Mechanism of T-Cell-Mediated Cytolysis: The Lethal Hit Stage
First, only model cytotoxicity experiments done in vitro will be described or discussed, irrespective of whether similar cytotoxic phenomena occur or do not occur in vivo. Cell-mediated cytotoxicity will thus be considered here, not from a utilitarian immunologic point of view, but as a problem of cell physiology studied under test-tube conditions.
KeywordsTarget Cell Effector Cell Specific Adsorption Recognition Stage Metabolic Complexity
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- Benacerraf, B., Unanue, E.R., Dorff, M.E., and Kennedy, L.J., 1975, Binding of the terpolymer of L-glutamic acid, L-alanine, L-tyrosine by mouse thymic lymphocytes: Inhibition by anti-H-2 alloantisera, in: Membrane Receptors of Lymphocytes, pp. 127–130 (M. Seligmann, J.L. Preud’homme, and F. M. Kourilsky, eds.), North-Holland Publishing Co., Amsterdam.Google Scholar
- Brondz, B.D., 1968, Complex specificity of immune lymphocytes in allogeneic cell cultures, Folia Biol. 14:115.Google Scholar
- Cerottini, J.-C., and Brunner, K.T., 1972, Reversible inhibition of lymphocyte-mediated cytotoxicity by Cytochalasin B, Nature (London) New Biol. 237:272.Google Scholar
- Golstein, P., 1975, Cell mediated cytolysis. Foetal liver cells as non-T effector cells, in vitro educated spleen cells as T effector cells, Proceedings of the XIth International Cancer Congress, Excerpta Med. Int. Congr. Ser. pp. 280–284.Google Scholar
- Hämmerling, G.J., Lonai, P., and McDevitt, H.O., 1975, Specificity and temperature requirements for T cell interaction with an antigen, in: Membrane Receptors of Lymphocytes, pp. 121–126 (M. Seligmann, J.L. Preud’homme, and F.M. Kourilsky, eds.), North-Holland Publishing Co., Amsterdam.Google Scholar
- Orange, R.P., Kaliner, M.A., and Austen, K.F., 1971, The immunological release of histamine and slow-reacting substance of anaphylaxis from human lung. III. Biochemical control mechanisms involved in the immunologic release of the chemical mediators, in: Biochemistry of the Acute Allergic Reactions, pp. 189–204 (K.F. Austen and E.L. Becker, eds.), Blackwell Scientific Publications, Oxford.Google Scholar
- Rosenau, W., 1963, Interaction of lymphoid cells with target cells in tissue culture, in: Cell-Bound Antibodies, p. 75 (B. Amos and H. Koprowski, eds.), The Wistar Institute Press, Philadelphia.Google Scholar
- Taylor, R.B., Duffus, W.P.H., Raff, M.C., and de Petris, S., 1971, Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by anti-immunoglobulin antibody, Nature (London) New Biol. 233:225. Todd, R.F., 1975, Inhibition of binding between cytotoxic (T) lymphocytes and tumor target cells by inhibitors of energy metabolism, Transplantation 20:350.Google Scholar
- Wagner, H., Trostmann, H., Pfizenmaier, K., and Röllinghoff, M., 1975, The cytotoxic activity of mouse T lymphocytes against allogeneic cytotoxic T cells, Z. Immunitaets-forsch. 150:81.Google Scholar
- Wilson, D.B., 1965, Quantitative studies on the behavior of sensitized lymphocytes in vitro. I. Relationship of the degree of destruction of homologous target cells to the number of lymphocytes and to the time of contact in culture and consideration of the effects of isoimmune serum, J. Exp. Med. 122:143.PubMedCrossRefGoogle Scholar