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Substitutions and Additions in the Heterocyclic Rings of Nucleic Acid Bases and their Derivatives

  • N. K. Kochetkov
  • E. I. Budovskii

Abstract

Substitution reactions in the heterocyclic ring of the bases of nucleic acids are characteristic of both purine and pyrimidine derivatives. They include electrophilic replacement of protons bound to carbon or nitrogen atoms composing the ring and also nucleophilic substitution of exocyclic amino groups. Addition reactions at the carbon — carbon double bond of the heterocyclic ring, which can be either electrophilic or nucleophilic, are at present known only for pyrimidine bases, for in purines the C4 — C5 bond is evidently very stable. Electrophilic reactions at the nitrogen atoms of the pyridine type, which possess a free electron pair, can also be included conventionally among addition reactions, as they are in this book. As a result of these reactions a new group appears in the heterocyclic ring without the removal of any groups or atoms previously present in the ring before the reaction.

Keywords

Addition Reaction Heterocyclic Ring Pyrimidine Derivative Pyrimidine Base Dimethyl Sulphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Company Ltd. 1972

Authors and Affiliations

  • N. K. Kochetkov
  • E. I. Budovskii

There are no affiliations available

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