Natural Immunity to Endogenous Oncornaviruses in Mice

  • James N. Ihle
  • M. G. HannaJr.
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 6)


Murine C-type viruses have been etiologically linked to spontaneous leukemias in mice (Gross, 1951). These viruses are endogenous in mice and are vertically transmitted (Huebner and Todaro, 1969; Rowe et al., 1971; Aaronson et al., 1971). A number of biologically distinguishable C-type viruses occur naturally in various strains of mice. Ecotropic viruses, which include the AKR or Gross-type viruses, are capable of replicating in mouse cells. These viruses have been further differentiated by their preference for replication in various mouse cells into N- or B-tropic viruses (Pincus et al., 1971), although by hybridization experiments the N and B viruses are closely related (Callahan et al., 1974). Xenotropic viruses are characterized by their ability to replicate in cells of other species (Levy, 1973). Two groups of xenotropic viruses have been identified by serological techniques (Stephenson et al., 1974) and by hybridization experiments (Callahan et al., 1975). The xenotropic viruses are only partially related to the ecotropic viruses, as determined by hybridization (Callahan et al., 1974), and to date have not been implicated in any spontaneous neoplasia of mice.


Murine Leukemia Virus Natural Antibody African Swine Fever Virus Expression Immune Seron 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • James N. Ihle
    • 1
  • M. G. HannaJr.
    • 1
  1. 1.Basic Research ProgramNCI Frederick Cancer Research CenterFrederickUSA

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