C3-Receptor Sites on Leukocytes: Possible Role in Opsonization and in the Immune Response
In recent years the membrane of lymphocytes has been the subject of intensive study by immunologists, geneticists, and cell biologists. The reasons for this interest are multiple. For example, lymphoid cells can be readily obtained in suspension and in relatively large numbers. They may constitute a model for problems of cellular recognition and differentiation, since they may acquire and lose membrane markers during differentiation (Boyce and Old, 1969; Takahashi et al., 1970; Owen and Raff, 1970), and furthermore, in contact with antigen and other substances, they may be induced to proliferate in vitro. For the immunologist, the plasma membrane of lymphocytes is of particular interest because it may contain the specific recognition unit which, after interaction with the antigen, triggers the immunological process (and also the synthesis and/or release of other substances, specific or nonspecific, some of which are mediators of the inflammatory process; Lawrence and Landy, 1969). In addition, the plasma membrane of lymphocytes, as we shall see, bears the markers which allow for their separation into subpopulations which probably have distinct functions in the immune response.
KeywordsLymphoid Organ Thoracic Duct Normal Rabbit Serum Chicken Erythrocyte Dendritic Reticular Cell
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