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Ergot Alkaloids and Related Substances

  • Chapter
Poisons of Plant Origin

Abstract

Ergot has been called a treasure-house of drugs; possibly no other source of biological products has so many active constituents with such a wide spectrum of pharmacological properties, which has been further expanded by the production of derivatives with qualitatively new actions. Ergot consists of the sclerotia or resting stage produced by fungi of the genus Claviceps, most commonly C. purpurea, which is principally parasitic on the rye, Secale cereale. Many other varieties of ergot are known; over 50 species of Claviceps have been described, infesting over 600 recorded host species of the family Gramineae (grasses and cereals) (Bové, 1970). Although possible allusions to ergot are found in early records (see Bové, 1970), the earliest undisputable reference to ergot itself was made in 1582 by Lonicer, who described its use in midwifery. However, it was not widely accepted by physicians until the nineteenth century. The history and pharmacognosy of ergot have been extensively reviewed by Barger (1931) and by Bové (1970).

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References

  • Abrahams, V. C., Hilton, S. M., and Zbroiyna, A. W., 1960, Active muscle vasodilation produced by stimulation of the brain stem: Its significance in the defence reaction, J. Physiol. (Lond.) 154: 491.

    CAS  Google Scholar 

  • Abrahams, V. C., Hilton, S. M., and Zbrozyna, A. W., 1964, The role of active muscle vasodilation in the altering stage of the defence reaction, J. Physiol. (Lond.) 171: 189.

    CAS  Google Scholar 

  • Aeilig, W. H., and Berde, B., 1969, Studies of the effect of natural and synthetic polypeptide type ergot compounds on a peripheral vascular bed, Brit. J. Pharmacol. 36: 561.

    Article  Google Scholar 

  • Aghajanian, G. K., 1972a, LSD and CNS transmission, Ann. Rev. Pharmacol. 12: 157.

    Article  PubMed  CAS  Google Scholar 

  • Aghajanian, G. K., 1972b, Influence of drugs on the firing of serotonin-containing neurons in brain, Fed. Proc. 31: 91.

    PubMed  CAS  Google Scholar 

  • Aghajanian, G. K., 1972c, Chemical feedback regulation of serotonin-containing neurons in brain, Ann. N.Y. Acad. Sci. 193: 86.

    Article  PubMed  CAS  Google Scholar 

  • Aghajanian, G. K., Haigler, H. J., and Bloom, F. E., 1972, Lysergic acid diethylamide and serotonin: Direct actions on serotonin-containing neurons in rat brain, Life Sci. 11:615 (Part I).

    Google Scholar 

  • Ambache, N., Dunk, L. P., Verney, J., and Aboo Zar, M., 1973, An inhibition of postganglionic motor transmission in the mammalian vas deferens by D-lysergic acid diethylamide, J. Physiol. (Lond.) 231: 251.

    Google Scholar 

  • Andén, N.-E., Corrodi, H., Fuxe, K., and Hökfelt, T., 1968, Evidence for a central 5- hydroxytryptamine receptor stimulation by lysergic acid diethylamide, Brit. J. Pharmacol. 34: 1.

    Article  Google Scholar 

  • Anderson, E. G., 1972, Bulbospinal serotonin-containing neurons and motor control, Fed. Proc. 31: 107.

    PubMed  CAS  Google Scholar 

  • Anthony, M., Hinterberger, H., and Lance, J. W., 1969, The possible relationship of serotonin to the migraine syndrome, Res. Clin. Stud. Headache 2: 29.

    CAS  Google Scholar 

  • Appel, J. B., and Freedman, D. X., 1964, Chemically-induced alterations in the behavioral effects of LSD-25, Biochem. Pharmacol. 13: 861.

    Article  PubMed  CAS  Google Scholar 

  • Appel, J. B., Lovell, R. A., and Freedman, D. X., 1970a, Alterations in the behavioral effects of LSD by pretreatment with p-chlorophenylalanine and α-methyl-p-tyrosine, Psychopharmacologia (Berl.) 18: 387.

    Article  CAS  Google Scholar 

  • Appel, J. B., Sheard, M. H., and Freedman, D. X., 1970b, Alterations in the behavioral effects of LSD by midbrain raphe lesions, Commun. Behav. Biol. 5: 237.

    Google Scholar 

  • Arcari, G., Dorigotti, L., Fregnan, G. B., and Glässer, A. H., 1968, Vasodilating and alpha- receptor blocking activity of a new ergoline derivative, Brit. J. Pharmacol. 34: 700 P.

    Google Scholar 

  • Avery, D. D., 1972, Thermoregulatory effects of intrahypothalamic injections of adrenergic and cholinergic substances at different environmental temperatures, J. Physiol. (Lond.) 220: 257.

    CAS  Google Scholar 

  • Barasi, S., and Roberts, M. H. T., 1973, The action of 5-hydroxytryptamine antagonists and precursors on bulbospinal facilitation of spinal reflexes, Brain Res. 52: 385.

    Article  PubMed  CAS  Google Scholar 

  • Barcroft, H., Konzett, H., and Swan, H. J. C., 1951, Observations on the action of the hydrogenated alkaloids of the ergotoxine group on the circulation in man, J. Physiol. (Lond.) 112: 273.

    CAS  Google Scholar 

  • Barger, G., 1931, Ergot and Ergotism, Gurney and Jackson, London.

    Google Scholar 

  • Beretta, C., Ferrini, R., and Glässer, A. H., 1965, l-Methyl-8β-carbobenzyloxy-aminomethyl- 10α-ergoline, a potent and long-lasting 5-hydroxytryptamine antagonist, Nature (Lond.) 207: 421.

    Google Scholar 

  • Bergström, S., Farnebo, L.-O., and Fuxe, K., 1973, Effect of prostaglandin E2 on central and peripheral catecholamine neurons, Europ. J. Pharmacol. 21: 362.

    Article  Google Scholar 

  • Berridge, M. J., and Prince W. T., 1973, Mode of action of hallucinogenic molecules, Nature New Biol. 243: 283.

    Article  PubMed  CAS  Google Scholar 

  • Bhargava, K. P., Mishra, N., and Tangri, K. K., 1972, An analysis of central adrenoceptors for control of cardiovascular function, Brit. J. Pharmacol. 45: 596.

    Article  CAS  Google Scholar 

  • Björklund, A., and Falck, B., 1969, Histochemical characterization of a tryptamine-like substance stored in cells of the mammalian adenohypophysis, Acta Physiol. Scand. 77: 475.

    Article  PubMed  Google Scholar 

  • Björklund, A., and Nobin, A., 1973, Fluorescence histochemical and microspectrofluorometric mapping of dopamine and noradrenaline cell groups in the rat diencephalon, Brain Res. 51: 193.

    Article  PubMed  Google Scholar 

  • Björklund, A., Moore, R. Y., Nobin, A., and Stenevi, U., 1973, The organisation of tuberohypophyseal and reticulo-infundibular catecholamine neuron systems in the rat brain, Brain Res. 51: 171.

    Article  PubMed  Google Scholar 

  • Bluntschli, H. J., and Goetz, R. H., 1948, The effect of ergot derivatives on the circulation in man with special reference to two new hydrogenated compounds (dihydroergotamine and dihydroergocornine), Am. Heart J. 35: 873.

    Article  CAS  Google Scholar 

  • Boakes, R. J., Bradley, P. B., Briggs, I., and Dray, A., 1970, Antagonism of 5- hydroxytryptamine by LSD 25 in the central nervous system: A possible neuronal basis for the actions of LSD 25, Brit. J. Pharmacol. 40: 202.

    Article  CAS  Google Scholar 

  • Bolme, P., and Fuxe, K., 1973, Pharmacological studies on a possible role of central noradrenaline neurons in respiratory control, J. Pharm. Pharmacol. 25: 351.

    Article  PubMed  CAS  Google Scholar 

  • Bolme, P., Fuxe, K., and Lidbrink, P., 1972, On the function of central catecholamine neurons-Their role in cardiovascular and arousal mechanisms, Res. Commun. Chem. Pathol. Pharmacol. 4: 657.

    PubMed  CAS  Google Scholar 

  • Borison, H. L., and Clark, W. G., 1967, Drug actions on thermoregulatory mechanisms, Advan. Pharmacol. 5: 129.

    Article  CAS  Google Scholar 

  • Bove, F. J., 1970, The Story of Ergot, Karger, Basel.

    Google Scholar 

  • Bradley, P. B., and Briggs, I., 1974, Further studies on the mode of action of psychotomimetic drugs: Antagonism of the excitatory actions of serotonin by methylated derivatives of tryptamine, Brit. J. Pharmacol. 50: 345–354.

    Article  CAS  Google Scholar 

  • Brawley, P., and Duffield, J. C., 1972, The pharmacology of hallucinogens, Pharmol. Rev. 24: 31.

    CAS  Google Scholar 

  • Brody, T. M., and Diamond, J., 1967, Blockade of the biochemical correlates of contraction and relaxation in uterine and intestinal smooth muscle, Ann. N. Y. Acad. Sci. 139: 772.

    Article  PubMed  CAS  Google Scholar 

  • Bronzino, J. D., 1972, Evoked response study of postulated neural circuit associated with sleep-waking process, Life Sci. 11:419 (Part I).

    Google Scholar 

  • Bronzino, J. D., Morgane, P. J., and Stern, W. C., 1972, EEG synchronization following application of serotonin to area postrema, Am. J. Physiol. 223: 376.

    PubMed  CAS  Google Scholar 

  • Brown, P. S., 1968, The effect of drugs on induced ovulation, J. Reprod. Fertil. Suppl. 4: 61.

    Google Scholar 

  • Bucknell, A., and Whitney, B., 1964, A preliminary investigation of the pharmacology of the human isolated taenia coli preparation, Brit. J. Pharmacol 23: 164.

    PubMed  CAS  Google Scholar 

  • Carlsson, A., and Lindqvist, M., 1972, The effect of L-tryptophan and some psychotropic drugs on the formation of 5-hydroxytryptophan in the mouse brain in vivo, J. Neural Trans. 33: 23.

    Article  CAS  Google Scholar 

  • Cerletti, A., 1959, in: Neuropsychopharmacology, Proceedings of the First International Congress of Neuropsychopharmacology (P. B. Bradley, P. Deniker, and C. Radouco- Thomas, eds.) pp. 117–123, Elsevier, Amsterdam.

    Google Scholar 

  • Cerletti, A., and Doepfner, W., 1958, Comparative study on the serotonin antagonism of amide derivatives of lysergic acid and of ergot alkaloids, J. Pharmacol. Exptl. Therap. 122: 124.

    CAS  Google Scholar 

  • Chalmers, J. P., and Wurtman, R. J., 1971, Participation of central noradrenergic neurons in arterial baroreceptor reflexes in the rabbit, Circ. Res. 28: 480.

    Article  PubMed  CAS  Google Scholar 

  • Chan, P. S., and Ellis, S., 1969, Dihydroergotamine antagonism of glucose release by rabbit liver slices induced by catecholamines, glucagon and 3,5 -AMP, Fed. Proc. 28: 742.

    Google Scholar 

  • Chu, D., and Stuermer, E., 1973, Studies on the mechanism of action of dihydroergotamine (DHE) on the vascular bed of cat skeletal muscle, Brit. J. Pharmacol. 48: 33 I P.

    Google Scholar 

  • Cohen, S., 1967, Psychotomimetic agents, Ann. Rev. Pharmacol. 7: 301.

    Article  PubMed  CAS  Google Scholar 

  • Connell, P. H., 1972, Hallucinogens, in: Side Effects of Drugs, Vol. VII ( Meyler, L., Herxheimer, A., eds.) pp. 38–50, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Coote, J. H., and Macleod, V.H., 1972, The possibility that noradrenaline is a sympathoin- hibitory transmitter in the spinal cord, J. Physiol. (Lond.) 225: 44 P.

    Google Scholar 

  • Coote, J. H., Hilton, S. M., and Zbroiyna, A. W., 1973, The pontomedullary area integrating the defence reaction in the cat and its influence on muscle blood flow, J. Physiol. (Lond.) 229: 257.

    CAS  Google Scholar 

  • Corrodi, H., Fuxe, K., and Hökfelt, T., 1967, A possible role played by central monoamine neurons in thermo-regulation, Acta Physiol. Scand. 71: 224.

    Article  PubMed  CAS  Google Scholar 

  • Corrodi, H., Fuke, K., Hökfelt, T., Lidbrink, P., and Ungerstedt, U., 1973, Effect of ergot drugs on central catecholamine neurons: Evidence for a stimulation of central dopamine neurons, J. Pharm. Pharmacol. 25: 409.

    Article  PubMed  CAS  Google Scholar 

  • Costa, E., 1956, Effects of hallucinogenic and tranquilizing drugs on serotonin evoked uterine contractions, Proc. Soc. Exptl. Biol. Med 91: 39.

    CAS  Google Scholar 

  • Costa, E., and Zetler, G., 1959, Interactions between epinephrine and some psychotomimetic drugs, J. Pharmacol. Exptl. Therap. 125: 230.

    CAS  Google Scholar 

  • Couch, J. R., 1970, Responses of neurons in the raphe nuclei to serotonin, norepinephrine and acetylcholine and their correlation with an excitatory synaptic input, Brain Res. 19: 137.

    Article  PubMed  CAS  Google Scholar 

  • Cranley, J. J., Krause, R. J., Strasser, E. S., and Hafner, C. D., 1963, Impending gangrene of four extremities secondary to ergotism, New Engl. J. Med. 269: 727.

    Article  PubMed  CAS  Google Scholar 

  • Cumings, J. N., and Hilton, B. P., 1971, Effects of methysergide on platelets incubated with reserpine, Brit. J. Pharmacol. 42: 611.

    Article  CAS  Google Scholar 

  • Curran, D. A., Hinterberger, H., and Lance, J. W., 1967, Methysergide, Res. Clin. Stud. Headache 1: 74.

    CAS  Google Scholar 

  • Dalessio, D. J., 1972, Wolffs Headache and Other Head Pain, 3rd ed., Oxford University Press, New York.

    Google Scholar 

  • Daughaday, W. H., and Jacobs, L. S., 1972, Human prolactin, Ergeb. Physiol. 67: 169.

    Article  PubMed  CAS  Google Scholar 

  • Davidson, N., Edwardson, J. A., and Schwab, D. I., 1969, Agroclavine antagonises depression induced by noradrenaline in the cerebral cortex of the rat, Nature (Lond.) 223: 1166.

    Article  CAS  Google Scholar 

  • Davies, B. N., Horton, E. W., and Withrington, P. G., 1968, The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation, Brit. J. Pharmacol. 32: 127.

    PubMed  CAS  Google Scholar 

  • de Groat, W. C., and Volle, R. L., 1966a, The actions of the catecholamines on transmission in the superior cervical ganglion of the cat, J. Pharmacol. Exptl. Therap. 154: 1.

    Google Scholar 

  • de Groat, W. C., and Volle, R. L., 1966b, Interactions between the catecholamines and ganglionic stimulating agents in sympathetic ganglia, J. Pharmacol. Exptl. Therap. 154: 200.

    Google Scholar 

  • Delay, J., and Thuillier, J., 1956, Dualite d’action du diethylamide de 1’acid lysergique sur la contraction uterine provoquee par la 5-hydroxytryptamine (Serotonine), Compt. Rend. Soc. Biol. 150: 1335.

    CAS  Google Scholar 

  • Del Bianco, P. L., Franchi, G., Fanciullacci, M., and Sicuteri, F., 1972, Clinical pharmacology of 5-hydroxytryptamine and catecholamines venomotor receptors, Arch. Int. Pharmacodyn. Therap. 196: Suppl. 113.

    Google Scholar 

  • Del Pozo, E., Brun del Re, R., Varga, L., and Friesen, H., 1972, The inhibition of prolactin secretion in man by CB154 (2-bromo-alpha-ergocryptine), J. Clin. Endocrinol. Metab. 35: 768.

    Article  PubMed  Google Scholar 

  • Dengler, H. J., Spiegel, H. E., and Titus, E. O., 1961, Effects of drugs on uptake of isotopic norepinephrine by cat tissues, Nature (Lond.) 191: 816.

    Article  CAS  Google Scholar 

  • Der Marderosian, A., 1967, Hallucinogenic indole compounds from higher plants, Lloydia 30: 23.

    Google Scholar 

  • Diaz, J.-L., and Huttunen, M. O., 1971, Persistent increase in brain serotonin turnover after chronic administration of LSD in the rat, Science 174: 62.

    Article  PubMed  CAS  Google Scholar 

  • Dishotsky, N. I., Loughman, W. D., Mogar, R. E., and Lipscomb, W. R., 1971, LSD and genetic damage, Science 172: 431.

    Article  PubMed  CAS  Google Scholar 

  • Downman, C. B. B., 1972, The vasomotor centre, in: Modern Trends in Physiology (Downman, C.B.B.,ed.) pp. 292–308, Butterworth, London.

    Google Scholar 

  • Dyer, D. C., and Gant, D. W., 1973, Vasoconstriction produced by hallucinogens on isolated human and sheep umbilical vasculature, J. Pharmacol. Exptl. Therap. 184: 366.

    CAS  Google Scholar 

  • Eiduson, S., Geller, E., Yuwiler, A., and Eiduson, B. T., 1964, Biochemistry and Behavior, Van Nostrand, Princeton, N.J.

    Google Scholar 

  • Erspamer, V., 1966, Peripheral physiological and pharmacological actions of indolealkylamines, Handbook Exptl. Pharmacol. 19: 245.

    CAS  Google Scholar 

  • European Breast Cancer Group, 1972, Clinical trial of 2-Br-α-ergocryptine (CB 154) in advanced breast cancer, Europ. J. Cancer 8: 155.

    Google Scholar 

  • Evarts, E. V., 1957, A review of the neurophysiological effects of lysergic acid diethylamide (LSD) and other psychotomimetic agents, Ann. N. Y. Acad. Sci. 66: 479.

    Article  PubMed  CAS  Google Scholar 

  • Ezdinli, E. Z., Rouliah, J., Owens, G., and Sokal, J. E., 1968, Effect of high spinal cord section on epinephrine hyperglycemia, Am. J. Physiol. 214: 1019.

    PubMed  CAS  Google Scholar 

  • Fain, J. N., 1973, Biochemical aspects of drug and hormone action on adipose tissue, Pharmacol. Rev. 25: 67.

    PubMed  CAS  Google Scholar 

  • Fanchamps, A., Doepfner, W., Weidmann, H., and Cerletti, A., 1960, Pharmakologische Charakterisierung von Deseril, einem Serotonin-Antagonisten, Schweiz. Med. Wschr. 90: 1040.

    PubMed  CAS  Google Scholar 

  • Farnebo, L.-O., and Hamberger, B., 1971, Drug-induced changes in the release of [3H]-noradrenaline from field stimulated rat iris, Brit. J. Pharmacol. 43: 97.

    Article  CAS  Google Scholar 

  • Fedotin, M. S., and Hartmann, C., 1970, Ergotamine poisoning producing renal arterial spasm, New Engl. J. Med. 283: 518.

    Article  PubMed  CAS  Google Scholar 

  • Florendo, N. T., Barrnett, R. J., and Greengard, P., 1971, Cyclic 3’,5 -nucleotide phosphodiesterase: Cytochemical localization in cerebral cortex, Science 173: 745.

    Article  PubMed  CAS  Google Scholar 

  • Flückiger, E., and Wagner, H. R., 1968, 2-Br-α-ergokryptin: Beeinflussung von Fertilität und Laktation bei der Ratte, Experientia 24: 1130.

    Google Scholar 

  • Fredholm, B., and Rosell, S., 1968, Effects of adrenergic blocking agents on lipid mobilization from canine subcutaneous adipose tissue after sympathetic nerve stimulation, J. Pharmacol. Exptl. Therap. 159: 1.

    CAS  Google Scholar 

  • Freedman, D. X., 1963, Psychotomimetic drugs and brain biogenic amines, Am. J. Psychiat. 119: 843.

    PubMed  CAS  Google Scholar 

  • Freedman, D. X., 1969, The psychopharmacology of hallucinogenic agents, Ann. Rev. Med. 20: 409.

    Article  PubMed  CAS  Google Scholar 

  • Freedman, D. X., Gottlieb, R., and Lovell, R. A., 1970, Psychotomimetic drugs and brain 5- hydroxytryptamine metabolism, Biochem. Pharmacol. 19: 1181.

    Article  CAS  Google Scholar 

  • Fregnan, G. B., and Glässer, A. H., 1968, Structure- activity relationship of various acyl derivatives of 6-methyl-8ß-aminomethyl-10α-ergoline (dihydrolysergamine), Experientia 24: 150.

    Article  PubMed  CAS  Google Scholar 

  • Freis, E. D., Stanton, J. R., Litter, J., Culbertson, J. W., Halperin, M. H., Moister, F. C., and Wilkins, R. W., 1949, The hemodynamic effects of hypotensive drugs in man. II. Dihydroergocornine, J. Clin. Invest. 28: 1387.

    Article  PubMed  CAS  Google Scholar 

  • Fuxe, K., and Owman, C., 1965, Cellular localization of monoamines in the area postrema of certain mammals, J. Comp. Neurol. 125: 337.

    Article  PubMed  CAS  Google Scholar 

  • Fuxe, K., and Sjöqvist, F., 1972, Hypothermic effect of apomorphine in the mouse, J. Pharm. Pharmacol. 24: 702.

    Article  PubMed  CAS  Google Scholar 

  • Gaddum, J. H., and Hameed, K. A., 1954, Drugs which antagonize 5-hydroxytryptamine. Brit. J. Pharmacol. 9: 240.

    PubMed  CAS  Google Scholar 

  • Gaddum, J. H., Hebb, C. O., Silver, A., and Swan, A. A. B., 1953, 5-Hydroxy try ptamine: Pharmacological action and destruction in perfused lungs, Quart. J. Exptl. Physiol. 38: 255.

    Google Scholar 

  • Gessner, P. K., 1970, Pharmacological studies of 5-methoxy-N,N-dimethyltryptamine, LSD and other hallucinogens, in: Psychotomimetic Drugs ( Efron, D.H., ed.) pp. 105–118, Raven Press, New York.

    Google Scholar 

  • Ginzel, K. H., and Kottegoda, S. R., 1953, A study of the vascular actions of 5- hydroxytryptamine, tryptamine, adrenaline and noradrenaline, Quart. J. Exptl. Physiol. 38: 225.

    CAS  Google Scholar 

  • Gothelf, B., and Ellis, S., 1972, Effect of dihydroergotamine (DHE) on liver glycogenolysis and hyperglycemia induced by epinephrine, glucagon and cyclic AMP (cAMP) in the rat, in: Fifth International Congress of Pharmacology, San Francisco, p. 86 (abst.).

    Google Scholar 

  • Graham, J. R., 1967, Methysergide, Practitioner 198:302:

    Google Scholar 

  • Graham, J. R., Suby, H. I., Le Compte, P. M., and Sadowsky, N. L., 1967, Inflammatory fibrosis associated with methysergide therapy, Res. Clin. Stud. Headache 1: 123.

    Google Scholar 

  • Greenfield, A. D. M., 1966, Survey of the evidence for active neurogenic vasodilatation in man, Fed. Proc. 25: 1607.

    PubMed  CAS  Google Scholar 

  • Haefely, W. E., 1969, Effects of catecholamines in the cat superior cervical ganglion and their postulated role as physiological modulators of ganglionic transmission, Prog. Brain Res. 31: 61.

    Article  PubMed  CAS  Google Scholar 

  • Haeusler, G., 1973, Activation of the central pathway of the baroreceptor reflex, a possible mechanism of the hypotensive action of Clonidine, Naunyn-Schmiedeberg’s Arch. Pharmakol. 278: 231.

    Article  CAS  Google Scholar 

  • Haigler, H. J., and Aghajanian, G. K., 1972, Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain, Europ. J. Pharmacol. 21: 53.

    Article  Google Scholar 

  • Harvey, S. C., Wang, C.-Y., and Nickerson, M., 1951, Blockade of epinephrine-induced hyperglycemia, J. Pharmacol. Exptl. Therap. 104: 363.

    Google Scholar 

  • Hasse, H. E., Scheifgen, W., and Schönhöfer, P. S., 1971, Notfallsituationen bei jugendlichen Drogenkonsumenten, Deutsch. Med. Wschr. 96: 449.

    Article  PubMed  CAS  Google Scholar 

  • Hellon, R., 1972, Central transmitters and thermoregulation, in: Essays on Temperature Regulation ( Bligh, J., Moore, R.E., eds.) pp. 71–85, North-Holland, Amsterdam.

    Google Scholar 

  • Heyck, H., 1969, Pathogenesis of migraine, Res. Clin. Stud. Headache 2: 1.

    Google Scholar 

  • Hilton, B. P., and Cumings, J. N., 1972, 5-Hydroxytryptamine levels and platelet aggregation responses in subjects with acute migraine headache, J. Neurol. Neurosurg. Psychiat. 35: 505.

    Google Scholar 

  • Himms-Hagen, J., 1970, Adrenergic receptors for metabolic responses in adipose tissue, Fed. Proc. 29: 1388.

    PubMed  CAS  Google Scholar 

  • Hoffer, A., and Osmond, H., 1967, The Hallucinogens, Academic Press, New York.

    Google Scholar 

  • Hökfelt, T., and Fuxe, K., 1972a, On the morphology and the neuroendocrine role of the hypothalamic catecholamine neurons, in: Brain-Endocrine Interaction. Median Eminence: Structure and Function ( Knigge, K.M., Scott, D. E., Weindl, A., eds.) pp. 181–223, Karger, Basel.

    Google Scholar 

  • Hökfelt, T., and Fuxe, K., 1912b, Effects of prolactin and ergot alkaloids on the tuberoinfundibular dopamine (DA) neurons, Neuroendocrinology 9: 100.

    Google Scholar 

  • Hollister, L. E., 1972, Psychiatric syndromes due to drugs, in: Drug-Induced Diseases, Vol. 4 ( L. Meyler and H. M. Peck, eds.) pp. 561–570, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Horeyseck, G., Jänig, W., Kirchner, F., and Thämer, V., 1972, Electrophysiological studies on the hindlimb vasodilators on anesthesized cats, Pflügers Arch. 332: Suppl. R64.

    Google Scholar 

  • Horita, A., and Dille, J. M., 1954, Pyretogenic effect of lysergic acid diethylamide, Science 120: 1100.

    Article  PubMed  CAS  Google Scholar 

  • Horita, A., and Hamilton, A. E., 1973, The effects of DL-α-methyltyrosine and L-DOPA on the hyperthermic and behavioral actions of LSD in rabbits, Neuropharmacology, 12: 471.

    Article  PubMed  CAS  Google Scholar 

  • Horn, G., and McKay, J. M., 1973, Effects of lysergic acid diethylamide on the spontaneous activity and visual receptive fields of cells in the lateral geniculate nucleus of the cat, Exptl. Brain. Res. 17: 271.

    Article  CAS  Google Scholar 

  • Hornbrook, K. R., 1970, Adrenergic receptors for metabolic responses in the liver, Fed. Proc. 29: 1381.

    PubMed  CAS  Google Scholar 

  • Hornbrook, K. R., and Brody, T. M., 1963, Phosphorylase activity in rat liver and skeletal muscle after catecholamines, Biochem. Pharmacol. 12: 1407.

    Article  PubMed  CAS  Google Scholar 

  • Innes, I. R., 1962, Identification of the smooth muscle excitatory receptors for ergot alkaloids, Brit. J. Pharmacol. 19: 120.

    PubMed  CAS  Google Scholar 

  • Isbell, H., and Gorodetsky, C. W., 1966, Effect of alkaloids of ololiuqui in man, Psychopharmacologia (Berl.) 8: 331.

    CAS  Google Scholar 

  • Isbell, H., and Logan, C. R., 1957, Studies on the diethylamide of lysergic acid. II. Effects of chlorpromazine, azacyclonol and reserpine on the intensity of the LSD-reaction, A.M.A. Arch. Neurol. Psychiat. 77: 350.

    Article  CAS  Google Scholar 

  • Isbell, H., Miner, E. J., and Logan, C. R., 1959, Relationships of psychotomimetic to antiserotonin potencies of congeners of lysergic acid diethylamide (LSD-25), Psychopharmacologia (Berl.) 1: 20.

    Article  CAS  Google Scholar 

  • Ito, A., and Schanberg, S. M., 1972, Central nervous system mechanisms responsible for blood pressure elevation induced by p-chlorphenylalanine, J. Pharmacol. Exptl. Therap. 181: 65.

    CAS  Google Scholar 

  • Iwangoff, P., and Enz, A., 1972, The influence of various dihydroergotamine analogues on cyclic adenosine-3’,5’-monophosphate phosphodiesterase in the grey matter of cat brain in vitro, Agents and Actions 2: 223.

    Article  PubMed  CAS  Google Scholar 

  • Jacobson, C. B., and Berlin, C. M., 1972, Possible reproductive detriment in LSD users, J.A.M.A. 222: 1367.

    Article  PubMed  CAS  Google Scholar 

  • Jouvet, M., 1972, The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle, Ergeb. Physiol. 64: 166.

    PubMed  CAS  Google Scholar 

  • Karlsberg, P., Elliott, H. W., and Adams, J. E., 1963, Effect of various pharmacologic agents on cerebral arteries, Neurology 13: 772.

    Article  PubMed  CAS  Google Scholar 

  • Katz, R. I., and Kopin, I. J., 1969, Effect of D-LSD and related compounds on release of norepinephrine-H3 and serotonin-H3 evoked from brain slices by electrical stimulation, Pharmacol. Res. Commun. 1: 54.

    Article  CAS  Google Scholar 

  • Kebabian, J. W., and Greengard, P., 1971, Dopamine-sensitive adenyl cyclase: Possible role in synaptic transmission, Science 174: 1346.

    Article  PubMed  CAS  Google Scholar 

  • Key, B. J., 1965a, Effect of lysergic acid diethylamide on potentials evoked in the specific sensory pathways, Brit. Med. Bull. 21: 30.

    PubMed  CAS  Google Scholar 

  • Key, B. J., 19656, The effects of drugs in relation to the afferent collateral system of the brain stem, Electroenceph. Clin. Neurophysiol. 18: 670.

    Google Scholar 

  • King, A. R., Seymour, K. A., and Martin, I. L., 1972, Reversal learning enhanced by LSD 25: Correlation with levels of brain amines, Psychopharmacologia (Ber.) 26: Suppl. 121.

    Google Scholar 

  • Koella, W. P., 1969, Neurohumoral aspects of sleep control, Biol. Psychiat. 1: 161.

    PubMed  CAS  Google Scholar 

  • Konzett, H., 1960, Specific antagonism of dibenamine to ergometrine, in: Adrenergic Mechanisms, CIBA Foundation Symposium ( Vane, J.R., Wolstenholme, G.E.W., O’Connor, M., eds.) pp. 463–465, J. & A. Churchill, London.

    Google Scholar 

  • Konzett, H., and Rothlin, E., 1953, Investigations on the hypotensive effect of the hydrogenated ergot alkaloids, Brit. J. Pharmacol. 8: 201.

    PubMed  CAS  Google Scholar 

  • Kovalyov, G. V., 1967, Localization and characteristics of the influence of some neurotropic drugs on the bulbar vasomotor centre, Prog. Brain Res. 20: 187.

    Article  Google Scholar 

  • Krnjević, K., and Phillis, J. W., 1963, Actions of certain amines on cerebral cortical neurones, Brit. J. Pharmacol. 20: 471.

    PubMed  Google Scholar 

  • Levy, B., and Ahlquist, R. P., 1961, An analysis of adrenergic blocking activity, J. Pharmacol. Exptl. Therap. 133: 202.

    CAS  Google Scholar 

  • Levy, B., and Tozzi, S., 1963, The adrenergic receptive mechanism of the rat uterus, J. Pharmacol. Exptl. Therap. 142: 178.

    CAS  Google Scholar 

  • Lewis, P. J., and Lee, M. R., 1972, Renin release in the rabbit produced by ergometrine infusion, Brit. J. Exptl. Pathol. 53: 150.

    CAS  Google Scholar 

  • Libet, B., 1970, Generation of slow inhibitory and excitatory postsynaptic potentials, Fed. Proc. 29: 1945.

    PubMed  CAS  Google Scholar 

  • Lin, R. C., Ngai, S. H., and Costa, E., 1969, Lysergic acid diethylamide: Role in conversion of plasma tryptophan to brain serotonin (5-hydroxytryptamine), Science 166: 237.

    Article  PubMed  CAS  Google Scholar 

  • Lomax, P., and Schönbaum, E. (eds.), 1973, The Pharmacology of Thermoregulation, Karger, Basel.

    Google Scholar 

  • Long, S. Y., 1972, Does LSD induce chromosomal damage and malformations? A review of the literature, Teratology 6: 75.

    Article  PubMed  CAS  Google Scholar 

  • Mabry, P. O., and Campbell, B. A., 1973, Serotonergic inhibition of catecholamine-induced behavioral arousal, Brain Res. 49: 381.

    Article  PubMed  CAS  Google Scholar 

  • McCann, S. M., Kalra, P. S., Donoso, A. O., Bishop, W., Schneider, H. P. G., Fawcett, C. P., and Krulich, L., 1972, The role of monoamines in the control of gonado-tropin and prolactin secretion, in: Brain-Endocrine Interaction. Median Eminence: Structure and Function ( Knigge, K.M., Scott, D.E., Weindl, A., eds.) pp. 224–235, Karger, Basel.

    Google Scholar 

  • McCulloch, M. W., Rand, M. J., and Story, D. F., 1972, Inhibition of 3H-noradrenaline release from sympathetic nerves of guinea-pig atria by a presynaptic α-adrenoceptor mechanism, Brit. J. Pharmacol. 46: 523.

    Article  Google Scholar 

  • Meites, J., and Clemens, J. A., 1972, Hypothalamic control of prolactin secretion, Vitam. Horm. 30: 165.

    Article  PubMed  CAS  Google Scholar 

  • Meites, J., Lu, K. H,. Wuttke, W., Welsch, C. W., Nagasawa, H., and Quadri, S. K., 1972, Recent studies on functions and control of prolactin secretion in rats, Ree. Prog. Horm. Res. 28: 471.

    CAS  Google Scholar 

  • Meldrum, B. S., and Naquet, R., 1971, Effects of psilocybin, dimethyltryptamine, mescaline and various lysergic acid derivatives on the EEG and on photically induced epilepsy in the baboon (Papio papio), Electroenceph. Clin. Neurophysiol. 31: 563.

    Article  PubMed  CAS  Google Scholar 

  • Mellander, S., and Johansson, B., 1968, Control of resistance, exchange and capacitance functions in the peripheral circulation, Pharmacol. Rev. 20: 117.

    PubMed  CAS  Google Scholar 

  • Mellander, S., and Nordenfeit, I., 1970, Comparative effects of dihydroergotamine and noradrenaline on resistance, exchange and capacitance functions in the peripheral circulation, Clin. Sci. 39: 183.

    PubMed  CAS  Google Scholar 

  • Miller, J. W., 1967, Adrenergic receptors in the myometrium, Ann. N.Y. Acad. Sci. 139: 788.

    Article  PubMed  CAS  Google Scholar 

  • Miller, M. D., and Marshall, J. M., 1965, Uterine response to nerve stimulation; relation to hormonal status and catecholamines, Am. J. Physiol. 209: 859.

    PubMed  CAS  Google Scholar 

  • Monachon, M.-A., Burkard, W. P., Jalfre, M., and Haefely, W., 1972, Blockade of central 5- hydroxytryptamine receptors by methiothepin, Naunyn-Schmiedeberg’s Arch. Pharmakol. 274: 192.

    Article  CAS  Google Scholar 

  • Morest, D. K., 1967, Experimental study of the projections of the nucleus of the tractus solitarius and the area postrema of the cat, J. Comp. Neurol. 130: 277.

    Article  PubMed  CAS  Google Scholar 

  • Morgane, P. J., and Stern, W. C., 1972, Relationship of sleep to neuroanatomical circuits, biochemistry and behavior, Ann. N.Y. Acad. Sci. 193: 95.

    Article  PubMed  CAS  Google Scholar 

  • Murad, F., Chi, Y.M., Rail, T. W., and Sutherland, E. W., 1962, Adenyl cyclase III: The effect of catecholamines and choline esters on the formation of adenosine 3’,5’-phosphate by preparations from cardiac muscle and liver, J. Biol. Chem. 237: 1233.

    PubMed  CAS  Google Scholar 

  • Nakano, J., Ishii, T., Oliver, R. D., and Gin, A. C., 1969, Effect of dihydroergotamine and propranolol on dibutyryl cyclic 3’,5’-AMP-induced lipolysis in isolated rat fat cells, Proc. Soc. Exptl. Biol. Med. 132: 150.

    CAS  Google Scholar 

  • Nichols, W. W., 1972, The relationship of chromosome aberrations to drugs, in: Drug-Induced Diseases, Vol. 4 ( L. Meyler and H. M. Peck, eds.) pp. 60–80, Excerpta Medica, Amsterdam.

    Google Scholar 

  • Nishi, S,. 1970, Cholinergic and adrenergic receptors at sympathetic preganglionic nerve terminals, Fed. Proc. 29: 1957.

    PubMed  CAS  Google Scholar 

  • Northrop, G., and Parks, R. E., Jr., 1964, The effects of adrenergic blocking agents and theophylline on 3’,5’-AMP-induced hyperglycemia, J. Pharmacol. Exptl. Therap. 145: 87.

    CAS  Google Scholar 

  • Owen, D. A. A., and Stuermer, E., 1971, Effect of dihydroergotamine (DHG) on the capacitance, resistance and precapillary sphincter vessels of denervated cat skeletal muscle, Brit. J. Pharmacol. 42: 655.

    Google Scholar 

  • Owen, D. A. A., and Stuermer, E., 1972, The effects of Hydergine on acutely denervated cat skeletal muscle vasculature, Nauyn-Schmiedeberg’s Arch. Pharmakol. 272: 395.

    Article  CAS  Google Scholar 

  • Pacha, W., and Salzmann, R., 1970, Inhibition of the re-uptake of neuronally liberated noradrenaline and a-receptor blocking action of some ergot alkaloids, Brit. J. Pharmacol. 38: 439.

    Google Scholar 

  • Palmer, G. C., and Burks, T. F., 1971, Central and peripheral adrenergic blocking actions of LSD and BOL, Europ. J. Pharmacol. 16: 113.

    Article  CAS  Google Scholar 

  • Porter, J. C., Kamberi, I. A., and Ondo, J. G., 1972, Role of biogenic amines and cerebrospinal fluid in the neurovascular transmittal of hypophysiotrophic substances, in: Brain-Endocrine Interaction. Median Eminence: Structure and Function ( Knigge, K.M., Scott, D. E., Weindl, A., eds.) pp. 245–253, Karger, Basel.

    Google Scholar 

  • Purpura, D. P., 1957, Experimental analysis of the inhibitory action of lysergic acid diethylamide on cortical dendritic activity, Ann. N.Y. Acad. Sci. 66: 515.

    Article  PubMed  CAS  Google Scholar 

  • Ramstad, E., 1968, Chemistry of alkaloid formation in ergot, Lloydia 31: 327.

    CAS  Google Scholar 

  • Richardson, B. P., 1973, Evidence for a physiological role of prolactin in osmoregulation in the rat after its inhibition by 2-bromo-α-ergokryptine, Brit. J. Pharmacol. 47: 623.

    Google Scholar 

  • Roberts, M. H. T., and Straughan, D. W., 1967, Excitation and depression of cortical neurones by 5-hydroxytryptamine, J. Physiol. (Lond.) 193: 269.

    CAS  Google Scholar 

  • Rosenberg, F. J., and DiStefano, V., 1962, A central nervous system component of epinephrine hyperglycemia, Am. J. Physiol. 203: 782.

    PubMed  CAS  Google Scholar 

  • Rothlin, E., 1947, The pharmacology of the natural and dihydrogenated alkaloids of ergot, Bull. Schweiz. Akad. Med. Wiss. 2: 249.

    PubMed  CAS  Google Scholar 

  • Rothlin, E., 1957, Pharmacology of lysergic acid diethylamide and some of its related compounds, J. Pharm. Pharmacol. 9: 569.

    Article  PubMed  CAS  Google Scholar 

  • Rothlin, E., Konzett, H., and Cerletti, A., 1954, The antagonism of ergot alkaloids towards the inhibitory response of the isolated rabbit intestine to epinephrine and norepinephrine, J. Pharmacol. Exptl. Therap. 112: 185.

    CAS  Google Scholar 

  • Salmoiraghi, G. C., McCubbin. J. W., and Page, I. H., 1957, Effects of d-lysergic acid diethylamide and its brom derivative on cardiovascular responses to serotonin and on arterial pressure, J. Pharmacol. Exptl. Therap. 119: 240.

    CAS  Google Scholar 

  • Samanin, R., Valzelli, L., and Gumulka, W., 1972, Inhibitory effect of midbrain raphe stimulation on cortical evoked potentials in rats, Psychopharmacologia (Berl.) 24: 373.

    Article  CAS  Google Scholar 

  • Savini, E. C., 1956, The antagonism between 5-hydroxytryptamine and certain derivatives of lysergic acid, Brit. J. Pharmacol. 11: 313.

    PubMed  CAS  Google Scholar 

  • Saxena, P. R., 1972, The effects of antimigraine drugs on the vascular responses by 5- hydroxytryptamine and related biogenic substances on the external carotid bed of dogs: Possible pharmacological implications to their antimigraine action, Headache 12: 44.

    Article  PubMed  CAS  Google Scholar 

  • Schally, A. V., Arimura, A., and Kastin, A. J., 1973, Hypothalamic regulatory hormones, Science 179: 341.

    Article  PubMed  CAS  Google Scholar 

  • Schmitt, H., and Fenard, S., 1970, Effects des alcaloides de l’ergot de seigle sur les centres vasomoteurs et leur inhibition par la Clonidine, Compt. Rend. Soc. Biol. 164: 1006.

    CAS  Google Scholar 

  • Shaar, C. J., and Clemens, J. A., 1972, Inhibition of lactation and prolactin secretion in rats by ergot alkaloids, Endocrinology 90: 285.

    Article  PubMed  CAS  Google Scholar 

  • Share, N. N., 1973, “Alpha” and “beta” adrenergic receptors in the medullary vasomotor center of the cat, Arch. Int. Pharmacodyn. Therap. 202:362.

    Google Scholar 

  • Shemano, I., and Nickerson, M., 1958, Effect of ambient temperature on thermal responses to drugs, Can. J. Biochem. Physiol. 36: 1243.

    Article  PubMed  CAS  Google Scholar 

  • Shields, P. J., and Eccleston, D., 1973, Evidence for the synthesis and storage of 5- hydroxytryptamine in two separate pools in the brain, J. Neurochem. 20: 881.

    Article  PubMed  CAS  Google Scholar 

  • Sicuteri, F., 1967, Vasoneuractive substances and their implication in vascular pain, Res. Clin. Stud. Headache 1: 6.

    CAS  Google Scholar 

  • Sicuteri, F., Buffoni, F., Anselmi, B., and Del Bianco, P. L., 1972, An enzyme (MAO) defect on the platelets in migraine, Res. Clin. Stud. Headache 3: 245.

    Google Scholar 

  • Sicuteri, F., Anselmi, B., and Del Bianco, P. L., 1973, 5-Hydroxytryptamine supersensitivity as a new theory of headache and central pain: A clinical pharmacological approach with N-chlorophenylalanine, Psychopharmacologia (Berl.) 29: 347.

    Google Scholar 

  • Simmonds, M. A., 1970, Effect of environmental temperature on the turnover of 5- hydroxytryptamine in various areas of rat brain, J. Physiol. (Lond.) 211: 93.

    CAS  Google Scholar 

  • Smart, R. G., and Bateman, K., 1967, Unfavourable reactions on LSD: A review and analysis of the available case reports, Can. Med. Ass. J. 97: 1214.

    PubMed  CAS  Google Scholar 

  • Starke, K., 1972, Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart, Naunyn-Schmiedeberg’s Arch. Pharmakol. 274: 18.

    Article  CAS  Google Scholar 

  • Stern, W. C., Morgane, P. J., and Bronzino, J. D., 1972, LSD: Effects on sleep patterns and spiking activity in the lateral geniculate nucleus, Brain Res. 41: 199.

    Article  PubMed  CAS  Google Scholar 

  • Stjärne, L., 1973, Alpha-adrenoceptor mediated feedback control of sympathetic neurotransmitter secretion in guinea-pig vas deferens, Nature New Biol. 241: 190.

    PubMed  Google Scholar 

  • Stöll, B. A., 1972, Brain catecholamines and breast cancer: A hypothesis, Lancet 1: 431.

    Article  PubMed  Google Scholar 

  • Stone, T. W., 1973, Studies on the central nervous system effects of agroclavine, an ergot alkaloid, Arch. Int. Pharmacodyn. Therap. 202: 62.

    CAS  Google Scholar 

  • Tabushi, K., and Himwich, H. E., 1971, Electroencephalographic study of the effects of methysergide on sleep in the rabbit, Electroenceph. Clin. Neurophysiol. 31: 491.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, R. L., Maurer, J. I., and Tinklenberg, J. R., 1970, Management of “bad trips” in an evolving drug scene, J.A.M.A.2\3mA22.

    Google Scholar 

  • Tebecis, A. K., and Di Maria, A., 1972, A re-evaluation of the mode of action of 5- hydroxytryptamine on lateral geniculate neurones: Comparison with catecholamines and LSD, Exptl. Brain. Res. 14: 480.

    Article  CAS  Google Scholar 

  • Ulrich, J., and Siggaard-Andersen, J., 1972, Vascular effects of dihydrogenated ergot alkaloids: Comparative effects of dihydroergostine and dihydroergotamine on the blood flow and the capacitance vessels in the human calf studied by plethysmography, Angiology 22: 622.

    Article  Google Scholar 

  • Uvnäs, B., 1960, Central cardiovascular control, in: Handbook of Physiology, Section 1: Neurophysiology, Vol. II ( J. Field, ed.) pp. 1131–1162, American Physiological Society, Washington, D.C.

    Google Scholar 

  • Voss, E. W., Jr., Babb, J. E., Metzel, P., and Winkelhake, J. L., 1973, In vitro effect of d-lysergic acid diethylamide on immunoglobulin synthesis, Biochem. Biophys. Res. Commun. 50: 950.

    Article  PubMed  CAS  Google Scholar 

  • Vuillon-Cacciuttolo, G., and Balzano, E., 1972, Action de quatre derives de Pergot sur la photosensibilite de l’E.E.G. du Papio papio, J. Pharmacol. (Paris) 3: 31.

    CAS  Google Scholar 

  • Walter, S., Balzano, E., Vuillon-Cacciuttolo, G., and Naquet, R., 1971, Effets comportementaux et electrographiques du diethylamide de l’acide D-lysergique (LSD-25) sur le Papio papio photosensible, Electroenceph. Clin. Neurophysiol. 30: 294.

    Article  PubMed  CAS  Google Scholar 

  • Wang, S. C., 1965, Emetic and antiemetic drugs, in: Physiological Pharmacology, Vol. 2 ( Root, W.S., Hofmann, F. G., eds.) pp. 255–328, Academic Press, London.

    Google Scholar 

  • Weiss, B. L., and Aghajanian, G. K., 1971, Activation of brain serotonin metabolism by heat: Role of midbrain raphe neurons, Brain Res. 26: 37.

    Article  CAS  Google Scholar 

  • White, R. P., Heaton, J. A., and Denton, I. C., 1971, Pharmacological comparison of prostaglandin F2α, serotonin and norepinephrine on cerebrovascular tone of monkey, Europ. J. Pharmacol. 15: 300.

    Article  CAS  Google Scholar 

  • Whitney, B., 1965, A preliminary investigation of the pharmacology of longitudinal muscle strips from human isolated jejunum, J. Pharm. Pharmacol. 17: 465.

    Article  PubMed  CAS  Google Scholar 

  • Willems, J. L., 1972, On the pharmacology of autonomic ganglia, Arch. Int. Pharmacodyn. Therap. 196: Suppl. 244.

    Google Scholar 

  • Wuttke, W., Cassell, E. and Meites, J., 1971, Effects of ergocornine on serum prolactin and LH, and on hypothalamic contents of PIF and LRF, Endocrinology, 88: 737.

    Article  PubMed  CAS  Google Scholar 

  • Ylitalo, P., Tammisto, T., and Pohto, P., 1970, Effect of anaesthesia on the behaviour of exogenous 5HT in area postrema of rat and mouse brain studied by fluorescence microscopy, Ann. Med. Exptl. Fenn. 48: 94.

    CAS  Google Scholar 

  • Yui, T., and Takeo, Y., 1958, Neuropharmacological studies on a new series of ergot alkaloids, Jap. J. Pharmacol. 7: 157.

    Article  PubMed  CAS  Google Scholar 

  • Yui, T., and Takeo, Y., 1964, Increase in anti-5HT activity by 1-methylation of clavine-type ergot alkaloids, Jap. J. Pharmacol. 14: 107.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Medical Research Council Neuropharmacology Unit The Medical School, University of Birmingham, Birmingham, England

    P. B. Bradley & I. Briggs

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  1. Department of Pharmacology College of Physicians and Surgeons, Columbia University, New York, New York, USA

    Lance L. Simpson

  2. Department of Psychiatry College of Physicians and Surgeons, Columbia University, New York, New York, USA

    Lance L. Simpson

  3. Department of Pharmacology, Australian National University, Canberra, Australia

    David R. Curtis

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Bradley, P.B., Briggs, I. (1974). Ergot Alkaloids and Related Substances. In: Simpson, L.L., Curtis, D.R. (eds) Poisons of Plant Origin. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2943-5_7

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