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Mechanism of T-Cell-Mediated Cytolysis: The Lethal Hit Stage

  • Pierre Golstein
  • Evan T. Smith
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 7)

Abstract

The existence of cell-mediated cell-destruction systems in higher organisms (extensively reviewed by Perlmann and Holm, 1969, and Cerottini and Brunner, 1974) raises two basic questions, namely: (1) Why; i.e., what is the selective advantage for the reproductive multicellular individual of possessing cytotoxic devices? (2) How; i.e., by which mechanism(s) is a cell able to destroy another cell? This chapter deals exclusively with the latter question, delineated as follows:

First, only model cytotoxicity experiments done in vitro will be described or discussed, irrespective of whether similar cytotoxic phenomena occur or do not occur in vivo. Cell-mediated cytotoxicity will thus be considered here, not from a utilitarian immunologic point of view, but as a problem of cell physiology studied under test-tube conditions.

Keywords

Target Cell Effector Cell Specific Adsorption Recognition Stage Metabolic Complexity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Pierre Golstein
    • 1
  • Evan T. Smith
    • 1
  1. 1.Department of ZoologyUniversity College LondonLondonEngland

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