, An objective measure of hyperactivity, Amer. J. Ment. Def. 64: 455.Google Scholar
  16. Strauss, A.A. and Lehtinen, L.E., 1947, Psychopathology and Education of the Brain Injured Child“, Grune & Stratton, New York.Google Scholar
  17. Wheatley, M.D., 1944, The hypothalamus and affective behavior in cats. A study of the effects of experimental lesions, with anatomic correlations, Arch. Neurol. Psychiat. 52: 298.Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • J. Gordon Millichap
    • 1
  1. 1.Departments of Neurology and PediatricsNorthwestern University Medical SchoolChicagoUSA

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