Slow Biological Processes in Memory Storage and “Recovery” of Memory
Despite all the evidence which has been reviewed at this symposium, the hypothesis that RNA and protein synthesis are required for long-term memory storage has not yet been firmly established. Although it is difficult to conceive of long-term memory storage in the brain without mediation of the prime cellular regulatory mechanisms which rely heavily on the synthesis of RNA and proteins, the various experiments which have been described here do not prove conclusively that these macromolecules are required. One could argue, for example, that increased incorporation of radioactive precursors into brain macromolecules during a learning experience is attributable to generalized cerebral activation or to changes in the specific radioactivity of precursor pools. Likewise, studies with inhibitors of cerebral protein synthesis can be faulted because of the known side effects of both puromycin (Cohen, Ervin and Barondes, 1966) and cycloheximide (Segal, Squire and Barondes, 1971). However, though we may challenge the interpretation of the experiments which have been presented, the general hypothesis remains supported.
KeywordsNerve Ending Passive Avoidance Memory Storage Autocatalytic Process Axoplasmic Transport
Unable to display preview. Download preview PDF.
- Agranoff, B.W. Further studies on memory formation in the goldfish. This volume.Google Scholar
- Barondes, S.H. and Cohen, H.D. 1967. Delayed and sustained effect of acetoxycycloheximide on memory in mice. Proc. Nat. Acad. Sci. 14, 371–376.Google Scholar
- Deutsch, J.A. The cholinergic synapse and the site of memory. This volume.Google Scholar
- Serota, R.G. 1971. Acetoxycycloheximide and transient amnesia in the rat. Proc. Nat. Acad. Sci., 56, 730–735.Google Scholar
- Squire, L.R. and Barondes, S.H. Variable decay of memory and its recovery in cycloheximide-treated mice. Proc. Nat. Acad. Sci., in press.Google Scholar