Intracellular and Systemic Regulation of Biologically Distinguishable Endogenous Type C RNA Viruses of Mouse Cells
The inherited basis for factors involved in leukemogenesis in mice was established many years ago with the development of inbred strains having extremely high susceptibility to the natural occurrence of leukemia (Furth et al., 1933; MacDowell and Richter, 1935). The first evidence that viruses were etiologically involved in this disease was provided by Gross (1951), who demonstrated transmission of leukemia to mice by filtrates from tumors of high-leukemia-incidence strains. Subsequent studies in vivo have confirmed and extended these observations, documenting the intimate association of type C RNA viruses with the mouse and the etiological role of the virus in leukemia.
KeywordsMouse Cell Murine Leukemia Virus Embryo Cell Virus Release Endogenous Virus
Unable to display preview. Download preview PDF.
- Aaronson, S. A., Stephenson, J. R., and Greenberger, J. S., 1914b, Cellular replication and persistence of inducible RNA type C viruses, J. Virol. 13: 1404.Google Scholar
- Chattopadhyay, S. K., Lowy, D. R., Teich, N. M., Levine, A. S., and Rowe, W. P., 1974, Evidence that the AKR murine-leukemia-virus genome is complete in DNA of the high-virus AKR mouse and incomplete in the DNA of the “virus-negative” NIH mouse, Proc. Natl. Acad. Sci U.S.A. 71: 167.PubMedCrossRefGoogle Scholar
- Furth, J., Seibold, H. R., and Rathbone, R. R., 1933, Experimental studies on lymphomatosis of mice, Am. J. Cancer 19: 521.Google Scholar
- Gelb, L. D., Milstien, J. B., Martin, M. A., and Aaronson, S. A., 1973, Characterization of murine leukemia virus-specific DNA present in normal mouse cells, Nature (London) New Biol 244: 76.Google Scholar
- Klement, V., Nicolson, M. O., and Huebner, R. J., 1971, Rescue of the genome of focus-forming virus from rat nonproductive lines by 5′-bromodeoxyuridine, Nature (London) New Biol. 234: 12.Google Scholar
- MacDowell, E. C., and Richter, M. N., 1935, Mouse leukemia, IX. The role of heredity in spontaneous cases, Arch. Pathol. 20: 709.Google Scholar
- Stephenson, J. R., Aaronson, S. A., Arnstein, P., Huebner, R. J., and Tronick, S. R., 1974a, Demonstration of two immunologically distinct xenotropic RNA type-C viruses of mouse cells, Virology 61: 244.Google Scholar