Significance of the Major Histocompatibility Complex As Assessed by T-Cell-Mediated Lympholysis Involving Syngeneic Stimulating Cells
The major histocompatibility complex (MHC), which is known to code for cell-surface antigens responsible for allograft rejection (Gorer et al., 1948; Shreffler and David, 1975), has also been shown to play an essential role in a number of functions associated with the immune systems of several animal species (Benacerraf and McDevitt, 1972; McDevitt and Bodmer, 1974). The murine MHC, which is known as the H-2 complex, has been divided into four major regions, which include two serologic regions known as H-2K and H-2D, or K and D, separated by two other regions designated I and S (Shreffler and David, 1975). The K and D regions determine the strong serologically detectable transplantation antigens of the mouse, which appear to be important as the target antigens for thymus-derived-(T-)cell-mediated lympholysis generated by culturing lymphocytes with H-2-incompatible stimulating cells (Alter et al., 1973; Abbasi et al., 1973; Schendel et al., 1973; Nabholz et al., 1974; Bevan, 1975a). Cytotoxic effector cells can be generated without inducing strong proliferation by culturing mixtures of cells differing only at the K or D region or both, whereas cell mixtures differing only at the I region induce strong proliferative responses in the absence or presence of only weak cytotoxic responses (Widmer et al., 1973; Plate, 1974; Wagner et al., 1975; Hodes et al., 1976). The S region is positioned adjacent to and to the left of the D region with respect to the centromere.
KeywordsMajor Histocompatibility Complex Effector Cell Mixed Lymphocyte Reaction Splenic Lymphocyte Parental Haplotype
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