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Some Analyses of Amnesic Syndromes in Brain-Damaged Patients

  • Nelson Butters
  • Laird Cermak

Abstract

The contribution of the hippocampus to the normal operation of human memory processes has been quite clearly delineated by Milner and her collaborators during the past 15 years. These investigators have documented the nature of the memory disorder following injury to the hippocampus and, in addition, have provided support for the dual process theory of memory. Since these investigations are quite well known, only a brief summary of their major findings will be presented here prior to a more thorough discussion of two closely related issues: (1) an analysis of the amnesic disorders of alcoholic Korsakoff patients and (2) an examination of the amnesic syndromes produced by different forms of brain damage. The alcoholic Korsakoff patient is clinically similar to patients with bilateral hippocampal damage but, unlike these patients, he has suffered extensive midline limbic-diencephalic damage involving the nucleus medialis dorsalis and/or mammillary bodies (Victor et al., 1971). Since both of these structures have major anatomical connections with the hippocampus as well as other limbic entities, a thorough behavioral investigation of the amnesia of Korsakoff patients may enrich our understanding of the manner in which various limbic and diencephalic structures interact in the processing of information.

Keywords

Retention Interval Proactive Interference False Recognition Retrograde Amnesia Amnesic Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baddeley, A. D., and Dale, H. C. A. The effect of semantic similarity on retroactive interference in long- and short-term memory. Journal of Verbal Learning and Verbal Behavior, 1966, 5, 417–420.CrossRefGoogle Scholar
  2. Baddeley, A. D., and Warrington, E. K. Amnesia and the distinction between long- and short-term memory. Journal of Verbal Learning and Verbal Behavior, 1970, 9, 176–189.CrossRefGoogle Scholar
  3. Baddeley, A. D., and Warrington, E. K. Memory coding and amnesia. Neuropsychologia, 1973, 11, 159–165.PubMedCrossRefGoogle Scholar
  4. Bahrick, H. P. Measurement of memory by prompted recall. Journal of Experimental Psychology, 1969, 79, 213–219.CrossRefGoogle Scholar
  5. Bregman, A. Forgetting curves with semantic, phonetic, graphic and contiguity cues. Journal of Experimental Psychology, 1968, 78, 539–546.CrossRefGoogle Scholar
  6. Butters, N., Lewis, R., Cermak, L. S., and Goodglass, H. Material-specific memory deficits in alcoholic Korsakoff patients. Neuropsychologia, 1973, 11, 291–299.PubMedCrossRefGoogle Scholar
  7. Cermak, L. S.Human memory: Research and theory. New York: Ronald Press, 1972.Google Scholar
  8. Cermak, L. S., and Butters, N. The role of interference and encoding in the short-term memory deficits of Korsakoff patients. Neuropsychologia, 1972, 10, 89–95.PubMedCrossRefGoogle Scholar
  9. Cermak, L. S., Butters, N., and Goodglass, H. The extent of memory loss in Korsakoff patients. Neuropsychologia, 1971, 9, 307–315.PubMedCrossRefGoogle Scholar
  10. Cermak, L. S., Butters, N., and Gerrein, J. The extent of the verbal encoding ability of Korsakoff patients. Neuropsychologia, 1973, 11, 85–94.PubMedCrossRefGoogle Scholar
  11. Cermak, L. S., Butters, N., and Moreines, J. Some analyses of the verbal encoding deficit of alcoholic Korsakoff patients. Brain and Language, 1974, 2, 141–150.CrossRefGoogle Scholar
  12. Corkin, S. Tactually-guided maze-learning in man: Effects of unilateral cortical excisions and bilateral hippocampal lesions. Neuropsychologia, 1965, 3, 339–351.CrossRefGoogle Scholar
  13. Corkin, S. Acquisition of motor skill after bilateral medial temporal-lobe excision. Neuropsycho logia, 1968, 6, 255–266.CrossRefGoogle Scholar
  14. Corsi, P. M. Verbal memory impairment after unilateral hippocampal excisions. Paper presented at the 40th Annual Meeting of the Eastern Psychological Association, Philadelphia, April 1969.Google Scholar
  15. Craik, F. I. M., and Lockhart, R. S. Levels of processing: A framework for memory research. Journal of Verbal Learning and Verbal Behavior, 1972, 11, 671–684.CrossRefGoogle Scholar
  16. Goodglass, H., and Peck, E. A. Dichotic ear order effects in Korsakoff and normal subjects. Neuropsychologia, 1972, 10, 211–217.PubMedCrossRefGoogle Scholar
  17. Kimura, D. Right temporal-lobe damage. Archives of Neurology, 1963, 8, 264–271.PubMedCrossRefGoogle Scholar
  18. Klüver, H., and Bucy, P. S. “Psychic blindness” and other symptoms following bilateral temporal lobectomy in rhesus monkeys. American Journal of Physiology, 1937, 119, 352–353.Google Scholar
  19. Lattanzio, S. Analysis of deficiencies in the verbal memory processes of amnesic patients. Unpublished Ph.D. thesis, State University of New York at Buffalo, 1973.Google Scholar
  20. Lhermitte, F., and Signoret, J-L. Analyse neuropsychologique et différenciation des syndromes amnésiques. Revue Neurologique, 1972, 126, 161–178.PubMedGoogle Scholar
  21. Milner, B. Les troubles de la memoire accompagnant des lesions hippocampiques bilaterales. In Physiologie de l’hippocampe. Paris: C.N.R.S., pp. 257–272, 1962. [English translation in P. M. Milner and S. Glickman (Eds.), Cognitive processes and the brain. Princeton, N.J.: Van Nostrand, pp. 97–111, 1965.]Google Scholar
  22. Milner, B. Visually-guided maze learning in man: Effects of bilateral hippocampal, bilateral frontal, and unilateral cerebral lesions. Neuropsychologia, 1965, 3, 317–338.CrossRefGoogle Scholar
  23. Milner, B. Amnesia following operation on the temporal lobes. In C. W. M. Whitty and O. L. Zangwill (Eds.), Amnesia. London: Butterworths, pp. 109–133, 1966.Google Scholar
  24. Milner, B. Brain mechanisms suggested by studies of temporal lobes. In F. L. Darley (Ed.), Brain mechanisms underlying speech and language. New York: Grune and Stratton, pp. 122–145, 1967.Google Scholar
  25. Milner, B. Visual recognition and recall after right temporal-lobe excisions in man. Neuropsychologia, 1968, 6, 191–210.CrossRefGoogle Scholar
  26. Milner, B. Memory and the medial temporal regions of the brain, In K. H. Pribram and D.E. Broadbent (Eds.), Biology of memory. New York: Academic Press, pp. 29–50, 1970.Google Scholar
  27. Milner, B., Corkin, S., and Teuber, H. -L. Further analysis of the hippocampal amnesic syndrome. Neuropsychologia, 1968, 6, 267–282.CrossRefGoogle Scholar
  28. Murdock, B. B. Recent developments in short-term memory. British Journal of Psychology, 1967, 58, 421–433.PubMedCrossRefGoogle Scholar
  29. Oscar-Berman, M. O. Hypothesis testing and focusing behavior during concept formation by amnesic Korsakoff patients. Neuropsychologia, 1973, 11, 191–198.PubMedCrossRefGoogle Scholar
  30. Oscar-Berman, M. O., and Samuels, I. Stimulus-preference and memory factors in Korsakoff’s syndrome. Paper presented at the American Psychological Association meetings, Montreal, August 1973.Google Scholar
  31. Oscar-Berman, M. O., Goodglass, H., and Cherlow, D. G. Perceptual laterality and iconic recognition of visual materials by Korsakoff patients and normal adults. Journal of Comparative and Physiological Psychology, 1973, 82, 316–321.PubMedCrossRefGoogle Scholar
  32. Penfield, W., and Milner, B. Memory deficit produced by bilateral lesions in the hippocampal zone. A.M.A. Archives of Neurology and Psychiatry, 1958, 79, 475–497.PubMedGoogle Scholar
  33. Prisko, L. Short-term memory in focal cerebral damage. Unpublished Ph.D. thesis, McGill University, 1963.Google Scholar
  34. Samuels, I., Butters, N., and Goodglass, H. Visual memory deficits following cortical and limbic lesions: Effect of field of presentation. Physiology and Behavior, 1971a, 6, 447–452.CrossRefGoogle Scholar
  35. Samuels, I., Butters, N., Goodglass, H., and Brody, B. A comparison of subcortical and cortical damage on short-term visual and auditory memory. Neuropsychologia, 1971b, 9, 293–306.PubMedCrossRefGoogle Scholar
  36. Scoville, W. B., and Milner, B. Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery, and Psychiatry, 1957, 20, 11–21.PubMedCrossRefGoogle Scholar
  37. Sidman, M., Stoddard, L. T., and Mohr, J. P. Some additional quantitative observations of immediate memory in a patient with bilateral hippocampal lesions. Neuropsychologia, 1968, 6, 245–254.CrossRefGoogle Scholar
  38. Talland, G.Deranged memory. New York: Academic Press, 1965.Google Scholar
  39. Terzian, H., and DalleOre, G. Syndrome of Klüver and Buey reproduced in man by bilateral removal of the temporal lobes Neurology, 1955, 5, 373–380.PubMedGoogle Scholar
  40. Tulving, E. Short- and long-term memory: Different retrieval mechanisms. In K. H. Probram and D. E. Broadbent (Eds.), Biology of memory. New York: Academic Press, pp. 7–9, 1970.Google Scholar
  41. Underwood, B. J. False recognition by implicit verbal response. Journal of Experimental Psychology, 1965, 70, 122–129.PubMedCrossRefGoogle Scholar
  42. Victor, M., Adams, R. D., and Collins, G. H.The Wernicke-Korsakoff syndrome. Philadelphia: F. A. Davis, 1971.Google Scholar
  43. Warrington, E. K., and Weiskrantz, L. Amnesic syndrome: Consolidation or retrieval? Nature (London), 1970, 228, 628–630.CrossRefGoogle Scholar
  44. Warrington, E. K., and Weiskrantz, L. Organisational aspects of memory in amnesic patients. Neuropsychologia, 1971, 9, 67–73.PubMedCrossRefGoogle Scholar
  45. Warrington, E. K., and Weiskrantz, L. An analysis of short-term and long-term memory defects in man. In J. A. Deutsch (Eds.), The physiological basis of memory. New York: Academic Press, pp. 365–395, 1973.Google Scholar
  46. Weiskrantz, L., and Warrington, E. K. A study of forgetting in amnesic patients. Neuropsycho logia, 1970, 8, 281–288.CrossRefGoogle Scholar
  47. Wickens, D. D. Encoding categories of words: An empirical approach to meaning. Psychological Review, 1970, 77, 1–15.CrossRefGoogle Scholar
  48. Zangwill, O. L. The amnesic syndrome. In C. W. M. Whitty and O. L. Zangwill (Eds.), Amnesia. London and Washington, D. C.: Butterworths, pp. 77–91, 1966.Google Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Nelson Butters
    • 1
  • Laird Cermak
    • 2
  1. 1.Psychology ServiceBoston Veterans Administration HospitalBostonUSA
  2. 2.Aphasia Research Unit, Neurology DepartmentBoston University School of MedicineBostonUSA

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