Comparative Immunology of Carcinogenesis by DNA Viruses

  • Satvir S. Tevethia
  • Fred Rapp
Part of the Contemporary Topics in Immunobiology book series (CTI, volume 6)


Investigations during the last decade have established a definitive role for certain viruses in the induction and maintenance of neoplasia under natural and laboratory conditions. Although the causal relationship between viruses and neoplasia in animals is well established, no viruses have yet been demonstrated to be the direct cause of human cancer. A close association, however, has been made between the DNA-containing herpesvirus, Epstein-Barr virus (EBV), and Burkitt’s lymphoma (BL) and nasopharyngeal carcinoma (NPC) in the human population. DNA-containing tumor viruses differ from one another in morphology, nucleic acid content, host range, mode of replication, and ability to undergo latency and to cause neoplasia in their natural host. These include viruses that cause neoplasia in the host in which they replicate (herpes-, pox-, and papovaviruses) and viruses that induce tumors in heterologous hosts in which they undergo abortive infection (papovaviruses and adenoviruses). These viruses invariably transform both permissive and nonpermissive cells in culture to malignancy. One of the consequences of viral transformation of mammalian cells both in vitro and in vivo is the synthesis of macromolecules by the transformed cells, which are distinctly antigenic in the autochthonous or syngeneic host and to which the host makes both a cellular and a humoral immune response. The new antigens expressed in virally transformed cells may be directly coded by the viral genome integrated into the host chromosome or they may be of cellular origin.


Simian Virus Adenovirus Type Polyoma Virus Comparative Immunology SV40 Genome 
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Copyright information

© Plenum Press, New York 1977

Authors and Affiliations

  • Satvir S. Tevethia
    • 1
  • Fred Rapp
    • 2
  1. 1.Department of Pathology and Cancer Research CenterTufts University School of MedicineBostonUSA
  2. 2.Department of Microbiology and Specialized Cancer Research Center The Milton S. Hershey Medical CenterThe Pennsylvania State University College of MedicineHersheyUSA

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