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Chemotherapy of Depression

  • Gerald L. Klerman
Part of the Advances in Behavioral Biology book series (ABBI, volume 1)

Abstract

It is now thirteen years since the simultaneous introduction in 1957 of iproniazid (Marsilid), the prototypic monoamine oxidase inhibitor, and imipramine (Tofranil), the prototypic tricyclic antidepressant. Since then, a large number of new compounds has been developed and introduced for therapeutic usage. Numerous symposiums have been held and a large number of papers have appeared about the clinical efficacy of these drugs and the biochemical bases of their actions. Nonetheless, considerable controversy continues. There are unresolved questions as to toxicity and as to therapeutic efficacy. Moreover, there is a lack of consensus as to the etiology and nosology of depressions, and whether specific patient types respond better to one or another treatment.

Keywords

Depressed Patient Affective Disorder Antidepressant Drug Placebo Response Depressive Illness 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Gerald L. Klerman
    • 1
  1. 1.Harvard Medical SchoolMassachusetts General HospitalBostonUSA

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