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Biological and Structural Pleomorphism of the Oncornavirus Envelope Glycoprotein, gp70

  • Bert C. Del Villano
  • Stephen J. Kennel
  • Richard A. Lerner
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 6)

Abstract

It has been postulated that oncornaviruses play a role in development and differentiation, and that neoplasia is an unforunate consequence of an otherwise important symbiosis (Huebner and Todaro, 1969; Huebner et al., 1970). These concepts are attractive on a theoretical basis, but remained unproved. Nevertheless, the relationship between viral gene expression and normal host-cell functions has been studied in some detail, especially in the case of the interactions between the oncornaviruses and lymphoid cells of the mouse (Tooze, 1973; Gross, 1970). Conceptually, one of the major advances in understanding this relationship has been the demonstration that a protein related to the major envelope glycoprotein of the MuLV gp70 can be a component of normal cells, even in the absence of detectable virus (Del Villano et al., 1975; Tung et al., 1975; Kennel and Feldman, 1976). In this chapter, we review our data which led to this conclusion.

Keywords

Virus Particle Sperm Cell Murine Leukemia Virus Envelope Glycoprotein Virus Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

MuLV

murine leukemia virus

SLV

Scripps leukemia virus

SDS PAGE

sodium dodecylsulfate—polyacrylamide gel electrophoresis

MW app.

apparent molecular weight

FMR

Friend-Moloney-Rauscher

G

Gross

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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Bert C. Del Villano
    • 1
  • Stephen J. Kennel
    • 1
  • Richard A. Lerner
    • 1
  1. 1.Department of ImmunopathologyScripps Clinic and Research FoundationLa JollaUSA

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