Toxicologic Significance of the Physicochemical Properties of Metals
The toxicity of a metal or its compounds in a biologic system is influenced by a number of factors: (1) the dose of the toxic metal, (2) the intrinsic toxicity of the metal, (3) the combining capacity of the metal, (4) the action of the biologic system to absorb and transport the metal to the target organ most susceptible to the metal intoxication, (5) the capacity of the metal to undergo biotransformation to a less toxic or a more toxic form at the target organ or during transfer, (6) the ability of the metal to bind to essential macromolecules, and (7) the homeostatic mechanisms of the organism to either excrete or sequester the metal or both. Large doses of some nontoxic metal compounds may interfere with normal cellular or physiologic processes by nonspecific activity such as changing the osmotic pressure and pH or physically changing the gastrointestinal tract.
KeywordsToxic Metal Metal Chelate Donor Atom Essential Metal Soft Acid
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