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Hippocampal Protein Synthesis and Spike Discharges in Relation to Memory

  • Shinshu Nakajima

Abstract

In the past 10 years or so, a great number of experiments have been conducted to examine the role played by the hippocampus in the formation and retention of memory. Earlier studies in this field were no doubt inspired by a clinical observation of deficits in recent memory in man after resection of the temporal lobe (Scoville and Milner, 1957). However, the accumulated results of animal experiments, particularly those on rats and mice, now form a body of knowledge which requires separate consideration. The scope of this chapter is therefore limited to the studies on nonprimate species.

Keywords

Entorhinal Cortex Passive Avoidance Retention Test Conditioned Suppression Retrograde Amnesia 
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References

  1. Agranoff, B. W., Davis, R. E., Casola, L., And Lim, R. Actinomycin D Blocks Formation Of Memory Of Shock-Avoidance In Goldfish. Science, 1967, 158, 1600–1601.PubMedCrossRefGoogle Scholar
  2. Avis, H. H., And Carlton, P. L. Retrograde Amnesia Produced By Hippocampal Spreading Depression. Science, 1968, 161, 73–75.PubMedCrossRefGoogle Scholar
  3. Barondes, S. H., And Cohen, H. D. Puromycin Effect On Successive Phase Of Memory Storage. Science, 1966, 151, 594–595.PubMedCrossRefGoogle Scholar
  4. Beach, G., Emmens, M., Kimble, D. P., And Lickey, M. Autoradiographic Demonstration Of Biochemical Changes In The Limbic System During Avoidance Training. Proceedings Of The National Academy Of Sciences U. S. A., 1969, 62, 692–696.CrossRefGoogle Scholar
  5. Berry, R. W. Ribonucleic Acid Metabolism Of A Single Neuron: Correlation With Electrical Activity. Science, 1969, 166, 1021–1023.PubMedCrossRefGoogle Scholar
  6. Bohdanecka, M., Bohdanecky, Z., And Jarvik, M. E. Amnesic Effects Of Small Bilateral Brain Puncture In The Mouse. Science, 1967, 157, 335–336.CrossRefGoogle Scholar
  7. Bowman, R. E., And Strobel, D. A. Brain Rna Metabolism In The Rat During Learning. Journal Of Comparative And Physiological Psychology, 1969, 67, 448–456.PubMedCrossRefGoogle Scholar
  8. Bresnahan, E., And Routtenberg, A. Memory Disruption By Unilateral Low Level, Sub-Seizure Stimulation Of The Medial Amygdaloid Nucleus. Physiology And Behavior, 1972, 9, 513–525.PubMedCrossRefGoogle Scholar
  9. Brunner, R. L., Rossi, R. R., Stutz, R. M., And Roth, T. G. Memory Loss Following Post-Trial Electrical Stimulation Of The Hippocampus. Psychonomic Science, 1970, 18, 159–160.Google Scholar
  10. Bures, J., Buresova, O., And Weiss, T. Functional Consequences Of Hippocampal Spreading Depression. Physiologia Bohemoslovenica, 1960, 9, 219–227.Google Scholar
  11. Carlton, P. L., And Markiewicz, B. Studies Of The Physiological Bases Of Memory. Progress In Physiological Psychology, 1973, 5, 125–153.Google Scholar
  12. Cohen, H. D., And Barondes, S. H. Puromvcin Effect On Memory May Be Due To Occult Seizure. Science, 1967, 157, 333–334.PubMedCrossRefGoogle Scholar
  13. Cohen, H. D., Ervin, F., And Barondes, S. H. Puromycin And Cycloheximide: Different Effects On Hippocampal Electrical Activity. Science, 1966, 154, 1557–1558.PubMedCrossRefGoogle Scholar
  14. Cottrell, G. A. Effect Of Corticosteroid Injection Into Limbic Structures On Cycloheximide-Induced Passive Avoidance Deficits. M. A. Thesis, Dalhousie University, 1975.Google Scholar
  15. Davidson, J. M., And Levine, S. Endocrine Regulation Of Behavior. Annual Review Of Physiology, 1972, 34, 375–408.PubMedCrossRefGoogle Scholar
  16. Deutsch, J. A. The Physiological Basis Of Memory. Annual Review Of Psychology, 1969, 20, 85–104.PubMedCrossRefGoogle Scholar
  17. Deutsch, J. A. The Cholinergic Synapses And The Site Of Memory. Science, 1971, 174, 788–794.PubMedCrossRefGoogle Scholar
  18. Deutsch, J. A., Hamburg, M. D., And Dahl, H. Anticholinesterase-Induced Amnesia And Its Temporal Aspects. Science, 1966, 151, 221–223.PubMedCrossRefGoogle Scholar
  19. Digiusto, E. L., Cairncross, K., And King, M. G. Hormonal Influences On Fear-Motivated Responses. Psychological Bulletin, 1971, 75, 432–444.CrossRefGoogle Scholar
  20. Dorfman, L. J., Bohdanecka, M., Bohdanecky, Z., Andjarvik, M. E. Retrograde Amnesia Produced By Small Cortical Stab Wounds In The Mouse. Journal Of Comparative And Physiological Psychology, 1969, 69, 324–328.PubMedCrossRefGoogle Scholar
  21. Douglas, R. J. The Hippocampus And Behavior. Psychological Bulletin, 1967, 67, 416–442.PubMedCrossRefGoogle Scholar
  22. Elul, R. Regional Differences In The Hippocampus Of The Cat. II. Projections Of The Dorsal And Ventral Hippocampus. Electroencephalography And Clinical Neurophysiology, 1964, 16, 489–502.Google Scholar
  23. Erickson, C. K., And Patel, J. B. Facilitation Of Avoidance Learning By Post-Trial Hippocampal Electrical Stimulation. Journal Of Comparative And Physiological Psychology, 1969, 68, 400–406.PubMedCrossRefGoogle Scholar
  24. Ferguson, J. J. Metabolic Inhibitors And Adrenal Function. In K. W. Mckerns (Ed.), Functions of the adrenal cortex. Vol. 1. New York: Appleton, 1968, pp. 463–478.Google Scholar
  25. Flexner, J. B., And Flexner, L. B. Restoration Of Expression Of Memory Lost After Treatment With Puromycin. Proceedings Of The National Academy Of Sciences U. S. A., 1967, 57, 1651–1654.CrossRefGoogle Scholar
  26. Flexner, J. B., And Flexner, L. B. Puromycin: Effect On Memory Of Mice When Injected With Various Cations. Science, 1969A, 165, 1143–1144.Google Scholar
  27. Flexner, J. B., And Flexner, L. B. Studies On Memory: Evidence For A Widespread Memory Trace In The Neocortex After The Suppression Of Recent Memory By Puromycin. Proceedings Of The National Academy Of Sciences U. S. A., 1969b, 62, 729–732.CrossRefGoogle Scholar
  28. Flexner, J. B., Flexner, L. B., Stellar, E., De La Haba, G., And Roberts, R. B. Inhibition Of Protein Synthesis In Brain And Learning And Memory Following Puromycin. Journal Of Neuro Chemistry, 1962, 9, 595–605.Google Scholar
  29. Flexner, J. B., Flexner, L. B., And Stellar, E. Memory In Mice As Affected By Intracerebral Puromycin. Science, 1963, 141, 57–59.PubMedCrossRefGoogle Scholar
  30. Flexner, L. B., And Flexner, J. B. Intracerebral Saline: Effect On Memory Of Trained Mice Treated With Puromycin. Science, 1968A, 159, 330–331.Google Scholar
  31. Flexner, L. B., And Flexner, J. B. Studies On Memory: The Long Survival Of Peptidyl-Puromycin In Mouse Brain. Proceedings Of The National Academy Of Sciences U. S. A., 19686, 60, 923–927.Google Scholar
  32. Flexner, L. B., Flexner, J. B., Roberts, R. B., And De La Haba, G. Loss Of Recent Memory In Mice As Related To Regional Inhibition Of Cerebral Protein Synthesis. Proceedings Of The National Academy Of Sciences U. S. A., 1964, 52, 1165–1169.CrossRefGoogle Scholar
  33. Flexner, L. B., Flexner, J. B., De La Haba, G., And Roberts, R. B. Loss Of Memory As Related To Inhibition Of Cerebral Protein Synthesis. Journal Of Neurochemistry, 1965A, 12, 535–542.Google Scholar
  34. Flexner, L. B., Flexner, J. B., And Stellar, E. Memory And Cerebral Protein Synthesis In Mice As Affected By Graded Amounts Of Puromycin. Experimental Neurology, 1965B, 13, 264–272.CrossRefGoogle Scholar
  35. Flexner, L. B., Flexner, J. B., And Roberts, R. B. Memory In Mice Analyzed With Antibiotics. Science, 1967, 155, 1377–1383.PubMedCrossRefGoogle Scholar
  36. Garren, L. D., Ney, R. L., And Davis, W. W. Studies On The Role Of Protein Synthesis In The Regulation Of Corticosterone Production By Adrenocorticotropic Hormone In Vivo. Proceedings Of The National Academy Of Sciences U. S. A., 1965, 53, 1443–1450.CrossRefGoogle Scholar
  37. Garren, L. D., Davis, Vv. W., Crocco, R. M., And Ney, R. L. Puromycin Analogs: Action Of Adrenocorticotropic Hormone And The Role Of Glycogen. Science, 1966, 152, 1386–1388.Google Scholar
  38. Gerlach, J. L., And Mcewen, B. S. Rat Brain Binds Adrenal Steroid Hormone: Radioautography Of Hippocampus With Corticosterone. Science, 1972, 175, 1133–1136.PubMedCrossRefGoogle Scholar
  39. Goddard, G. V. Amygdaloid Stimulation And Learning In The Rat. Journal Of Comparative And Physiological Psychology, 1964, 58, 23–30.PubMedCrossRefGoogle Scholar
  40. Goddard, G. V. Development Of Epileptic Seizures Through Brain Stimulation At Low Intensity. Nature (London), 1967, 214, 1020–1021.CrossRefGoogle Scholar
  41. Goddard, G. V., Mcintyre, D. C., And Leech, C. K. A Permanent Change In Brain Function Resulting From Daily Electrical Stimulation. Experimental Neurology, 1969, 25, 295–330.PubMedCrossRefGoogle Scholar
  42. Grossman, S. P., And Mountford, H. Learning And Extinction During Chemically Induced Disturbance Of Hippocampal Functions. American Journal Of Physiology, 1964, 207, 1387–1393.PubMedGoogle Scholar
  43. Hirano, T. Effects Of Functional Disturbances Of The Limbic System On The Memory Consolidation. Japanese Psychological Research, 1965, 7, 171–182.Google Scholar
  44. Hostetter, G. Hippocampal Lesions In Rats Weaken The Retrograde Amnesic Effect Of Ecs. Journal Of Comparative And Physiological Psychology, 1968, 66, 349–353.PubMedCrossRefGoogle Scholar
  45. Huges, R. A. Retrograde Amnesia In Rats Produced By Hippocampal Injections Of Potassium Chloride: Gradient Of Effect And Recovery. Journal Of Comparative And Physiological Psychology, 1969, 68, 637–644.CrossRefGoogle Scholar
  46. Huppert, F. A., And Deutsch, J. A. Improvement In Memory With Time. Quarterly Journal Of Experimental Psychology, 1969, 21, 267–271.CrossRefGoogle Scholar
  47. Hyden, H., And Lange, P. Vv. Protein Synthesis In The Hippocampal Pyramidal Cells Of Rats During A Behavioral Test. Science, 1968, 159, 1370–1373.Google Scholar
  48. Hyden, H., And Lange, P. W. Brain Cell Protein Synthesis Specifically Related To Learning. Proceedings Of The National Academy Of Sciences U. S. A., 1970, 65, 898–904.CrossRefGoogle Scholar
  49. Kapp, B. S., And Schneider, A. M. Selective Recovery From Retrograde Amnesia Produced By Hippocampal Spreading Depression. Science, 1971, 173, 1149–1151.PubMedCrossRefGoogle Scholar
  50. Kesner, R. P., And Doty, R. W. Amnesia Produced In Cats By Local Seizure Activity Initiated From The Amygdala. Experimental Neurology, 1968, 21, 58–68.PubMedCrossRefGoogle Scholar
  51. Kimble, D. P. Hippocampus And Internal Inhibition. Psychological Bulletin, 1968, 70, 285–295.PubMedCrossRefGoogle Scholar
  52. Lidnsky, A., And Slotnick, B. M. Electrical Stimulation Of The Hippocampus And Ecs Produce Similar Amnesic Effects In Mice. Neuropsychologia, 1970, 8, 363–369.CrossRefGoogle Scholar
  53. Lidsky, T. I., Levine, M. S., Kreinick, C. J., And Schwartzbaum, J. S. Retrograde Effects Of Amygdaloid Stimulation On Conditioned Suppression (CER) in rats. Journal of Comparative and Physiological Psychology, 1970, 73, 135–149.PubMedCrossRefGoogle Scholar
  54. Magni, G., Motta, M., And Martini, L. Control Of Adrenocorticotropic Hormone Secretion. In L. Martini And W. F. Ganong (Eds.), Neuro endocrinology. Vol. 1. New York: Academic Press, 1966, pp. 297–370.Google Scholar
  55. Mahut, H. Effects Of Subcortical Electrical Stimulation On Learning In The Rat. Journal Of Comparative And Physiological Psychology, 1962, 55, 472–477.PubMedCrossRefGoogle Scholar
  56. Mcdonough, J. H., And Kesner, R. P. Amnesia Produced By Brief Electrical Stimulation Of Amygdala Or Dorsal Hippocampus In Cats. Journal Of Comparative And Physiological Psychology, 1971, 77, 171–178.PubMedCrossRefGoogle Scholar
  57. Mcewen, B. S., Weiss, J. M., And Schwartz, L. S. Uptake Of Corticosterone By Rat Brain And Its Concentration By Certain Limbic Structures. Brain Research, 1969, 16, 227–241.PubMedCrossRefGoogle Scholar
  58. Mcewen, B. S., Weiss, J. M., And Schwartz, L. S. Retention Of Corticosterone By Cell Nuclei From Brain Regions Of Adrenalectomized Rats. Brain Research, 1970, 17, 471–482.PubMedCrossRefGoogle Scholar
  59. Means, L. W., Woodruff, M. L., And Isaacson, R. L. The Effect Of A Twenty-Four Hour Intertrial Interval On The Acquisition Of Spatial Discrimination By Hippocampally Damaged Rats. Physiology And Behavior, 1972, 8, 457–462.PubMedCrossRefGoogle Scholar
  60. Nakajima, S. Interference With Relearning In The Rat After Hippocampal Injection Of Actinomycin D. Journal Of Comparative And Physiological Psychology, 1969, 67, 457–461.PubMedCrossRefGoogle Scholar
  61. Nakajima, S. Proactive Effect Of Actinomycin D On Maze Performance In The Rat. Physiology And Behavior, 1972, 8, 1063–1067.PubMedCrossRefGoogle Scholar
  62. Nakajima, S. Biochemical Disruption Of Memory: Re-Examinations. In W. B. Essman And S. Nakajima (Eds.), Current biochemical approaches to learning and memory. New York: Halsted, 1973, pp. 133–146.Google Scholar
  63. Nakajima, S. Amnesic Effect Of. Cycloheximide In The Mouse Mediated By Adrenocortical Hormones. Journal Of Comparative Physiological Psychology, 1975, 88, 378–385.CrossRefGoogle Scholar
  64. Olds, J., And Hirano, T. Conditioned Responses Of Hippocampal And Other Neurons. Electroencephalography And Clinical Neurophysiology, 1969, 26, 159–166.PubMedCrossRefGoogle Scholar
  65. Olds, J., Mink, W. D., And Best, P. J. Single Unit Patterns During Anticipatory Behavior. Electroencephalography And Clinical Neurophysiology, 1969, 26, 144–158.PubMedCrossRefGoogle Scholar
  66. Olton, D. S. Specific Deficits In Active Avoidance Behavior Following Penicillin Injection Into Hippocampus. Physiology And Behavior, 1970, 5, 957–963.PubMedCrossRefGoogle Scholar
  67. Pfaff, D. W., Silva, M. T., And Weiss, J. M. Telemetered Recording Of Hormone Effects On Hippocampal Neurons. Science, 1971, 172, 394–395.PubMedCrossRefGoogle Scholar
  68. Roberts, R. B., Flexner, J. B., And Flexner, L. B. Some Evidence For The Involvement Of Adrenergic Sites In The Memory Trace. Proceedings Of The National Academy Of Sciences U. S. A., 1970, 66, 310–313.CrossRefGoogle Scholar
  69. Rosenbaum, M., Cohen, H. D., And Barondes, S. H. Effect Of Intracerebral Saline On Amnesia Produced By Inhibitors Of Cerebral Protein Synthesis. Communications In Behavioral Biology, 1968, Part A, 2, 47–50.Google Scholar
  70. Russell, P. J. D. The Effect Of Intrahippocampal Injection Of Puromycin In The Rat. M. A. Thesis, Dalhousie University, 1969.Google Scholar
  71. Schmaltz, L. W. Deficit In Active Avoidance Learning In Rats Following Penicillin Injection Into Hippocampus. Physiology And Behavior, 1971, 6, 661–61A.CrossRefGoogle Scholar
  72. Scoville, W. B., And Milner, B. Loss Of Recent Memory After Bilateral Hippocampal Lesions. Journal Of Neurology, Neurosurgery, And Psychiatry, 1957, 20 (11), 11–19.PubMedCrossRefGoogle Scholar
  73. Shinkman, P. G., and Kaufman, K. P. Post-trial hippocampal stimulation and CER acquisition in the rat. Journal of Comparative and Physiological Psychology, 1972, 80, 283–292.PubMedCrossRefGoogle Scholar
  74. Stein, D. G., and Chorover, S. L. Effects of post-trial electrical stimulation of hippocampus and caudate nucleus on maze learning in the rat. Physiology and Behavior, 1968, 3, 787–792.CrossRefGoogle Scholar
  75. Steiner, F. A., Ruf, K., and Akert, K. Steroid-sensitive neurons in the rat brain: Anatomical localization and responses to neurohumours and ACTH. Brain Research, 1969, 12, 74–85.PubMedCrossRefGoogle Scholar
  76. Uretsky, E., and Mccleary, R. A. Effect of hippocampal isolation on retention. Journal of Comparative and Physiological Psychology, 1969, 68, 1–8.PubMedCrossRefGoogle Scholar
  77. Woodruff, M. L., and Isaacson, R. L. Discrimination learning in animals with lesions of hippocampus. Behavioral Biology, 1972, 7, 489–501.PubMedCrossRefGoogle Scholar
  78. Woodruff, M. L., Kearley, R. C., and Isaacson, R. L. Deficient brightness discrimination acquisition produced by daily intracranial injections of penicillin in rats. Behavioral Biology, 1974, 12, 445–460.PubMedCrossRefGoogle Scholar
  79. Wyers, E. J., Peeke, H. V., Williston, J. S., and Herz, M. J. Retroactive impairment of passive avoidance learning by stimulation of the caudate nucleus. Experimental Neurology, 1968, 22, 350–366.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Shinshu Nakajima
    • 1
  1. 1.Dalhousie UniversityHalifaxCanada

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