Studies on the Mechanism of Action of 6-Methoxytetrahydro-β-Carboline in Elevating Brain Serotonin
Over many years, the involvement of biogenic amines in the mediation of depression has been substantiated. Still remaining to be answered is the question whether low brain serotonin (5-HT) or norepinephrine (NE) is specifically responsible for this abnormal state. The evidence that elevating the level of brain 5-HT alleviates depression was first presented by Coppen, Shaw, and Farrell (1963). They reported that administration of tryptophan to depressed patients potentiated the antidepressant action of a monoamine oxidase (MAO) inhibitor. Additional elaboration on this subject was presented by Glassman (1969). If resolution of the problem as to the function of these amines lies in the differential elevation of a specific amine, then it would seem desirable to have an agent that would specifically elevate only one brain amine.
KeywordsMouse Brain Propylene Glycol Tryptophan Hydroxylase Brain Serotonin Large Percentage Increase
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