Cellular Basis of Immunological Unresponsiveness

  • Jacques M. Chiller
  • William O. Weigle


Injection of an antigen into a vertebrate may be followed by a number of different immunological alternatives. Most commonly, a specific immune response is manifested in the form of cell-associated immunity, humoral immunity, or both. In other instances, antigen may specifically prime the challenged host without resulting in expression of a detectable immune response. Finally, antigen may induce the immunological antithesis of a responsive state, that is, a state of specific unresponsiveness. The specific cellular events involved in these differing pathways share at least one facet; i.e., initiation involves the interaction between antigen and a specific cell or cells. The present discussion will consider the experimental data concerning the cellular events and consequences of the interaction between antigen and antigen-reactive cells which lead to the state of specifically induced unresponsiveness. The emphasis will be placed on the cellular phenomena involved in the induction, maintenance, and termination of immunological unresponsiveness as it specifically relates to the block in the formation of humoral antibody.


Bone Marrow Cell Spleen Cell Cellular Basis Sheep Erythrocyte Thymus Cell 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Jacques M. Chiller
    • 1
  • William O. Weigle
    • 1
  1. 1.Department of Experimental PathologyScripps Clinic and Research FoundationLa JollaUSA

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