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Mechanism of Specific Tumor-Cell Lysis by Alloimmune T Lymphocytes: Resolution and Characterization of Discrete Steps in the Cellular Interaction

  • Eric Martz
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 7)

Abstract

A cytolytic thymus-derived lymphocyte (CTL)* is a specialized cell the recognized function of which is immune killing. CTLs are generated by a process of antigen-induced clonal selection, proliferation, and differentiation. Each CTL apparently recognizes a single H-2 alloantigen. CTL targets are eukaryotic tissue cells bearing specific membrane-associated antigen, such as virus-infected autologous cells, grafted cells of genetically different origin, tumor cells, or autologous cells made more immunogenic by chemical modification. CTLs are believed to play a uniquely important role in physiological immune tissue destruction (for which serum immunoglobulins are usually insufficient), probably utilizing mononuclear phagocytes as an amplifying mechanism.

Keywords

Target Cell Divalent Cation Adhesion Formation Specific Lysis P81S Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

ADCC

antibody-dependent cell-mediated cytotoxicity

cAMP

cyclic adenosine monophosphate

CCB

cytochalasin B

CMF

“calcium-and-magnesium-free” medium

CTL

cytolytic thymus-derived lymphocyte

DCM

dextran-containing medium

EDTA

ethylenediaminetetraacetate, a divalent ion chelator

EGTA

ethylene glycol-bis (β-amino-ethyl-ether) N,N’-tetraacetic acid, a calcium-specific chelator

KCIL

killer-cell-independent lysis

TSL

T-lymphocyte-mediated specific lysis

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Eric Martz
    • 1
  1. 1.Department of PathologyHarvard Medical SchoolBostonUSA

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