The Hippocampus as a Model for Studying Anatomical Plasticity in the Adult Brain

  • Gary Lynch
  • Carl W. Cotman


The suggestion that intact axons might grow new branches (“sprout”) in response to damage of their neighbors appears to have been made at various times throughout the century-long argument that revolved around the issue of peripheral nerve regeneration. One of the earliest references was made by Haighton, who in 1795 reported a series of “physiological” studies on regeneration (or “reproduction”) which included controls for “a difficulty which naturally presents itself here, and this is, the possibility of the stomach and vocal organs having received an additional supply of nervous energy from another source” (p. 198). Exner (1885), according to Edds (1953), provided a clear description of sprouting at the neuromuscular junction, and Kennedy in his 1897 review listed several authors who mentioned the need to control for growth by undamaged nerves into deafferented sites in evaluating studies on regeneration.


Granule Cell Dentate Gyrus Entorhinal Cortex Molecular Layer Terminal Field 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Gary Lynch
    • 1
  • Carl W. Cotman
    • 1
  1. 1.Department of PsychobiologyUniversity of CaliforniaIrvineUSA

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