The concept of linkage was unknown to Gregor Mendel and it must be a moot point whether his analytical mind could have provided the correct explanation for it. As it is, the discovery of associations of genes did in fact open up a temporary false trail (the reduplication hypothesis). However, the realization of the fundamental connection of genes and chromosomes soon led to an appreciation that linkage was the genetic expression of physical change between the chromosome strands. Thus, the final chapter of Mendel’s classical exposition of gene assortment was written. Many genes assort independently but, since the number of chromosomes are few and the number of genes per organism are legion, all eventually will fall into definable linkage groups equal in number to the haploid chromosome number.
KeywordsLinkage Group House Mouse Product Ratio Chiasma Frequency Haploid Chromosome Number
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