Thyroid-Imipramine Interaction: Clinical Results and Basic Mechanism
When imipramine alone is given, men respond much faster than women.
When T3 is added to imipramine, women benefit enormously and men benefit little, if at all.
Whether patients are retarded or agitated has no influence on the T3 phenomenon, though it has some influence on basic response to imipramine.
KeywordsThyroid Hormone Normal Woman Placebo Patient Depressed Woman Vanillylmandelic Acid
Unable to display preview. Download preview PDF.
- Dairman, W. R.; Gordon, R.; Spector, S.; Sjoerdsma, A.; and Udenfriend, S. 1968. Effect of alpha-blockers on catecholamine biosynthesis. Fed. Proc. 27:240..Google Scholar
- Earle, B. V. 1970. Thyroid hormone and tricyclic antidepressants in resistant depressions. Amer. J. Psychiat. 126:143.Google Scholar
- Goetsch, E. 1918. Newer methods in the diagnosis of thyroid disorders: pathological and clinical. New York J. Med., 18:259.Google Scholar
- Lipton, M. A.; Prange, A. J., Jr.; Dairman, W.; and Udenfriend, S. 1968. Increased rate of norepinephrine biosynthesis in hypothy-roid rats. Fed. Proc. Abstracts 27:399.Google Scholar
- Long, C. (ed.) 1968. Biochemist’s Handbook. Princeton, N. J.: D. Van Nostrand, p. 926.Google Scholar
- Maas, J. W. Personal communication.Google Scholar
- McClane, T.; Wilson, I. C.; and Prange, A. J., Jr. The effects of imipramine and L-triiodothyronine on mental activity, thyroid state, and response to norepinephrine infusion in normal women. In preparation.Google Scholar
- McClure, D. J.; and Cleghorn, R. A. 1968. Suppression studies in affective disorders. Canad. Psychiat. Assoc. J. 13:477.Google Scholar
- Park, S.; Prange, A. J., Jr.; and Happy, J. The effects of altered thyroid state in phenothiazine response distribution and metabolism in the rat. In preparation.Google Scholar
- Prange, A. J., Jr.; Wilson, I. C.; and Lipton, M. A. In preparation.Google Scholar
- Prange, A. J., Jr.; Wilson, I. C.; Rabon, A. M.; and Lipton, M. A. 1968. Enhancement of imipramine by triiodothyronine in unselected depressed patients. Excerpta Medica International Congress Series. No. 180, p. 532.Google Scholar
- Rosenblatt, S.; Chanley, J. D.; and Leighton, W. P. 1969a. The investigation of adrenergic metabolism with 7H3-norepinephrine in psychiatric disorders—I. Temporal change in the distribution of urinary tritiated metabolites and the effects of drugs. J. Psychiat. Res. 6:307.PubMedCrossRefGoogle Scholar
- Rosenblatt, S.; Chanley, J. D.; and Leighton, W. P. 1969b. The investigation of adrenergic metabolism with 7H3-norepinephrine in psychiatric disorders—II. Temporal changes in the distribution of urinary tritiated metabolites in affective disorders. J. Psychiat. Res. 6:321.PubMedCrossRefGoogle Scholar
- Taniguchi, K.; Kakimoto, Y.; and Armstrong, M. D. 1964. Quantitative determination of metanephrine and normetanephrine in urine. J. Lab. Clin. Med. 64.Google Scholar
- Wheatley, D. A comparative trial of amitryptyline with two dose levels of L-triiodothyronine in depressed outpatients. In preparation.Google Scholar