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Comparative Immunology of Carcinogenesis by DNA Viruses

  • Satvir S. Tevethia
  • Fred Rapp
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 6)

Abstract

Investigations during the last decade have established a definitive role for certain viruses in the induction and maintenance of neoplasia under natural and laboratory conditions. Although the causal relationship between viruses and neoplasia in animals is well established, no viruses have yet been demonstrated to be the direct cause of human cancer. A close association, however, has been made between the DNA-containing herpesvirus, Epstein-Barr virus (EBV), and Burkitt’s lymphoma (BL) and nasopharyngeal carcinoma (NPC) in the human population. DNA-containing tumor viruses differ from one another in morphology, nucleic acid content, host range, mode of replication, and ability to undergo latency and to cause neoplasia in their natural host. These include viruses that cause neoplasia in the host in which they replicate (herpes-, pox-, and papovaviruses) and viruses that induce tumors in heterologous hosts in which they undergo abortive infection (papovaviruses and adenoviruses). These viruses invariably transform both permissive and nonpermissive cells in culture to malignancy. One of the consequences of viral transformation of mammalian cells both in vitro and in vivo is the synthesis of macromolecules by the transformed cells, which are distinctly antigenic in the autochthonous or syngeneic host and to which the host makes both a cellular and a humoral immune response. The new antigens expressed in virally transformed cells may be directly coded by the viral genome integrated into the host chromosome or they may be of cellular origin.

Keywords

Simian Virus Adenovirus Type Polyoma Virus Comparative Immunology SV40 Genome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abrahams, P. J., Mulder, C., Van der Voorde, A., Warnaar, S. O., and Van der Eb, A. J., 1975, Transformation of primary rat kidney cells by fragments of simian virus 40 DNA, Virology 16: 818–823.Google Scholar
  2. Ahmed, M., and Schidlovsky, G., 1972, Detection of virus-associated antigen on membranes of cells productively infected with Marek’s disease herpesvirus, Cancer Res. 32: 187–192.PubMedGoogle Scholar
  3. Albrecht, T., and Rapp, F., 1973, Malignant transformation of hamster embryo fibroblasts following exposure to ultraviolet-irradiated human cytomegalovirus, Virology 55: 53–61.PubMedCrossRefGoogle Scholar
  4. Allison, A. C., and Law, L. W., 1968, Effects of antilymphocyte serum on virus oncogenesis, Proc. Soc. Exp. Biol. Med. 127: 207–212.PubMedGoogle Scholar
  5. Allison, A. C., and Taylor, R. B., 1967, Observations on thymectomy and carcinogenesis, Cancer Res. 27: 703–707.PubMedGoogle Scholar
  6. Allison, A. C., Chesterman, F. C., and Baron, S., 1967, Induction of tumors in adult hamsters with simian virus 40, J. Natl. Cancer Inst. 38: 567–572.PubMedGoogle Scholar
  7. Allison, A. C., Monga, J. N., and Hammond, V., 1974, Increased susceptibility to virus oncogenesis of congenitally thymus-deprived nude mice, Nature (London) 252: 746–747.CrossRefGoogle Scholar
  8. Altstein, A. D., Deichman, G. I., Sarycheva, O. F., Dodonova, N. N., Tsetlin, E. M., and Vassilieva, N. N., 1967a, Oncogenic and transforming activity of hydroxylamine-inactivated SV40 virus, Virology 33: 746–748.PubMedCrossRefGoogle Scholar
  9. Altstein, A. D., Sarycheva, O. F., and Dodonova, N. N., 1967b, Detection of defective (T-antigen inducing, but noninfectious) particles in preparations of SV40 virus, Virology 33: 744–746.PubMedCrossRefGoogle Scholar
  10. Ambrose, K. R., Anderson, N. G., and Coggin, J. H., 1971, Interruption of SV40 oncogenesis with human foetal cells, Nature (London) 233: 194.CrossRefGoogle Scholar
  11. Anderson, J. P., McCormick, K. J., Stenback, W. A., and Trentin, J. J., 1971, Induction of hepatomas by an avian adenovirus (CELO), Proc. Soc. Exp. Biol. Med. 137: 421–423.Google Scholar
  12. Ankerst, J., and Sjögren, H. O., 1970, Demonstration of two group-specific TSTAs in adenovirus-induced tumors, Int. J. Cancer 6: 84–94.PubMedCrossRefGoogle Scholar
  13. Ankerst, J., Jonsson, N., Kjelldn, L., Norrby, E., and Sjögren, H. O., 1974, Induction of mammary fibroadenomas in rats by adenovirus type 9, Int. J. Cancer 13: 286–290.PubMedCrossRefGoogle Scholar
  14. Aurelian, L., Strandberg, J. D., Melendez, L. V., and Johnson, L. A., 1971, Herpesvirus type 2 isolated from cervical tumor cells grown in tissue culture, Science 174: 704–707.PubMedCrossRefGoogle Scholar
  15. Baldwin, R. W., Embleton, M. J., Price, M. R., and Vose, B. M., 1974, Embryonic antigen expression on experimental rat tumors, Transplant. Rev. 20: 77–99.PubMedGoogle Scholar
  16. Bansal, S. C. and Sjögren, H. O., 1971, “Unblocking” serum activity in vitro in the polyoma system may correlate with antitumor effects of antiserum in vivo, Nature (London) 233:76–77.Google Scholar
  17. Bansal, S. C., and Sjögren, H. O., 1972, Counteraction of the blocking of cell-mediated tumor immunity by inoculation of unblocking sera and splenectomy: immunotherapeutic effects on primary polyoma tumors in rats, Int. J. Cancer, 9: 490–509.PubMedCrossRefGoogle Scholar
  18. Bansal, S. C., Hargreaves, R., and Sjögren, H. O., 1972, Facilitation of polyoma tumor growth in rats by blocking sera and tumor eluate, Int. J. Cancer 9: 97–108.PubMedCrossRefGoogle Scholar
  19. Baranska, W., Koldovsky, P., and Koprowski, H., 1970, Antigenic study unfertilized mouse eggs: cross reactivity with SV40-induced antigens, Proc. Natl Acad. Sci U.S.A. 67: 193–199.PubMedCrossRefGoogle Scholar
  20. Barski, G., and Youn, J. K., 1969, Evolution of cell-mediated immunity in mice bearing an antigenic tumor. Influce of tumor growth and surgical removal, J. Natl. Cancer Inst. 43: 111–112.PubMedGoogle Scholar
  21. Baum, S. G., Reich, P. R., Hybner, C. J., Rowe, W. P., and Weissman, S. M., 1966, Biophysical evidence for linkage of adenovirus and SV40 DNA’s in adenovirus 7-SV40 hybrid particles, Proc. Natl. Acad. Sci. U.S.A. 56: 1509–1515.PubMedCrossRefGoogle Scholar
  22. Berman, L. D., 1967, On the nature of transplantation immunity in the adenovirus tumor system, J. Exp. Med. 125: 983–1000.PubMedCrossRefGoogle Scholar
  23. Biggs, P. M., 1973, Marek’s disease, in: The Herpesviruses ( A. Kaplan, ed.), pp. 557–594, Academic Press, New York.Google Scholar
  24. Black, P. H., 1968, The oncogenic DNA viruses: A review of in vitro transformation studies, Annu. Rev. Microbiol. 22: 391–426.PubMedCrossRefGoogle Scholar
  25. Black, P. H., Rowe, W.P., Turner, H. C., and Huebner, R. J., 1963, A specific complement-fixing antigen present in SV40 tumor and transformed cells, Proc. Natl Acad. Sci. U.S.A. 50: 1148–1156.PubMedCrossRefGoogle Scholar
  26. Blasecki, J. W., and Tevethia, S. S., 1973, In vitro assay of cellular immunity to tumor-specific antigen(s) of virus-induced tumors by macrophage migration inhibition, J. Immunol. 110: 590–594.PubMedGoogle Scholar
  27. Blasecki, J. W., and Tevethia, S. S., 1975a, In vitro studies on the cellular immune response of tumor-bearing mice to SV40-transformed cells, J. Immunol 114: 244–249.PubMedGoogle Scholar
  28. Blasecki, J. W., and Tevethia, S. S., 19752b, Restoration of specific immunity against SV40 tumor-specific transplantation antigen to lymphoid cells from tumor-bearing mice, Int. J. Cancer 16: 275–283.Google Scholar
  29. Boiron, M., Lévy, J. P., and Thomas, M., 1965, Production de tumeurs chez le hamster par inoculation d’acide désoxyribonucléique extrait de cellules infectées par le virus SV40, Ann. Inst. Pasteur Paris 108: 298–305.Google Scholar
  30. Brugge, J. S., and Butel, J. S., 1975, Role of simian virus 40 gene A function in maintenance of transformation, J. Virol 15: 619–635.PubMedGoogle Scholar
  31. Burkitt, D., and Kyalwazi, S. K., 1967, Spontaneous remission of African lymphoma. Br. J. Cancer 21: 14–16.PubMedCrossRefGoogle Scholar
  32. Butel, J. S., Guentzel, M. J., and Rapp, F., 1969. Variants of defective simian papovavirus 40 (PARA) characterized by cytoplasmic localization of simian papovavirus 40 tumor antigen, J. Virol 4: 632–641.PubMedGoogle Scholar
  33. Butel, J. S., Tevethia, S. S., and Nachtigal, M., 1971, Malignant transformation in vitro by “nononcogenic” variants of defective SV40 (PARA), J. Immunol 106: 969–974.PubMedGoogle Scholar
  34. Butel, J. S., Tevethia, S. S., and Melnick, J. L., 1972, Oncogenicity and cell transformation by papovavirus SV40: The role of the viral genome, in: Advances in Cancer Research, Vol. 15 ( G. Klein and S. Weinhouse, eds.), pp. 1–55, Academic Press, New York.Google Scholar
  35. Carroll, R. B., Hager, L., and Dulbecco, R., 1974, Simian virus 40 T antigen binds to DNA, Proc. Natl Acad. Sci U.S.A. 71: 3754–3757.PubMedCrossRefGoogle Scholar
  36. Casto, B. C., 1973, Biologic parameters of adenovirus transformation, Prog. Exp. Tumor Res. 18: 166–198.Google Scholar
  37. Cerottini, J. C., and Brunner, K. T., 1974, Cell mediated cytotoxicity: Allograft rejection and tumor immunity, Adv. Immunol 18: 67–132.PubMedCrossRefGoogle Scholar
  38. Chen, J. H., and Purchase, H. G., 1970, Surface antigen on chick kidney cells infected with herpesvirus of Marek’s disease, Virology 40: 410–412.PubMedCrossRefGoogle Scholar
  39. Chou, J. Y., and Martin, R. G., 1974, Complementation analysis of simian virus 40 mutants, J. Virol 13: 1101–1109.PubMedGoogle Scholar
  40. Chou, J. Y., and Martin, R. G., 1975, DNA infectivity and the induction of host DNA synthesis with temperature-sensitive mutants of simian virus 40, J. Virol 15: 145–150.PubMedGoogle Scholar
  41. Clifford, P., Singh, S., Sternsward, J., and Klein, G., 1967, Long term survival of patients with Burkitt’s lymphoma; an assessment of treatment and other factors which may relate to survival, Cancer Res. 27: 2578–2615.PubMedGoogle Scholar
  42. Coggin, J. H., and Ambrose, K. R., 1969, A rapid in vivo assay for SV40 tumor immunity in hamsters, Proc, Soc. Exp. Biol. Med. 130: 246–252.Google Scholar
  43. Coggin, J. H., and Anderson, N. G., 1974, Cancer, differentiation and embryonic antigens: some central problems, in: Advances in Cancer Research, Vol. 19 ( G. Klein and S. Weinhouse, eds.), pp. 105–165, Academic Press, New York.Google Scholar
  44. Coggin, J. H., Ambrose, K. R., and Anderson, N. G., 1970, Fetal antigen capable of inducing transplantation immunity against SV40 hamster tumor cells, J. Immunol 105: 524–526.PubMedGoogle Scholar
  45. Coggin, J. H., Ambrose, K. R., Bellomy, B. B., and Anderson, N. G., 1971, Tumor immunity in hamsters immunized with fetal tissue, J. Immunol 107: 526–533.PubMedGoogle Scholar
  46. Coggin, J. H., Ambrose, K. R., Dierlam, P. J., and Anderson, N. G., 1974, Proposed mechanism by which autochthonous neoplasms escape tumor rejection, Cancer Res. 34: 2092–2101.PubMedGoogle Scholar
  47. Collard, W., Thornton, H., and Green, M., 1973, Cells transformed by human herpesvirus type 2 transcribe virus-specific RNA sequences shared by herpesvirus type 1 and 2, Nature (London) New Biol 243: 264–266.Google Scholar
  48. Collins, J. J., and Black, P. H., 1913a, Analysis of surface antigens on simian virus 40-transformed cells. I. Unique antigencity of simian virus 40-transformed outbred hamster kidney cell lines, J. Natl Cancer Inst. 51: 95–114.Google Scholar
  49. Collins, J. J., and Black, P. H., 19736, Analysis of surface antigens on simian virus 40-transformed cells. II. Exposure of simian virus 40-induced antigens on transformed rabbit kidney and inbred hamster kidney cells by phospholipase C, J. Natl Cancer Inst. 51: 115–134.Google Scholar
  50. Collins, J. J., Black, P. H., Strosberg, A. D., Haber, E., and Bloch, K. J., 1974, Transformation by simian virus 40 of spleen cells from a hyperimmune-rabbit: evidence for synthesis of immunoglobulin by the transformed cells, Proc. Natl Acad. Sci. U.S.A. 71: 260–262.PubMedCrossRefGoogle Scholar
  51. Datta, S. K., and Vandeputte, M., 1971, Studies on cellular and humoral immunity to tumor-specific antigens in polyoma virus-induced tumors of rats, Cancer Res. 31: 882–889.Google Scholar
  52. Davoli, D., and Fareed, G. C., 1974, Formation of reiterated simian virus 40 DNA, Cold Spring Harbor Symp. Quant. Biol 39: 137–146.CrossRefGoogle Scholar
  53. Defendi, V., 1963, Effects of SV40 virus immunization on growth of transplantable SV40 and polyoma virus tumors in hamsters, Proc. Soc. Exp. Biol Med. 113: 12–16.PubMedGoogle Scholar
  54. Defendi, V., and Jensen, F., 1967, Oncogenicity by DNA tumor viruses: Enhancement after ultraviolet and cobalt-60 radiation, Science 157: 703–705.PubMedCrossRefGoogle Scholar
  55. Deichman, G. I., 1969, Immunological aspects of carcinogenesis by deoxyribonucleic acid tumor viruses, in: Advances in Cancer Research, Vol. 12 ( G. Klein and S. Weinhouse, eds.), pp. 101–136, Academic Press, New York.Google Scholar
  56. Deichman, G. I., and Kluchareva, T. E., 1964, Immunological determinants of oncogenesis in hamsters infected with SV40 virus, Virology 24: 131–137.PubMedCrossRefGoogle Scholar
  57. Deichman, G. I., and Kluchareva, T. E., 1966, Loss of transplantation antigen in primary simian virus 40-induced tumors and their metastases, J. Natl Cancer Inst. 36: 647–655.PubMedGoogle Scholar
  58. Deinhardt, F. W., Falk, L. S., and Wolfe, L. G., 1974, Simian herpesviruses and neoplasia, in: Advances in Cancer Research, Vol. 19 ( G. Klein and S. Weinhouse, eds.), pp. 167–205, Academic Press, New York.Google Scholar
  59. Del Villano, B. C., and Defendi, V., 1973, Characterization of SV40 T antigen, Virology 51: 34–46.PubMedCrossRefGoogle Scholar
  60. Diamandopoulos, G. Th., 1973, Induction of lymphocytic leukemia, lymphosarcoma, reticulum cell sarcoma, and osteogenic sarcoma in the Syrian golden hamster by oncogenic DNA simian virus 40, J. Natl Cancer Inst. 50: 1347–1365.PubMedGoogle Scholar
  61. Diamandopoulos, G. Th., and McLane, M. F., 1974, Development of antibodies to viral and tumor antigens before tumor induction, J. Immunol 13: 1450–1456.Google Scholar
  62. Diamandopoulos, G. Th., Tevethia, S. S., Rapp, F., and Enders, J. F., 1968, Development of S and T antigens and oncogenicity in hamster embryonic cell lines exposed to SV40, Virology 34: 331–336.PubMedCrossRefGoogle Scholar
  63. Dierlam, P., Anderson, N. G., and Coggin, J. H., 1971, Immunization against tumors with fetal antigens: Detection of immunity by the colony inhibition test and by adoptive transfer, in: Embryonic and Fetal Antigens in Cancer (N. G. Anderson et al., eds.), pp. 203–214, Proceedings of the First Conference and Workshop on Embryonic and Fetal Antigens in Cancer, Oak Ridge, Tenn., May 24–26, 1971.Google Scholar
  64. Dougherty, R. M., and DiStefano, H. S., 1974, Isolation and characterization of a papovavirus from human urine, Proc. Soc. Exp. Biol Med. 146: 481–487.PubMedGoogle Scholar
  65. Drapkin, M. S., Apella, E., and Law, L. W., 1974, Immunogenic properties of a soluble tumor-specific transplantation antigen induced by simian virus 40, J. Natl Cancer Inst. 52: 259–264.PubMedGoogle Scholar
  66. Dubbs, D. R., Rachmeler, M., and Kit, S., 1974, Recombination between temperature- sensitive mutants of simian virus 40, Virology 57: 161–174.PubMedCrossRefGoogle Scholar
  67. Duff, R., and Rapp, F., 1970a, Reaction of serum from pregnant hamsters with surface of cells transformed by SV40, J. Immunol 105: 521–523.PubMedGoogle Scholar
  68. Duff, R., and Rapp, F., 1970, Quantitative characteristics of the transformation of hamster cells by PARA (defective simian virus 40)-adenovirus 7, J. Virol 5: 568–577.PubMedGoogle Scholar
  69. Duff, R., and Rapp, R., 1971, Properties of hamster embryo fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2, J. Virol 8: 469–477.PubMedGoogle Scholar
  70. Duff, R., and Rapp, F., 1973, Oncogenic transformation of hamster embryo cells after exposure to inactivated herpes simplex virus type 1, J. Virol 12: 209–217.PubMedGoogle Scholar
  71. Duff, R., Knight, P., and Rapp, F., 1972, Variation in oncogenic and transforming potential of PARA (defective simian virus 40)-adenovirus 7, Virology 47: 849–853.PubMedCrossRefGoogle Scholar
  72. Duff, R., Doller, E., and Rapp, F., 1973, Immunologic manipulation of metastases due to herpesvirus transformed cells, Science 180: 79–81.PubMedCrossRefGoogle Scholar
  73. Eddy, B., 1964, Simian virus 40 (SV40); an oncogenic virus, Prog. Exp. Tumor Res. 4: 1–26.PubMedGoogle Scholar
  74. Else, R. W., 1974, Vaccinal immunity to Marek’s disease in bursectomized chickens, Vet Rec. 95: 182–187.PubMedCrossRefGoogle Scholar
  75. Epstein, M. A., 1970, Aspects of the EB virus, Adv. Cancer Res. 13: 383–411.PubMedCrossRefGoogle Scholar
  76. Epstein, M. A., Achong, B. G., and Barr, Y., 1964, Virus particles in cultured lymphoblasts from Burkitt’s lymphoma, Lancet 1: 702–703.PubMedCrossRefGoogle Scholar
  77. Evans, C. A., and Ito, Y., 1966, Antitumor immunity in the Shope papilloma-carcinoma complex of rabbits. III. Response to reinfection with viral nucleic acid, J. Natl Cancer Inst. 36: 1161–1166.PubMedGoogle Scholar
  78. Evans, C. A., Weiser, R. S., and Ito, Y., 1962, Antiviral and antitumor immunologic mechanisms operative in the Shope papilloma-carcinoma system, Cold Spring Harbor Symp. Quant. Biol 27: 453–462.CrossRefGoogle Scholar
  79. Evans, R., and Grant, C. K., 1972, Role of macrophages in tumour immunity. III. Cooperation between macrophages and lymphoid factors in an in vitro allograft situation, Immunology 23: 667–687.Google Scholar
  80. Fass, L., Herberman, R. B., and Ziegler, J., 1970, Delayed cutaneous hypersensitivity reactions to autologous extracts of Burkitt-lymphoma cells. N. Engl J. Med. 282: 776–780.PubMedCrossRefGoogle Scholar
  81. Feldman, L. A., Butel, J. S., and Rapp, F., 1966, Interaction of a simian papovavirus and adenoviruses. I. Induction of adenovirus tumor antigen during abortive infection of simian cells, J. Bacteriol. 91: 813–818.PubMedGoogle Scholar
  82. Finkelstein, J. Z., and McAllister, R. M., 1969, Ultraviolet inactivation of the cytocidal and transforming activities of human adenovirus type 1, J. Virol 3: 353–354.Google Scholar
  83. Freeman, A. E., Black, P. H., Vanderpool, E. A., Henry, P. H., Austin, J. B., and Huebner, R. J., 1967, Transformation of primary rat embryo cells by adenovirus type 2, Proc. Natl Acad. Sci. U.S.A. 58: 1205–1212.PubMedCrossRefGoogle Scholar
  84. Frenkel, N., Roizman, B., Cassai, E., and Nahmias, A., 1972, A DNA fragment of herpes simplex 2 and its transcripts in human cervical cancer tissue, Proc. Natl. Acad. Sci. U.S.A. 69: 3784–3789.PubMedCrossRefGoogle Scholar
  85. Frenkel, N., Locker, H., Roizman, B., and Rapp, F., 1975, Viral DNA sequences in hamster cell lines transformed by UV-irradiated HSV-2, Session W-33, Third International Congress for Virology, p. 120, Madrid, Spain.Google Scholar
  86. Fujinaga, F., Sekikawa, K., Yamazaki, H., and Green, M., 1974, Analysis of multiple viral genome fragments in adenovirus 7-transformed hamster cells, Cold Spring Harbor Symp. Quant. Biol 39: 633–636.CrossRefGoogle Scholar
  87. Gallimore, P. H., 1972, Tumor production in immunosuppressed rats with cells transformed in vitro by adenovirus type 2, J. Gen. Virol 16: 99–102.PubMedCrossRefGoogle Scholar
  88. Gardner, S. D., Field, A. M., Coleman, D. V., and Hulme, B., 1971, New human papovavirus (B.K.) isolated from urine after renal transplantation, Lancet 1: 1253–1257.PubMedCrossRefGoogle Scholar
  89. Gerber, P., and Hoyer, B. H., 1971, Induction of cellular DNA synthesis in human leukocytes by Epstein-Barr virus, Nature (London) 231: 46–47.CrossRefGoogle Scholar
  90. Gerber, P., Whang-Peng, J., and Monroe, J. H., 1969, Transformation and chromosome changes induced by Epstein-Barr virus in normal human leukocyte cultures, Proc. Natl Acad. Sci U.S.A. 63: 740–747.CrossRefGoogle Scholar
  91. Gerber, P., Nonoyama, M., Lucas, S., Perlin, E., and Goldstein, L. I., 1972, Oral excretion of Epstein-Barr virus by healthy subjects and patients with infectious mononucleosis, Lancet 2: 988–989.PubMedCrossRefGoogle Scholar
  92. Gergely, L., Klein, G., and Ernberg, I., 1971c, Appearance of Epstein-Barr virus-associated antigens in infected Raji cells, Virology 45: 10–21.PubMedCrossRefGoogle Scholar
  93. Gergely, L., Klein, G., and Ernberg, I., 1971, The action of DNA antagonists on Epstein- Barr virus (EBV)-associated early antigen (EA) in Burkitt lymphoma lines, Int. J. Cancer 7: 293–302.PubMedCrossRefGoogle Scholar
  94. Gilden, R. V., Kern, J., Heberling, R. L., and Huebner, R. J., 1968, Serological studies of the T and tumor antigens of the oncogenic simian adenoviruses, Appl. Microbiol 16: 1015–1018.PubMedGoogle Scholar
  95. Gilead, Z., and Ginsberg, H. S., 1968, Characterization of the tumorlike (T) antigen induced by Type 12 adenovirus. II. Physical and chemical properties, J. Virol 2: 15–20.PubMedGoogle Scholar
  96. Ginsberg, H. S., Ensinger, M. J., Kauffman, R. S., Mayer, A. J., and Lundholm, U., 1974, Cell transformation: A study of regulation with types 5 and 12 adenovirus temperature-sensitive mutants, Cold Spring Harbor Symp. Quant. Biol 39: 419–426.CrossRefGoogle Scholar
  97. Girardi, A. J., 1965, Prevention of SV40 virus oncogenesis in hamsters, I. Tumor resistance induced by human cells transformed by SV40, Proc. Natl Acad. Sci. U.S.A. 54: 445–451.PubMedCrossRefGoogle Scholar
  98. Girardi, A. J., 1967, Tumor resistance and tumor enhancement with SV40 virus-induced tumors, in: Germinal Centers in Immune Responses ( H. Cottier, N. Odartchenko, R. Schindler, and C. C. Congdon, eds.), pp. 422–427, Springer-Verlag, New York.Google Scholar
  99. Girardi, A. J., and Defendi, V., 1970, Induction of SV40 transplantation antigen (TrAg) during the lytic cycle, Virology 42: 688–698.PubMedCrossRefGoogle Scholar
  100. Girardi, A. J., and Roosa, R. A., 1967, Prevention of SV40 virus oncogenesis in hamsters. II. The effect of thymectomy on induction of tumor resistance by SV40-transformed human cells, J. Immunol 99: 1217–1220.PubMedGoogle Scholar
  101. Girardi, A. J., Reppucci, P., Dierlam, P., Rutala, W., and Coggin, J. H., 1973, Prevention of simian virus 40 tumors by hamster fetal tissue: Influence of parity status of donor females on immunogenicity of fetal tissue and on immune cell cytotoxicity, Proc. Natl Acad. Sci U.S.A. 70: 183–186.PubMedCrossRefGoogle Scholar
  102. Goldman, R. D., Chang, C., and Williams, J. F., 1974, Properties and behavior of hamster embryo cells transformed by human adenovirus type 5, Cold Spring Harbor Symp. Quant. Biol 39: 601–614.CrossRefGoogle Scholar
  103. Goldner, H., Girardi, A. J., Larson, V. M., and Hilleman, M. R., 1964, Interruption of SV40 virus tumorigenesis using irradiated homologous tumor antigen, Proc. Soc. Exp. Biol Med. 117: 851–857.PubMedGoogle Scholar
  104. Graessmann, A., Graessmann, M., Hoffmann, H., Niebel, J., Brandner, G., and Mueller, N., 1974, Inhibition by interferon of SV40 tumor antigen formation in cells injected with SV40 cRNA transcribed in vitro, FEBS Lett. 39: 249–251.PubMedCrossRefGoogle Scholar
  105. Graham, F. L., Van der Eb, A. J., and Heijneker, H. L., 1974A, Size and location of the transforming region in human adenovirus type 5 DNA, Nature (London) 251: 687–691.Google Scholar
  106. Graham, F. L., Abrahams, J., Mulder, C., Heijneker, H., Warnaar, S. O., de Vries, F. A. J., and Van der Eb, A. J., 1914b, Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40, Cold Spring Harbor Symp. Quant. Biol 39: 637–650.CrossRefGoogle Scholar
  107. Gunvén, P., Klein, G., Clifford, P., and Singh, S., 1974, Epstein-Barr virus-associated membrane-reactive antibodies during long term survival after Burkitt’s lymphoma, Proc. Natl Acad. Sci U.S.A. 71: 1422–1426.PubMedCrossRefGoogle Scholar
  108. Habel, K., 1961, Resistance of polyoma virus immune animals to transplanted polyoma tumors, Proc. Soc. Exp. Biol Med. 106: 722–725.PubMedGoogle Scholar
  109. Habel, K., 1962, Immunological determinants of polyoma virus oncogenesis, J. Exp. Med. 115: 181–193.PubMedCrossRefGoogle Scholar
  110. Habel, K., and Eddy, B. E., 1963, Specificity of resistance to tumor challenge of polyoma and SV40 virus-immune hamsters, Proc. Soc. Exp. Biol Med. 113: 1–4.PubMedGoogle Scholar
  111. Hampar, B., Derge, J. G., Tanaka, A., and Nonoyama, M., 1974, Sequence of Epstein-Barr virus productive cycle in human lymphoblastoid cells, Cold Spring Harbor Symp, Quant. Biol. 39: 811–816.CrossRefGoogle Scholar
  112. Hargis, B. J., and Malkiel, S., 1975, Induction of sarcomas in mice by SV40 virus, Fed. Proc. 34: 973.Google Scholar
  113. Hayry, P., and Defendi, V., 1968, Use of mixed hemagglutination technique in detection of virus-induced antigen(s) on SV40-transformed cell surface, Virology 36: 317–321.PubMedCrossRefGoogle Scholar
  114. Hayry, P., and Defendi, V., 1970, Surface antigen(s) of SV40-transformed tumor cells, Virology 41: 22–29.PubMedCrossRefGoogle Scholar
  115. Hellström, I., and Hellström, K. E., 1975a, Cytotoxic effect of lymphocytes from pregnant mice on cultivated tumor cells. I. Specificity, nature of effector cells and blocking by serum, Int. J. Cancer 15: 1–16.PubMedCrossRefGoogle Scholar
  116. Hellström, I., and Hellström, K. E., 1975ft, Cytotoxic effect of lymphocytes from pregnant mice on cultivated tumor cells. II. Blocking and unblocking of cytotoxicity, Int. J. Cancer 15: 30–38.Google Scholar
  117. Hellström, I., and Sjögren, H. O., 1965, Demonstration of H-2 isoantigens and polyoma specific tumor antigens by measuring colony formation in vitro, Exp. Cell Res. 40: 212–215.PubMedCrossRefGoogle Scholar
  118. Hellström, I., and Sjögren, H. O., 1967, In vitro demonstration of humoral and cell-bound immunity against common specific transplantation antigen(s) of adenovirus 12-induced mouse and hamster tumors, J. Exp. Med. 125: 1105–1118.PubMedCrossRefGoogle Scholar
  119. Hellström, I., Evans, C. A., and Hellström, K. E., 1969, Cellular immunity and its serum-mediated inhibition in Shope-virus-induced rabbit papillomas, Int. J. Cancer 4: 601–607.PubMedCrossRefGoogle Scholar
  120. Hellström, K. E., and Hellström, I., 1969, Cellular immunity against tumor antigens, in: Advances in Cancer Research, Vol. 12 ( G. Klein and W. Weinhouse, eds.), pp. 167–223, Academic Press, New York.Google Scholar
  121. Hellström, K. E., and Hellström, I., 1974, Lymphocyte-mediated cytotoxicity and blocking serum activity to tumor antigens, Adv. Immunol 18: 209–277.PubMedCrossRefGoogle Scholar
  122. Henle, G., and Henle, W., 1966, Immunofluorescence in cells derived from Burkitt’s lymphoma, J. Bacteriol. 91: 1248–1256.PubMedGoogle Scholar
  123. Henle, G., Henle, W., and Diehl, V., 1968, Relation of Burkitt’s tumor associated herpes type virus to infectious mononucleosis, Proc. Natl. Acad. Sci U.S.A. 59: 94–101.PubMedCrossRefGoogle Scholar
  124. Henle, G., Henle, W., Clifford, P., Diehl, V., Kafuko, G. W., Kirya, B. B., Klein, G., Morrow, R. H., Munube, G. M. R., Pite, P., Tukei, P. M., and Ziegler, J. L., 1969, Antibodies to Epstein-Barr virus in Burkitt’s lymphoma and control groups, J. Natl. Cancer Inst. 43: 1147–1157.PubMedGoogle Scholar
  125. Henle, G., Henle, W., and Klein, G., 1971, Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus-infected cells, Int. J. Cancer 8: 272–282.PubMedCrossRefGoogle Scholar
  126. Henle, G., Henle, W., and Horwitz, C. A., 1974, Antibodies to Epstein-Barr virus associated nuclear antigen in infectious mononucleosis, J. Infect. Dis. 130: 231–239.PubMedCrossRefGoogle Scholar
  127. Henle, W., and Henle, G., 1973, Epstein-Barr virus, and infectious mononucleosis, N. Engl. J. Med. 288: 263–264.PubMedCrossRefGoogle Scholar
  128. Henle, W., and Henle, G., 1974, Epstein-Barr virus and human malignancies, Cancer 34: 1368–1374.PubMedCrossRefGoogle Scholar
  129. Henle, W., Diehl, V., Kohn, G., Zur Hausen, H., and Henle, G., 1967, Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells, Science 157: 1064–1065.PubMedCrossRefGoogle Scholar
  130. Henle, W., Henle, G., Zajac, B., Pearson, G., Waubke, R., and Scriba, M., 1970, Differential reactivity of human sera with early antigens induced by Epstein-Barr virus, Science 169: 188–190.PubMedCrossRefGoogle Scholar
  131. Henle, W., Henle, G., Gunvén, P., Klein, G., Clifford, P., and Singh, S., 1973, Patterns of antibodies to Epstein-Barr virus induced early antigens in fatal cases of Burkitt’s lymphoma and long term survivors, J. Natl. Cancer Inst. 50: 1163–1173.PubMedGoogle Scholar
  132. Hewetson, J., Gothoskar, B., Klein, G., and Singh, S., 1972, Radioiodine labeled antibody test for the detection of membrane antigens associated with Epstein-Barr virus, J. Natl. Cancer Inst. 48: 87–94.PubMedGoogle Scholar
  133. Hinuma, Y., and Grace, J. T., 1967, Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures, Proc. Soc. Exp. Biol. Med. 124: 107–111.PubMedGoogle Scholar
  134. Hinze, H. C., 1971, Induction of lymphoid hyperplasia and lymphoma-like disease in rabbits by Herpesvirus sylvilagus, Int. J. Cancer 8: 514–522.PubMedGoogle Scholar
  135. Howell, S. B., Dean, J. H., Esber, E. C., and Law, L. W., 1974, Cell interactions in adoptive immune rejection of a syngeneic tumor, Int. J. Cancer 14: 662–674.PubMedCrossRefGoogle Scholar
  136. Howell, S. B., Dean, J. H., and Law, L. W., 1975, Defects in cell-mediated immunity during growth of a syngeneic simian virus-induced tumor, Int. J. Cancer 15: 152–169.PubMedCrossRefGoogle Scholar
  137. Hudson, L., and Payne, L. N., 1973, An analysis of the T and B cells in Marek’s disease lymphoma of the chicken, Nature (London) 241: 5 2–53.CrossRefGoogle Scholar
  138. Huebner, R. J., Rowe, W. P., Turner, H. C., and Lane, W. T., 1963, Specific adenovirus complement-fixing antigens in virus-free hamster and rat tumors, Proc. Natl. Acad. Sci. U.S.A. 50: 379–389.PubMedCrossRefGoogle Scholar
  139. Huebner, R. J., Chanock, R. M., Rubin, B. A., and Casey, M. J., 1964c, Induction by adenovirus type 7 of tumors in hamsters having the antigenic characteristics of SV40 virus, Proc. Natl. Acad. Sci. U.S.A. 52: 1333–1340.PubMedCrossRefGoogle Scholar
  140. Huebner, R. J., Pereira, H. G., Allison, A. C., Hollinshead, A. C., and Turner, H. C., 1964ft, Production of type specific C antigen in virus-free hamster tumor cells induced by adenovirus type 12, Proc. Natl. Acad. Sci U.S.A. 51: 432–439.Google Scholar
  141. Huebner, R. J., Casey, M. J., Chanock, R. M., and Schell, K., 1965, Tumors induced in hamsters by a strain of adenovirus type 3: Sharing of tumor antigens and “neoantigens” with those produced by adenovirus type 7 tumors, Proc. Natl. Acad. Sci. U.S.A. 54: 381–388.PubMedCrossRefGoogle Scholar
  142. Inbar, M., Rabinowitz, Z., and Sachs, L., 1969, The formation of variants with a reversion of properties of transformed cells. III. Reversion of the structure of the cell surface membrane, Int. J. Cancer 4: 690–696.PubMedCrossRefGoogle Scholar
  143. Irlin, I. S., 1967, Immunofluorescent demonstration of a specific surface antigen in cells infected or transformed by polyoma virus, Virology 32: 725–728.PubMedCrossRefGoogle Scholar
  144. Jaenisch, R., and Mintz, B., 1974, Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA, Proc. Natl Acad. Sci U.S.A. 71: 1250–1254.PubMedCrossRefGoogle Scholar
  145. Jensen, F., and Defendi, V., 1968, Transformation of African green monkey kidney cells by irradiated adenovirus 7-simian virus 40 hybrid, J. Virol. 2: 173–177.PubMedGoogle Scholar
  146. Jessel, D., Hudson, J., Landau, T., Tenen, D., and Livingston, D. M., 1975, Interaction of partially purified simian virus 40 T antigen with circular viral DNA molecules, Proc. Natl. Acad. Sci U.S.A. 72: 1960–1969.PubMedCrossRefGoogle Scholar
  147. Jondal, M., Svedmyr, E., Klein, E., and Klein, G., 1975, Epstein-Barr virus (EBV) specific T and K cell cytotoxicity in vitro, Proc. Vllth Int. Symp. Comp. Leuk. Res. (in press).Google Scholar
  148. Kaplan, P. M., Melnick, J. L., and Tevethia, S. S., 1971, Development of nononcogenic SA 7-adenovirus 2 populations that immunize against SA 7-transformed cells, J. Natl. Cancer Inst. 46: 565–576.PubMedGoogle Scholar
  149. Kelly, F., and Sambrook, J., 1974, Variants of simian virus 40-transformed mouse cells resistant to cytochalasin B, Cold Spring Harbor Symp. Quant. Biol. 39: 345–353.CrossRefGoogle Scholar
  150. Kelly, T. J., Jr., and Rose, J. A., 1971, Simian virus 40 integration site in an adenovirus 7-simian virus 40 hybrid DNA molecule, Proc. Natl. Acad. Sci. U.S.A., 68: 1037–1041.PubMedCrossRefGoogle Scholar
  151. Kelly, T. J., Lewis, A. M., Levine, A. S., and Siegel, S., 1974, Structural studies on two adenovirus 2-SV40 hybrids containing the entire SV40 genome, Cold Spring Harbor Symp. Quant. Biol 39: 409–417.CrossRefGoogle Scholar
  152. Khera, K. S., Ashkenazi, A., Rapp, F., and Melnick, J. L., 1963, Immunity in hamsters to cells transformed in vitro and in vivo by SV40. Tests for antigenic relationship among papovaviruses, J. Immunol 91: 604–613.PubMedGoogle Scholar
  153. Khoury, G., Howley, P., Garon, C., Mullarkey, M. F., Takemoto, K. K., and Martin, M. A., 1975, Homology and relationship between the genomes of papovaviruses, BK virus and simian virus 40, Proc. Natl Acad. Sci U.S.A. 72: 2563–2567.PubMedCrossRefGoogle Scholar
  154. Kimura, G., and Itagaki, A., 1975, Initiation and maintenance of cell transformation by simian virus 40: A viral genetic property, Proc. Natl Acad. Sci U.S.A. 72: 673–677.PubMedCrossRefGoogle Scholar
  155. Kimura, S., Esparza, J., Benyesh-Melnick, M., and Schaffer, P. A., 1974, Enhanced replication of temperature-sensitive mutants of herpes simplex virus type 2 (HSV-2) at the nonpermissive temperature in cells transformed by HSV-2, Intervirology 3: 162–169.PubMedCrossRefGoogle Scholar
  156. Kimura, S., Flannery, V. L., Levy, B., and Schaffer, P., 1975, Oncogenic transformation of primary hamster cells by herpes simplex virus type 2 (HSV-2) and an HSV-2 temperature-sensitive mutant, Int. J. Cancer 15: 786–798.PubMedCrossRefGoogle Scholar
  157. Kirschstein, R. L., and Gerber, P., 1962, Ependymomas produced after intracerebral inoculation of SV40 into newborn hamsters, Nature (London) 195: 299–300.CrossRefGoogle Scholar
  158. Kit, S., Kurimura, T., and Dubbs, D. R., 1969, Transplantable mouse tumor line induced by injection of SV40-transformed mouse kidney cells, Int. J. Cancer 4: 384–392.PubMedCrossRefGoogle Scholar
  159. Klein, G., 1966, Tumor antigens, Annu. Rev. Microbiol 20: 223–252.PubMedCrossRefGoogle Scholar
  160. Klein, G., 1969, Experimental studies in tumor immunology, Fed. Proc. 28: 1739–1753.PubMedGoogle Scholar
  161. Klein, G., 1973, The Epstein-Barr virus, in: The Herpesviruses ( A. S. Kaplan, ed.), pp. 521–555, Academic Press, New York.Google Scholar
  162. Klein, G., 1974, Studies on the Epstein-Barr virus genome and the EBV-determined nuclear antigen in human malignant disease, Cold Spring Harbor Symp. Quant. Biol. 39: 783–790.CrossRefGoogle Scholar
  163. Klein, G., and Vonka, V., 1974, Relationship between the Epstein-Barr virus-determined complement-fixing antigen and the nuclear antigen detected by anticomplement fluorescence, J. Natl Cancer Inst. 53: 1645–1646.PubMedGoogle Scholar
  164. Klein, G., Clifford, P., Klein, E., and Stjernswärd, J., 1966, Search for tumor specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction, Proc. Natl Acad. Sci U.S.A. 55: 1628–1635.PubMedCrossRefGoogle Scholar
  165. Klein, G., Clifford, P., Klein, E., Smith, R. T., Minowada, J., Kourilsky, F. M., and Burchenal, J. H., 1967, Membrane immunofluorescence reactions of Burkitt lymphoma cells from biopsy specimens and tissue cultures, J. Natl Cancer Inst. 39: 1027–1044.PubMedGoogle Scholar
  166. Klein, G., Pearson, G., Henle, W., Diehl, V., and Niederman, J. C., 1968, Relation between Epstein-Barr viral and cell membrane immunofluorescence in Burkitt tumor cells, J. Exp. Med. 128: 1021–1030.PubMedCrossRefGoogle Scholar
  167. Klein, G., Clifford, P., Henle, G., Henle, W., Geering, G., and Old, L. J., 1969, EBV-associated serological patterns in a Burkitt lymphoma patient during regression and recurrence, Int. J. Cancer 4: 416–421.PubMedCrossRefGoogle Scholar
  168. Klein, G., Gergely, L., and Goldstein, G., 1971, Two-color immunofluorescence studies on EBV-determined antigens, Clin. Exp. Immunol 8: 593–602.PubMedGoogle Scholar
  169. Klein, G., Giovanella, B. C., Lindahl, T., Fialkow, P. J., Singh, S., and Stehlin, J. S., 1974, Direct evidence for the presence of EBV DNA and nuclear antigen in malignant epithelial cells from patients with poorly differentiated carcinoma of the nasopharynx, Proc. Natl Acad. Sci U.S.A. 71: 4737–4741.PubMedCrossRefGoogle Scholar
  170. Kluchareva, T. E., Shachanina, K. L., Belova, S., Chibisova, V., and Deichman, G. I., 1967, Use of immunofluorescence for detection of specific membrane antigen in simian virus 40-infected nontransformed cells, J. Natl Cancer Inst. 39: 825–832.PubMedGoogle Scholar
  171. Koprowski, H., Sawicki, W., and Koldovsky, P., 1971, Immunological cross-reactivity between antigen of unfertilized mouse eggs and mouse cells transformed by simian virus 40, J. Natl Cancer Inst. 46: 1317–1323.PubMedGoogle Scholar
  172. Kutinová, L., Vonka, V., and Broueek, J., 1973, Increased oncogenicity and synthesis of herpesvirus antigens in hamster cells exposed to herpes simplex type 2 virus, J. Natl Cancer Inst. 50: 759–766.PubMedGoogle Scholar
  173. Lai, C., and Nathans, D., 1974, Mapping of temperature-sensitive mutants of simian virus 40: Rescue of mutants by fragments of viral DNA, Virology 60: 466–475.PubMedCrossRefGoogle Scholar
  174. Larson, V. M., Girardi, A. J., Hilleman, M. R., and Zwickey, R. E., 1965, Studies of oncogenicity of adenovirus type 7 viruses in hamsters, Proc. Soc. Exp. Biol. Med. 118: 15–24.PubMedGoogle Scholar
  175. Lausch, R. N., and Rapp, F., 1971, Concomitant immunity in hamsters bearing syngeneic transplants of tumors induced by PARA-adenovirus 7, simian adenovirus 7 and 9, 10 dimethylbenzanthracene, Int. J. Cancer 7: 322–330.PubMedCrossRefGoogle Scholar
  176. Lausch, R. N., Tevethia, S. S., and Rapp, F., 1968. Evidence of SV40-specific transplanta-tion and surface antigens in cells transformed by PARA-adenovirus 12, J. Immunol 101: 645–649.PubMedGoogle Scholar
  177. Lausch, R. N., Tevethia, S. S., and Rapp, F., 1970, Evidence for tolerance to SV40 tumor antigen in hamsters bearing PARA-adenovirus 12 tumor transplants, J. Immunol. 104: 305–311.PubMedGoogle Scholar
  178. Lausch, R. N., Sofranko, J., and Prather, S. O., 1975c, Analysis of sera from SV40 immunized and tumor bearing hosts for blocking activity and antibody dependent cellular cytotoxicity, J. Immunol. 115: 682–687.PubMedGoogle Scholar
  179. Lausch, R. N., Jones, C., Christie, D., Hay, K. A., and Rapp, F., 1975Z?, Spleen cell mediated cytotoxicity of hamster cells transformed by herpes simplex virus: Evidence for virus specific membrane antigen, J. Immunol. 114: 459–465.Google Scholar
  180. Laux, D., and Lausch, R. N., 1974, Reversal of tumor-mediated suppression of immune reactivity by in vitro incubation of spleen cells, J. Immunol 112: 1900–1908.PubMedGoogle Scholar
  181. Lavi, S., and Winocour, E., 1972, Acquisition of sequences homologous to host deoxyribonucleic acid by closed circular simian virus 40 deoxyribonucleic acid, J. Virol 9: 309–316.PubMedGoogle Scholar
  182. Law, L. W., 1966, Immunologic responsiveness and the induction of experimental neoplasms, Cancer Res. 26: 1121–1132.PubMedGoogle Scholar
  183. Law, L. W., and Ting, R. C., 1965, Immunologic competence and induction of neoplasms by polyoma virus, Proc. Soc. Exp. Biol Med. 119: 823–829.PubMedGoogle Scholar
  184. Law, L. W., Ting, R. C., and Leckband, E., 1967, Prevention of virus induced neoplasms in mice through passive transfer of immunity by sensitized syngeneic lymphoid cells, Proc. Natl Acad. Sci U.S.A. 57: 1068–1075.PubMedCrossRefGoogle Scholar
  185. Levin, M. J., Oxman, M. N., Diamandopoulos, G. Th., Levine, A. S., Henry, P. H., and Enders, J. F., 1969, Virus-specific nucleic acids in SV40 exposed hamster embryo cell lines: Correlation with S and T antigens, Proc. Natl Acad. Sci U.S.A. 62: 589–596.PubMedCrossRefGoogle Scholar
  186. Levine, A. S., Oxman, M. N., Henry, P. H., Levin, M. J., Diamandopoulos, G. Th., and Enders, J. F., 1970, Virus-specific deoxyribonucleic acid in simian virus 40-exposed hamster cells: Correlation with S and T antigens, J. Virol 6: 199–207.PubMedGoogle Scholar
  187. Levy, M. H., and Wheelock, E. F., 1974, The role of macrophages in defense against neoplastic disease, Adv. Cancer Res. 20: 131–163.PubMedCrossRefGoogle Scholar
  188. Lewis, A. M., Jr., and Rowe, W. P., 1970, Isolation of two plaque variants from the adenovirus type 2-simian virus 40 hybrid population which differ in their efficiency in yielding simian virus 40, J. Virol 5: 413–420.PubMedGoogle Scholar
  189. Lewis, A. M., Jr., and Rowe, W. P., 1971, Studies on nondefective adenovirus-simian virus hybrid viruses. I. A newly characterized simian virus 40 antigen induced by the Ad2+ND1 virus. J. Virol 7: 189–197.PubMedGoogle Scholar
  190. Lewis, A. M., Jr., and Rowe, W. P., 1973, Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. VIII. Association of simian virus 40 transplantation antigen with a specific region of the early viral genome, J. Virol 12: 836–840.PubMedGoogle Scholar
  191. Lewis, A. M., Jr., Levin, M. J., Weise, W. H., Crumpacker, C. S., and Henry, P. H., 1969, A nondefective (competent) adenovirus-SV40 hybrid isolated from the Ad2-SV40 hybrid population, Proc. Natl Acad. Sci U.S.A. 63: 1128–1135.PubMedCrossRefGoogle Scholar
  192. Lewis, A. M., Jr., Levine, A. S., Crumpacker, C. S., Levin, M. J., Samaha, R. J., and Henry, P. H., 1973, Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. V. Isolation of additional hybrids which differ in their simian virus 40-specifïc biological properties, J. Virol. 11: 655–664.PubMedGoogle Scholar
  193. Lewis, A. M., Rabson, A. S., and Levine, A. S., 1974a, Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. Transformation of hamster kidney cells by adenovirus 2 and nondefective hybrid viruses, J. Virol 13: 1291–1301.PubMedGoogle Scholar
  194. Lewis, A. M., Breeden, J. H., Wewerka, Y. L., Schnipper, L. E., and Levine, A. S. 19746, Studies of hamster cells transformed by adenovirus 2 and the nondefective Ad2-SV40 hybrids, Cold Spring Harbor Symp. Quant. Biol. 39: 651–656.Google Scholar
  195. Lherisson, A. M., Meyer, G., and Bonneau, H., 1967, Détection d’un antigène de membrane dans le système tumoral polyome-hamster, Bull. Cancer 54: 419–422.PubMedGoogle Scholar
  196. Mackaness, G. B., 1971, Delayed hypersensitivity and the mechanism of cellular resistance to infection, Prog. Immunol. 1: 413–424.Google Scholar
  197. Macnab, J. C. M., 1974, Transformation of rat embryo cells by temperature-sensitive mutants of herpes simplex virus, J. Gen. Virol. 24: 143–153.PubMedCrossRefGoogle Scholar
  198. Major, E. O., and Di Mayorca, G., 1973, Malignant transformation of BHK21 clone 13 cells by BK virus-A human papovavirus, Proc. Natl. Acad. Sci. U.S.A. 70: 3210–3212.PubMedCrossRefGoogle Scholar
  199. Malmgren, R. A., Takemoto, K. K., and Carney, P. G., 1968, Immunofluorescent studies of mouse and hamster cell surface antigens induced by polyoma virus, J. Natl. Cancer Inst. 40: 263–268.PubMedGoogle Scholar
  200. Marek, J. 1908, Multiple Nerventziindung (polyneuritis) bei Hiihnern, Dtsch. Tieraerztl. Wochenschr. 15: 417–421.Google Scholar
  201. Martin, R. G., and Chou, J. Y., 1975, Simian virus 40 functions required for the establishment and maintenance of malignant transformation, J. Virol. 15: 599–612.PubMedGoogle Scholar
  202. McAllister, R. M., Nicholson, M. O., Reed, G., Kern, J., Gilden, R. V., and Huebner, R. J., 1969, Transformation of rodent cells by adenovirus 19 and other group D adeno-viruses, J. Natl. Cancer Inst. 43: 917–923.PubMedGoogle Scholar
  203. McDougall, J. K., Dunn, A. R., and Gallimore, P. H., 1974, Recent studies on the characteristics of adenovirus-infected and -transformed cells, Cold Spring Harbor Symp. Quant. Biol. 39: 591–600.CrossRefGoogle Scholar
  204. Melendez, L. V., Daniel, M. D., Hunt, R. D., and Garcia, F. G., 1968, An apparently new herpesvirus from primary kidney culture of the squirrel monkey (Saimiri sciureus), Lab. Anim. Care 18: 374–381.PubMedGoogle Scholar
  205. Melendez, L. V., Hunt, R. D., King, N. W., Barahona, H. H., Daniel, M. D., Fraser, C. E. O., and Garcia, F. G., 1972, Herpesvirus ateles, a new lymphoma of monkeys, Nature (London) New Biol 235: 182–184.Google Scholar
  206. Mertz, J. E., Carbon, J., Herzberg, M., Davis, R. W., and Berg, P., 1974, Isolation and characterization of individual clones of simian virus 40 mutants containing deletions, duplications and insertions in their DNA, Cold Spring Harbor Symp. Quant. Biol 39: 69–84.CrossRefGoogle Scholar
  207. Metzgar, R. S., and Oleinick, S. R., 1968, The study of normal and malignant cell antigens by mixed agglutination, Cancer Res. 28: 1366–1371.PubMedGoogle Scholar
  208. Meyer, G., and Birg, F., 1970, Sensitivity to inactivation by ultraviolet light of certain functions of polyoma virus: Cell surface antigen, J. Gen. Virol 9: 127–131.PubMedCrossRefGoogle Scholar
  209. Mikulska, Z. B., Smith, C., and Alexander, P., 1966, Evidence for an immunological reaction of the host directed against its own actively growing primary tumor, J. Natl Cancer Inst. 36: 29–35.PubMedGoogle Scholar
  210. Miller, G., Niederman, J. C., and Stitt, D. A., 1972, Infectious mononucleosis: Appearance of neutralizing antibody to Epstein-Barr virus measured by inhibition of formation of lymphoblastoid cell lines, J. Infect. Dis. 125: 403–406.PubMedCrossRefGoogle Scholar
  211. Miller, G., Niederman, J. C., and Andrews, L. L., 1973, Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis, N. Engl J. Med. 288: 229–232.PubMedCrossRefGoogle Scholar
  212. Miller, G., Robinson, J., Heston, L., and Lipman, M., 1974, Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference, Proc. Natl Acad. Sci U.S.A. 71: 4006–4010.PubMedCrossRefGoogle Scholar
  213. Murasko, D. M., 1975, Demonstration of virus associated antigens on hamster cells trans-formed by cytomegalovirus, Ph.D. thesis, Pennsylvania State University.Google Scholar
  214. Murasko, D. M., and Lausch, R. N., 1974, Cellular immune response to virus specific antigen in hamsters bearing isografts of cytomegalovirus-transformed cells, Int. J. Cancer 14: 451–460.PubMedCrossRefGoogle Scholar
  215. Nadkarni, J. S., Nadkarni, J. J., Klein, G., Henle, W., Henle, G., and Clifford, P., 1970, EB viral antigens in Burkitt tumor biopsies and early cultures, Int. J. Cancer 6: 10–17.PubMedCrossRefGoogle Scholar
  216. Nahmias, A. J., Josey, W. E., Naib, Z. M., Luce, C., and Guest, B., 1910a, Antibodies to herpesvirus hominis types 1 and 2 in humans. II. Women with cervical cancer, Am. J. Epidemiol 91: 547–552.Google Scholar
  217. Nahmias, A. J., Naib, Z. M., Josey, W. E., Murphy, F. A., and Luce, C. F., 1970, Sarcomas after inoculation of newborn hamsters with herpesvirus hominis type 2 strains, Proc. Soc. Exp. Biol Med. 134: 1065–1069.Google Scholar
  218. Nazerian, K., 1973, Marek’s disease: a neoplastic disease of chickens caused by a herpes-virus, in: Advances in Cancer Research, Vol. 17 ( G. Klein and S. Weinhouse, eds.), pp. 279–315, Academic Press, New York.Google Scholar
  219. Nazerian, K., and Chen, J. H., 1973, Immunoferritin studies of Marek’s disease virus directed intracellular and membrane antigens, Arch. Gesamte Virusforsch. 41: 59–65.PubMedCrossRefGoogle Scholar
  220. Nazerian, K., Lindahl, T., Klein, G., and Lee, L. F., 1973, Deoxyribonucleic acid of Marek’s disease virus in virus-induced tumors, J. Virol 12: 841–846.PubMedGoogle Scholar
  221. Nelson, D. S., 1974, Immunity to infection, allograft immunity and tumour immunity: Parallels and contrasts, Transplant. Rev. 19: 226–254.PubMedGoogle Scholar
  222. Niederman, J. C., McCollum, R. W., Henle, G., and Henle, W., 1968, Infectious mononucleosis: Clinical manifestations in relation to EB virus antibodies, J. Amer. Med. Assoc. 203: 205–209.CrossRefGoogle Scholar
  223. Nilsson, K., Klein, G., Henle, W., and Henle, G., 1971, The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV, Int. J. Cancer 8: 443–450.PubMedGoogle Scholar
  224. Nonoyama, M., Huang, C. H., Pagano, J. S., Klein, G., and Singh, S., 1973, DNA of Epstein-Barr virus detected in tissue of Burkitt’s lymphoma and nasopharyngeal carcinoma, Proc. Natl Acad. Sci. U.S.A. 70: 3265–3268.PubMedCrossRefGoogle Scholar
  225. Okazaki, W., Purchase, H. G., and Burmester, B. R., 1970, Protection against Marek’s disease by vaccination with a herpesvirus of turkeys (HVT), Avian Dis. 14: 413–429.PubMedCrossRefGoogle Scholar
  226. Osborn, M., and Weber, K., 1975, Simian virus 40 gene A function and maintenance of transformation, J. Virol 15: 636–644.PubMedGoogle Scholar
  227. Oxman, M. N., and Black, P. H., 1966, Inhibition of SV40 T antigen formation by interferon, Proc. Natl Acad. Sci. U.S.A. 55: 1133–1140.PubMedCrossRefGoogle Scholar
  228. Oxman, M. N., Takemoto, K. K., and Eckhart, W., 1972, Polyoma T antigen synthesis by temperature-sensitive mutants of polyoma virus, Virology 49: 675–682.PubMedCrossRefGoogle Scholar
  229. Padgett, B. L., Walker, D. L., ZuRhein, G. M., Eckroade, R. J., and Dessel, B. H., 1971, Cultivation of papova-like virus from human brain with progressive multifocal leukoencephalopathy, Lancet 1: 1257–1260.PubMedCrossRefGoogle Scholar
  230. Pattengale, P. K., Smith, R. W., and Gerber, P., 1974, B-Cell characteristics of human peripheral and cord blood lymphocytes transformed by Epstein-Barr virus, J. Natl Cancer Inst. 52: 1081–1086.PubMedGoogle Scholar
  231. Paulin, D., and Cuzin, F., 1975, Polyoma virus T antigen. I. Synthesis of modified heat-labile T antigen in cells transformed with a ts-a mutant, J. Virol 15: 393–397.PubMedGoogle Scholar
  232. Pauluzzi, S., and Rapp, F., 1969, Antigenic and oncogenic properties of a cell line derived from a hamster brain tumor induced by simian adenovirus 7, J. Natl. Cancer Inst. 43: 1165–1173.PubMedGoogle Scholar
  233. Payne, L. N., and Biggs, P. M., 1967, Studies on Marek’s disease. II. Pathogenesis, J. Natl. Cancer Inst. 39: 281–302.PubMedGoogle Scholar
  234. Payne, L. N., and Rennie, M., 1970, Lack of effect of bursectomy on Marek’s disease, J. Natl. Cancer Inst. 45: 387–397.PubMedGoogle Scholar
  235. Penny, J. B., and Narayan, O., 1973, Studies of the antigenic relationships of the new human papovaviruses by electron microscopy agglutination, Infect. Immun. 8: 299–300.Google Scholar
  236. Pollack, R. E., Green, H., and Todaro, G. J., 1968, Growth control in cultured cells: Selection of sublines with increased sensitivity to contact inhibition and decreased tumor-producing ability, Proc. Natl Acad. Sci U.S.A. 60: 126–133.PubMedCrossRefGoogle Scholar
  237. Pope, J. H., and Rowe, W. P., 1964, Detection of specific antigen in SV40-transformed cells by immunofluorescence, J. Exp. Med. 120: 121–127.PubMedCrossRefGoogle Scholar
  238. Pope, J. H., Home, M. K., and Scott, W., 1969, Identification of the filterable leukocyte-transforming factor of QIMR-WIL cells as herpes-like virus, Int. J. Cancer 4: 255–260.PubMedCrossRefGoogle Scholar
  239. Powell, P. C., 1975, Immunity to Marek’s disease induced by glutaraldehyde treated cells of Marek’s disease lymphoblastoid cell lines, Nature (London) 257: 684–685.CrossRefGoogle Scholar
  240. Powell, P. C., Payne, L. N., Frazier, J. A., and Rennie, M., 1974, Lymphoblastoid cell lines from Marek’s disease lymphomas, Nature (London) 251: 79–80.CrossRefGoogle Scholar
  241. Prevost, J. M., Orr, T. W., and Pearson, G. R., 1975, Augmentation of lymphocyte cytotoxicity by antibody to Herpesvirus saimiri associated antigens, Proc. Natl Acad. Sci. U.S.A. 72: 1671–1675.PubMedCrossRefGoogle Scholar
  242. Purchase, H. G., 1974, Marek’s disease virus and the herpesvirus of turkeys, in: Progress in Medical Virology, Vol. 18 ( J. L. Melnick, ed.), pp. 178–197, S. Karger, Basel.Google Scholar
  243. Purchase, H. G., and Biggs, P. M., 1967, Characterization of five isolates of Marek’s disease, Res. Vet. Sci 8: 440–449.PubMedGoogle Scholar
  244. Purchase, H. G., and Okazaki, W., 1971, Effect of vaccination with herpesvirus of turkeys (HVT) on horizontal spread of Marek’s disease (herpesvirus), Avian Dis. 15: 391–397.PubMedCrossRefGoogle Scholar
  245. Purchase, H. G., and Sharma, J. M., 1975, Amelioration of Marek’s disease and absence of vaccine protection in immunologically deficient chickens, Nature 248: 419–421.CrossRefGoogle Scholar
  246. Pyrhonen, S., and Johansson, E., 1975, Regression of warts, an immunological study, Lancet 1: 1–10.Google Scholar
  247. Rabinowitz, Z., and Sachs, L., 1968, Reversion of properties in cells transformed by polyoma virus, Nature (London) 220: 1203–1206.CrossRefGoogle Scholar
  248. Rabinowitz, Z., and Sachs, L., 1969, The formation of variants with a reversion of properties of transformed cells. I. Variants from polyoma-transformed cells grown in vivo, Virology 38: 336–342.PubMedCrossRefGoogle Scholar
  249. Rabinowitz, Z., and Sachs, L. 1970, The formation of variants with reversion of properties of transformed cells. IV. Loss of detectable polyoma transplantation antigen, Virology 40: 193–198.PubMedCrossRefGoogle Scholar
  250. Rapp, F., 1974, Herpesviruses and cancer, in: Advances in Cancer Research, Vol. 19 ( G. Klein and S. Weinhouse, eds.), pp. 265–302, Academic Press, New York.Google Scholar
  251. Rapp, F., and Duff, R., 1971, Quantitative aspects of virus-induced transformation of mammalian cells, in: From Molecules to Man: The Gustav Stern Symposium on Perspectives in Virology VII, pp. 37–53, Academic Press, New York.Google Scholar
  252. Rapp, F., and Duff, R. G., 1973, Transformation of hamster embryo fibroblasts by herpes simplex viruses type 1 and type 2, Cancer Res. 33: 1527–1534.PubMedGoogle Scholar
  253. Rapp, F., and Li, J. L. H., 1974, Demonstration of the oncogenic potential of herpes simplex viruses and human cytomegalovirus, Cold Spring Harbor Symp. Quant. Biol 39: 747–763.CrossRefGoogle Scholar
  254. Rapp, F., and Westmoreland, D., 1976, Cell transformation by DNA-containing viruses, Biochim. Biophys. Acta 458: 167–211.PubMedGoogle Scholar
  255. Rapp, F., Butel, J. S., and Melnick, J. L., 1964A, Virus induced intranuclear antigen in cells transformed by papovavirus SV40, Prac. Soc. Exp. Biol Med. 116: 1131–1135.Google Scholar
  256. Rapp, F., Kitahara, T., Butel, J. S., and Melnick, J. L., 1964b, Synthesis of SV40 tumor antigen during replication of simian papovavirus (SV40), Proc. Natl Acad. Sci. U.S.A. 52: 1138–1142.PubMedCrossRefGoogle Scholar
  257. Rapp, F., Melnick, J. L., Butel, J. S., and Kitahara, T., 1964c, The incorporation of SV40 genetic material into adenovirus 7 as measured by intranuclear synthesis of SV40 tumor antigen, Proc. Natl Acad. Sci. U.S.A. 52: 1348–1352.PubMedCrossRefGoogle Scholar
  258. Rapp, F., Butel, J. S., Feldman, L. A., Kitahara, T., and Melnick, J. L., 1965, Differential effects of inhibitors on the steps leading to the formation of SV40 tumor and virus antigens, J. Exp. Med. 121: 935–944.PubMedCrossRefGoogle Scholar
  259. Rapp, F., Tevethia, S. S., and Melnick, J. L., 1966, Papovavirus SV40 transplantation immunity conferred by an adenovirus-SV40 hybrid, J. Natl Cancer Inst. 36: 707–708.Google Scholar
  260. Rapp, F., Tevethia, S. S., Rawls, W. E., and Melnick, J. L., 1967, Production of antibodies to papovavirus SV40 tumor antigen in African green monkeys, Proc. Soc. Exp. Biol Med. 125: 794–798.PubMedGoogle Scholar
  261. Rapp, F., Jerkofsky, M., Melnick, J., and Levy, B., 1968, Variation in the oncogenic potential of human adenoviruses carrying a defective SV40 genome (PARA), J. Exp. Med. 127: 77–90.PubMedCrossRefGoogle Scholar
  262. Rapp, F., Pauluzzi, S., and Butel, J. S., 1969, Variation in properties of plaque progeny of PARA (defective simian papovavirus 40)-adenovirus 7, J. Virol 4: 626–631.PubMedGoogle Scholar
  263. Rapp, F., Li, J. L. H., and Jerkofsky, M., 1973, Transformation of mammalian cells by DNA-containing viruses following photodynamic inactivation, Virology 55: 339–346.PubMedCrossRefGoogle Scholar
  264. Rapp, F., Geder, L., Murasko, D., Lausch, R., Ladda, R., Huang, E.-S., and Webber, M. M., 1975, Long-term persistence of cytomegalovirus genome in cultured human cells of prostatic origin, J. Virol 16: 982–990.PubMedGoogle Scholar
  265. Rawls, W. E., Tompkins, W. A. F., and Melnick, J. L., 1969, The association of herpes-virus type 2 and carcinoma of the uterine cervix, Am. J. Epidemiol 89: 547–554.PubMedGoogle Scholar
  266. Reed, C. L., Cohen, G. H., and Rapp, F., 1975, Detection of a virus-specific antigen on the surface of herpes simplex virus-transformed cells, J. Virol 15: 668–670.PubMedGoogle Scholar
  267. Reed, S. I., Ferguson, J., Davis, R., and Stark, G. R., 1975, T antigen binds to Simian virus 40 DNA at the origin of replication, Proc. Natl Acad. Sci. U.S.A. 72: 1605–1609.PubMedCrossRefGoogle Scholar
  268. Reedman, B. M., and Klein, G., 1973, Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines, Int. J. Cancer 11: 499–502.PubMedCrossRefGoogle Scholar
  269. Riggs, J. L., Takemori, N., and Lennette, E. H., 1968, Cross-reactivity between T antigens of adenoviral immunotypes of proved and currently unproved oncogenic potential, J. Immunol. 100: 348–354.PubMedGoogle Scholar
  270. Risser, R., Rifkin, D., and Pollack, R., 1974, The stable classes of transformed cells induced by SV40 infection of established 3T3 cells and primary rat embryonic cells, Cold Spring Harbor Symp. Quant. Biol 39: 317–324.CrossRefGoogle Scholar
  271. Robb, J. A., and Martin, R. G., 1972, Genetic analysis of simian virus 40. III. Characteriza-tion of a temperature sensitive mutant blocked at an early stage of productive infection in monkey cells, J. Virol 9: 956–968.PubMedGoogle Scholar
  272. Robb, J. A., Tegtmeyer, P., Ishikawa, A., Stark, G. R., and Ozer, H. L., 1974, Antigenic phenotypes and complementation groups of temperature-sensitive mutants of simian virus 40, J. Virol 13: 662–665.PubMedGoogle Scholar
  273. Robinson, J., and Miller, G., 1975, Assay for Epstein-Barr virus based on stimulation of DNA synthesis in mixed leukocytes from human umbilical cord blood, J. Virol 15: 1065–1072.PubMedGoogle Scholar
  274. Roizman, B., and Kieff, D., 1975, Herpes simplex and Epstein-Barr viruses in human cells and tissues: A study in contrasts, in: Cancer: A Comprehensive Treatise, Vol. 2 ( F. Becker, ed.), pp. 241–322, Plenum Press, New York.Google Scholar
  275. Rollinghoff, M., and Warner, N. L., 1973, Specificity of in vivo tumor rejection assessed by mixing immune spleen cells with target and unrelated tumor cells, Proc. Soc. Exp. Biol Med. 144: 813–818.PubMedGoogle Scholar
  276. Rowe, W. P., and Baum, S. G., 1964, Evidence for a possible genetic hybrid between adenovirus type 7 and SV40 viruses, Proc. Natl Acad. Sci. U.S.A. 52: 1340–1347.PubMedCrossRefGoogle Scholar
  277. Royston, I., and Aurelian, L., 1970, Immunofluorescent detection of herpesvirus antigens in exfoliated cells from human cervical carcinoma, Proc. Natl Acad. Sci. U.S.A. 61: 204–212.CrossRefGoogle Scholar
  278. Sadowski, J. M., and Rapp, F., 1975, Inhibition by levamisole of metastases by cells transformed by herpes simplex virus type 1, Proc. Soc. Exp. Biol Med. 149: 219–222.PubMedGoogle Scholar
  279. Sambrook, J., 1973, Transformation by polyoma virus and simian virus 40, in: Advances in Cancer Research, Vol. 16 ( G. Klein and S. Weinhouse, eds.), pp. 141–180, Academic Press, New York.Google Scholar
  280. Sambrook, J., Botchan, M., Gallimore, P. M., Ozanne, B., Pettersson, U., Williams, J., and Sharp, P., 1974, Viral DNA sequences in cells transformed by simian virus 40, adenovirus type 2 and adenovirus type 5, Cold Spring Harbor Symp. Quant. Biol 39: 615–632.CrossRefGoogle Scholar
  281. Sambrook, J., Williams, J., Sharp, P. A., and Grodzicker, T., 1975, Physical mapping of temperature-sensitive mutations of adenoviruses, J. Mol. Biol 97: 369–390.PubMedCrossRefGoogle Scholar
  282. Sauer, G., Koprowski, H., and Defendi, V., 1967. The genetic heterogeneity of simian virus 40, Proc. Natl Acad. Sci. U.S.A. 58: 599–606.PubMedCrossRefGoogle Scholar
  283. Schaller, J. P., and Yohn, D. S., 1974, Transformation potential of the noninfectious (defective) component in pools of adenoviruses type 12 and simian adenovirus 7, J. Virol. 14: 392–401.PubMedGoogle Scholar
  284. Seemayer, N. H., Hirai, K., and Defendi, V., 1973, Analysis of minimal functions of simian virus 40. I. Oncogenic transformation of Syrian hamster kidney cells in vitro by photodynamically inactivated SV40, Int. J. Cancer 12: 524–531.PubMedCrossRefGoogle Scholar
  285. Sharma, J. M., 1975, The role of T cells in herpesvirus induced Marek’s disease lymphoma, in: VIIth International Symposium on Comparative Leukemia Research, in press.Google Scholar
  286. Shin, S. I., Freedman, V. H., Risser, R., and Pollack, R., 1975, Tumorigenicity of virus- transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro, Proc. Natl Acad. Sci U.S.A. 72: 4435–4439.PubMedCrossRefGoogle Scholar
  287. Shope, T., Dechairo, D., and Miller, G., 1973, Malignant lymphoma in cottontop marmosets following inoculation with Epstein-Barr virus, Proc. Natl Acad. Sci. U.S.A. 70: 2487–2491.PubMedCrossRefGoogle Scholar
  288. Silvestre, D., Kourilsky, F., Klein, G., Yata, Y., Neauport-Sautes, C., and Levy, J., 1971, Relationship between EBV-associated membrane antigen on Burkitt lymphoma cells and the viral envelope, demonstrated by immunoferritin labelling, Int. J. Cancer 8: 222–233.PubMedCrossRefGoogle Scholar
  289. Singh, S. B., Smith, J. W., Rawls, W. E., and Tevethia, S. S., 1973, Demonstration of cytotoxic antibodies in rabbits bearing tumors induced by Shope fibroma virus, Infect. Immun. 5: 352–358.Google Scholar
  290. Sjögren, H. O., 1964, Studies on specific transplantation resistance to polyoma-virus-induced tumors. II. Mechanism of resistance induced by polyoma virus infection, J. Natl Cancer Inst 32: 375–393.Google Scholar
  291. Sjögren, H. O., 1965, Transplantation methods as a tool for detection of tumor-specific antigens, Prog. Exp. Tumor Res. 6: 289–322.PubMedGoogle Scholar
  292. Sjögren, H. O., and Bansal, S. C., 1971, Antigens in virally induced tumors, in: Progress in Immunology, ( B. Amos, ed.), pp. 921–938, Academic Press, New York.Google Scholar
  293. Sjögren, H. O., and Borum, K., 1971, Tumor-specific immunity in the course of primary polyoma and Rous tumor development in intact and immunosuppressed rats, Cancer Res. 31: 890–900.PubMedGoogle Scholar
  294. Sjögren, H. O., Hellstrom, I., and Klein, G., 1961, Resistance of polyoma virus immunized mice against transplantation of established polyoma tumors, Exp. Cell Res. 23: 204–208.CrossRefGoogle Scholar
  295. Sjögren, H. O., Minowada, M. D., and Ankerst, J., 1967, Specific transplantation antigens of mouse sarcomas induced by adenovirus type 12, J. Exp. Med. 125: 689–701.PubMedCrossRefGoogle Scholar
  296. Smith, H. S., Scher, C. D., and Todaro, G. J., 1971, Induction of cell division in medium lacking serum growth factor by SV40, Virology 44: 359–370.PubMedCrossRefGoogle Scholar
  297. Smith, H. S., Gelb, L. D., and Martin, M. A., 1972, Detection and quantitation of simian virus 40 genetic material in abortively transformed BALB/3T3 clones, Proc. Natl. Acad. Sci. U.S.A. 69: 152–156.PubMedCrossRefGoogle Scholar
  298. Smith, R. W., Morganroth, J., and Mora, P. T., 1970, SV40 virus-induced tumor specific transplantation antigen in cultured mouse cells, Nature (London) 227: 141–145.CrossRefGoogle Scholar
  299. Stutman, O., 1975, Tumor development after polyoma infection in athymic nude mice, J. Immunol. 114: 1213–1217.PubMedGoogle Scholar
  300. Svedmyr, E., Demissie, A., Klein, G., and Clifford, P., 1970, Antibody patterns in different human sera against intracellular and membrane antigen complexes associated with Epstein-Barr virus, J. Natl. Cancer Inst. 44: 595–610.PubMedGoogle Scholar
  301. Svedmyr, E., and Jondal, M., 1975, Cytotoxic effector cells for B cell lines transformed by Epstein-Barr virus present in patients with infectious mononucleosis, Proc. Natl. Acad. Sci U.S.A. 72: 1622–1626.PubMedCrossRefGoogle Scholar
  302. Syverton, J. T., Dascomb, H. E., Wells, E. B., Koomen, J., and Berry, G. P., 1950, The virus-induced papilloma-to-carcinoma sequence. II. Carcinomas in the natural host, the cottontail rabbit, Cancer Res. 10: 440.PubMedGoogle Scholar
  303. Tai, H. T., Smith, C. A., Sharp, P. A., and Vinograd, J., 1972, Sequence heterogeneity in closed simian virus 40 deoxyribonucleic acid, J. Virol. 9: 317–325.PubMedGoogle Scholar
  304. Takemoto, K. K., and Mullarkey, M. F., 1973, Human papovavirus, BK strain: Biological studies including antigenic relationship to simian virus 40, J. Virol. 12: 625–631.PubMedGoogle Scholar
  305. Takemoto, K. K., Ting, R. C. Y., Ozer, H. L., and Fabisch, P., 1968, Establishment of a cell line from an inbred mouse strain for viral transformation studies: simian virus 40 transformation and tumor production, J. Natl. Cancer Inst. 41: 1401–1409.PubMedGoogle Scholar
  306. Tegtmeyer, P., 1972, Simian virus 40 deoxyribonucleic acid synthesis: The viral replicon, Virology 10: 591–598.Google Scholar
  307. Tegtmeyer, P., 1975, Function of simian virus 40 gene A in transforming infection, J. Virol. 15: 613–618.PubMedGoogle Scholar
  308. Tegtmeyer, P., and Ozer, H. L., 1971, Temperature-sensitive mutants of simian virus 40: Infection of permissive cells, J. Virol. 8: 516–524.PubMedGoogle Scholar
  309. Tegtmeyer, P., and Ozer, H. L., 1972, Synthesis and assembly of simian virus 40 II. Synthesis of the major capsid protein and its incorporation into viral particles, J. Virol 9: 52–60.PubMedGoogle Scholar
  310. Tegtmeyer, P., Schwartz, M., Collins, J. K., and Rundell, K., 1975, Regulation of tumor antigen synthesis by simian virus 40 gene A, J. Virol. 16: 168–178.PubMedGoogle Scholar
  311. Tenser, R. B., and Hsiung, G. D., 1973, Infection of thymus cells in vivo and in vitro with a guinea pig herpes-like virus and the effect of antibody on virus replication in organ culture, Immunol 110: 552–560.Google Scholar
  312. Tevethia, M. J., and Tevethia, S. S., 1976, Biology of SV40 transplantation antigen (TrAg). I. Demonstration of SV40 TrAg on gluteraldehyde-fixed SV40-infected African green monkey kidney cells, Virology 69: 474–489.PubMedCrossRefGoogle Scholar
  313. Tevethia, S. S., 1967, Characterization of hamster antibody reacting with papovavirus SV40 tumor antigen, J. Immunol 98: 1257–1264.PubMedGoogle Scholar
  314. Tevethia, S. S., 1970, Immune response of rabbits to purified papovavirus SV40, J. Immunol 104: 72–78.PubMedGoogle Scholar
  315. Tevethia, S. S., 1974, Evidence for virus-specific transplantation antigen in cells of lymphoid neoplasms induced by papovavirus SV40, Int. J. Cancer 13: 494–499.PubMedCrossRefGoogle Scholar
  316. Tevethia, S. S., 1975, Immunofluorescence staining of DNA tumor virus-induced antigens, Ann. N.Y. Acad. Sci. 254: 541–550.PubMedCrossRefGoogle Scholar
  317. Tevethia, S. S., and McMillan, V. L., 1974, Acquisition of malignant properties by SV40-transformed mouse cells: relationship to type-C viral antigen expression, Intervirology 3: 269–276.PubMedCrossRefGoogle Scholar
  318. Tevethia, S. S., and Tevethia, M. J., 1975a, DNA virus (SV40) induced antigens, in: Cancer, A Comprehensive Treatise, Vol. 4 ( F. Becker, ed.), 185–207, Plenum Press, New York.Google Scholar
  319. Tevethia, S. S., and Tevethia, M. J. 19756, Cell surface antigens of DNA virus (SV40) infected and transformed cells, in: Cellular Membranes and Tumor Cell Behavior, pp. 447–467, Williams and Wilkins, Baltimore.Google Scholar
  320. Tevethia, S. S., and Tevethia, M. J., 1976, Cell-mediated immunity to virus-induced tumors: Generation of lymphocytes sensitized to specific transplantation antigen in mouse cells infected with papovavirus SV40, in: Progress in Medical Virology, Vol. 21 ( F. Rapp, ed.), pp. 103–117, S. Karger, Basel.Google Scholar
  321. Tevethia, S. S., and Zarling, J. M., 1972, Participation of macrophages in tumor immunity, Natl Cancer Inst. Monogr. 35: 279–282.PubMedGoogle Scholar
  322. Tevethia, S. S., Katz, M., and Rapp, F., 1965, New surface antigen in cells transformed by simian papovavirus SV40, Proc. Soc. Exp. Biol. Med. 119: 896–901.PubMedGoogle Scholar
  323. Tevethia, S. S., Couvillon, L. A., and Rapp, F., 1968a, Development in hamsters of antibodies against surface antigens present in cells transformed by papovavirus SV40, J. Immunol. 100: 358–362.PubMedGoogle Scholar
  324. Tevethia, S. S., Diamandopoulos, G. Th., Rapp, F., and Enders, J. F., 1968b, Lack of relationship between virus-specific and transplantation antigens in hamster cells trans-formed by simian papovavirus SV40, J. Immunol 101: 1192–1198.PubMedGoogle Scholar
  325. Tevethia, S. S., Dreesman, G. R., Lausch, R. N., and Rapp, F., 1968c, Effect of anti-hamster thymocyte serum on papovavirus SV40-induced transplantation immunity, J. Immunol 101: 1105–1110.Google Scholar
  326. Tevethia, S. S., Crouch, N. A., Melnick, J. L., and Rapp, F., 1970, Detection of specific surface antigens by colony inhibition in cells transformed by papovavirus SV40, Int. J. Cancer 5: 176–184.PubMedCrossRefGoogle Scholar
  327. Tevethia, S. S., McMillan, V. L., Kaplan, P. M., and Bushong, S. C., 1971, Variation in immunosensitivity of SV40 transformed hamster cells, J. Immunol 106: 1295–1300.PubMedGoogle Scholar
  328. Tevethia, S. S., Blasecki, J. W., Waneck, G., and Goldstein, A., 1974, Requirement of thymus-derived 0 positive lymphocytes for rejection of DNA virus (SV40) tumors in mice, J. Immunol. 113: 1417–1423.PubMedGoogle Scholar
  329. Tevethia, S. S., Zarling, J. M., and Flax, M., 1976, Macrophages and the destruction of syngeneic virus-induced tumors, in: Immunology of Macrophage (D. S. Nelson, ed.), Academic Press, New York, in press.Google Scholar
  330. Thompson, D. M. P., 1975, Soluble tumor-specific antigen and its relationship to tumor growth, Int. J. Cancer 15: 1016–1029.CrossRefGoogle Scholar
  331. Ting, C. C., and Herberman, R. B., 1971, Detection of tumor-specific antigen of simian virus 40-induced tumors by the isotopic antiglobulin technique, Int. J. Cancer 7: 499–506.PubMedCrossRefGoogle Scholar
  332. Ting, C. C., Larvin, D. H., Shiv, G., and Herberman, R. B., 1972, Expression of fetal antigens in tumor cells, Proc. Natl. Acad. Sci. U.S.A. 69: 1664–1668.PubMedCrossRefGoogle Scholar
  333. Ting, C. C., Rodrigues, D., and Herberman, R. B., 1973, Expression of fetal antigens and tumor-specific antigens in SV40-transformed cells. II. Tumor transplantation studies, Int. J. Cancer 12: 519–523.PubMedCrossRefGoogle Scholar
  334. Tockstein, G., Polasa, H., Piña, M., and Green, M., 1968, A simple purification procedure for adenovirus type 12 T and tumor antigens and some of their properties, Virology 36: 377–386.PubMedCrossRefGoogle Scholar
  335. Tompkins, W. A. F., Adams, C., and Rawls, W. E., 1970a, An in vitro measure of cellular immunity to fibroma virus, J. Immunol. 104: 502–510.PubMedGoogle Scholar
  336. Tompkins, W. A. F., Crouch, N. A., Tevethia, S. S., and Rawls, W. E., 19706, Characterization of surface antigen on cells infected by fibroma virus, J. Immunol. 105: 1181–1189.Google Scholar
  337. Tooze, J. (ed), 1973, The molecular biology of tumor viruses, Cold Spring Harbor Laboratory, New York.Google Scholar
  338. Trentin, J. J., and Bryan, E., 1966, Virus induced transplantation immunity to human adenovirus type 12 tumors of the hamster and mouse, Proc. Soc. Exp. Biol. Med. 121: 1216–1219.PubMedGoogle Scholar
  339. Trentin, J. J., Yabe, Y., and Taylor, G., 1962, The quest for human cancer viruses, Science 137: 835–841.PubMedCrossRefGoogle Scholar
  340. Trentin, J. J., Van Hoosier, G. L., Jr., and Samper, L., 1968, The oncogenicity of human adenoviruses in hamsters, Proc. Soc. Exp. Biol. Med. 127: 683–689.PubMedGoogle Scholar
  341. Tubergen, D. G., and Feldman, J. D., 1971, The role of thymus and bone marrow cells in delayed hypersensitivity, J. Exp. Med. 134: 1144–1154.PubMedCrossRefGoogle Scholar
  342. Uchida, S., and Watanabe, S., 1969. Tumorigenicity of the antigen-forming defective virions of simian virus 40, Virology 35: 166–168.CrossRefGoogle Scholar
  343. Uchida, S., Yoshiike, K., Watanabe, S., and Furino, A., 1968, Antigen forming defective virions of simian virus 40, Virology 34: 1–8.PubMedCrossRefGoogle Scholar
  344. Vandeputte, M., 1969, Antilymphocyte serum and polyoma virus oncogenesis in rats, Transplant. Proc. 1: 100–105.PubMedGoogle Scholar
  345. Vandeputte, M., Denys, P., Leyten, R., and De Somer, P., 1963, The oncogenic activity of the polyoma virus in thymectomized rats, Life Sci. 2: 475–478.CrossRefGoogle Scholar
  346. Vandeputte, M., Eyssen, H., Sobis, H., and De Somer, P., 1974, Induction of polyoma virus tumors in athymic nude mice, Int. J. Cancer 14: 445–450.PubMedCrossRefGoogle Scholar
  347. Van Der Noordaa, J., 1968, Transformation of rat cells by adenovirus types 1, 2, and 3, J. Gen. Virol. 3: 303–304.PubMedCrossRefGoogle Scholar
  348. Volkers, S., and Pitts, J., 1973, Virus specific surface antigens in cells productively infected with polyoma virus, Nature (London) New Biol. 244: 274–275.Google Scholar
  349. Volkman, A., and Collins, F. M., 1971, The restorative effect of peritoneal macrophages on delayed hypersensitivity following ionizing radiation, Cell Immunol. 2: 552–566.PubMedCrossRefGoogle Scholar
  350. Vonka, V., Zavadova, H. Kutinova, L., and Rezacova, D., 1967, Development of antibodies against viral and tumor antigens of papovavirus SV40 in monkeys, Proc. Soc. Exp. Biol. Med. 125: 790–793.PubMedGoogle Scholar
  351. Vonka, V., Benyesh-Melnick, M., and McCombs, R., 1970, Antibodies in human sera to soluble and viral antigens found in Burkitt lymphoma and other lymphoblastoid cell lines, J. Natl. Cancer Inst. 44: 865–872.PubMedGoogle Scholar
  352. Vonka, V., Vlckova, I., Zonadova, H., Kouba, K., Lazovska, J., and Duber, J., 1972, Antibodies to EBV virus capsid antigen and to soluble antigen of lymphoblastoid cells in infectious mononucleosis patients, Int. J. Cancer 9: 529–535.PubMedCrossRefGoogle Scholar
  353. Walker, D. L., Padgett, B. L., Zu Rhein, G. M., Albert, A. E., and Marsh, R. F., 1973, Human papovavirus (JC): Induction of brain tumors in hamsters, Science 181: 674–676.PubMedCrossRefGoogle Scholar
  354. Weiner, L. P., Herndon, R. M., Narayan, O., and Johnson, R. T., 1972, Further studies of a simian virus 40 like virus isolated from human brain, J. Virol. 10: 147–152.PubMedGoogle Scholar
  355. Weiss, A. F., Portmann, R., Fischer, H., Simon, J., and Zang, K. D., 1975, Simian virus 40-related antigens in three human meningiomas with defined chromosome loss, Proc. Natl. Acad. Sci. U.S.A. 72: 609–613.PubMedCrossRefGoogle Scholar
  356. Wesslen, T., 1970. SV40 tumorigenesis in mouse, Acta Pathol. Microbiol. Scan. 78: 479–487.Google Scholar
  357. Wilkie, N. M., Ustacelebi, S., and Williams, J. F., 1973, Characterization of temperature-sensitive mutants of adenovirus type 5: nucleic acid synthesis, Virology 51: 499–503.PubMedCrossRefGoogle Scholar
  358. Williams, J. F., Young, C. S. H., and Austin, P. E., 1974, Genetic analysis of human adenovirus type 5 in permissive and nonpermissive cells, Cold Spring Harbor Symp. Quant. Biol 39: 427–437.CrossRefGoogle Scholar
  359. Witter, R. L., 1972, Turkey herpesvirus: Lack of oncogenicity for turkeys, Avian Dis. 16: 660–670.Google Scholar
  360. Witter, R. L., Solomon, J. J., Champion, L. R., and Nazerian, K., 1971, Long term studies of Marek’s disease infection in individual chickens, Avian Dis. 15: 346–365.PubMedCrossRefGoogle Scholar
  361. Witter, R. L., Stephens, E. A., Sharma, J. M., and Nazerian, K., 1975, Demonstration of a tumor-associated surface antigen in Marek’s disease, J. Immunol 115: 177–183.PubMedGoogle Scholar
  362. Wolf, H., zur Hausen, H., and Becker, V., 1973, EB viral genomes in epithelial nasopharyngeal carcinoma cells, Nature (London) New Biol. 244: 245–247.Google Scholar
  363. Wright, P. W., and Law, L. W., 1971, Quantitative in vitro measurement of simian virus 40 tumor-specific antigens, Proc. Natl. Acad. Sci. U.S.A. 69: 973–976.CrossRefGoogle Scholar
  364. Wright, P. W., Smith, H. S., and McCoy, J., 1973, Tumorigenicity and antigenicity of mouse cells infected with simian virus 40. I. Relationship of growth in vitro and in vivo in immunosuppressed and immunocompetent recipients, J. Natl. Cancer Inst. 51: 951–959.PubMedGoogle Scholar
  365. Yohn, D. S., 1973, Sex related resistance in hamsters to adenovirus oncogenesis, Prog. Exp. Tumor Res. 18: 138–165.PubMedGoogle Scholar
  366. Yoshiike, K., 1968, Studies on DNA from low-density particles of SV40. II. Noninfectious virions associated with a large-plaque variant, Virology 34: 402–409.CrossRefGoogle Scholar
  367. Zarling, J. M., and Tevethia, S. S., 1973a, Transplantation immunity to simian virus 40-transformed cells in tumor-bearing mice. I. Development of cellular immunity to simian virus 40 tumor-specific transplantation antigens during tumorigenesis by transformed cells, J. Natl. Cancer Inst. 50: 137–147.PubMedGoogle Scholar
  368. Zarling, J. M., and Tevethia, S. S., 1973b, Transplantation immunity to simian virus 40-transformed cells in tumor bearing mice. II. Evidence for macrophage participation at the effector level of tumor cell rejection, J. Natl. Cancer Inst. 50: 149–157.PubMedGoogle Scholar
  369. Zbar, B., Wepsic, H. T., Rapp, H. J., Stewart, L. C., and Borsos, T., 1970, Two-step mechanism of tumor graft rejection in syngeneic guinea pigs. II. Initiation of reaction by a cell fraction containing lymphocytes and neutrophils, J. Natl. Cancer Inst. 44: 701–717.PubMedGoogle Scholar
  370. Zembala, M., Ptak, W., and Hanczakowska, M., 1973, The role of macrophages in the cytotoxic killing of tumor cells in vitro. I. Primary immunization of the lymphocytes in vitro for target cell killing and the mechanism of lymphocyte macrophage cooperation, Immunology 25: 631–644.PubMedGoogle Scholar
  371. zur Hausen, H., Henle, W., Hummeler, K., Diehl, V., and Henle, G., 1967, Comparative study of cultured Burkitt tumor cells by immunofluorescence, autoradiography and electron microscopy, J. Virol. 1: 830–837.PubMedGoogle Scholar
  372. zur Hausen, H., Schulte-Holthausen, H., Klein, G., Henle, W., Henle, G., Clifford, P., and Santesson, L., 1970, EB-virus DNA in biopsies of Burkitt tumors and anaplastic carcinomas of the nasopharynx, Nature (London) 228: 1056–1058.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Satvir S. Tevethia
    • 1
  • Fred Rapp
    • 2
  1. 1.Department of Pathology and Cancer Research CenterTufts University School of MedicineBostonUSA
  2. 2.Department of Microbiology and Specialized Cancer Research Center The Milton S. Hershey Medical CenterThe Pennsylvania State University College of MedicineHersheyUSA

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