Immunogenicity and MuMTV-like Antigenicity of Human Breast Cancer Tissues
In 1936 Bittner reported that a transmissible factor in murine milk was related to the development of mammary tumors. Since that time, Bittner’s milk factor has been shown to be a specific type of RNA virus, and the relationship between this RNA virus and murine mammary carcinogenesis has been extensively documented by biological, ultrastructural, immunological, and biochemical techniques (Moore and Charney, 1975). Despite such compelling observations regarding the viral etiology of murine mammary tumors, parallel studies of human mammary cancers have, until recently, yielded essentially negative data. Viral particles are rarely demonstrable in human mammary tissues, benign or malignant. Nor do temporal or geographic variations in incidence rates of human breast cancer correlate with nursing habits (MacMahon et al., 1970). Nevertheless, within the past several years there have been a number of reports indicating that some human breast tissues may harbor particles and/or RNA components which resemble murine mammary tumor virus (MuMTV) (Spiegelman et al., 1972; Schlom et al., 1972, 1973; Seman and Dmochowski, 1973; Müller and Grossmann, 1972; Müller et al., 1972, 1973; Moore, 1974). While such findings are of interest, it remains to be shown that they are specifically related to the development and/or behavior of human breast cancers.
KeywordsBreast Cancer Breast Cancer Patient Mammary Tumor Breast Cancer Tissue Mammary Carcinogenesis
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