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Autoimmunity, Oncornaviruses, and Lymphomagenesis

  • Martin S. Hirsch
  • Max R. Proffitt
  • Paul H. Black
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 6)

Abstract

C-type oncornaviruses have been associated with a variety of disease states in experimental animals (Hirsch and Black, 1974; Dixon et al., 1974; Levy, 1974; Todaro and Huebner, 1972). Much attention has been directed toward evaluating their role in lymphoproliferative disorders; recently, they have also been considered to play important roles in the induction of, or maintenance of, autoimmune diseases (Hirsch and Proffitt, 1975; Levy, 1974; Dixon et al., 1974). C-type viral genetic information may be acquired through horizontal infection either by experimental injection or by natural transmission of infectious virus; such genetic information may also be vertically transmitted through germ cells from parent to offspring, and may be in the form of integrated proviral DNA (Hirsch and Black, 1974; Todaro and Huebner, 1972; Temin, 1972).

Keywords

Systemic Lupus Erythematosus Renal Transplant Recipient Mixed Lymphocyte Reaction Virus Activation Renal Allograft Recipient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Martin S. Hirsch
    • 1
  • Max R. Proffitt
    • 1
  • Paul H. Black
    • 1
  1. 1.Infectious Disease Unit Massachusetts General Hospital and Department of MedicineHarvard Medical SchoolBostonUSA

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