Advertisement

C3-Receptor Sites on Leukocytes: Possible Role in Opsonization and in the Immune Response

  • Victor Nussenzweig
  • Carolyn S. Pincus

Abstract

In recent years the membrane of lymphocytes has been the subject of intensive study by immunologists, geneticists, and cell biologists. The reasons for this interest are multiple. For example, lymphoid cells can be readily obtained in suspension and in relatively large numbers. They may constitute a model for problems of cellular recognition and differentiation, since they may acquire and lose membrane markers during differentiation (Boyce and Old, 1969; Takahashi et al., 1970; Owen and Raff, 1970), and furthermore, in contact with antigen and other substances, they may be induced to proliferate in vitro. For the immunologist, the plasma membrane of lymphocytes is of particular interest because it may contain the specific recognition unit which, after interaction with the antigen, triggers the immunological process (and also the synthesis and/or release of other substances, specific or nonspecific, some of which are mediators of the inflammatory process; Lawrence and Landy, 1969). In addition, the plasma membrane of lymphocytes, as we shall see, bears the markers which allow for their separation into subpopulations which probably have distinct functions in the immune response.

Keywords

Lymphoid Organ Thoracic Duct Normal Rabbit Serum Chicken Erythrocyte Dendritic Reticular Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ada, G. L., Nossal, G. J. V., and Pye, J., 1964a. Aust. J. ExptL Biol. Med. Sci. 42: 295.CrossRefGoogle Scholar
  2. Ada, G. L., Nossal, G. J. V., and Austin, C. M., 1964b. Aust. J. Exptl. BioL Med. Sci. 42: 331.CrossRefGoogle Scholar
  3. Ada, G. L., Parish, C. R., Nossal, G. J. V., and Abbot, A., 1967. Cold Spring Harbor Symp. Quant. BioL 32: 381.CrossRefGoogle Scholar
  4. Bianco, C., and Nussenzweig, V., 1971. Science 173: 154.PubMedCrossRefGoogle Scholar
  5. Bianco, C., Patrick, R., and Nussenzweig, V., 1970. J. ExptL Med. 132: 702.CrossRefGoogle Scholar
  6. Bistany, T. S., and Tomasi, T. B., Jr., 1970. Immunochemistry 7: 453.PubMedCrossRefGoogle Scholar
  7. Bloch-Shtacher, N., Hirschhorn, K., and Uhr, J. W., 1968. Clin. Exptl. Immunol 3: 889.Google Scholar
  8. Boyse, E. A., and Old, L. J., 1969. Ann. Rev. Genet. 3: 269.CrossRefGoogle Scholar
  9. Brown, J. C., DeJesus, D. G., and Holborow, E. J., 1970. Nature 228: 367.PubMedCrossRefGoogle Scholar
  10. Cerottini, J. C., McConahey, P. J., and Dixon, F. J., 1969. J. Immunol 102: 1008.PubMedGoogle Scholar
  11. Chang, H., Schneck, S., Brody, N. I., Deutsch, A., and Siskind, G. W., 1969. J. Immunol. 102: 37.PubMedGoogle Scholar
  12. Diener, E., and Feldmann, M., 1970. J. ExptL Med. 132: 31.CrossRefGoogle Scholar
  13. Dukor, P., Bianco, C., and Nussenzweig, V., 1970. Proc. NatL Acad. Sci. 67: 991.PubMedCrossRefGoogle Scholar
  14. Dukor, P., Bianco, C., and Nussenzweig, V., 1970. Proc. NatL Acad. Sci. 67: 991.PubMedCrossRefGoogle Scholar
  15. Grant, C. K., Denham, S., Hall, J. G., and Alexander, P., 1970. Nature 227: 509.PubMedCrossRefGoogle Scholar
  16. Hanna, M. G., Jr., and Hunter, R. L., 1971. In Lindahl-Kiessling, K., Alm, G., andHanna, M. G., Jr., eds., Morphological and Functional Aspects of Immunity, Plenum Press, New York, p. 257.Google Scholar
  17. Hanna, M. G., Jr., Makinodan, T., and Fisher, W. D., 1967. In Cottier, H., Odartchenko, N., Schindler, R., and Congdon, C. C., eds., Germinal Centers in Immune Response, Springer-Verlag, New York, p. 86.Google Scholar
  18. Hanna, M. G., Jr., Francis, M. W., and Peters, L. C., 1968. Immunology 15: 75.PubMedGoogle Scholar
  19. Henry, C., and Jerne, N. K., 1968. J. Exptl. Med. 128: 133.CrossRefGoogle Scholar
  20. Humphrey, J. H., and Frank, M. M., 1967. Immunology 13: 87.PubMedGoogle Scholar
  21. Lawrence, H. S., and Landy, M., eds., 1969. Mediators of Cellular Immunity, Academic Press, New York.Google Scholar
  22. Lay, W. H., and Nussenzweig, V., 1968. J. Exptl. Med. 128: 991.CrossRefGoogle Scholar
  23. Lay, W. H., and Nussenzweig, V., 1969. J. Immunol 102: 1172.PubMedGoogle Scholar
  24. Mayer, M. M., 1970. Immunochemistry 7: 485.PubMedCrossRefGoogle Scholar
  25. Mayer, M. M., Shin, H. S., and Miller, J. A., 1967. Protides BioL Fluids 15: 411.Google Scholar
  26. McDevitt, H. O., Askonas, B. A., Humphrey, J. H., Schechter, I., and Sela, M., 1966. Immunology 11: 337.PubMedGoogle Scholar
  27. Miller, R. G., and Phillips, R. A., 1969. J. Cell. PhysioL 73: 191.PubMedCrossRefGoogle Scholar
  28. Mitchell, J., and Abbot, A., 1965. Nature 208: 500.PubMedCrossRefGoogle Scholar
  29. Möller, G., 1969. Clin. ExptL Immunol. 4: 65.Google Scholar
  30. Müller-Eberhard, H. J., 1968. Advan. Immunol. 8: 1.CrossRefGoogle Scholar
  31. Nossal, G. J. V., Ada, G. L., Austin, C. M., and Pye, J., 1965. Immunology 9: 349.PubMedGoogle Scholar
  32. Nussenzweig, V., Lay, W. H., and Miescher, P. A., 1969. In Smith, R. T., and Good, R. A., eds., Cellular Recognition, Appleton-Century-Crofts, New York, p. 317. Owen, J. J. T., and Raff, M. C., 1970. J. Exptl. Med. 132:1216.Google Scholar
  33. Parrott, D. M. V., deSousa, M. A. B., and East, J., 1966. J. Immunol. 123: 91.Google Scholar
  34. Pearlman, D. S., 1967. J. Exptl. Med. 126: 127.CrossRefGoogle Scholar
  35. Perlmann, P., and Holm, G., 1969. Advan. Immunol. 11: 117.CrossRefGoogle Scholar
  36. Perlmann, P., and Perlmann, H., 1970. CelL Immunol. 1: 300.PubMedCrossRefGoogle Scholar
  37. Phillips-Quagliata, J. M., Levine, B. B., Quagliata, F., and Uhr, J. W., 1971. J. Exptl. Med. 133: 589.CrossRefGoogle Scholar
  38. Pincus, C., and Nussenzweig, V., 1969. Nature 222: 594.PubMedCrossRefGoogle Scholar
  39. Pincus, C., Lamm, M. E., and Nussenzweig, V., 1971. J. Exptl. Med. 133: 987.CrossRefGoogle Scholar
  40. Pollack, W., Gorman, J. G., Hager, H. J., Freda, V. J., and Tripodi, D., 1968. Transfusion 8: 134.PubMedCrossRefGoogle Scholar
  41. Rabellino, E., Colon, S., Grey, H. M., and Unanue, E. R., 1971a. J. Exptl. Med. 133: 156.CrossRefGoogle Scholar
  42. Rabellino, E., Grey, H., and Unanue, E., 1971b. Fed. Proc. 30: 588.Google Scholar
  43. Raff, M. C., 1969. Nature 224: 378.PubMedCrossRefGoogle Scholar
  44. Raff, M. C., 1970. Immunology 19: 637.PubMedGoogle Scholar
  45. Raff, M. C., Sternberg, M., and Taylor, R. B., 1970. Nature 225: 553.PubMedCrossRefGoogle Scholar
  46. Reif, A. E., and Allen, J. M. V., 1964. J. ExptL Med. 120: 413.CrossRefGoogle Scholar
  47. Rowley, D. A., and Fitch, F. W., 1968. In Cinader, B., ed., Regulation of the Antibody Response, Charles C Thomas, Publisher, Springfield, Ill., p. 127.Google Scholar
  48. Rubin, D. J., Borsos, T., Rapp, H. J., and Colten, H. R., 1971. J. Immunol. 106:295. Schlesinger, M., and Yron, I., 1970. J. Immunol. 104: 698.Google Scholar
  49. Stecher, V. J., and Thorbecke, G. J., 1967. Immunology 12: 475.PubMedGoogle Scholar
  50. Takahashi, T. L., Old, L. J., and Boyse, E. A., 1970. J. Exptl. Med. 131: 1325.CrossRefGoogle Scholar
  51. Tao, T. W., and Uhr, J. W., 1966. Nature 212: 208.PubMedCrossRefGoogle Scholar
  52. Tomasi, T. B., Jr., and Bienenstock, J., 1968. Advan. Immunol. 9:1.CrossRefGoogle Scholar
  53. Uhr, J. W., and Möller, G., 1968. Advan. Immunol. 8: 81.CrossRefGoogle Scholar
  54. Williams, G. M., 1966. Immunology 11: 475.PubMedGoogle Scholar
  55. Zatz, M. M., and Lance, E. M., 1971. Fed. Proc. 30: 409.Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Victor Nussenzweig
    • 1
  • Carolyn S. Pincus
    • 1
  1. 1.Department of PathologyNew York University School of MedicineNew YorkUSA

Personalised recommendations