Systems of Lymphocytes in Mouse and Man: An Interim Appraisal

  • A. J. S. Davies
  • R. L. Carter


Advances in immunology are taking place with an increasing tempo and on a broadening front. Progress has been particularly marked in the field of cellular immunology, where much effort is being directed toward identifying the origins of cells which take part in immune responses. The different contributions made by immunologists, developmental biologists, geneticists, biochemists, and pathologists are disclosing a situation of considerable complexity, and the occasional reviewer cannot hope to produce more than an interim account. In the present review, we shall concentrate mainly on current theories that deal with the origin, structure, and functional organization of the mammalian system of lymphocytes. Although the emphasis will be on the experimental animal rather than man, we are very conscious of the need to establish the wider relevance of results obtained from such experimental systems. We believe that these results are not (in W. H. Auden’s phrase) “abstract models of events, derived from dead experiments,” and we shall consider some of their clinical implications in the last section of this review.


Chronic Lymphocytic Leukemia Germinal Center Lymphoid Organ DiGeorge Syndrome Postcapillary Venule 
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© Plenum Press, New York 1972

Authors and Affiliations

  • A. J. S. Davies
    • 1
  • R. L. Carter
    • 1
  1. 1.Chester Beatty Research InstituteInstitute of Cancer Research: Royal Cancer HospitalLondonEngland

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