Natural Immunity to Murine Mammary Tumor Viruses

  • P. Bentvelzen
  • P. C. Creemers
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 6)


The best-known route of transmission of the mouse mammary tumor virus (MTV) is via the milk (Bittner, 1936). In inbred mouse strains selected for a high incidence of mammary carcinoma, a milkborne tumor-inciting agent has been passed for numerous generations. Disregarding the occasional loss of virus from such high-cancer strains (Andervont and Dunn, 1962), the perpetuation of the virus and the disease for so many years has been regarded as indicative for true viral tolerance of high-cancer-strain mice. The immunogenicity of MTV to its natural host was very much in doubt (Bittner, 1962; Squartini, 1966; Andrewes and Pereira, 1967), while its antigenicity to other species was clearly demonstrated at an early stage of mammary tumor virus research (Andervont and Bryan, 1944; Green et al., 1946; Bittner and Imagawa, 1955).


Spleen Cell Mouse Mammary Tumor Virus Inbred Mouse Strain Mammary Tumor Cell Mouse Seron 


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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • P. Bentvelzen
    • 1
  • P. C. Creemers
    • 1
  1. 1.Radiobiological InstituteTNORijswijkThe Netherlands

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