Advertisement

Regulation of the Immune Response by T-Cell Subclasses

  • Harvey Cantor
  • Edward Boyse
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 7)

Abstract

Purified T lymphocytes mediate a wide variety of immunologic functions. These cells can generate cytotoxic responses to alloantigens (Cerottini and Brunner, 1974; Cantor et al., 1975a), exert helper (Transplantation Reviews, 1969) and suppressive (Gershon, 1974) effects on the production of antibody, and initiate graft-vs.-host (Cantor, 1972) and delayed-type inflammatory responses (David and David, 1972). One may ask whether this diversity of function reflects a functional heterogeneity of T cells existing prior to antigen stimulation. According to this model, each T-cell function might be mediated by a subclass of T cells that has been programmed during differentiation to express a single or limited type of immune response. Alternatively, a single mature pluripotent T cell may be induced by antigen to give rise to cells capable of mediating the complete range of T-dependent responses.

Keywords

Natural Killer Natural Killer Cell Spleen Cell Natural Killer Activity Sheep Erythrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Alter, B.J., Schendel, D.J., Bach, M.L., Bach, F.H., and Klein, J., 1971, J. Exp. Med. 137:1303.CrossRefGoogle Scholar
  2. Amsbaugh, D.F., Hansen, C.T., Prescott, B., Stashak, P.W., Barthold, D.R., and Baker, P.J., 1972, 7. Exp. Med. 136:931.CrossRefGoogle Scholar
  3. Armerding, D., and Katz, D.H., 1974, J. Exp. Med. 140:19.PubMedCrossRefGoogle Scholar
  4. Bach, J.F., Cantor, H., Roelants, G., and Stutman, O., 1976, in: Biological Activity of Thymic Hormones (D.W.V. Bekkum, ed.), Kyooker Publications, Rotterdam.Google Scholar
  5. Bevan, M.J., 1975, Nature (London) 256:419.CrossRefGoogle Scholar
  6. Binz, H., and Wigzell, H., 1975, J. Exp. Med. 152:197.CrossRefGoogle Scholar
  7. Boyse, E.A., Miyazawa, M., Aoki, T., and Old, L.J., 1968, Proc. Soc. London Ser. B. 170:175.CrossRefGoogle Scholar
  8. Boyse, E.A., Itakura, K., Stockert, E., Iritaru, C., and Miura, M., 1971, Transplantation 11:351.PubMedCrossRefGoogle Scholar
  9. Cantor, H., 1972, Cell Immunol. 3:461.PubMedCrossRefGoogle Scholar
  10. Cantor, H., and Boyse, E.A., 1975a, J. Exp. Med. 141:1376.PubMedCrossRefGoogle Scholar
  11. Cantor, H., and Boyse, E.A., 1975b, J. Exp. Med. 141:1390.PubMedCrossRefGoogle Scholar
  12. Cantor, H., and Weissman, I., 1976, Prog. Allergy. 20:1.PubMedCrossRefGoogle Scholar
  13. Cantor, H., Simpson, E., Sato, V., Fathman, G., and Herzenberg, L.A., 1975a, Cell. Immunol. 15: 180.PubMedCrossRefGoogle Scholar
  14. Cantor, H., Shen, F.W., and Boyse, E.A., 1975b, J. Exp. Med. 143:1391.CrossRefGoogle Scholar
  15. Cerottini, J.C., and Brunner, K.T., 1974, Adv. Immunol. 19:67.CrossRefGoogle Scholar
  16. Chao, N., Gershon, R.K., and Cantor, H., 1976, manuscript in preparation.Google Scholar
  17. Cohn, P.L., Scher, I., and Mosier, D.E., 1976, J. Immunol. 116:301.Google Scholar
  18. Darling, J.Z., Nowinski, R.C., and Bach, F.H., 1975, Proc. Natl. Acad. Sci. U.S.A. 72:2780.CrossRefGoogle Scholar
  19. David, J.R., and David, R.A., 1972, Prog. Allergy. 16:300.PubMedCrossRefGoogle Scholar
  20. Debre, P., Kapp, J.A., Dorf, M.E., and Benacerraf, B., 1975, J. Exp. Med. 142:1447.PubMedCrossRefGoogle Scholar
  21. Dutton, R.W., Falkoff, R., Hirst, J., Hoffman, M., Kappler, J.W., Kettman, J.R., Lesley, J.F., and Vann, D., 1971, Prog. Immunol. 1:355.Google Scholar
  22. Eichmann, K., and Rajewsky, J., 1975, Eur. J. Immunol. 5:661.PubMedCrossRefGoogle Scholar
  23. Finkelman, F.D., Smith, A.H., Sher, I., and Paul, W.E., 1975, J. Exp. Med. 142:1316.PubMedCrossRefGoogle Scholar
  24. Gershon, R.K., 1974, Contemp. Top. Immunobiol 3:1.PubMedCrossRefGoogle Scholar
  25. Glimcher, L., Shen, F.W., and Cantor, H., 1977, J. Exp. Med. 145:1.PubMedCrossRefGoogle Scholar
  26. Gordon, R.D., Simpson, E., and Samuelson, L., 1975, J. Exp. Med. 142:1108.PubMedCrossRefGoogle Scholar
  27. Greenberg, A.H., and Playfair, J.H., 1974, Clin. Exp. Immunol. 16:99.PubMedGoogle Scholar
  28. Hanna, M.G., Jr., Tennant, R.W., Yuhas, J.-M., Clapp, N.K., Batzig, B.L., and Snodgrass, M.J., 1972, Cancer Res. 32:2226.PubMedGoogle Scholar
  29. Herberman, R.B., Nunn, M.E., and Lavrin, D.H., 1975a, Int. J.Cancer 16:216.PubMedCrossRefGoogle Scholar
  30. Herberman, R.B., Nunn, M.F., and Lavrin, D.H., 1975b, Int. J. Cancer 16:230.PubMedCrossRefGoogle Scholar
  31. Herzenberg, L.A., Okamura, K., Cantor, H., Sato, V., Shen, F.W., Boyse, E.A., and Herzenberg, L.A., 1976, J. Exp. Med., in press.Google Scholar
  32. Huber, B., Devinsky, O., Gershon, R., and Cantor, H., 1976a, J. Exp. Med. 143:1424.CrossRefGoogle Scholar
  33. Huber, B., Shen, F.W., Boyse, E.A., and Cantor, H., 1976b, J. Exp. Med. 144:1128.PubMedCrossRefGoogle Scholar
  34. Ihle, J.N., Yurconic, M., Jr., and Hanna, M.G., Jr., 1970, J. Exp. Med. 138:194.CrossRefGoogle Scholar
  35. Itakura, K., Hutton, J.J., Boyse, E.A., and Old, L.K., 1972, Transplantation 13:239.PubMedCrossRefGoogle Scholar
  36. Jandinski, J., Cantor, H., Tadakuma, T., Peavy, D.L., and Pierce, C.W., 1976, J. Exp. Med. 143:1382.PubMedCrossRefGoogle Scholar
  37. Jerne, N.K., 1971, Eur. J. Immunol. 1:1.PubMedCrossRefGoogle Scholar
  38. Kapp, J.A., Pierce, C.W., Schlossman, S., and Benacerraf, B., 1974, (GAT), J. Exp. Med. 140:648.PubMedCrossRefGoogle Scholar
  39. Katz, D.H., and Benacerraf, B., 1975, Transplant. Rev. 22:175.PubMedGoogle Scholar
  40. Katz, D.H., Hamoaka, T., and Benacerraf, B., 1973, J. Exp. Med. 137:1405.PubMedCrossRefGoogle Scholar
  41. Kiessling, R., Klein, E., and Wigzell, H., 1975a, Eur. J. Immunol. 5:112.PubMedCrossRefGoogle Scholar
  42. Kiessling, R., Klein, E., Pross, H., and Wigzell, H., 1975b, Eur. J. Exp. Med. 5:7.Google Scholar
  43. Miller, J.F.A.P., Vadas, M.A., Whitelaw, A., and Gamble, J., 1975, Proc. Natl. Acad. Sci. U.S.A. 72:5095.PubMedCrossRefGoogle Scholar
  44. Mosier, D.E., Scher, I., Ruhl, H., Cohen, P.L., Zitron, I., and Paul, W.E., 1975, in press.Google Scholar
  45. Nowinski, R.C., and Kaehler, S.L., 1974, Science 185:869.PubMedCrossRefGoogle Scholar
  46. Oldstone, M.B.A., Aoki, T., and Dixon, F.J., 1972, Proc. Natl. Acad. Sci. U.S.A. 69:134.PubMedCrossRefGoogle Scholar
  47. Petranyi, G., Kiessling, R., Klein, G., and Wigzell, H., 1975a, Int. J. Cancer 15:935.Google Scholar
  48. Petranyi, G., Kiessling, R., and Klein, G., 1975b, Immunogenetics 2:53.CrossRefGoogle Scholar
  49. Pierce, C.W., Kapp, J., and Benacerraf, B., 1976, J. Exp. Med., in press.Google Scholar
  50. Raff, M.C., and Cantor, H., 1971, Prog. Immunol. 4:93.Google Scholar
  51. Scher, I., Frantz, M., and Steinberg, A.D., 1973, J. Immunol. 110:396.Google Scholar
  52. Scher, I., Ahmed, A., Strong, D.M., Steinberg, A.D., and Paul, W.E., 1975a, J. Exp. Med. 141:788.PubMedGoogle Scholar
  53. Scher, I., Steinberg, A.D., Berning, A.K., and Paul, W.E., 1975b, J. Exp. Med. 142:637.PubMedCrossRefGoogle Scholar
  54. Scher, I., Sharrow, S.O., and Paul, W.E., 1975c, Fed Proc. Fed. Amer. Soc. Exp. Biol. 34:999.Google Scholar
  55. Scher, I., Ahmed, A., Sharrow, S.O., Steinberg, A.D., and Paul, W.E., 1975d, in press.Google Scholar
  56. Sendo, F.T., Aoki, T., Boyse, E.A., and Buafo, C.K., 1975, J. Natl. Cancer Inst., in press.Google Scholar
  57. Shearer, G.M., Rehn, T., and Gabardino, C.A., 1975, J. Exp. Med. 141:1348.PubMedCrossRefGoogle Scholar
  58. Shen, F.W., Boyse, E.A., and Cantor, H., 1975, Immunogenetics 2:591.CrossRefGoogle Scholar
  59. Shevach, E.M., 1976, J. Immunol. 116:1482.PubMedGoogle Scholar
  60. Tada, T., Taniguchi, M., and Takemori, T., 1976, Transplant. Rev. 26:119.Google Scholar
  61. Transplantation Reviews 1, 1969 (G. Moller, ed.), Williams & Wilkins, Baltimore.Google Scholar
  62. Wilson, D.B., and Nowell, P. C., 1972, Transplant. Rev. 12:3.PubMedGoogle Scholar
  63. Zinkernagel, R.M., and Doherty, P.C., 1975, J. Exp. Med. 141:1427.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Harvey Cantor
    • 1
  • Edward Boyse
    • 2
  1. 1.Department of Medicine, Farber Cancer CenterHarvard Medical SchoolBostonUSA
  2. 2.Sloan-Kettering Institute for Cancer ResearchNew YorkUSA

Personalised recommendations