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Regulation of Catecholamine Biosynthesis: Tyrosine Hydroxylase and Dihydropteridine Reductase

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 1))

Abstract

It is generally accepted that catecholamines have an important role in the regulation of several brain functions, and there is increasing evidence that they may be involved in the development of certain affective disorders. Most of the agents used in the treatment for depression and mania are known to affect either the synthesis, storage, and release of catecholamines or the central adrenergic receptors. These brief considerations are sufficient to justify an examination of the enzymes that are considered important for the regulation of catecholamine biosynthesis.

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References

  • Alousi, A., and Weiner, N. 1966. The regulation of norepinephrine synthesis in sympathetic nerves: Effect of nerve stimulation, cocaine, and catecholamine-releasing agents. Proc. Nat. Acad. Sci. 56:1491.

    Article  PubMed  CAS  Google Scholar 

  • Besson, M. J., Cheramy, A.; Musacchio, J. M.; and Glowinski, J. In preparation.

    Google Scholar 

  • Brenneman, A. R., and Kaufman, S. 1964. The role of tetrahydropter-idines in the enzymatic conversion of tyrosine to 3,4-dihydroxy-phenylalanine. Biochem. Biophys. Res. Commun. 17:177.

    Article  CAS  Google Scholar 

  • Bygdeman, S., and von Euler, U. S. 1958. Resynthesis of catechol hormones in the cat’s adrenal medulla. Acta Physiol. Scand. 44:375.

    Article  PubMed  CAS  Google Scholar 

  • de Duve, C. 1964. Principles of tissue fractionation. J. Theor. Biol. 6:33.

    Article  PubMed  CAS  Google Scholar 

  • von Euler, U. S., and Hellner-Björkman, S. 1955. Effect of increased adrenergic nerve activity on the content of noradrenaline and adrenaline in cat organs. Acta Physiol. Scand. 118:17.

    Google Scholar 

  • Goldstein, M.; Ohi, Y.; and Backstrom, T. 1970. The effect of ouabain on catecholamine biosynthesis in rat brain cortex slices. J. Pharmacol. Exp. Ther. 174:77.

    PubMed  CAS  Google Scholar 

  • Gordon, R., Reid, J. V. O.; Sjoerdsma, A.; and Udenfriend, S. 1966. Increased synthesis of norepinephrine in the rat heart on electrical stimulation of the stellate ganglia. Molec. Pharmacol. 2:606.

    Google Scholar 

  • Hökfelt, B., and McLean, J. 1950. The adrenaline and noradrenaline content of the suprarenal glands of the rabbit under normal conditions and after various forms of stimulation. Acta Physiol. Scand. 21:258.

    Article  PubMed  Google Scholar 

  • Holland, W. C., and Schümann, H. J. 1956. Formation of catechol amines during splanchnic stimulation of the adrenal gland of the cat. Brit. J. Pharmacol. 11:449.

    PubMed  CAS  Google Scholar 

  • Ikeda, M.; Fahien, L. A.; and Udenfriend, S. 1966. A kinetic study of bovine adrenal tyrosine hydroxylase. J. Biol. Chem. 241:4452.

    PubMed  CAS  Google Scholar 

  • Kopin, I. J.; Weise, V. K.; and Sedvall, G. C. 1969. Effect of false transmitters on norepinephrine synthesis. J. Pharmacol. Exp. Ther. 170:246.

    PubMed  CAS  Google Scholar 

  • Laduron, P., and Belpaire, F. 1968. Tissue fractionation and cat-echolamines-II. Biochem. Pharmacol. 17:1127.

    Article  PubMed  CAS  Google Scholar 

  • Levitt, M.; Spector, S.; Sjoerdsma, A.; and Udenfriend, S. 1965. Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused guinea-pig heart. J. Pharmacol. Exp. Ther. 148:1.

    PubMed  CAS  Google Scholar 

  • Lloyd, T. A. 1969. Isolation of tyrosine hydroxylase cofactor from bovine adrenal medulla and sheep brain. Fed. Proc. 28:873.

    Google Scholar 

  • Lloyd, T., and Weiner, N. 1970. Isolation and characterization of the tyrosine hydroxylase cofactor from bovine adrenal medulla. Pharmacologist 12:287.

    Google Scholar 

  • Mueller, R. A.; Thoenen, H.; and Axelrod, J. 1969. Increase in tyrosine hydroxylase activity after reserpine administration. J. Pharmacol. Exp. Ther. 169:74.

    PubMed  CAS  Google Scholar 

  • Musacchio, J. M. 1967. Subcellular distribution of adrenal tyrosine hydroxylase. Pharmacologist 9:210.

    Google Scholar 

  • Musacchio, J. M. 1968. Subcellular distribution of adrenal tyrosine hydroxylase. Biochem. Pharmacol. 17:1470.

    Article  PubMed  CAS  Google Scholar 

  • Musacchio, J. M. 1969. Beef adrenal medulla dihydropteridine reductase. Biochem. Biophys. Acta 191:485.

    PubMed  CAS  Google Scholar 

  • Musacchio, J. M., and Castellucci, L. B. 1969. Effect of adrenal medulla dihydropteridine reductase and tyrosine hydroxylase adrenal cofactor on DOPA formation. Pharmacologist 11:274.

    Google Scholar 

  • Musacchio, J. M.; Julou, L.; Kety, S. S.; and Glowinski, J. 1969. Increase in rat brain tyrosine hydroxylase activity produced by electroconvulsive shock. Proc. Nat. Acad. Sci. 63:1117.

    Article  PubMed  CAS  Google Scholar 

  • Musacchio, J. M., and Weise, V. K. 1965. Effects of decentralization on norepinephrine biosynthesis from tyrosine, DOPA and dopamine. Pharmacologist 7:156.

    Google Scholar 

  • Musacchio, J. M.; Wurzburger, R. J.; and D’Angelo, G. L. 1971. Different molecular forms of bovine adrenal tyrosine hydroxylase. Molec. Pharmacol. 7:(#2), in press.

    Google Scholar 

  • Nagatsu, T.; Levitt, M.; and Udenfriend, S. 1964a. Conversion of L-tyrosine to 3,4-dihydroxyphenylalanine by cell-free preparation of brain and sympathetically innervated tissues. Biochem. Biophys. Res. Commun. 14:543.

    Article  PubMed  CAS  Google Scholar 

  • Nagatsu, T.; Levitt, M.; and Udenfriend, S. 1964b. Tyrosine hydroxylase: The initial step in norepinephrine biosynthesis. J. Biol. Chem. 239:2910.

    PubMed  CAS  Google Scholar 

  • Neff, V. H., and Costa, E. 1966. The influence of monoamine oxidase inhibition on catecholamine synthesis. Life Sci. 5:951.

    Article  PubMed  CAS  Google Scholar 

  • Oliverio, A., and Stjärne, L. A. 1965. Acceleration of noradrenaline turnover in the mouse heart by cold exposure.Life Sci. 4:2339.

    Article  PubMed  CAS  Google Scholar 

  • Petrack, B.; Sheppy, F.; and Fetzer, V. 1968. Studies on tyrosine hydroxylase from bovine adrenal medulla. J. Biol. Chem. 243:743.

    PubMed  CAS  Google Scholar 

  • Sage, H. J.; Smith, W. J.; and Kirshner, N. 1967. Mechanism of secretion from the adrenal medulla. Molec. Pharmacol. 3:81.

    CAS  Google Scholar 

  • Sedvall, G. C., and Kopin, I. J. 1967. Influence of sympathetic denervation and nerve impulse activity of tyrosine hydroxylase in the rat submaxillary gland. Biochem. Pharmacol. 16:39.

    Article  CAS  Google Scholar 

  • Thoenen, H.; Mueller, R. A.; and Axelrod, J. 1969. Trans-synaptic induction of adrenal tyrosine hydroxylase. J. Pharmacol. Exp. Ther. 169:249.

    PubMed  CAS  Google Scholar 

  • Udenfriend, S.; Zaltzman-Nirenberg, P.; and Nagatsu, T. 1965. Inhibitors of purified beef adrenal tyrosine hydroxylase. Biochem. Pharmaco1. 14:837.

    Article  CAS  Google Scholar 

  • Viveros, O. H.; Arqueros, L.; Connett, R. J.; and Kirshner, N. 1969. Mechanism of secretion from the adrenal medulla. Molec. Pharmacol. 5:60.

    CAS  Google Scholar 

  • Weiner, N., and Selvaratnam, I. 1968. The effect of tyramine on the synthesis of norepinephrine. J. Pharmacol. Ex. Ther. 161:21.

    CAS  Google Scholar 

  • Wurzburger, R. J., and Musacchio, J. M. 1971. Subcellular distribution and aggregation of bovine adrenal tyrosine lydroxylase. J. Pharmacol. Exp. Ther. in press.

    Google Scholar 

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© 1971 Plenum Press, New York

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Musacchio, J.M. (1971). Regulation of Catecholamine Biosynthesis: Tyrosine Hydroxylase and Dihydropteridine Reductase. In: Ho, B.T., McIsaac, W.M. (eds) Brain Chemistry and Mental Disease. Advances in Behavioral Biology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3057-8_3

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  • DOI: https://doi.org/10.1007/978-1-4684-3057-8_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3059-2

  • Online ISBN: 978-1-4684-3057-8

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