• Ronald W. Ryall


Nicotine is l-methyl-2-(3-pyridyl)pyrrolidine. It has an empirical formula C10H14N2 and a molecular weight of 162.23. Its structural formula is shown in Fig. 1, from which it will be seen that nicotine can exist as two optically active isomers, with the asymmetrical carbon atom at position 2 in the pyrrolidine ring. The natural (−) isomer has an S-configuration and is more potent that the (+)-R isomer (Barlow, 1968).


Nerve Cell Nerve Terminal Nicotinic Receptor Carotid Body Muscle Spindle 
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  1. Ambache, N., 1951, Unmasking, after cholinergic paralysis by botulinum toxin, of a reversed action of nicotine on the mammalian intestine, revealing the probable presence of local inhibitory ganglion cells in the enteric plexus, Brit. J. Pharmacol. 6: 51.PubMedGoogle Scholar
  2. Ambache, N., and Edwards, J., 1951, Reversed nicotine action on the intestine by atropine, Brit. J. Pharmacol. 6: 311.PubMedGoogle Scholar
  3. Ambache, N., and Roche e Silva, M., 1951, Analysis of certain interactions of nicotine with bradykinin and histamine, Brit. J. Pharmacol. 6: 68.PubMedGoogle Scholar
  4. Ambache, N., Perry, W. L. M., and Robertson, R. A., 1956, The effect of muscarine on perfused superior cervical ganglia of cats, Brit. J. Pharmacol. 11: 442.PubMedGoogle Scholar
  5. Applegren, L. E., Hansson, E., and Schmitterlow, C. G., 1963, Localization of radio-activity in the superior cervical ganglion of cats following injection of C14 labelled nicotine, Acta Physiol. Scand. 59: 330.CrossRefGoogle Scholar
  6. Ariens, E. J., and van Rossum, J. M., 1956, Nicotine induced contracture of the rectus abdominis muscle of the frog, Acta Physiol. Pharmacol. Neerl. 5: 259.PubMedGoogle Scholar
  7. Armitage, A. K., and Hall, G. H., 1969, Mode of action of intravenous nicotine in causing a fall of blood pressure in the cat, Europ. J. Pharmacol. 7: 23.CrossRefGoogle Scholar
  8. Armitage, A. K., and Milton, A. S., 1965, The release of adrenaline by nicotine from the adrenal medulla, in: Tobacco Alkaloids and Related Compounds, Proceedings of Fourth International Symposium at Wenner-Gren Center, Stockholm, 1964, Pergamon Press, Oxford.Google Scholar
  9. Armitage, A. K., Hall, G. H., and Morrison, C. F., 1968, Pharmacological basis for the smoking habit, Nature (Lond.) 217: 331.CrossRefGoogle Scholar
  10. Armitage, A. K., Hall, G. H., and Sellers, C. M., 1969, Effects of nicotine on electrocortical activity and acetylcholine release from the cat cerebral cortex, Brit. J. Pharmacol. 35: 152.CrossRefGoogle Scholar
  11. Bacq, Z. M., and Brown, G. L., 1937, Pharmacological experiments on mammalian voluntary muscle, in relation to the theory of chemical transmission, J. Physiol. (Lond.) 89: 45.Google Scholar
  12. Barlow, R. B., 1968, Introduction to Chemical Pharmacology, Methuen, London.Google Scholar
  13. Beränek, R., and Vyskocil, F., 1967, The action of tubocurarine and atropine on the normal and denervated rat diaphragm, J. Physiol. (Lond.) 188: 53.Google Scholar
  14. Bradley, P. B., 1968, Synaptic transmission in the central nervous system and its relevance for drug action, Internat. Rev. Neurobiol. 11: 1.CrossRefGoogle Scholar
  15. Brown, D. A., and Halliwell, J. V., 1972, Intracellular pH in rat isolated superior cervical ganglia in relation to nicotine depolarization and nicotine uptake, Brit. J. Pharmacol. 45: 349.CrossRefGoogle Scholar
  16. Brown, D. A., and Scholfield, C. N., 1972, Nicotine washout rates from isolated rat ganglia in relation to recovery from nicotine depolarization, Brit. J. Pharmacol. 45: 29.CrossRefGoogle Scholar
  17. Brown, D. A., Jones, K. B., Halliwell, J. V., and Quilliam, J. P., 1970, Evidence against a presynaptic action of acetylcholine during ganglionic transmission, Nature (Lond.) 226: 958.CrossRefGoogle Scholar
  18. Brown, G. L., and Gray, J. A. B., 1948, Some effects of nicotine-like substances and their relation to sensory nerve endings, J. Physiol. (Lond.) 107: 306.Google Scholar
  19. Burnstock, G., 1972, Purinergic nerves, Pharmacol. Rev. 24: 509.PubMedGoogle Scholar
  20. Byck, R., 1961, The effect of hexamethonium on the carotid chemoreceptor response to nicotine and cyanide, Brit. J. Pharmacol. 16: 15.PubMedGoogle Scholar
  21. Chiou, C. Y., Long, J. P., Potrepka, R., and Spratt, J. L., 1970, The ability of various nicotinic agents to release acetylcholine from synaptic vesicles, Arch. Int. Pharmacodyn. Therap. 187: 88.Google Scholar
  22. Collier, B., and Katz, H. S., 1970, The release of acetylcholine by acetylcholine in the cat’s superior cervical ganglion. Brit. J. Pharmacol. 39: 428.CrossRefGoogle Scholar
  23. Coon, J. M., and Rothman, S., 1940, The nature of the pilomotor response to acetylcholine; some observations on the pharmacodynamics of the skin, J. Pharmacol. Exptl. Therap. 68: 301.Google Scholar
  24. Crawford, J. M., and Curtis, D. R., 1966, Pharmacological studies on feline Betz cells, J. Physiol. (Lond.) 186: 121.Google Scholar
  25. Crawford, J. M., Curtis, D. R., Voorhoeve, P. E., and Wilson, V. J., 1966, Acetylcholine sensitivity of cerebellar neurones in the cat, J. Physiol. (Lond.) 186: 139.Google Scholar
  26. Crawshaw, H. A., 1944, Nicotine poisoning in lambs, Vet. Ree. 56: 276.Google Scholar
  27. Curtis, D. R., and Crawford, J. M., 1969, Central synaptic transmission-Microelectrophoretic studies, Ann. Rev. Pharmacol. 9: 209.PubMedCrossRefGoogle Scholar
  28. Curtis, D. R., and Eccles, R. M., 1958, The excitation of Renshaw cells by pharmacological agents applied electrophoretically, J. Physiol. (Lond.) 141: 435.Google Scholar
  29. Curtis, D. R., and Ryall, R. W., 1966α, The excitation of Renshaw cells by cholinomimetics, Exptl. Brain Res. 2: 49.Google Scholar
  30. Curtis, D. R., and Ryall, R. W., 1966b, The acetylcholine receptors of Renshaw cells, Exptl. Brain Res. 2: 66.Google Scholar
  31. Curtis, D. R., and Ryall, R. W., 1966c, The synaptic excitation of Renshaw cells, Exptl. Brain Res. 2: 81.Google Scholar
  32. Curtis, D. R., Eccles, J. C., and Eccles, R. M., 1957, Pharmacological studies on spinal reflexes, J. Physiol. (Lond.) 136: 420.Google Scholar
  33. Curtis, D. R., Ryall, R. W., and Watkins, J. C., 1966, The action of cholinomimetics on spinal interneurones, Exptl. Brain Res. 2: 97.Google Scholar
  34. Dale, H. H., and Gasser, H. S., 1926, The pharmacology of denervated mammalian muscle. Part I. The nature of the substances producing contracture, J. Pharmacol. Exptl. Therap. 29: 53.Google Scholar
  35. de Groat, W. C., and Ryall, R. W., 1969, Reflexes to sacral parasympathetic neurones concerned with micturition in the cat, J. Physiol (Lond.) 200: 87.Google Scholar
  36. Dettbarn, W. D., 1966, in: Biochemistry and Pharmacology of the Basal Ganglia, (E. Costa, L. J. Cote, and M. D. Yahr, eds.) pp. 57–61, Raven Press, New York.Google Scholar
  37. Douglas, W. W., 1952, The effect of a ganglion-blocking drug, hexamethonium, on the response of the cat’s carotid body to various stimuli, J. Physiol. (Lond.) 118: 373.Google Scholar
  38. Douglas, W. W., and Ritchie, J. M., 1960, The excitatory action of acetylcholine on cutaneous non-myelinated fibrers, J. Physiol. (Lond.) 150: 501.Google Scholar
  39. Eccles, J. C., Eccles, R. M., and Fatt, P., 1956, Pharmacological investigations on a central synapse operated by acetylcholine, J. Physiol. (Lond.) 131: 154.Google Scholar
  40. Eccles, R. M., 1956, The effect of nicotine on synaptic transmission in the sympathetic ganglion, J. Pharmacol. Exptl. Therap. 118: 26.Google Scholar
  41. Eccles, R. M., and Libet, B., 1961, Origin and blockade of the synaptic responses of curarized sympathetic ganglia, J. Physiol. (Lond.) 157: 484.Google Scholar
  42. Eyzaguirre, C., and Koyano, H., 1965, Effects of some pharmacological agents on chemoreceptor discharges, J. Physiol. (Lond.) 178: 410.Google Scholar
  43. Eyzaguirre, C., Nishi, K., and Fidone, S., 1972, Chemoreceptor synapses in the carotid body, Fed. Proc. 31: 1385.PubMedGoogle Scholar
  44. Feldberg, W., and Gaddum, J. H., 1934, The chemical transmitter at synapses in a sympathetic ganglion, J. Physiol. (Lond.) 81: 305.Google Scholar
  45. Feldberg, W., and Vartiainen, A., 1935, Further observations on the physiology and pharmacology of a sympathetic ganglion, J. Physiol. (Lond.) 83: 103.Google Scholar
  46. Feurt, S. D., Jenkins, J. H., Haynes, F. A., and Crockford, H. A., 1958, Pharmacology and toxicology of nicotine with special reference to species variation, Science 127: 1054.PubMedCrossRefGoogle Scholar
  47. Fischer, E., Silvette, H., Larson, P., and Haag, H. B., 1960, Effect of nicotine and tobacco on muscle function, Am. J. Phys. Med. 39: 63.PubMedCrossRefGoogle Scholar
  48. Fletcher, C. M., and Horn, D., 1971, Smoking and Health World Health Organization (WHO). Printed for Her Majesty’s Stationery Office by J. W. Arrowsmith Ltd., Bristol, England.Google Scholar
  49. Gaede, D,. 1940, Über die Wirkung fortgesetzer Nikotininjektionen bei Kanarienvögeln, Arch. Exptl. Pathol. Pharmakol. 196: 164.CrossRefGoogle Scholar
  50. Gasser, H. S., 1930, Contractures of skeletal muscle, Physiol. Rev. 10: 35.Google Scholar
  51. Gebber, G. L., 1968, Dissociation of depolarization and ganglionic blockade induced by nicotine, J. Pharmacol. Exptl. Therap. 160: 124.Google Scholar
  52. Ginsborg, B. C., 1971, On the presynaptic acetylcholine receptors in sympathetic ganglia of the frog, J. Physiol (Lond.) 216: 237.Google Scholar
  53. Ginsborg, B. C., and Guerro, S. J., 1964, On the action of depolarizing drugs on sympathetic ganglion cells of the frog, J. Physiol. (Lond.) 172: 189.Google Scholar
  54. Ginzel, K. H., Eldred, E., and Sasaki, Y., 1969, Comparative study of the actions of nicotine and succinylcholine on the monosynaptic reflex and spindle afferent activity, Internat. J. Neuropharmacol. 8: 515.CrossRefGoogle Scholar
  55. Ginzel, K. H., Klupp, H., Sotrmann, H., and Werner, G., 1953, Hemmung des Patellarsehnen-reflexes durch zentral und peripher wirkende Stoffe, Arch. Exptl. Pathol. Pharmakol. 218: 308–312.Google Scholar
  56. Goldfarb, J., 1971, Action of nicotine on reflexes in spinal cats, Neuropharmacology 10: 399.PubMedCrossRefGoogle Scholar
  57. Goldfarb, J., and Sharpless, S. K., 1971, Effects of nicotine and recurrent inhibition on monosynaptic reflexes in acute and chronic spinal cats, Neuropharmacology 10: 413.PubMedCrossRefGoogle Scholar
  58. Goodman, L. S., and Gilman, A., 1970, The Pharmacological Basis of Therapeutics, 4th ed., Macmillan, London.Google Scholar
  59. Gray, J. A. B., and Diamond, J., 1957, Pharmacological properties of sensory receptors and their relation to those of the autonomic nervous system, Brit. Med. Bull. 13: 185.PubMedGoogle Scholar
  60. Hall, G. H., 1968, Influence of nicotine on intraventricular cerebrospinal fluid pressure in the anaesthetized cat, Internat. J. Neuropharmacol. 7: 365.CrossRefGoogle Scholar
  61. Hall, G. H., 1970, Effects of nicotine and tobacco smoke on the electrical activity of the cerebral cortex and olfactory bulb, Brit. J. Pharmacol. 38: 271.CrossRefGoogle Scholar
  62. Hall, G. H., 1972α, Effects of nicotine, carbon monoxide and tobacco smoke on regional blood flow in the cerebral cortex, Europ. J. Pharmacol. 19: 385.Google Scholar
  63. Hall, G. H., 19726, Changes in body temperature produced by cholinomimetic substances injected into the cerebral ventricles of unanaesthetized cats, Brit. J. Pharmacol. 44: 634.Google Scholar
  64. Hall, G. H., and Myers, R. D., 1972, Temperature changes produced by nicotine injected into the hypothalamus of the conscious monkey, Brain Res. 37: 241.PubMedCrossRefGoogle Scholar
  65. Hall, G. H., and Turner, D. M., 1972, Effects of nicotine on the release of 3H-noradrenaline from the hypothalamus, Biochem. Pharmacol. 21: 1829.PubMedCrossRefGoogle Scholar
  66. Hanzlik, P. J., and Wood, D. A., 1929, The mechanism of digitalis-emesis in pigeons, J. Pharmacol. Exptl. Therap. 37: 67.Google Scholar
  67. Herxheimer, N., 1965, Bronchoconstrictor agents and their antagonists in the intact guinea- pig, Arch. Int. Pharmacodyn. Therap. 106: 371.Google Scholar
  68. Heymans, C., Bouckaert, J. J., and Dautrebande, L., 1931, Sinus carotidien et reflexes respiratoires. III. Sensibilite des sinus carotidiens aux substances chimiques. Action stimulante respiratoire reflexe du sulfure de sodium, du cyanure du potassium, de la nicotine et de la lobeline, Arch. Int. Pharmacodyn. Therap. 40: 54.Google Scholar
  69. Hoffman, D., and Wynder, E. C., 1972, Smoke of cigarettes and little cigars: An analytical comparison, Science 178: 197.CrossRefGoogle Scholar
  70. Hofstatter-Von, R., 1923, Experimentelle Studie über die Einwirkung des Nicotins auf die Keimdrüsen und auf die Fortpflanzung, Virchow’s Arch. 244: 183.CrossRefGoogle Scholar
  71. Hunt, C. C., 1952, Drug effects on mammalian muscle spindles, Fed. Proc. 11: 75.Google Scholar
  72. Jordan, L. M., and Phillis, J. W., 1972, Acetylcholine inhibition in the intact and chronically isolated cerebral cortex, Brit. J. Pharmacol. 45: 584.CrossRefGoogle Scholar
  73. Katz, B., and Thesleff, S., 1957, A study of desensitization produced by acetylcholine at the motor and plate, J. Physiol. (Lond.) 138: 63.Google Scholar
  74. Keele, C. A., and Armstrong, D., 1964, Substances Producing Pain and Itch, Edward Arnold, London.Google Scholar
  75. Knox, G. V., Campbell, C., and Lomax, P., 1973, The effects of acetylcholine and nicotine on unit activity in the hypothalamic thermoregulatory centres of the rat, Brain Res. 51: 215.PubMedCrossRefGoogle Scholar
  76. Krivoy, W. A., and Willis, J. H., 1956, Adaptation to constant concentrations of acetylcholine, J. Pharmacol. Exptl. Therap. 116: 220.Google Scholar
  77. Krnjevic, K., and Phillis, J. W., 1963, Pharmacological properties of acetylcholine-sensitive cells in the cerebral cortex, J. Physiol. (Lond.) 166: 328.Google Scholar
  78. Kuffler, S. W., 1943, Specific excitability of the end plate region in normal and denervated muscle, J. Neurophysiol. 6: 99.Google Scholar
  79. Laffan, R. J., and Borison, H. L., 1957, Emetic action of nicotine and lobeline, J. Pharmacol. Exptl. Therap. 121: 468.Google Scholar
  80. Langley, J. N., 1890α, On the physiology of salivary secretion. Part VI. Chiefly upon the connection of peripheral nerve cells with the nerve fibres which run to the sublingual and sub-maxillary glands, J. Physiol. (Lond.) 11: 123.Google Scholar
  81. Langley, J. N., 1890b, Action of various poisons upon nerve fibres and peripheral nerve cells, J. Physiol. (Lond.) 11: 509.Google Scholar
  82. Langley, J. N., 1896, On the nerve cell connections of the splanchnic nerve fibres, J. Physiol. (Lond.) 20: 223.Google Scholar
  83. Langley, J. N., 1899–1900, On axon reflexes in the preganglionic fibres of the sympathetic system, J. Physiol. (Lond.) 25: 364.Google Scholar
  84. Langley, J. N., 1901, On the stimulation and paralysis of nerve cells and of nerve endings. Part I, J. Physiol (Lond.) 21: 224.Google Scholar
  85. Langley, J. N., 1905, On the reaction of cells and of nerve endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari, J. Physiol. (Lond.) 33: 374.Google Scholar
  86. Langley, J. N., 1906, On nerve endings and on special excitable substances in cells, Proc. Roy. Soc. Lond. Ser. B 78: 170.CrossRefGoogle Scholar
  87. Langley, J. N., 1907–1908, On the contraction of muscle, chiefly in relation to the presence of “receptive” substances. Part 1, J. Physiol. (Lond.) 36: 347.Google Scholar
  88. Langley, J. N., 1908α, On the contraction of muscle, chiefly in relation to the presence of “receptive” substances. Part 11, J. Physiol. (Lond.) 37: 165.Google Scholar
  89. Langley, J. N., 19086, On the contraction of muscle, chiefly in relation to the presence of “receptive” substances. Part III. The reaction of frog’s muscle to nicotine after denervation, J. Physiol. (Lond.) 37: 285.Google Scholar
  90. Langley, J. N., 1909, On the contraction of muscle, chiefly in relation to the presence of “receptive” substances. Part IV. The effect of curari and of some other substances on the nicotine response of the sartorius and gastrocnemius muscles of the frog, J. Physiol. (Lond.) 39: 235.Google Scholar
  91. Langley, J. N., 1910a, Note on the action of nicotine and curari on the receptive substance of the frog’s rectus abdominis muscle, J. Physiol. Lond. 40:lix.Google Scholar
  92. Langley, J. N., 1910b, Inhibitory fibres for the bladder in the pelvic nerve: Antagonism by curare of the nicotine stimulations of nerve cells, J. Physiol. (Lond.) 40:lxii.Google Scholar
  93. Langley, J. N,. 1910c, The sympathetic innervation of the skin of the frog, J. Physiol. (Lond.) 40:lxiii.Google Scholar
  94. Langley, J. N., 1911, The action of salts on the neural and non-neural regions of muscle, J. Physiol. (Lond.) 42:xxiv.Google Scholar
  95. Langley, J. N., 1911–1912, The effect of various poisons upon the response to nervous stimuli chiefly in relation to the bladder, J. Physiol. (Lond.) 43: 125.Google Scholar
  96. Langley, J. N., 1912–1913, Observations on vascular reflexes chiefly in relation to the effect of strychnine, J. Physiol. (Lond.). 45: 239.Google Scholar
  97. Langley, J. N., 1913, The protracted contraction of muscle caused by nicotine and other substances chiefly in relation to rectus abdominis muscle of the frog, J. Physiol. (Lond.) 47: 159.Google Scholar
  98. Langley, J. N., 1914, The antagonism of curari and nicotine in skeletal muscle, J. Physiol. (Lond.) 48: 73.Google Scholar
  99. Langley, J. N., 1918–1919, Persistence of the central somatic effect of strychnine after a large dose of nicotine, J. Physiol. (Lond.) 52:xliv.Google Scholar
  100. Langley, J. N., and Anderson, H. K., 1894, On reflex action from sympathetic ganglia, J. Physiol. (Lond.) 14: 410.Google Scholar
  101. Langley, J. N., and Anderson, H. K., 1895, The innervation of the pelvic and adjoining viscera, Part V. Position of nerve cells on the course of the efferent nerve fibres. J. Physiol. (Lond.) 19: 131.Google Scholar
  102. Langley, J. N., and Dickinson, W. L., 1889a, On the local paralysis of peripheral ganglia, and on the connexion of different classes of nerve fibres with them, Proc. Roy. Soc. Lond. 46: 432.Google Scholar
  103. Langley, J. N., and Dickinson, W. L., 18896, On the progressive paralysis of the different classes of nerve cells in the superior cervical ganglion, Proc. Roy. Soc. Lond. 47: 379.Google Scholar
  104. Langley, J. N., and Dickinson, W. L., 1890, Pituri and nicotine, J. Physiol. (Lond.) 11: 265.Google Scholar
  105. Langley, J. N., and Sherrington, C. S., 1891, On pilo-motor nerves, J. Physiol. (Lond.) 12: 278.Google Scholar
  106. Larson, P. S., Haag, H. B., and Silvette, H., 1961, Tobacco: Experimental and Clinical Studies, Williams and Wilkins, Baltimore.Google Scholar
  107. Lehman, A. J., 1948, The toxicology of the newer agricultural chemicals, Bull. Ass Food Drug Officials 12: 82.Google Scholar
  108. Lundberg, A., and Thesleff, S., 1953, Dual action of nicotine on the sympathetic ganglion of the cat, Acta Physiol. Scand. 28: 218.PubMedCrossRefGoogle Scholar
  109. McCance, I., and Phillis, J. W., 1968, Cholinergic mechanisms in the cerebellar cortex, Internat. J. Neuropharmacol. 7: 447.CrossRefGoogle Scholar
  110. Mclntyre, A. R., and Braverman, I., 1947, The action of certain drugs on an actomyosin-ATP system, Fed. Proc. 6: 158.Google Scholar
  111. Merck Index, 1968, 8th ed., Merck & Co., Rahway, N.J.Google Scholar
  112. Meyer, J., 1891, Beitrag zur Kenntnis der Wirkung des Nicotins, Inaugural Dissertation Kiel. Quoted by Larson et al. (1961).Google Scholar
  113. Miledi, R., 1960, The acetylcholine sensitivity of frog muscle fibres after complete or partial denervation, J. Physiol. (Lond.) 151: 1.Google Scholar
  114. Paintal, A. S., 1954, The response of gastric stretch receptors and certain other abdominal and thoracic vagal receptors to some drugs, J. Physiol. (Lond.) 126: 271.Google Scholar
  115. Paintal, A. S., 1955, Impulses in vagal afferent fibres from specific pulmonary deflation receptors: The response of these receptors to phenyl diguanide, potato starch, 5-hydroxytryptamine, and nicotine, and their role in respiratory and cardiovascular reflexes, Quart. J. Exptl. Physiol. (Lond.) 40: 89.Google Scholar
  116. Paintal, A. S., 1964, Effects of drugs on vertebrate mechanoreceptors, Pharmacol. Rev. 16: 341.PubMedGoogle Scholar
  117. Paintal, A. S., 1971, Action of drugs on sensory nerve endings, Ann. Rev. Pharmacol. 11: 231.PubMedCrossRefGoogle Scholar
  118. Paton, W. D. M., 1961, A theory of drug action based on the rate of drug-receptor combination, Proc. Roy. Soc. Lond. B 154: 21.CrossRefGoogle Scholar
  119. Paton, W. D. M., and Perry, W. L. M., 1951, Depolarization and transmission block in the cat’s superior cervical ganglion, J. Physiol. (Lond.) 112: 48 P.Google Scholar
  120. Paton, W. D. M., and Perry W. L. M., 1953, The relationship between depolarization and block in the cat’s superior cervical ganglion, J. Physiol. (Lond.) 119: 43.Google Scholar
  121. Phillis, J. W., 1971, The pharmacology of thalamic and geniculate neurons, Internat. Rev. Neurobiol. 14: 1.CrossRefGoogle Scholar
  122. Phillis, J. W., and York, D. H., 1968a, Pharmacological studies on a cholinergic inhibition in the cerebral cortex, Brain Res. 10: 297.PubMedCrossRefGoogle Scholar
  123. Phillis, J. W., and York, D. H., 19686, Nicotine, smoking and cortical inhibition, Nature (Lond.) 219: 89.Google Scholar
  124. Purinton, T., Fletcher, T., and Bradley, W., 1971, Sensory perikarya in autonomic ganglia, Nature New Biol. 231: 63.PubMedGoogle Scholar
  125. Rang, H. R., and Ritter, J. M., 1969, A new kind of drug antagonism: Evidence that agonists cause a molecular change in acetylcholine receptors, Mol. Pharmacol. 5: 394.PubMedGoogle Scholar
  126. Rang, H. R., and Ritter, J. M., 1970a, On the mechanism of desensitization at cholinergic receptors, Mol. Pharmacol. 6: 357.PubMedGoogle Scholar
  127. Rang, H. R., and Ritter, J. M., 1970b, The relationship between desensitization and the metaphilic effect at cholinergic receptors, Mol. Pharmacol. 6: 383.PubMedGoogle Scholar
  128. Riker, W. K., 1968, Ganglion cell depolarization and transmission block by ACH: Independent events, J. Pharmacol. Exptl, The rap. 159: 345.Google Scholar
  129. Riker, W. F.-, and Okamoto, M., 1969, Pharmacology of motor nerve terminals, Ann. Rev. Pharmacol. 9: 173.PubMedCrossRefGoogle Scholar
  130. Ryall, R. W., Piercey, M. F., Goldfarb, J., and Polosa, C., 1972, Excitation of Renshaw cells in relation to orthodromic and antidromic excitation of motoneurones, J. Neurophysiol. 35: 137.PubMedGoogle Scholar
  131. Sampson, S. R., 1971, Effects of mecamylamine on responses of carotid body chemoreceptors in vivo to physiological and pharmacological stimuli, J. Physiol. (Lond.) 212: 655.Google Scholar
  132. Schweitzer, A., and Wright, S., 1938, Action of nicotine on the spinal cord, J. Physiol. (Lond.) 94: 136.Google Scholar
  133. Silvette, H., Hoff, E. C., Larson, P. S., and Haag, H. B., 1962, The actions of nicotine on the central nervous system functions, Pharmacol. Rev. 14: 137.PubMedGoogle Scholar
  134. Thesleff, S., 1955, The mode of neuromuscular block caused by acetylcholine, nicotine, decamethonium and succinylcholine, Acta Physiol. Scand. 34: 218.CrossRefGoogle Scholar
  135. Trendelenburg, U., 1966, Observations on the ganglion stimulating action of angiotensin and bradykinin, J. Pharmacol. Exptl. Therap. 154: 418.Google Scholar
  136. Udenfriend, S., 1969. Fluorescence Assay in Biology and Medicine, Vol. II, Academic Press, New York and London.Google Scholar
  137. Verhey, B. A., and Voorhoeve, P. E., 1963, Activation of group IA and group II muscle spindle afferents by succinylcholine and other cholinergic drugs, Acta Physiol. Pharmacol. Neerl. 12: 23.PubMedGoogle Scholar
  138. Volle, R. L., 1966a, Muscarinic and nicotine stimulant actions at autonomic ganglia, in: International Encyclopedia of Pharmacology and Therapeutics, Sect. 12, Vol. 1, Pergamon Press, Oxford.Google Scholar
  139. Volle, R. L., 19666, Modification by drugs of synaptic mechanisms in autonomic ganglia, Pharmacol. Rev. 18: 839.Google Scholar
  140. Volle, R. L., 1969, Ganglionic transmission, Ann. Rev. Pharmacol. 9: 135.PubMedCrossRefGoogle Scholar
  141. Volle, R. L., and Hancock, J. C., 1970, Transmission in sympathetic ganglia, Fed. Proc. 29: 1913.PubMedGoogle Scholar
  142. Yamamoto, K., and Domino, E. F., 1965, Nicotine-induced EEG and behavioural arousal, Internat. J. Neuropharmacol. 4: 359.CrossRefGoogle Scholar

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© Plenum Press, New York 1974

Authors and Affiliations

  • Ronald W. Ryall
    • 1
  1. 1.Department of PharmacologyUniversity of CambridgeCambridgeEngland

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