Slow Biological Processes in Memory Storage and “Recovery” of Memory
Part of the
Advances in Behavioral Biology
book series (ABBI, volume 4)
Despite all the evidence which has been reviewed at this symposium, the hypothesis that RNA and protein synthesis are required for long-term memory storage has not yet been firmly established. Although it is difficult to conceive of long-term memory storage in the brain without mediation of the prime cellular regulatory mechanisms which rely heavily on the synthesis of RNA and proteins, the various experiments which have been described here do not prove conclusively that these macromolecules are required. One could argue, for example, that increased incorporation of radioactive precursors into brain macromolecules during a learning experience is attributable to generalized cerebral activation or to changes in the specific radioactivity of precursor pools. Likewise, studies with inhibitors of cerebral protein synthesis can be faulted because of the known side effects of both puromycin (Cohen, Ervin and Barondes, 1966) and cycloheximide (Segal, Squire and Barondes, 1971). However, though we may challenge the interpretation of the experiments which have been presented, the general hypothesis remains supported.
KeywordsNerve Ending Passive Avoidance Memory Storage Autocatalytic Process Axoplasmic Transport
Agranoff, B.W. Further studies on memory formation in the goldfish. This volume.Google Scholar
Barondes, S.H. 1965. Relationship of biological regulatory mechanisms to learning and memory. Nature
, 18–21.CrossRefGoogle Scholar
Barondes, S.H. 1968. Further studies of the transport of protein to nerve endings. J. Neurochem.
, 343–350.CrossRefGoogle Scholar
Barondes, S.H. 1970. Cerebral protein synthesis inhibitors block long-term memory. Internat. Rev. Neurobiol.
, 177–205.CrossRefGoogle Scholar
Barondes, S.H. and Cohen, H.D. 1967. Delayed and sustained effect of acetoxycycloheximide on memory in mice. Proc. Nat. Acad. Sci. 14
, 371–376.Google Scholar
Cohen, H., Ervin, F. and Barondes, S.H. 1966. Puromycin and cyclo-heximide: Different effects on hippocampal electrical activity. Science
, 1557–1558.CrossRefGoogle Scholar
Daniels, D. 1971. Acquisition, storage, and recall of memory for brightness discrimination by rats following intracerebral infusion of acetoxycycloheximide. J. Comp. Physiol. Psychol.
, 110–118.CrossRefGoogle Scholar
Deutsch, J.A. The cholinergic synapse and the site of memory. This volume.Google Scholar
Droz, B. and Barondes, S.H. 1969. Nerve endings: Rapid appearance of labeled protein shown by electron microscope radioautography. Science
, 1131–1132.CrossRefGoogle Scholar
Feit, H., Dutton, G.R., Barondes, S.H. and Shelanski, M.L. 1971. Microtubule protein: Identification in and transport to nerve endings. J. Cell Biol.
, 138–147.CrossRefGoogle Scholar
Flexner, L.B., Flexner, J.B. and Roberts, R.B. 1966. Stages of memory in mice treated with acetoxycycloheximide before or immediately after learning. Proc. Nat. Acad. Sci.
, 730–735.CrossRefGoogle Scholar
Flexner, J.B., Flexner, L.B. and Stellar, E. 1963. Memory in mice as affected by intracerebral puromycin. Science
, 57–59.CrossRefGoogle Scholar
Geller, A., Robustelli, F., Barondes, S.H., Cohen, H.D. and Jarvik, M.E. 1969. Impaired performance by post-trial injections of cycloheximide in a passive-avoidance task. Psychopharmacologia
, 371–376.CrossRefGoogle Scholar
McEwen, B.S. and Grafstein, B. 1968. Fast and slow components in axonal transport of protein. J. Cell Biol.
, 494–508.CrossRefGoogle Scholar
Ochs, S., Sabir, M.E. and Ranish, N. 1969. Somal site of synthesis of fast transported materials in mammalian nerve fibers. J.Neurobiol.
, 329–344.CrossRefGoogle Scholar
Quartermain, D. and McEwen, B.S. 1970. Temporal characteristics of amnesia induced by protein synthesis inhibitor: Determination by shock level. Nature
, 677–678.CrossRefGoogle Scholar
Roberts, R.B. and Flexner, L.B. 1969. The biochemical basis of long-term memory. Quart. Rev. Biophys.
Sampson, F. 1971. Mechanism of axoplasmic transport. J. Neurobiol. 2
, 347–360.CrossRefGoogle Scholar
Segal, D.S., Squire, L.R. and Barondes, S.H. 1971. Cycloheximide: Its effects on activity are dissociable from its effect on memory. Science
, 82–84.CrossRefGoogle Scholar
Serota, R.G. 1971. Acetoxycycloheximide and transient amnesia in the rat. Proc. Nat. Acad. Sci.
, 730–735.Google Scholar
Squire, L.R. and Barondes, S.H. 1970. Actinomycin-D: Effects on memory at different times after training. Nature
, 649–650.CrossRefGoogle Scholar
Squire, L.R. and Barondes, S.H. Variable decay of memory and its recovery in cycloheximide-treated mice. Proc. Nat. Acad. Sci.
, in press.Google Scholar
Uretsky, E. and McCleary, J. 1969. Effect of hippocampal isolation on retention. J. Comp. Physiol. Psychol.
, 1–8.CrossRefGoogle Scholar
© Plenum Press, New York 1972