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Significance of the Major Histocompatibility Complex As Assessed by T-Cell-Mediated Lympholysis Involving Syngeneic Stimulating Cells

  • Gene M. Shearer
  • Anne-Marie Schmitt-Verhulst
  • Terry G. Rehn
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 7)

Abstract

The major histocompatibility complex (MHC), which is known to code for cell-surface antigens responsible for allograft rejection (Gorer et al., 1948; Shreffler and David, 1975), has also been shown to play an essential role in a number of functions associated with the immune systems of several animal species (Benacerraf and McDevitt, 1972; McDevitt and Bodmer, 1974). The murine MHC, which is known as the H-2 complex, has been divided into four major regions, which include two serologic regions known as H-2K and H-2D, or K and D, separated by two other regions designated I and S (Shreffler and David, 1975). The K and D regions determine the strong serologically detectable transplantation antigens of the mouse, which appear to be important as the target antigens for thymus-derived-(T-)cell-mediated lympholysis generated by culturing lymphocytes with H-2-incompatible stimulating cells (Alter et al., 1973; Abbasi et al., 1973; Schendel et al., 1973; Nabholz et al., 1974; Bevan, 1975a). Cytotoxic effector cells can be generated without inducing strong proliferation by culturing mixtures of cells differing only at the K or D region or both, whereas cell mixtures differing only at the I region induce strong proliferative responses in the absence or presence of only weak cytotoxic responses (Widmer et al., 1973; Plate, 1974; Wagner et al., 1975; Hodes et al., 1976). The S region is positioned adjacent to and to the left of the D region with respect to the centromere.

Keywords

Major Histocompatibility Complex Effector Cell Mixed Lymphocyte Reaction Splenic Lymphocyte Parental Haplotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Gene M. Shearer
    • 1
  • Anne-Marie Schmitt-Verhulst
    • 1
  • Terry G. Rehn
    • 1
  1. 1.Immunology BranchNational Cancer InstituteBethesdaUSA

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