The Development of Hippocampal Function: Implications for Theory and for Therapy

  • Robert J. Douglas


One thesis of this chapter is that the hippocampus may have two different but related modes of functioning. The simpler of the two, present in infancy and at times in adulthood, consists of a gross or nonspecific inhibition of emotional reactivity in general. The generation of nonspecific inhibition requires only that the hippocampal pyramidal cells be functionally developed and that they be driven by some synchronized input such as the θ-pacing system. The second functional mode is called “stimulus-specific inhibition” because it corresponds to a specific inhibition of an emotional reaction to a particular stimulus or set of stimuli. Stimulus-specific inhibition can be carried out only when the hippocampal pyramidal cells are “informed” of the stimulus via the temporoammonic tract and its major target, the dentate gyrus. The specific form of inhibition is at best only rudimentarily developed at birth and develops in synchrony with the maturation of the dentate gyrus. The development of stimulus-specific inhibition, it will be argued, is interfered with by early stressful i experience. The harmful effects of early stress on adult behavior appear to be counteracted by drugs which enhance cholinergic transmission.


Dentate Gyrus Physiological Psychology Passive Avoidance Hippocampal Lesion Spontaneous Alternation 
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© Plenum Press, New York 1975

Authors and Affiliations

  • Robert J. Douglas
    • 1
  1. 1.University of WashingtonSeattleUSA

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