Tissue Transplantation in Diverse Marine Invertebrates

  • W. H. Hildemann
  • Trevor G. Dix
  • John D. Collins


The search for the origins and early mechanisms of immunocompetence among the invertebrates is now well underway. Tissue transplantation is recognized as a sensitive and perhaps universally applicable tool for investigation of immunoresponsiveness. Indeed, only orthotopic tissue transplantation may allow meaningful comparisons of reactivity to potentially immunogenic cells among phylogenetically diverse animals. This is because responses to xenogeneic or exotic macromolecules may be limited by the enzymes available to a species rather than by immunologic potential as such. Moreover, endotoxins inherent in many microbial antigen preparations may have effects ranging from stimulating to fatal, depending on the recipient species. A purified protein such as bovine serum albumin is an excellent, satisfactory, or poor immunogen depending on whether the recipient is a rabbit, goldfish, or mouse, respectively (Vredevoe, 1964, Trump, 1970). Thus the choice of test immunogen rather than the innate immunologic capacity of the recipient may be decisive and thus, results can be misleading.


Pacific Oyster Pearl Oyster Mantle Tissue Monofilament Nylon Acropora Species 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • W. H. Hildemann
    • 1
  • Trevor G. Dix
    • 1
  • John D. Collins
    • 1
  1. 1.School of Biological SciencesJames Cook University of North QueenslandTownsvilleAustralia

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