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The Hippocampus as a Model for Studying Anatomical Plasticity in the Adult Brain

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The Hippocampus

Abstract

The suggestion that intact axons might grow new branches (“sprout”) in response to damage of their neighbors appears to have been made at various times throughout the century-long argument that revolved around the issue of peripheral nerve regeneration. One of the earliest references was made by Haighton, who in 1795 reported a series of “physiological” studies on regeneration (or “reproduction”) which included controls for “a difficulty which naturally presents itself here, and this is, the possibility of the stomach and vocal organs having received an additional supply of nervous energy from another source” (p. 198). Exner (1885), according to Edds (1953), provided a clear description of sprouting at the neuromuscular junction, and Kennedy in his 1897 review listed several authors who mentioned the need to control for growth by undamaged nerves into deafferented sites in evaluating studies on regeneration.

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Authors and Affiliations

  1. Department of Psychobiology, University of California, Irvine, California, USA

    Gary Lynch & Carl W. Cotman

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  1. Gary Lynch
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  2. Carl W. Cotman
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Editors and Affiliations

  1. Department of Psychology, University of Florida, USA

    Robert L. Isaacson

  2. Department of Psychology, Stanford University, USA

    Karl H. Pribram

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© 1975 Plenum Press, New York

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Lynch, G., Cotman, C.W. (1975). The Hippocampus as a Model for Studying Anatomical Plasticity in the Adult Brain. In: Isaacson, R.L., Pribram, K.H. (eds) The Hippocampus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2976-3_6

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  • DOI: https://doi.org/10.1007/978-1-4684-2976-3_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-2978-7

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