An Electron Microscope Study of the Fate of Bacteria Phagocytized by Granulocytes of Crassostrea virginica

  • Thomas C. Cheng
  • Ann Cali


It is well established that the primary line of defense in molluscs, in all invertebrates for that matter, to foreign materials, biotic and abiotic, is what has been generally designated as cellular immunity (see Cheng, 1967, and Cheng and Rifkin, 1970, for reviews), although it could be argued that this may not be “immunity” sensu strictu since the involvement of antibodies in the form of immunoglobulins has not been demonstrated (Cheng, 1969, 1973). Nevertheless, as a rule, foreign elements, molecules, or organisms naturally or experimentally introduced into naive molluscs are phagocytized (Stauber, 1950; Tripp, 1958a, b, 1960, 1961; Feng, 1959, 1965; Arcadi, 1968; Cheng et al. 1969; Pauley and Krassner, 1972), encapsulated (Drew and De Morgan, 1910; Labbé, 1928, 1929, 1930; Newton, 1952, 1954; Brooks, 1953; Sudds, 1960;Mackin, 1961; Cheng and Rifkin, 1968), or nacrezized (Dubois, 1901, 1907; Perrier, 1903; Jameson, 1902; Giard, 1907; Alverdes, 1913; Nishikawa, 1917; Mikimoto, 1918; Tsujii, 1960). These appear to be highly efficient mechanisms for arresting and eliminating foreign materials, although exceptions are known (Naville, 1926; Goetsch and Scheuring, 1926; Yonge, 1936; Yonge and Nicholas, 1940; Prytherch, 1940; Mackin, 1951; Michelson, 1961; Feng, 1966; Feng and Stauber, 1968). In these instances, the foreign organisms are either not reacted against or are phagocytized but not degraded intracellularly. The reason(s) for these exceptions remains undetermined, although in the case of the organisms not reacted against, it is evident that the hosts do not recognize them as being nonself.


Electron Microscope Study Foreign Material Slime Mold Schistosoma Mansoni Crassostrea Virginica 


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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Thomas C. Cheng
    • 1
  • Ann Cali
    • 1
  1. 1.Institute for Pathobiology Center for Health SciencesLehigh UniversityBethlehemUSA

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