Biological and Structural Pleomorphism of the Oncornavirus Envelope Glycoprotein, gp70
It has been postulated that oncornaviruses play a role in development and differentiation, and that neoplasia is an unforunate consequence of an otherwise important symbiosis (Huebner and Todaro, 1969; Huebner et al., 1970). These concepts are attractive on a theoretical basis, but remained unproved. Nevertheless, the relationship between viral gene expression and normal host-cell functions has been studied in some detail, especially in the case of the interactions between the oncornaviruses and lymphoid cells of the mouse (Tooze, 1973; Gross, 1970). Conceptually, one of the major advances in understanding this relationship has been the demonstration that a protein related to the major envelope glycoprotein of the MuLV gp70 can be a component of normal cells, even in the absence of detectable virus (Del Villano et al., 1975; Tung et al., 1975; Kennel and Feldman, 1976). In this chapter, we review our data which led to this conclusion.
KeywordsVirus Particle Sperm Cell Murine Leukemia Virus Envelope Glycoprotein Virus Preparation
murine leukemia virus
Scripps leukemia virus
- SDS PAGE
sodium dodecylsulfate—polyacrylamide gel electrophoresis
- MW app.
apparent molecular weight
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