Effects of Drugs on Catecholamine Synthesis
Although the exact role of catecholamines in brain function is not clearly established, it is becoming increasingly evident that dopamine and norepinephrine do play important roles in control of movement, in determining affective state and alertness, and in neuroendocrine relationships. Utilization of catecholamines by neurons is associated with increased rates of synthesis, so that levels of the amines are altered only slightly compared to changes in their rates of utilization and replacement. Estimates of synthesis rates may, therefore, be more useful than determination of catecholamine levels in assessing changes in neuronal function.
KeywordsTyrosine Hydroxylase Catecholamine Synthesis Private Capacity Storage Vesicle Phenyl Ethanolamine
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