Changes in CSF Flow and Extracellular Space in the Developing Rat

  • Conrad E. Johanson
  • Dixon M. Woodbury
Part of the Advances in Behavioral Biology book series (ABBI, volume 8)


The effect of bulk flow of cerebrospinal fluid on the distribution of substances in the central nervous system has been a problem appreciated especially by those who have attempted to quantify the interstitial volume of the brain. The implications of this so-called “CSF sink” effect, particularly with regard to the measurement of brain extracellular space, have been treated thoroughly in reviews by Davson (1965) and by Woodbury (1967).


Biochemical Development Perfusion Fluid Interstitial Volume Volume Secretion Plexus Tissue 
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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Conrad E. Johanson
    • 1
  • Dixon M. Woodbury
    • 1
  1. 1.Department of PharmacologyUniversity of Utah College of MedicineSalt Lake CityUSA

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