Monoamine Neurons Innervating the Hippocampal Formation and Septum: Organization and Response to Injury

  • Robert Y. Moore

Abstract

The development of the concept of chemical transmission at the synapse and its application to the central nervous system has resulted in remarkable advances in our understanding of brain structure, function, and pathology. Among these, it has provided a basis for characterizing neuronal systems other than on morphological criteria. The utility of this characterization is best exemplified by our current knowledge of catecholamine and indolamine neuron systems in the mammalian brain. The presence of an indolamine (5-hydroxytryptamine, or serotonin) and catecholamines (norepinephrine, dopamine) in brain in a nonuniform pattern was first established 20 years ago (Twarog and Page, 1953; Amin et al., 1954; Bogdanski et al., 1957; Bertler and Rosengren, 1959) and led to the proposal that these compounds serve as chemical mediators of synaptic transmission (Amin et al., 1954; Vogt, 1954; Brodie and Shore, 1957). Subsequent studies in which brain amine content was analyzed following placement of localized destructive lesions indicated an association of specific neuron systems, particularly the medial forebrain bundle, with these putative neurotransmitters (Heller et al., 1962; Heller and Moore, 1968). It was not until the development of a specific and sensitive histochemical procedure for the intraneuronal localization of indolamines and catecholamines, the Falck-Hillarp method (Falck et al., 1962; Carlsson et al., 1962; Falck, 1962; Corrodi and Jonsson, 1967; Björklund et al., 1972), however, that significant advances were made in analyzing the specific neuronal systems which produce serotonin and catecholamines in brain.

Keywords

Dopamine Schizophrenia Serotonin Norepinephrine Tryptophan 

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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Robert Y. Moore
    • 1
  1. 1.Department of NeurosciencesUniversity of CaliforniaSan Diego, La JollaUSA

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