The Effect of Short Experiences on the Incorporation of Radioactive Phosphate into Acid-Extractable Nuclear Proteins of Rat Brain

  • Edward Glassman
  • Barry Machlus
  • John Eric Wilson
Part of the Advances in Behavioral Biology book series (ABBI, volume 4)


It is generally accepted that the associative processes that go on in the brain during learning involve the formation of functionally new neuronal pathways or networks, the nature of which encode the memory. It is not known how the pathways or networks are selected, or what the relationship of the pathway or network is to the encoded information. This process of changing interneur-onal communication and information flow in the brain must involve molecular changes that produce new properties in these neurons. It should be clear from the onset that the molecules themselves do not encode memory within their chemical structures, but act only to affect the neurons so new pathways and networks of interneuronal communication can form. Many hypotheses have been proposed concerning these molecular changes. In general these involve chemical changes that affect the efficiency of synaptic transmission or the connectivity between neurons. This could happen, for example, if there were changes in the amount of transmitter released, changes in the rate of transmitter destruction, changes in the size of the synapse, or alterations in the number or activity of receptor sites for the transmitter. Thus the possible number of theoretical models is very large. The major problem is the generation of data that will have bearing on the molecular events associated with changes in neuronal connectivity.


Term Memory Training Experience Grid Floor Trained Animal Chemical Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Edward Glassman
    • 1
  • Barry Machlus
    • 1
  • John Eric Wilson
    • 1
  1. 1.The Neurobiology Program and The Division of Chemical Neurobiology of the Department of Biochemistry, School of MedicineThe University of North CarolinaChapel HillUSA

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