• Robert L. Isaacson
  • Karl H. Pribram


When the editors of these volumes began their research, the hippocampal formation presented a prime example of an enigma wrapped within layers of puzzles. As recently as 1960, Green in the Handbook of Physiology could state that “ablation of the hippocampus without serious damage to large areas of the brain has not yet proved possible” and that “up to this time no truly satisfactory theory concerning the role of the hippocampus has been advanced.” Still this large structure of the brain was a delight to observe through the microscope. Its simplicity of organization, when viewed in cross-section, was unique and reminded one of a jelly roll whose layering invited electrophysiological analysis; its length and connections through the impressive fornix bundle (one of the largest tracts in the brain) attested to its importance. For some years the cellular architecture of the hippocampus had been worked out thoroughly (e.g., Ramón y Cajal, 1968) and some of its interrelations with adjacent cortical areas were already known. The fornix had been established as the major output channel, although the relationship between the hippocampus and the septum did not become clear until the early 1950s (for review, see Pribram and Kruger, 1954).


Temporal Lobe Physiological Psychology Temporal Lobectomy Attitude Theory Visual Agnosia 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • Robert L. Isaacson
  • Karl H. Pribram

There are no affiliations available

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