Metabolism of Insect Hemocytes During Phagocytosis
Phagocytosis by ameboid blood cells is a protective mechanism generally ascribed to both vertebrate and invertebrate animals. In simplest terms, this process involves ingestion of a particle recognized as foreign by a phagocytic cell. The exact basis for the phenomenon of recognition of foreignness is of central importance to immunology but is not within the scope of this review. Phagocytosed microorganisms are enclosed in intracellular vacuoles to which other membrane-bound cytoplasmic granules (lysosomes) fuse. These lysosomes release bactericidal products and hydrolytic enzymes into the phagocytic vacuoles. Thereafter microorganisms may be killed and digested; however, for a variety of reasons, cellular bactericidal capacity may be incomplete in some cases. Certain pathogenic bacteria can remain viable within the phagocyte; others may survive because of cellular or biochemical defects.
KeywordsLatex Particle Chronic Granulomatous Disease Zymosan Particle Bactericidal Capacity Phagocytic Vacuole
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