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Clinical Implications of Immunity to Oncogenic Viruses

  • Paul H. Levine
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 6)

Abstract

The evidence pointing to a viral etiology for at least some forms of human cancer, a possibility that has long been considered on the basis of animal studies, has continued to accumulate to such an extent that viral oncologists must now reevaluate their clinical and experimental data in order to consider which specific approaches are now ready for clinical trials. Although ethical restrictions continue to inhibit attempts to prove that specific viruses cause certain human tumors, as outlined by Bryan et al. (1967; Bryan, 1962), epidemiological studies have been able to suggest not only which human tumors are most likely to be caused by infectious agents (Burkitt, 1962; Cole et al., 1968; Correa and O’Conor, 1971; Heath and Hasterlik, 1963; Kessler, 1974; Levine, 1974; Levine and Gravell, 1975; Morrow et al., 1971) but some have even suggested the pattern of the agents’ transmission (Kessler, 1976; Vianna et al., 1971).

Keywords

Cervical Cancer Oncogenic Virus Familial Medullary Thyroid Carcinoma Herpesvirus Saimiri West Nile Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ablashi, D. V., and Pearson, G. R., 1974, Animal models: Herpesvirus saimiri, a nonhuman primate model for herpesvirus-associated neoplasia of man, Cancer Res. 34: 1232.PubMedGoogle Scholar
  2. Anderson, L. J., and Jarrett, W. F., 1971, Membranous glomerulonephritis associated with leukemia in cats, Res. Vet. Sci. 12: 179.PubMedGoogle Scholar
  3. Anderson, L. J., Jarrett, W. F. H., Jarrett, O., and Laird, H. M., 1971, Feline leukemia-virus infection of kittens: Mortality associated with atrophy of the thymus and lymphoid depletion, J. Natl. Cancer Inst. 47: 807.PubMedGoogle Scholar
  4. Anderson, P. N., Klein, D. L., Bias, W. B., Mullins, G. M., Burke, P. J., and Santos, G. W., 1974, Cell-mediated immunological reactivity of patients and siblings to blast cells from adult acute leukemias, Isr. J. Med. Sci. 10: 1033.Google Scholar
  5. Aurelian, L., Schumann, B., Marcus, R. L., and Davis, H. J., 1973a, Antibody to HSV-2 induced tumor specific antigens in serums from patients with cervical carcinoma, Science 181: 161.PubMedGoogle Scholar
  6. Aurelian, L., Davis, H. J., and Julian, C. G., 1973b, Herpesvirus type-2 induced tumor specific antigen in cervical carcinoma. Am. J. Epidemiol. 98: 1.PubMedGoogle Scholar
  7. Aurelian, L., Strandberg, J. D., and Marcus, R. L., 1974, Neutralization, immunofluorescence and complement fixation tests in identification of antibody to a herpes-virus type-2 induced tumor specific antigen in sera from squamous cervical carcinoma, Prog. Exp. Tumor Res. 19: 165.PubMedGoogle Scholar
  8. Baker, C. G., Carrese, L. M., and Rauscher, F., 1966, The special virus leukemia program of the National Cancer Institute: Scientific aspects and program logic, Proc. Zool. Soc. London 17: 259.Google Scholar
  9. Bates, H. A., Bankole, R. O., and Swaim, W. R., 1966, Immunofluorescent studies in human leukemia, Blood 34: 430.Google Scholar
  10. Bekesi, J. G., Roboz, J. P., Walter, L., and Holland, J. F., 1974, Stimulation of specific immunity against cancer by neuraminidase-treated tumor cells, Behring Inst. Mitt. 55: 309.Google Scholar
  11. Bekesi, J. G., Holland, J. F., Yates, J. W., Henderson, E., and Fleminger, R., 1975, Chemotherapy of acute myelogenous leukemia with neuraminidase treated allogeneic leukemia cells, Proc. Am. Assoc. Cancer Res. 16: 121.Google Scholar
  12. Bekesi, J. G., Roboz, J. P., Zimmerman, E., and Holland, J. F., 1976, Treatment of spontaneous leukemia in AKR mice with chemotherapy, immunotherapy, or interferon, Cancer Res. 36: 631.PubMedGoogle Scholar
  13. Bias, W. B., Santos, G. W., Burke, P. J., Mullins, G. M., and Humphrey, R. L., 1972, Cytologic antibody in normal human serums reactive with tumor cells from acute lymphocytic leukemia, Science 178: 304.PubMedGoogle Scholar
  14. Biggs, P. M., Payne, L. N., Milne, B. S., Churchill, A. E., Chubb, R. C., Powell, D. G., and Harris, A. H., 1970, Field trials with an attenuated cell associated vaccine for Marek’s disease, Vet. Rec. 87: 704.PubMedGoogle Scholar
  15. Bittner, J. J., 1952, Tumor-inducing properties of the mammary tumor agent in young and adult mice, Cancer Res. 12: 510.PubMedGoogle Scholar
  16. Bittner, J. J., 1960, Influence of the mammary-tumor agent on the genesis of mammary cancer in agent-free mice after milk transmission, J. Natl. Cancer Inst. 25: 177.PubMedGoogle Scholar
  17. Blair, P. B., and Lane, M-A., 1974, Immunologic evidence for horizontal transmission of MTV, J. Immunol. 113: 1446.PubMedGoogle Scholar
  18. Bowen, J. M., McBride, C. M., Miller, M. S., and Dmochowski, I., 1976, Relationship of nucleolar antigens in malignant melanoma cells to disease prognosis, Proc. 9th Int. Pigment Cell Conf. (in press).Google Scholar
  19. Bryan, W. R., 1962, The search for causative viruses in human cancer: A discussion of the problem, J. Natl. Cancer Inst. 29: 1027.PubMedGoogle Scholar
  20. Bryan, W. R., Dalton, A. J., and Rauscher, F. J., 1967, The viral approach to human leukemia and lymphoma: Its current status, Prog. Hematol. 5: 137.Google Scholar
  21. Buell, P., 1973, Changing incidence of breast cancer in Japanese-American women, J. Natl. Cancer Inst. 51: 1479.PubMedGoogle Scholar
  22. Burkitt, D., 1962, A “tumour safari” in East and Central Africa, Br. J. Cancer 16: 17.Google Scholar
  23. Chopra, H. C., and Mason, M. M., 1970, A new virus in a spontaneous mammary tumor of a Rhesus monkey, Cancer Res. 30: 2081.PubMedGoogle Scholar
  24. Churchill, A. E., and Biggs, P. M., 1968, Herpes-type virus isolated in cell culture from tumors of chickens with Marek’s disease. II. Studies in viivo, J. Natl. Cancer Inst. 49: 951.Google Scholar
  25. Churchill, A. E., Payne, L. N., and Chubb, R. C., 1969, Immunization against Marek’s disease using a live attenuated virus, Nature (London) 221: 744.Google Scholar
  26. Cole, P., MacMahon, B., and Aisenberg, A., 1968, Mortality from Hodgkin’s disease in the United States, Lancet 11: 1371.Google Scholar
  27. Correa, P., and O’Conor, G. T., 1971, Epidemiologic patterns of Hodgkin’s disease, Int. J. Cancer 8: 192.PubMedGoogle Scholar
  28. Crittenden, L. B., 1976, The epidemiology of avian lymphoid leukosis, Cancer Res. 36: 570.PubMedGoogle Scholar
  29. Eilber, F. R., and Morton, D. L., 1970, Immunologic studies of human sarcomas: Additional evidence suggesting an association sarcoma virus, Cancer 26: 588.PubMedGoogle Scholar
  30. Epstein, M. A., 1976, Implications of a vaccine for the prevention of Epstein-Barr virus infection: Ethical and logistic considerations, Cancer Res. 36: 711.PubMedGoogle Scholar
  31. Epstein, M. A., Achong, B. G., and Barr, Y. M., 1964, Virus particles in cultured lympho-blasts from Burkitt’s lymphoma, Lancet 1: 702.PubMedGoogle Scholar
  32. Epstein, M. A., Rabin, H., Ball, G., Rickinson, A. B., Jarvis, J., and Melendez, L. V., 1973, Pilot experiments with EB virus in owl monkeys (Aotus Trivirgatus). II. EB virus in a cell line from an animal with reticuloproliferative disease, Int. J. Cancer 12: 319.PubMedGoogle Scholar
  33. Essex, M., 1975, Horizontally and vertically transmitted oncornaviruses of cats, Adv. Cancer Res. 21: 175.PubMedGoogle Scholar
  34. Evans, A. S., Niederman, J. C., and McCollum, R. W., 1968, Seroepidemiologic studies of infectious mononucleosis with EB virus, N. Engl. J. Med. 279: 1121.PubMedGoogle Scholar
  35. Fialkow, P. J., Klein, G., Gartler, S. M., and Clifford, P., 1970, Clonal origin for individual Burkitt tumours, Lancet 1: 384.PubMedGoogle Scholar
  36. Fink, M. A., Karon, M., Rauscher, F. J., Malmgren, R. A., and Orr, H. C., 1965, Further observations on the immunofluorescence of cells in human leukemia, Cancer 18: 1317.PubMedGoogle Scholar
  37. Gallagher, R. E., and Gallo, R. C., 1975, Type C RNA tumor virus isolated from cultured human acute myelogenous leukemia cells, Science 187: 350.PubMedGoogle Scholar
  38. Gardner, M. B., Henderson, B. E., Estes, J. D., Rongey, R. W., Casagrande, J., Pike, M., and Huebner, R. J., 1976, The epidemiology and virology of C-type virus-associated hematological cancers and related diseases in wild mice, Cancer Res. 36: 574.PubMedGoogle Scholar
  39. Gerber, P., Nkrumah, F. K., Prichett, R., and Kieff, E., 1976, Comparative studies of Epstein-Barr virus strains from Ghana and the United States, Int. J. Cancer 17: 71.PubMedGoogle Scholar
  40. Geser, A., and de The, G., 1972, Does the Epstein-Barr virus play an aetiological role in Burkitt’s lymphoma? in: Oncogenesis and Herpesviruses (P. M. Biggs, G. de The, and L. N. Payne, eds.), p. 372, International Agency for Research on Cancer, Lyon, France.Google Scholar
  41. Gold, P., and Freedman, S. O., 1965a, Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques, J. Exp. Med. 121: 439.PubMedGoogle Scholar
  42. Gold, P., and Freedman, S. O., 1965b, Specific carcinoembryonic antigens of the human digestive system. J. Exp. Med. 122: 467.PubMedGoogle Scholar
  43. Goldenberg, G. J., and Brandes, L. J., 1976, In vivo and in vitro studies of immunotherapy of nasopharyngeal carcinoma with transfer factor, Cancer Res. 36: 720.PubMedGoogle Scholar
  44. Grose, C., Henle, W., Henle, G., and Feorino, P. M., 1975, Primary Epstein-Barr virus infections in acute neurologic diseases, N. Engl. J. Med. 292: 392.PubMedGoogle Scholar
  45. Gross, L., 1951, Pathogenic properties and “vertical” transmission of mouse leukemia agent, Proc. Soc. Exp. Biol 78: 342.PubMedGoogle Scholar
  46. Gutterman, J. U., Mvligit, G., Burgess, M. A., McCredie, K. B., Hunter, C., Freireich, E. J., and Hersh, E. M., 1974, Brief Communication: Immunodiagnosis of acute leukemia: Detection of residual disease, J. Natl Cancer Inst. 53: 389.PubMedGoogle Scholar
  47. Hardy, W. D., Jr., Hess, P. W., MacEwen, E. G., McClelland, A. J., Zuckerman, E. E., Essex, M., Cotter, S. M., and Jarrett, O., 1976, Biology of feline leukemia virus in the natural environment, Cancer Res. 36: 582.PubMedGoogle Scholar
  48. Heath, C. W., Jr., and Hasterlik, R. J., 1963, Leukemia among children in a suburban community, Am. J. Med. 34: 796.Google Scholar
  49. Hellström, I. E., Hellström, K. E., Pierce, G. E., and Bill, A. H., 1968, Demonstration of cell-bound and humoral immunity against neuroblastoma cells, Proc. Natl Acad. Sci. U.S.A. 60: 1231.PubMedGoogle Scholar
  50. Henle, G., Henle, W., Clifford, P., Diehl, V., Kafuko, G. W., Kirya, B. G., Klein, G., Morrow, R. H., Munube, G. M. R., Pike, P., Tukei, P. M., and Ziegler, J. L., 1969, Antibodies to Epstein-Barr virus in Burkitt’s lymphoma and control groups, J. Natl Cancer Inst. 43: 1147.PubMedGoogle Scholar
  51. Henle, G., Henle, W., and Klein, G., 1971a, Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus-infected cells, Int. J. Cancer 8: 272.PubMedGoogle Scholar
  52. Henle, G., Henle, W., Klein, G., Gunven, P., Clifford, P., Morrow, R. H., and Ziegler, J. L., 1971b, Antibodies to early Epstein-Barr virus-induced antigens in Burkitt’s lymphoma, J. Natl Cancer Inst. 46: 861.PubMedGoogle Scholar
  53. Henle, W., and Henle, G., 1972, Epstein-Barr virus: The cause of infectious mononucleosis—A review, in: Oncogenesis and Herpesviruses (P. M. Biggs, G. de The, and L. N. Payne, eds.), p. 269, International Agency for Research on Cancer, Lyon, France.Google Scholar
  54. Henle, W., and Henle, G., 1973a, Evidence for an oncogenic potential of the Epstein-Barr virus, Cancer Res. 33: 1419.PubMedGoogle Scholar
  55. Henle, W., and Henle, G., 1973b, Epstein-Barr virus-related serology in Hodgkin’s disease, J. Natl Cancer Inst. Monogr. 36: 79.Google Scholar
  56. Henle, W., Henle, G., Niederman, J. C., Klemola, E., and Haltia, K., 1971, Antibodies to early antigens induced by Epstein-Barr virus in infectious mononucleosis, J. Infect. Dis. 124: 58.PubMedGoogle Scholar
  57. Henle, W., Henle, G., Gunven, P., Klein, G., Clifford, P., and Singh, S., 1973a, Patterns of antibodies to Epstein-Barr virus-induced early antigens in Burkitt’s lymphoma. Comparison of dying patients with long-term survivors, J. Natl Cancer Inst. 50: 1163.PubMedGoogle Scholar
  58. Henle, W., Ho, H.-C., Henle, G., and Kwan, H. C., 1973b, Antibodies to Epstein-Barr virus-related antigens in nasopharyngeal carcinoma. Comparison of active cases with long-term survivors, J. Natl Cancer Inst. 51: 361.PubMedGoogle Scholar
  59. Henle, W., Henle, G. E., and Horwitz, C. A., 1974, Epstein-Barr virus specific diagnostic tests in infectious mononucleosis, Hum. Pathol 5: 551.PubMedGoogle Scholar
  60. Hersh, E. M., Gutterman, J. U., Mavligit, G., Gschwind, C. R., Freireich, E. J., Levine, P. H., and Plata, E. J., 1974a, Human immune response to active immunization with Rauscher leukemia virus. I. Cell-mediated and cell-associated immunity, J. Natl Cancer Inst. 53: 317.PubMedGoogle Scholar
  61. Hersh, E. M., Hanna, M. G., Jr., Gutterman, J. U., Mavligit, G., Yurconic, M., Jr., and Gschwind, C. R., 1974, Human immune response to active immunization with Rauscher leukemia virus. II. Humoral immunity, J. Natl Cancer Inst. 53: 327.Google Scholar
  62. Hinze, H. C., 1971, New member of the herpesvirus group isolated from wild cottontail rabbits, Infect. Immun. 3: 350.PubMedGoogle Scholar
  63. Hirshaut, Y., Glade, P., Viera, L. O. B. D., Ainbender, E., Dvorak, B., and Siltzbach, L. F., 1970, Sarcoidosis, another disease associated with serologic evidence for herpes-like virus infection, New Engl. J. Med. 283: 502.PubMedGoogle Scholar
  64. Hirshaut, Y., Pei, D. T., Marcove, R. C., Mukherji, B., Spielvogel, A. R., and Essner, E., 1974, Seroepidemiology of human sarcoma antigen (S1), New Engl. J. Med. 291: 1103.PubMedGoogle Scholar
  65. Holland, J. F., 1976, Immunological control of human leukemia: Discussion, Cancer Res. 36: 657.PubMedGoogle Scholar
  66. Holland, J. F., and Bekesi, J. G., 1976, Immunotherapy of human leukemia with neuraminidase modified cells, in: Symposium on immunotherapy in malignant diseases, Medical Clinics of North America, Vol. 60 (W. Terry, ed.), pp. 539–549.Google Scholar
  67. Hollinshead, A. C., Melnick, J. L., and Rawls, W. E., 1971, Reactivity between herpesvirus type 2-related soluble membrane antigens in cells from carcinoma of the cervix, vulva, and vagina and matched cancer and control sera, Int. Virol. 2: 105.Google Scholar
  68. Hollinshead, A. C., Lee, O., Chretien, P. B., Tarpley, J. L., Rawls, W. E., and Adam, E., 1973, Antibodies to herpesvirus nonvirion antigens in squamous carcinomas, Science 182: 713.PubMedGoogle Scholar
  69. Hollinshead, A. C., Chretien, P. B., Lee, O., Tarpley, J. L., Kerney, S. E., Silverman, N. A., and Alexander, J. C., 1976, In vivo and in vitro measurements of the relationship of human squamous carcinomas to herpes simplex virus tumor-associated antigens, Cancer Res. 36: 821.PubMedGoogle Scholar
  70. Huang, D. O., Ho, J. H. C., Henle, W., and Henle, G., 1974, Demonstration of Epstein-Barr virus-associated nuclear antigen in nasopharyngeal carcinoma cells from fresh biopsies, Int. J. Cancer 14: 580.PubMedGoogle Scholar
  71. Huebner, R. J., and Todaro, G. J., 1969, Oncogenes of RNA tumor viruses as determinants of cancer, Proc. Natl. Acad. Sci. U.S.A. 19: 1087.Google Scholar
  72. Hunt, R. D., Garcia, F. G., Barahona, H. H., King, N. W., Fraser, C. E. O., and Melendez, L. V., 1973, Spontaneous herpesvirus saimiri lymphoma in an owl monkey, J. Infect. Dis. 127: 723.PubMedGoogle Scholar
  73. Ioannides, A. K., Rosner, F., Brenner, M., and Lee, S. L., 1968, Immunofluorescent studies of human leukemic cells with antiserum to a murine leukemic virus (Rauscher strain), Blood 31: 381.PubMedGoogle Scholar
  74. Jarrett, W., Jarrett, O., Mackey, L., Laird, H., Hardy, W., Jr., and Essex, M., 1973, Horizontal transmission of leukemia virus and leukemia in the cat, J. Natl. Cancer Inst. 51: 833.PubMedGoogle Scholar
  75. Johansson, B., Klein, G., Henle, W., and Henle, G., 1970, Epstein-Barr virus (EBV)-associated antibody patterns in malignant lymphoma and leukemia. I. Hodgkin’s disease, Int. J. Cancer 6: 450.PubMedGoogle Scholar
  76. Johansson, B., Klein, G., Henle, W., and Henle, G., 1971, Epstein-Barr virus (EBV)-associated antibody patterns in malignant lymphoma and leukemia. II. Chronic lymphocytic leukemia and lymphocytic lymphoma, Int. J. Cancer 8: 475.PubMedGoogle Scholar
  77. Kaaden, O. R., and Dietzschold, B., 1974, Alterations of the immunological specificity of plasma membranes of cells infected with Marek’s disease and turkey herpes viruses, J. Gen. Virol. 25: 1.PubMedGoogle Scholar
  78. Kessler, I. I., 1974, Perspectives on the epidemiology of cervical cancer with specific reference to the herpesvirus hypothesis, Cancer Res 34: 1091.PubMedGoogle Scholar
  79. Kessler, I. I., 1976, Human cervical cancer as a venereal disease, Cancer Res. 36: 783.PubMedGoogle Scholar
  80. Klein, E., Klein, G., and Levine, P. H., 1976, Immunological control of human lymphoma: Discussion, Cancer Res. 36: 724.PubMedGoogle Scholar
  81. Klein, G., 1973, The Epstein-Barr virus, in: The Herpesviruses ( A. S. Kaplan, ed.), p. 521, Academic Press, New York.Google Scholar
  82. Klein, G., Clifford, P., Henle, G., Henle, W., Geering, G., and Old, L. J., 1969, EBV-associated serological patterns in a Burkitt lymphoma patient during regression and recurrence, Int. J. Cancer 4: 416.PubMedGoogle Scholar
  83. Laufs, R., and Steinke, H., 1975, Vaccination of non-human primates against malignant lymphoma, Nature (London) 53: 71.Google Scholar
  84. Lesnick, F., and Ross, L. J. N., 1975, Immunization against Marek’s disease using Marek’s disease virus-specific antigens free from infectious virus, Int. J. Cancer 16: 153.Google Scholar
  85. Levine, P. H., 1974, The etiology of Hodgkin’s disease, Pathobiol. Annu. 64: 143.Google Scholar
  86. Levine, P. H., and Gravell, M., 1975, The viral etiology of leukemia, Mod. Probl. Paediatr. 16: 137.Google Scholar
  87. Levine, P. H., Ablashi, D. V., Berard, C. W., Carbone, P. P., Waggoner, D. E., and Malan, L., 1971a, Elevated antibody titers to Epstein-Barr virus in Hodgkin’s disease, Cancer 27: 416.PubMedGoogle Scholar
  88. Levine, P. H., Merrill, D. A., Bethlenfalvay, N. C., Dabich, L., Stevens, D. A., and Waggoner, D. E., 1971b, A longitudinal comparison of antibodies to Epstein-Barr virus and clinical parameters in chronic lymphocytic leukemia and chronic myelocytic leukemia, Blood 38: 479.PubMedGoogle Scholar
  89. Levine, P. H., Herberman, R. B., Rosenberg, E. B., McClure, P. D., Roland, A., Pienta, R. J., and Ting, R. C. Y., 1972a, Acute leukemia in identical twins: Search for viral and leukemia-associated antigens, Natl. Cancer Inst. 49: 943.Google Scholar
  90. Levine, P. H., O’Conor, G. T., and Berard, C. W., 1972b, Antibodies to Epstein-Barr virus (EBV) in American patients with Burkitt’s lymphoma, Cancer 30: 610.PubMedGoogle Scholar
  91. Levine, P. H., Fraumeni, J. F., Jr., Reisher, J. I., and Waggoner, D. E., 1974, Antibodies to Epstein-Barr virus-associated antigens in relatives of cancer patients, J. Natl. Cancer Inst. 52: 1037.PubMedGoogle Scholar
  92. Li, F. P., Melvin, K. E. W., Tashjian, A. H., Jr., Levine, P. H., and Fraumeni, J. F., Jr., 1974, Brief communication: Familial medullary thyroid carcinoma and pheochromocytoma: Epidemiologic investigations, J. Natl. Cancer Inst. 52: 285.PubMedGoogle Scholar
  93. Mackey, L., 1975, Feline leukaemia virus and its clinical effects in cats, Vet Rec. 96: 5.PubMedGoogle Scholar
  94. Mann, D. L., Halterman, R., and Leventhal, B., 1974, Acute leukemia associated antigens, Cancer 34: 1446.PubMedGoogle Scholar
  95. McGrath, C. M., Grant, P. M., Soule, H. D., Glancy, T., and Rich, M. A., 1974, Replication of oncornavirus-like particle in human breast carcinoma cell line, MCF-7, Nature (London) 252: 247.Google Scholar
  96. Melendez, L. V., Daniel, M. D., Hunt, R. D., and Garcia, F. G., 1968. An apparently new herpesvirus from primary kidney cultures of the squirrel monkey (saimiri sciureus), Lab. Anim. Care 18: 374.PubMedGoogle Scholar
  97. Metzgar, R. S., Mohankumar, T., and Miller, D. S., 1972, Antigens specific for human lymphocytic and myeloid leukemia cells: Detection by nonhuman primate antiserums, Science 178: 986.PubMedGoogle Scholar
  98. Meyer, H. M., Jr., and Ennis, F. A., 1976, Regulatory approach toward vaccines against cancer: The benefit/risk ratio, Cancer Res. 36: 865.PubMedGoogle Scholar
  99. Miller, G., 1974, The oncogenicity of Epstein-Barr virus, J. Infect. Dis. 130: 187.PubMedGoogle Scholar
  100. Mohanakumar, T., Metzgar, R. S., and Miller, D. S., 1974, Human leukemia cell antigens: Serologic characterization with xenoantisera, J. Natl. Cancer Inst. 52: 1435.PubMedGoogle Scholar
  101. Morrow, R. H., Pike, M. C., Smith, P. G., Ziegler, J. L., and Kisuule, A., 1971, Burkitt’s lymphoma: A time-space cluster of cases in Bwamba County of Uganda, Br. Med. J. 2: 491.PubMedGoogle Scholar
  102. Morrow, R. H., Gutensohn, N., and Smith, P. G., 1976a, Epstein-Barr virus-malaria interaction models for Burkitt’s lymphoma: Implications for preventive trials, Cancer Res. 36: 667.PubMedGoogle Scholar
  103. Morrow, R. H., Kisuule, A., Pike, M. C., and Smith, P. G., 1976b, Burkitt’s lymphoma in the Mengo District of Uganda: Epidemiological features and their relationship to malaria, J. Natl Cancer Inst. 56: 479.PubMedGoogle Scholar
  104. Morton, D. L., and Malmgren, R. A., 1968, Human osteosarcomas: Immunologic evidence suggesting an associated infectious agent, Science 162: 1279.PubMedGoogle Scholar
  105. Morton, D. L., Malmgren, R. A., Holmes, E. C., and Ketcham, A. S., 1968, Demonstration of antibodies against human malignant melanoma by immunofluorescence, Surgery 64: 233.PubMedGoogle Scholar
  106. Morton, D. L., Hall, W. T., and Malmgren, R. A., 1969, Human liposarcomas: Tissue cultures containing foci of transformed cells with viral particles, Science 165: 813.PubMedGoogle Scholar
  107. Mukherji, B., and Hirshaut, Y., 1973, Evidence for fetal antigen in human sarcoma, Science 181: 440.PubMedGoogle Scholar
  108. Nahmias, A. J., Josey, W. E., Naib, Z. M., Luce, C., and Duffey, C., 1970, Antibodies to herpesvirus hominis type 1 and 2 in humans. I. Patients with genital herpetic infections, Am. J. Epidemiol. 91: 539.PubMedGoogle Scholar
  109. Nooter, K., Aarssen, A. M., Bentvelzen, P., Degroot, F. G., and Van Pelt, F. G., 1975, Isolation of infectious C-type oncornavirus from human leukaemic bone marrow cells, Nature (London) 256: 595.Google Scholar
  110. O’Conor, G. T., 1970, Persistent immunologic stimulation as a factor in oncogenesis, with special reference to Burkitt’s Tumor, Am. J. Med. 48: 279.Google Scholar
  111. Padgett, B. L., Walker, D. L., Zurhein, G. M., Eckroade, R. J., and Dessel, B. H., 1971, Cultivation of Papova-like virus from human brain with progressive multifocal leucoencephalopathy, Lancet 1: 1257.PubMedGoogle Scholar
  112. Panem, S., Prochownik, E. V., Reale, F. R., and Kirsten, W. H., 1975, Isolation of Type-C virions from a normal human fibroblast strain, Science 189: 297.PubMedGoogle Scholar
  113. Pasca, A. S., Kummerlander, L., Pejtsik, B., and Pali, K., 1975, Herpesvirus antibodies and antigens in patients with cervical anaplasia and in controls, J. Natl Cancer Inst. 55: 775.Google Scholar
  114. Priori, E. S., and Dmochowski, L., 1974, Immunofluorescence antibodies in human sera to antigens in cells of a type C virus producing human culture of tumor origin, Prog. Exp. Tumor Res. 19: 182.PubMedGoogle Scholar
  115. Priori, E. S., Dmochowski, L., Myers, B., and Wilbur, J. R., 1971a, Continuous type C virus production in a tissue culture of human origin (Burkitt lymphoma), 29th Ann. Proc. Electron Microsc. Soc., p. 376.Google Scholar
  116. Priori, E. S., Seman, G., Dmochowski, L., Gallager, H. S., and Anderson, D. E., 1971b, Immunofluorescence studies on sera of patients with breast carcinoma, Cancer 28: 1462.PubMedGoogle Scholar
  117. Priori, E. S., Wilbur, J. R., and Dmochowski, L., 1971c, Immunofluorescence tests on sera of patients with osteogenic sarcoma, J. Natl Cancer Inst. 46: 1299.PubMedGoogle Scholar
  118. Priori, E. S., Anderson, D. E., Williams, W. C., and Dmochowski, L., 1972, Immunological studies on human breast carcinoma and mouse mammary tumors, J. Natl Cancer Inst. 48: 1131.PubMedGoogle Scholar
  119. Purchase, H. G., 1976, Prevention of Marek’s disease: A review, Cancer Res. 36: 696.PubMedGoogle Scholar
  120. Rabin, H., Neubauer, R. H., Pearson, G. R., Cicmanec, J. L., Wallen, W. C., Loeb, W. F., and Valerio, M. G., 1975, Spontaneous lymphoma associated with herpesvirus saimiri in owl monkeys, J. Natl Cancer Inst. 54: 499.PubMedGoogle Scholar
  121. Reedman, B. M., Klein, G., Pope, J. H., Walters, M. K., Hilgers, J., Singh, S., and Johansson, B., 1974, Epstein-Barr virus-associated complement-fixing and nuclear antigens in Burkitt lymphoma biopsies, Int. J. Cancer 13: 755.PubMedGoogle Scholar
  122. Roizman, B., and Frenkel, N., 1975, Does genital herpes cause cancer? A midway assessment, in: Sexually Transmitted Diseases ( R. D. Catterrall and C. S. Nicol, eds.), p. 151, Academic Press, New York.Google Scholar
  123. Rosenberg, E. B., Herberman, R. B., Levine, P. H., Halterman, R. H., McCoy, J. L., and Wunderlich, J. R., 1972, Lymphocyte cytotoxicity reactions to leukemia-associated antigens in identical twins, Int. J. Cancer 9: 648.PubMedGoogle Scholar
  124. Royston, I., and Aurelian, L., 1970, Immunofluorescent detection of herpesvirus antigens in exfoliated cells from human cervical carcinoma, Proc. Natl. Acad. Sci. U.S.A. 67: 204.PubMedGoogle Scholar
  125. Sabin, A. B., 1974, Herpes simplex-genitalis virus nonvirion antigens and their implication in certain human cancers: unconfirmed, Proc. Natl. Acad. Sci. U.S.A. 71: 3248.PubMedGoogle Scholar
  126. Shope, T., Dechairo, D., and Miller, G., 1973, Malignant lymphoma in cottontip marmosets after inoculation with Epstein-Barr virus, Proc. Nat. Acad. Sci. U.S.A. 70: 2487.Google Scholar
  127. Smith, P. G., and Pike, M. C., 1976, Current epidemiological evidence for transmission of Hodgkin’s disease, Cancer Res. 36: 660.PubMedGoogle Scholar
  128. Sohier, R., and de The, G., 1972, Evolution of complement-fixing antibody titers with the development of Burkitt’s lymphoma, Int. J. Cancer 9: 524.PubMedGoogle Scholar
  129. Tarro, G., and Sabin, A. B., 1970, Virus-specific, labile, non-virion antigen in herpesvirus-infected cells, Proc. Natl. Acad. Sci. U.S.A. 65: 753.PubMedGoogle Scholar
  130. Tarro, G., and Sabin, A. B., 1973, Nonvirion antigens produced by herpes simplex viruses 1 and 2, Proc. Natl. Acad. Sci. U.S.A. 70: 1032.PubMedGoogle Scholar
  131. Teich, N. M., Weiss, R. A., Salahuddin, S. Z., Gallagher, R. E., Gillespie, D. H., and Gallo, R. C., 1975, Infective transmission and characterisation of a C-type virus released by cultured human myeloid leukaemia cells, Nature (London) 256: 551.Google Scholar
  132. Theilen, G. H., Gould, D., Fowler, M., and Dungworth, D. L., 1971, C-type virus in tumor tissue of a woolly monkey (Logothrix spp.) with fibrosarcoma, J. Natl. Cancer Inst. 47: 881.PubMedGoogle Scholar
  133. Thomas, E. D., Bryant, J. I., Buckner, C. D., Clift, R. A., Fefer, A., Johnson, F. L., Neiman, P., Ramberg, R. E., and Storb, R., 1972, Leukaemic transformation of engrafted human marrow cells in vivo, Lancet 1: 1310.PubMedGoogle Scholar
  134. Tischendorf, P., Shramek, G. J., Balagtas, R. C., Deinhardt, F., Knospe, W. H., Noble, G. R., and Maynard, J. E., 1970, Development and Persistence of Immunity to Epstein-Barr virus in man, J. Infect. Dis. 122: 401.PubMedGoogle Scholar
  135. Van Blitterswijk, W. J., Emmelot, P., Hilgers, J., Kamlag, D., Nusse, R., Feltkamp, C. A., 1975, Quantitation of virus induced (MLr) and normal (THY. 1.2) cell surface antigens in isolated plasma membranes and the extracellular ascites fluid of mouse leukemia cells, Cancer Res. 35: 2743.PubMedGoogle Scholar
  136. Vianna, N. J., Greenwald, P., and Davies, J. N. P., 1971, Nature of Hodgkin’s disease agent, Lancet 1: 733.PubMedGoogle Scholar
  137. Williams, E. H., Day, N. E., and Geser, A. G., 1974, Seasonal variation in onset of Burkitt’s lymphoma in the West Nile district of Uganda, Lancet 11: 19.Google Scholar
  138. Witter, R. L., 1976, Natural mechanisms of controlling lymphotropic herpesvirus infection (Marek’s disease) in the chicken, Cancer Res. 36: 681.PubMedGoogle Scholar
  139. Yohn, D. S., Horoszewicz, J. S., Ellison, R. R., Mittelman, A., Chai, L. S., and Grace, J. T., Jr., 1968, Immunofluorescent studies in human leukemia, Cancer Res. 28: 1692.Google Scholar
  140. Ziegler, J. L., Bluming, A. Z., Fass, L., and Morrow, R. H., Jr., 1972, Relapse patterns in Burkitt’s lymphoma, Cancer Res. 32: 1267.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Paul H. Levine
    • 1
  1. 1.Laboratory of Viral Carcinogenesis National Cancer InstituteNational Institutes of HealthBethesdaUSA

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